With Dostarlimab's "head-to-head" K drug, GSK announced that the PERLA study reached the primary endpoint of ORR
Time of Update: 2022-10-13
On 5 October, GSK announced that its PD-1 monoclonal antibody Jemperli (dostarlimab) combined with chemotherapy head-to-head comparison of Keytruda plus chemotherapy first-line therapy for metastatic non-squamous non-small cell lung cancer (NSCLC) Phase II PERLA trial achieved positive results, reaching the objective response rate (ORR) primary endpoint.
Cell: A neural map of the sense of smell
Time of Update: 2022-09-30
"essayER stress?transforms random olfactory receptor choice into axon targeting precision Image: Labeled red and green in this illustration are sensory cell axons of a single glomere within the olfactory bulb of the mouse brain.
Zeng Yi's group established a new method for in vitro long-term expansion of pancreatic islet organoids based on Procr stem cells
Time of Update: 2022-05-18
This work establishes a technical method for isolating Procr stem cells from mouse islets and long-term expansion of mouse islet organoids in vitro .
The Chinese research group Nature issued a document: the first time to provide an accurate image of the activation state of STING
Time of Update: 2022-04-15
To answer this question, the Zhang and Bai labs mixed purified STING protein with cGAMP and imaged the results using cryo-electron microscopy (cryoo-EM) .
"This newly discovered STING-activated binding site was completely unexpected, and we called it the 'mystery pocket' because it appears to have formed in response to the presence of C53 .
Academician Gui Jianfang's team published a long article review on rethinking fish biology and biotechnology in the newly created journal Water Biology and Security
Time of Update: 2021-12-31
Rethinking fish biology and biotechnologies in the challenge era for burgeoning genome resources and strengthening food security.
Designed to cure diabetes, CRISPR-edited cell replacement therapy enters the clinic
Time of Update: 2021-12-06
On November 16, 2021, ViaCyte and CRISPR Therapeutics jointly announced that Health Canada has approved a clinical trial application (CTA) for CRISPR gene-edited stem cell-derived therapy VCTX210 for the treatment of type 1 diabetes (T1D) .
Phase 3 clinical results of ready-to-use T cell therapy positively and significantly improve patient survival
Time of Update: 2021-11-12
On November 4, 2021, Atara Biotherapeutics announced that T cell immunotherapy tabelecleucel (tab-cel) is a critical phase 3 in the treatment of EB virus (EBV)-related post-transplant lymphoproliferative disease (EBV+PTLD) Positive results in clinical trials .
The Institute of Zoology collaborates to create a multi-omics database of regenerative biology
Time of Update: 2021-10-09
Facing the explosive growth of scientific data, there is an urgent need to establish an open database centered on regenerative biology, based on storing world-wide omics research data, to promote the continuous development of regeneration-related basic research and clinical translational applications .
Transplant drugs have become a new trend, and pharmaceutical giants are scrambling to enter the game
Time of Update: 2021-10-01
This drug is mainly used to treat patients with chronic graft-versus-host disease (cGVHD) aged 12 years and above.
In addition, Novartis and Incyte's JAK inhibitor Jakafi (ruxolitinib) was approved in May this year for the treatment of steroid-refractory acute graft-versus-host disease .
Plos Bio: The life-saving medicine is almost "deadly
Time of Update: 2021-08-26
Degranulation enhances presynaptic membrane packing, which protects NK cells from perforin-mediated autolysis Plos BiologyAs compared with other cells, NK cells show a highly ordered synaptic lipid membrane, so researchers speculate that the "fat shield" of NK cells may be a mysterious and unknown protein-made extracellular membrane lipid.
"Phytoplankton Factory"-from nutrients to algae growth
Time of Update: 2021-08-13
The lead author of the study, Scott McCain, a PhD student in the Department of Biology at Dalhousie University in Canada, explained: "You can imagine the growth of phytoplankton as industrial production in a factory: materials enter the factory, processed on the assembly line, and create the final product .
Sanofi's $1 billion bet on new targets, which strong doctor on the multiple myeloma circuit, Mai Meng broke the news
Time of Update: 2021-08-10
Click on the picture and register now July 9, 2021 Japan/MedClub News/--Recently, Eureka Therapeutics and Memorial Sloan Kettering Cancer Center (MSKCC) and Sanofi reached a license agreement on the "non-CAR use of human GPRC5D binding domain", aiming to develop potential Multiple myeloma therapy .
Fosun Kate CAR-T therapy officially approved
Time of Update: 2021-08-09
According to the latest announcement by the National Food and Drug Administration (NMPA), Fosun Kate's CAR-T cell therapy product Yiqililunsai injection (also known as Akirensai, code name: FKC876) has been officially approved .
A Method for Short-Term Culture of Human Gastric Epithelial Cells to Study the Effects of Helicobacter pylori
Time of Update: 2021-02-22
Here we describe a method for isolation and short-term culture of human primary gastric epithelial cells obtained from gastric biopsy specimens, and the use of these cells to evaluate the effect ofH.
A protein can cause breast cancer to worsen more rapidly, a study has found
Time of Update: 2021-02-18
The researchers found that the protein, called Creld2, is closely associated with several types of highly invasive breast cancer, which "hijacks" healthy cells to promote tumor growth.
Samuel said poor prognosms for these types of cancers, if they disrupt or block the protein's function, could prevent them from developing.