J Clin Oncol: Long-term efficacy of Margetuximab-cmkb in the treatment of metastatic HER2-positive breast cancer
Time of Update: 2022-11-14
The SOPHIA study, a randomized, open-label, pivotal Phase 3 clinical trial of Margetuximab in the treatment of breast cancer, showed that Margetuximab+ chemotherapy significantly reduced the risk of disease progression or death by 24% compared with trastuzumab + chemotherapy in patients with metastatic HER2-positive breast cancer who had previously received multiple anti-HER2 regimens.
European Radiology: AI-based correction of brain CT motion artifacts
Time of Update: 2022-10-31
SSIM, structural similarity index; PSNR, peak signal-to-noise ratio; MSE, mean squared error; MI, mutual informationIn summary, this study has been clinically verified by an AI-based cranial CT reconstruction algorithm.
Nature Medicine: Breakthrough in stem cell + gene therapy for frostbite
Time of Update: 2022-10-03
They conducted their first human clinical trial using this engineered neural progenitor cell (CNS10-NPC-GDNF), and through a 12-month clinical Phase 1/2a trial, as well as follow-up results from patients, they found that the new therapy was safe for ALS patients.
Under the continuous investment in research and development, the income of many pharmaceutical companies in innovative drugs has reached a new high
Time of Update: 2022-09-14
【Pharmaceutical Network Industry News】At present, the 2022 interim report of listed pharmaceutical companies has been disclosed one after another, and it can be seen from the reports of many pharmaceutical companies that through continuous investment in research and development, a number of pharmaceutical companies have achieved great results in innovative drugs, driving high revenue growth in the first half of the year.
A caffeine metabolite called 7-methylxanthine ("7-MX") may slow the progression of myopia
Time of Update: 2022-09-08
21 mm 7-MX treatment was associated with a decrease in the rate of myopia progression and a decrease in the length of the eye axis, and the higher the dose, the better the effect appearedBased on the data obtained, the researchers modeled the refractive errors evaluated longitudinally.
There are more than 50,000 confirmed cases of monkeypox worldwide, how many do you know
Time of Update: 2022-09-07
Human monkeypox cases are mainly distributed in the rainforests of central and western Africa, and since 1970 there have been monkeypox-like viruses in 11 African countries (Benin, Democratic Republic of the Congo, Republic of the Congo, Cameroon, Central African Republic, Nigeria, Côte d'Ivoire, Liberia, Sierra Leone, Gabon and South Sudan).
Sanofi's Sarclisa combination therapy has significant efficacy in the treatment of multiple myeloma
Time of Update: 2022-08-15
The trial is evaluating the addition of the CD38-targeting antibody Sarclisa (isatuximab) to the proteasome inhibitor Kyprolis (carfilzomib, cardinal) in patients with relapsed multiple myeloma (MM) who have received 1-3 prior anti-myeloma treatments.
The 2nd China-made Wanbang Pharmaceutical "Insulin Lispro" was approved for listing
Time of Update: 2022-03-09
On January 26, NMPA issued an approval document showing that Wanbang Pharmaceutical's insulin lispro injection was approved for marketing, becoming the second domestic company .
Previously, only Lilly and Gan & Lee's insulin lispro were approved for marketing in China .
The world's first
Time of Update: 2022-03-09
Article source: Medical Cube InfoAuthor: PickupOn January 20, the drug clinical trial registration and information publicity platform showed that Hengrui Medicine registered the phase I clinical study of CD112R/TIGIT dual anti-SHR-2002, aiming to evaluate the candidate drug alone or in combination with other anti-tumor treatments in the late stage.
In January 2022, the FDA approved two innovative drugs for insomnia and atopic dermatitis respectively
Time of Update: 2022-02-22
About 80% of the drug is eliminated after nighttime sleep On January 15, 2022, Pfizer announced that the US FDA approved its JAK1 inhibitor Cibinqo (abrocitinib) for the treatment of Adult patients with relapsing moderate-to-severe atopic dermatitis - who should not be treated with existing systemic therapies or whose condition is not controlled by these therapies .
Fosun Pharma Subsidiary Launches Phase 3 Clinical Trials of 2 New Drugs in China
Time of Update: 2022-02-19
Retrieved Jan 20, 2022, from http:// 2022-01-20 Fuchuang Medicine's new anti-tumor drug CDK4/6 inhibitor, the first patient in the US Phase I clinical trial.
ARD: Baseline Predictors of Treatment Success in Different Types of Rheumatoid Arthritis
Time of Update: 2022-01-22
Methods : Investigators used data from three rheumatoid arthritis (RA) trials (one for the primary analysis and two for the validation) to analyze patient and disease characteristics, core set measures, and composite index pairs to achieve different outcomes Effects of: response outcome (percentage of patients achieving relative response range); status outcome (remission or low disease activity, LDA ) and change outcome (numerical change on a metric scale) .
JAMA Pediatr: Low-dose prednisolone administered during upper respiratory tract infection does not reduce the risk of recurrence in children with hormone-sensitive nephropathy
Time of Update: 2022-01-08
In a previous small-scale study, low-dose prednisolone administered daily for 5 to 7 days when an upper respiratory tract infection occurs in children with SSNS can reduce the risk of recurrence of kidney disease .
JAHA: Analysis of the curative effect of intravenous thrombolysis before mechanical thrombus removal in acute ischemic stroke
Time of Update: 2021-12-03
StrokeRecently, the heart blood vessels published on the prestigious journal JAHA the areas of disease research article, researchers conducted a meta-analysis, mechanical thrombectomy (dMT) with mechanical thrombectomy more direct intravenous thrombolysis joint bridging (bridging therapy [BT]) Efficacy in patients with acute ischemic stroke .
Neurology: Clinical trials of cerebral apoplexy, the number of female patients included is too small
Time of Update: 2021-11-13
In an analysis of the personal data of more than 19,000 patients from randomized controlled trials of acute stroke , men had a higher mortality rate, while women suffered a greater loss of health-related quality of life .
Stroke Another systematic review of patient-reported results showed that women experience more participation restrictions or barriers than men .