The new crown causes nerve problems! Academician Bian Xiuwu and other teams have revealed the underlying mechanism of neurological symptoms caused by the new coronavirus
Time of Update: 2023-02-02
Structural damage and molecular alterations of the blood-brain barrier (BBB) in the brain of COVID-19Research significance 03 03 The study identified the molecular signature of COVID-19-associated encephalitis with monocytes infiltration and glial cell activation through systematic pathological and proteomic analysis of the COVID-19 autopsy brain.
Nature Biotechnology: New CRISPR-Cas methods lead to more precise DNA cutting
Time of Update: 2022-10-20
A team led by researchers at Massachusetts General Hospital (MGH) has overcome major limitations in cutting and editing DNA through the CRISPR-Cas enzyme and other technologies.
The Science large-scale study identified the effects of gender- and age-dependent genes on longevity
Time of Update: 2022-10-13
"Sex- and age-dependent genetics of longevity in a heterogeneous mouse population Maroun Bou Sleiman and his colleagues conducted a new study of more than 3,000 mice with different genes in a multicenter, multi-year healthy aging project, and they found several genome loci related to lifespan, providing new perspectives on how DNA variants affect longevity.
JAMA Netw Open: Relationship between age and course of diabetes diagnosis in older adults and morbidity and mortality
Time of Update: 2022-10-12
The relationship between diabetes and the incidence of key outcomes, including heart disease, stroke, disability, cognitive impairment, and all-cause mortality, was assessed, and the relationship between diabetes and non-diabetes was compared in the diagnosed age case and matching control groups.
A study of 70,000 Chinese people revealed that eating beans is related to increased uric acid, but eating meat has no effect
Time of Update: 2022-08-16
. Not only that, the researchers also specifically analyzed the association between each food group in the Deshu diet and hyperuricemia, the results showed: more vegetables, fruits, whole grains, less fat, sugar-sweetened beverages, Soy and dairy products are associated with a reduced risk of hyperuricemia .
JCC: Preterm birth, mode of delivery, and type of infant feeding are not associated with pediatric inflammatory bowel disease risk
Time of Update: 2022-05-09
Figure: Risk factors for the development of inflammatory bowel disease in children Therefore, this population-based study showed no association between mode of delivery, gestational age, or exclusive formula feeding at 6 weeks and the development of PIBD .
New study finds a long-neglected key factor in triggering multiple types of cancer
Time of Update: 2022-05-02
▲ The presence of clustered mutations on several representative driver genes is associated with changes in patient survival (Image source: Reference )The researchers also identified multiple factors that contribute to such aggregated somatic mutations, such as polybasic substitutions mostly produced by smoking or ultraviolet radiation .
JNNP: A review of cerebral cavernous malformations, a comparison of treatments
Time of Update: 2022-04-21
The aim was to clearly define (1) bleeding, (2) mortality, and (3) morbidity, as well as which sites (not only the brainstem, but also lobar, deep, and cerebellar CCMs) and whether gender and prior bleeding history were associated with bleeding risk level correlation .
Front Immunol: A retrospective study of the replacement and immunomodulatory activity of 20% subcutaneous immunoglobulin in patients with autoimmune myositis and CVID
Time of Update: 2022-03-04
Results support the beneficial effect and tolerability of 20% SCIg long-term treatment in PM/DM patients, reporting creatine kinase levels, muscle strength, skin condition, dysphagia, disease activity (MITAX score), and disability (HAQ-DI score) Significant improvement .
JAHA: Association between duration of diabetes and glycemic control and stroke incidence
Time of Update: 2022-03-04
Guidelines for Diagnosing Stroke in DiabetesIn a study published in JAHA, the leading journal in the field of cardiovascular disease, the researchers aimed to explore the relationship between the duration of diabetes and glycated hemoglobin and the incidence of stroke in patients with diabetes and newly diagnosed atrial fibrillation .
Why is "Cancer King" so aggressive
Time of Update: 2022-01-01
The researchers said that although the discovery is only preliminary, it opens up promising new treatment avenues for pancreatic cancer, an extremely aggressive cancer, and clarifies its metastasis mechanism .
Frontiers in Immunology: CRAC channel controls the differentiation of pathogenic B cells in lupus nephritis
Time of Update: 2021-12-02
In in vitro studies, YM-58483 's inhibition of CRAC channels or the down-regulation of ORAI1- specific small interfering RNA (siRNA) reduced Ca2+/ calmodulin-dependent protein kinase 2 (CaMK2) phosphorylation and inhibited human B cells Expression of Blimp-1 , leading to B cell differentiation and immunoglobulin G (IgG) Produce reduction .
Clin Chem: The relationship between the plasma phospholipid fatty acid profile during pregnancy and the diagnosis and treatment of gestational diabetes
Time of Update: 2021-10-20
Background: Plasma phospholipid fatty acids (FAs) in the first and second trimester of pregnancy have a prospective relationship with the risk of gestational diabetes (GDM) .
Plasma phospholipid fatty acids (FAs) in the first and second trimesters of pregnancy have a prospective relationship with the risk of gestational diabetes (GDM) .
Will the new coronavirus-19 vaccine cause testicular swelling and male infertility
Time of Update: 2021-10-09
Screenshot of the statement on the organizing committee website The US Centers for Disease Control and Prevention said: There is currently no evidence that any vaccine, including the COVID-19 vaccine, will cause fertility problems in women or men .
Durable stem cell-like cell population can predict prostate cancer treatment response
Time of Update: 2021-09-10
In the study "Single-cell ATAC and RNA sequencing reveals existing and persistent cells associated with recurrence of prostate cancer" led by Professor Marty Nicot of the University of Tampere and Dr.
. "Single-cell ATAC and RNA sequencing reveal pre-existing and persistent cells associated with prostate cancer relapseDOI10.