Zhao Yang's research group realizes chemical induction of fibroblasts into hepatocytes with metabolic and regenerative functions
Time of Update: 2022-08-20
This study developed a system that uses a chemical small molecule approach to stepwise activate endogenous transcription factors to induce reprogramming of fibroblasts into functional hepatocytes .
Ten years of sharpening a sword - the Institute of Microbiology, Chinese Academy of Sciences established a modern classification system for Chaetaceae fungi
Time of Update: 2022-05-13
Through analysis and comparison, the research group first determined the best molecular markers to distinguish different genera and species within the family, and established a set of methods to observe and study different morphological structures such as ascomas, ascus, ascospores, and asexual reproduction structures (as shown in Figure 1, 2) .
One article discusses: Lynch syndrome and the third-largest related tumor UTUC
Time of Update: 2022-01-10
A study systematically reviewed the incidence, diagnosis, clinicopathological features, and oncology results of LS/UTUC And the screening program and other related literature, and analyzed it, hoping to provide urologists with more detailed information about LS and UTUC .
Detecting mRNAin Tissue Sections with Digoxigenin-Labeled Probes
Time of Update: 2021-03-06
There are different types of nonradioactive labeling methods available, although recently digoxigenin-labeled probes ( 1 ) have become the most widely used for investigation on animal tissue, as they offer the advantage of low background noise and increased sensitivity ( 2 , 3 ).
There are brain regulation mechanisms behind different thirsts
Time of Update: 2021-03-01
This work is the first to illustrate how the brain distinguishes and regulates these two thirsty states, and the optimal single-cell transcription group sequencing method reveals for the first time a group of neurons with specific regulatory functions, further successfully re-hydrating the fluid ingestion esologics by photogenetic methods, and verifying the causal relationship between neuron group function and behavior.
New lysovirus therapy: intravenously break through the limits of the route of drugation
Time of Update: 2021-02-24
OncoMyx Therapeutics presented preclinical efficacy data for a multigene lysovirus therapy it developed at the 2020 Cancer Immunotherapy Association (SITC 2020) meeting: it was shown for the first time that the therapy significantly slowed the growth of multiple tumor types when administered intravenously or intracoma alone or in combination with immunosuppressants, and reduced tumor and prolonged animal life when used in combination with immunosuppressants.
Analysis of Chromatin Organization by Deep Sequencing Technologies
Time of Update: 2021-02-22
Protection from MNase cleavage has often been used to map transcription factor binding sites and nucleosomal positions on a single-gene basis; however, by combining MNase digestion with high-�throughput, paired-end DNA sequencing, it is now possible to simultaneously map DNA-protein interaction regions across the entire genome.
PCR orLowLevel Detection of Malaria Parasites in Blood
Time of Update: 2021-02-17
The detection of parasites byDNA hybridization depends largely on the ability of a DNA probe to identify a parasite DNA sequence that is absent in the host and other closely related parasites.
The ice-cold wolf in Game of Thrones is a distant relative of the modern wolf
Time of Update: 2021-01-23
Xinhua News Agency, Canberra, January 18 (Reporter Bai Xu Yue Dongxing) From the University of Adelaide, Australia and other institutions of the international research team through DNA (deoxybonucleic acid) sequencing found that the game appeared in the ice wolf is nearly 6 million years ago born branch, is a distant relative of modern wolves.
In Vivo Footprinting in Arabidopsis
Time of Update: 2021-01-18
The DNA/protein interactions targeted by m viva footprintmg can be visualized through the use of genomic sequencing, a technique that can provide strand-specific resolution of single bases ( 1 ).
Expression of Dominant-Negative Mutants to Study Host Factors Affecting Plant Virus Infections
Time of Update: 2021-01-15
The use of more diverse methods to study gene function in plants is increasing the probability of successfully identifying and characterizing host factors affecting virus replication in plant systems.
Chimeric Templates and Assays Used to Study Physarum Cotranscriptional Insertional Editing In Vitro
Time of Update: 2021-01-06
This chapter describes in vitro transcription systems in which mtTEC RNAs are elongated on repositioned parts of the genome or exogenous DNA, in order to investigate how the nontemplated insertions are directed.
Methods for the Investigation of Thyroid Function
Time of Update: 2020-12-26
Simple, readily available radioimmunoassay methods for the measurement of the thyroid hormones and an immunochemiluminometric assay for TSH are described.
Methods for the measurement of TSH receptor antibodies and for thyroid peroxidase and thyroglobulin antibodies used in the assessment of autoimmune thyroid disease are given.
Direct Dideoxy DNA Sequencing
Time of Update: 2020-11-30
The procedure requires a plasmid DNA template that is denatured to separate the DNA strands and a primer complementary to one of the strands of the plasmid vector adjacent to the cloning site that has been used.
J Invest Dermatol: Dupilumab's blocking effect on IL-4R alpha reduces the implantation of glucosin bacteria on the skin of patients with admissopathy and increases the diversity of microorganisms
Time of Update: 2020-09-02
The study included 54 patients with moderate to severe AD, randomly grouped (1:1), treated with dupiluma (200mg per week) or a placebo for 16 weeks, and analyzed bacterial DNA from swabs collected from lesions and non-pathogenic skin.