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Yocardi: The new LNP is targeted to prepare CAR-T in vivo, and the anti-tumor effect is remarkable
Time of Update: 2022-10-25
The researchers used CD3 antibody modified LNP to encapsulate short hairpin RNA (shRNA) containing human interleukin 6 (IL-6) and an integrated plasmid of CAR gene, which can produce CAR-T cells with missing IL-6 secretion function in mice through intravenous injection, and showed an anti-tumor effect comparable to conventional CAR-T treatment in mouse leukemia models, while reducing the release of IL-6 and reducing severeness The occurrence of CRS.
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NEJM: Oral drug for complicated urinary tract infection, efficacy is non-inferior to intravenous drip expert review
Time of Update: 2022-06-19
This phase 3 clinical trial, conducted in 95 hospitals worldwide, aims to demonstrate that tipipenem hydrobromide is noninferior to ertapenem in the treatment of complex UTIs, including acute pyelonephritis, with a non-inferiority margin The value of 12.
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U.S. upholstered furniture flammability standards will be implemented in June 2021
Time of Update: 2021-12-15
Although companies that sell upholstered furniture in California have been required to comply with the testing procedures of TB 117-2013, the federal law has added a new mandatory labeling requirement .
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The next generation of "synthetic lethal" ATR inhibitors are being developed
Time of Update: 2021-12-07
In addition, in 2020, Merck announced in The Lancet the results of a clinical trial of Berzosertib combined with gemcitabine in the treatment of patients with advanced ovarian cancer.
In addition, Merck and Bayer's ATR inhibitors have been approved by NMPA and are currently in phase I clinical trials .
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BMJ Sub-Journal: Suffering from arthritis, it is a bit difficult to be a father
Time of Update: 2021-10-02
Recently, a research team led by Luis Fernando Perez-Garcia of the Erasmus Medical Center in the Netherlands published an article in the famous specialist journal "Ann Rheum Dis" (Ann Rheum Dis), pointing out that before/during the peak of male childbearing age (31-40 years old) Diagnosed inflammatory arthritis is related to lower fertility rate, higher involuntary childlessness rate and fertility problems [1] .
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"PNAS" why diabetes is closely related to severe COVID-19
Time of Update: 2021-09-11
Starting with a mouse model of coronavirus infection, they found that SETDB2 was reduced in immune cells called macrophages in the inflammatory response of diabetic mice .
"To verify this, the research team injected interferon into diabetic mice infected with coronavirus and found that they can increase SETDB2 and reduce inflammatory cytokines .
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Children's intranasal cells will be "prepared" when "detecting" the new coronavirus
Time of Update: 2021-09-04
This different expression causes children to have a stronger early immune response to new coronavirus infections than adults .
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National Health Commission: Comprehensive research on the inclusion of HPV vaccination in the National Immunization Program
Time of Update: 2021-07-25
At the National Two Sessions in 2020, many representatives and committee members submitted suggestions and proposals, calling for the realization of the national planned immunization (free inoculation) of HPV (human papillomavirus) vaccine for girls of school age in China as soon as possible .
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COVID-19 bet failed Merck has lost $493 million
Time of Update: 2021-07-07
Recently, in a From 10-Q document submitted to the US Securities and Exchange Commission, Merck disclosed that a COVID-19 drug candidate obtained during the acquisition of Oncolmmune lost $170 million due to the termination of clinical development projects .
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NCB Chen Liang/Yang Pengyuan and others collaborate to reveal the immune memory mechanism of patients recovering from new coronary pneumonia
Time of Update: 2021-06-22
This work uses single-cell ATAC-seq technology and the newly developed single-cell multi-omics Ti-ATAC-seq technology to describe the accessibility of peripheral immune cells to chromatin multi-dimensional atlas in patients recovering from new coronary pneumonia, and to analyze monocytes, The epigenetic mechanism of B cell and T cell immune memory formation .
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Nature: Nod2 gene defect inhibits effective recovery of intestinal fibrosis and inflammation, leading to Crohn's disease
Time of Update: 2021-05-07
The author tried to understand what caused the inflammation and fibrosis of Crohn's disease, and through the use of human cells, human intestinal tissues and zebrafish models to conduct research to link these biological insights with NOD2.
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Following the United States, the European Union is expected to give a "green light" to the Johnson & Johnson adenovirus vaccine
Time of Update: 2021-03-24
On February 28, French Minister of Industry Agnes Pannier-Runacher stated that the single-dose COVID-19 vaccine of the US drugmaker Johnson & Johnson may be approved for use in the EU in early March, and the European Medicines Agency (EMA) is also evaluating information on the Johnson & Johnson vaccine.
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Nature Sub-Journal: To solve these 3 problems, rheumatoid arthritis may also be cured
Time of Update: 2021-03-22
By definition, in degenerative or inflammatory chronic diseases, cure is rare, and remission is usually a more realistic treatment goal.
Therefore, intestinal leakage may be a further driving factor for the influx of immune cells into the joints and promote disease recurrence.
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New research has found that two human genes are linked to bird flu
Time of Update: 2021-03-10
A team of researchers at the University of Chicago in the United States found that the H5N1 avian influenza virus infects human pulmonary endotment cells in a mechanism linked to two human genes, so new antiviral methods can be developed by affecting both genes.
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Junshi Bioanti-TIGIT Monoanti-JS006 Injection was approved for clinical trials
Time of Update: 2021-03-09
On January 27, Junshi Bio announced that the anti-TIGIT monoantigen JS006 injection was approved for clinical trials of the drug.
preclinical trials have shown that anti-TIGIT antibodies and anti-PD-1/PD-L1 antibodies can act in synergetic anti-tumor effects.
