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Resolving the genetic drivers of head and neck cancer
Time of Update: 2023-01-06
"We found that not only the 9p21 locus on chromosome 9p is involved, but also the 9p24 locus, which may be more important in driving resistance in immune checkpoint therapies; Surprisingly, we found that an increase in these gene regions, at least in the case of HPV-negative head and neck squamous cell carcinoma, was associated with ICT survival benefits.
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Resolving the genetic drivers of head and neck cancer
Time of Update: 2023-01-06
"We found that not only the 9p21 locus on chromosome 9p is involved, but also the 9p24 locus, which may be more important in driving resistance in immune checkpoint therapies; Surprisingly, we found that an increase in these gene regions, at least in the case of HPV-negative head and neck squamous cell carcinoma, was associated with ICT survival benefits.
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Biomarkers predict melanoma resistance to immunotherapy
Time of Update: 2023-01-05
Researchers at Duke Cancer Institute have identified potential biomarkers that predict the likelihood that checkpoint inhibitor drugs will backfire, driving hyperprogression in melanoma cells rather than releasing the immune system to fight them.
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1 article in Nature + 1 Cell sub-journal reveals that tumor bacteria help tumor progression and resistance to treatment
Time of Update: 2023-01-01
Dr. Susan Bullman, a cancer microbiome researcher at Fred Hutchinson Cancer Center and co-corresponding author of the two studies, said of the first study, "What we showed is that in some areas of the tumor, --- micro-niche regions, there is a large number of bacterial colonizations that are functionally different from areas without bacteria.
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The brain-gut axis adds to the evidence that the gut microbiota can talk directly to the brain to regulate diet and body temperature
Time of Update: 2022-11-15
Cerebral gut axis regulates metabolism: Eating leads to the expansion of the gut microbiota, which increases the release of muropeptides, a gut bacterium that, when in the brain, target inhibitory hypothalamic NOD2 receptors and reduce neuronal activity, helping to regulate satiety and body temperature.
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Biosensors can detect brain tumors with less than a drop of blood
Time of Update: 2022-10-14
DEEP Surveillance of Brain Cancer Using Self-Functionalized 3D Nanoprobes for Noninvasive Liquid Biopsy According to the National Cancer Institute, despite significant progress, the death rate from brain tumors remains high, with a 5-year survival rate of 36 percent.
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Sci Immuno iNKT cells help fight cancer
Time of Update: 2022-09-22
In 2022, the Giulia Casorati and Paolo Dellabona research group from Milan, Italy, presented a presentation in Science Immunology titled TCR-engineered iNKT cells induce robust antitumor response by dual targeting cancer and The suppressive myeloid cells article provides an in-depth study of the anti-tumor effects and mechanisms of iNKT cells.
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Quick overview of the article: An overview of commonly used drugs and treatment options for breast cancer
Time of Update: 2022-09-06
Common cancer chemotherapy regimens Breast cancer is one of the cancers with the highest morbidity and mortality among women in China, and its incidence is increasing year by year .
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Your baby's birth weight is linked to lifetime diabetes risk -- the lower your body weight, the sooner you may develop type 2 diabetes
Time of Update: 2022-06-13
Lower birth weight may be associated with lower age at onset of type 2 diabetes and BMI at diagnosis, according to a study published in the journal Diabetes Medicine .
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Targeting cancer stem cell antigens: novel dual antibodies have great potential
Time of Update: 2022-05-31
In conclusion, the research and development idea of MCLA-158 is extremely novel, focusing on the antigen targets of cancer stem cells, constructing double antibodies with EGFR and HER3, and screening candidate double antibody molecules through tumor organoids .
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Siemens Healthineers and Junxin Medical have reached a strategic cooperation to jointly open a new chapter in one-stop cancer diagnosis and treatment
Time of Update: 2022-05-21
The two parties will integrate their respective resource advantages, work together to empower the development of non-public oncology medical care in the Greater Bay Area, and jointly create a new model of oncology diagnosis and treatment that is international, professional, personalized, and multi-disciplinary, and provides cancer patients with a life-cycle service.
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One million yuan a shot of CAR-T cell therapy products, or fight for medical insurance
Time of Update: 2022-04-15
In addition, Fosun Pharma stated that the technology transfer of the second CAR-T product has been completed within the reporting period, and the clinical trial application for relapsed or refractory mantle cell lymphoma was approved for clinical trials by the State Food and Drug Administration in March 2022.
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Clin Cancer Res: Efficacy of olaparib maintenance monotherapy in Asian patients with platinum-sensitive recurrent ovarian cancer
Time of Update: 2022-03-04
Olaparib monotherapy maintenance therapy significantly prolongs progression-free survival (PFS) compared with placebo in patients with platinum-sensitive recurrent (PSR) ovarian cancer (OC) .
This study is the first to evaluate the efficacy and tolerability of olaparib in Asian patients with platinum-sensitive recurrent ovarian cancer .
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European Radiology: These MRI findings in mixed hepatocellular carcinoma-cholangiocarcinoma suggest prognosis
Time of Update: 2022-02-18
Recently, there has been increasing interest in clinicopathological features as prognostic indicators related to recurrence-free survival (RFS) and overall survival (OS) in cHCC-CCA patients , of which microvascular invasion (MVI), extrahepatic local invasion and lymph node metastasis are poor Independent predictors of long-term survival .
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Nature Cancer: Let cancer cells "stay awake
Time of Update: 2022-01-23
Comparison of collagen types between T-HEp3 (proliferating tumor) and D-HEp3 (dormant tumor) (Image source: Nature Cancer)Next, the researchers used a human-mouse xenograft system to further determine the relative contribution of tumor cells (human protein sequences) and stromal cells (mouse protein sequences) to matrix body production .
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