Practice-oriented, "move" the road to peers! ASCT Transplantation Scholar Ceremony - ASCT HOW came to a successful conclusion
Time of Update: 2022-09-15
"Move" the road together, although far will reach! Sponsored by the Hematology and Oncology Committee of the Chinese Anti-Cancer Association (CACA), the Autologous Hematopoietic Stem Cell Transplantat
Prof. Zhitao Ying: The first guideline for CAR-T treatment of hematological malignancies was released, helping to guide the application of CAR-T in China
Time of Update: 2022-06-03
Indications Evaluation of peripheral blood mononuclear cells before treatment Bridging therapy collection of peripheral blood mononuclear cells Lymphocyte depletion before chemotherapy Check the lymphocyte depletion chemotherapy regimen before reinfusion Confirmation of patient status before reinfusion Approaches ICANN's recommended treatment approach For multiple myeloma and acute B lymphocytic leukemia, although no corresponding CAR-T products have been approved in China, the corresponding clinical research is progressing smoothly, so BCMA-targeted CAR-T is recommended for previous recipients.
The "Physician Law" has opened the legal floodgate for the implementation of off-label drug use today
Time of Update: 2022-05-02
The second paragraph of Article 29 of the "Physicians' Law" clearly stipulates that "in special circumstances such as no effective or better treatment methods, after obtaining the patient's explicit informed consent, the physician may use the drug instructions that are not specified but have evidence-based methods.
BeiGene announced the latest clinical trial data on the safety and effectiveness of Baiyueze (Zebutinib) in the treatment of patients with relapsed/refractory B-cell malignancies who are intolerant
Time of Update: 2021-12-27
The data of this trial shows that Baiyueze® treatment is well tolerated and is unlikely to cause the recurrence of intolerable AE events that have occurred in previous BTK inhibitor treatments At the same time, Baiyueze® is also effective in maintaining or improving the remission from baseline at least, which indicates that Baiyueze® may become a treatment option for patients with hematological malignancies who are intolerant to other BTK inhibitor treatments .
In the controversial new drug for Alzheimer's disease, more than one-third of patients have cerebral edema after treatment
Time of Update: 2021-12-05
The paper reports on two large phase 3 clinical trials of aducanumab in the treatment of Alzheimer's disease, and focuses on the amyloid-related imaging abnormalities (ARIA) in patients during treatment .
ASH Preview: Looking at the XPO1 target from ASH 2021
Time of Update: 2021-12-01
Verdinexor (KPT-335, ATG- 527) SINE is a new compound effective to inhibit the tumor cell lines canine nucleoprotein XPO1, also reduce the level of viral replication, currently in clinical stage Ⅰ .
(2) BIIB-100 is developed a healthy Bo XPO1 inhibitor indicated for amyotrophic lateral sclerosis (ALS), currently in clinical stage Ⅰ .
The Gao Fu team of the Chinese Academy of Sciences Institute of Microbiology has made important progress in the research of GITR/GITRL recognition mechanism
Time of Update: 2021-10-11
Active immune checkpoint molecules such as 4-1BB and GITR are members of the TNF receptor (TNFR) superfamily that have attracted much attention in recent years.
In recent years, the team has carried out a series of research work on the ligand recognition mechanism of immune checkpoint receptor molecules and the mechanism of antibody drug action.
Radiation therapy reprograms cardiomyocytes to a young state
Time of Update: 2021-09-28
However, this new study shows that non-invasive radiotherapy, commonly used to treat cancer, can reprogram heart muscle cells to make them younger and even healthier, solving the electrical problems of the cells themselves, without the need for scar tissue.
Gastroenterology: bezafibrate can effectively improve moderate to severe skin itching in patients with cholestatic disease
Time of Update: 2021-08-13
The results of a double-blind, randomized, placebo-controlled trial (FITCH trial) published in Gastroenterology showed that bezafibrate can effectively relieve pruritus in patients with PSC, PBC, and SSC .
What happens 10 years after bariatric surgery
Time of Update: 2021-08-09
Data for more than 10 years shows that regardless of the surgical method, MBS will cause continuous weight loss, control of appetite has always existed, and also reduced complications and mortality caused by obesity , health-related quality of life (HRQoL) The score of) has also been improved in the long-term [3-5] .
Side effects of statins: feelings you shouldn’t ignore-higher doses may be needed
Time of Update: 2021-08-06
Other symptoms of heart disease include:Shortness of breathNumbness, weakness, or cold in the legs or arms Richard Hobbs, GP and head of the Department of Primary Care Health at Oxford University, elaborated on the use of statins .
Guidelines for the clinical management of adverse reactions of BCG vaccine in 2021
Time of Update: 2021-07-29
Recently, the Chinese Medical Association Tuberculosis Branch, in conjunction with the Chinese National Tuberculosis Association School and the Children’s Tuberculosis Prevention and Treatment Branch, organized experts to conduct in-depth discussions, and formulated and issued the "Guidelines for the Clinical Management of BCG Adverse Reactions", regarding the types of BCG, methods of use, and BCG adverse reactions The performance, diagnosis, treatment and prevention of the disease should be handled in a standardized manner .
The new method will help determine whether anti-cancer targeting drugs can be targeted
Time of Update: 2021-02-15
In a new issue of the journal American Chemical Society Nano, the researchers report that by studying the star-shaped gold nanoparticles used to carry drugs on cancer cell membranes, they found that the nanoparticles moved more widely and rotated faster, maintaining their unique signature motion even when surrounded by proteins, indicating that their targeting ability was not inhibited.
BMJ Gastroenterology: Age and pain scores before gastroenteroscopy in children are predictive indicators of postoperative pain
Time of Update: 2020-12-16
, the purpose of this study was to identify risk factors for longer recovery times and higher pain scores after gastrointestinal endoscopy in children.
Have immune inhibitors have a big side effect? Scientists have found that Treg cells suppress immunity
Time of Update: 2020-11-21
the safety of nTreg therapy after the use of immunosuppressants in patients after self-infusion minimized kidney transplantation.
analysis of biomarkers in patients in the nTreg treatment group and control group, the study showed that the nTreg was safe, well-to-resistant, and reduced the use of immunosuppressants.