Progress in rare disease drug research in China
Time of Update: 2022-10-12
(See Figure 2 for details) Although the economic return is not the most cost-effective, the proportion of rare disease drug research and development in the world's leading pharmaceutical companies is relatively high.
【Daily case 388 stage】A rare cause of abdominal pain in elderly men
Time of Update: 2022-09-30
(Figure B Upper gastrointestinal endoscopy as seen)The patient has progressively worsened symptoms of bloating and signs of peritoneal irritation 6 hours after gastroscopy【Thinking and Analysis】What is the most likely diagnosis for this patient?
Kite's CAR-T therapy approved by FDA for second-line treatment of lymphoma
Time of Update: 2022-04-27
S. Food and Drug Administration announced that it has approved the expanded scope of the CD19-targeted CAR-T therapy Yescarta (axicabtagene ciloleucel) developed by Kite Pharma, a subsidiary of Gilead Sciences, for the second-line treatment of large B-cell lymphoma (LBCL).
Domestic PD-(L)1 explodes in 2021, and imported drugs face extinction
Time of Update: 2022-01-09
In November of this year, Professor Lu Shun from the Thoracic Hospital of Shanghai Jiaotong University reported at the ESMO Asia conference the interim analysis results of the randomized, double-blind, multicenter phase III study ORIENT-31 (NCT03802240), showing that Sintilizumab is combined Bevacizumab biosimilars and chemotherapy for EGFR-positive locally advanced or metastatic non-squamous NSCLC patients who have progressed through EGFR-TKI treatment have obtained significant and clinically significant PFS prolongation .
"Cell Metabolism" A New Way to Regulate Blood Sugar Levels Independently of Insulin
Time of Update: 2022-01-07
Like insulin, FGF1 controls blood sugar by inhibiting lipolysis, but the two hormones work in different ways .
These similarities led the research team to doubt whether FGF1 and insulin use the same signaling (communication) pathway to regulate blood sugar.
Common sleep disorder combinations can be fatal
Time of Update: 2021-12-27
Researchers at Flinders University say that people who suffer from both insomnia and obstructive sleep apnea are more likely to develop heart disease and are nearly 50% more likely to die than people without these two symptoms.
Once a week
Time of Update: 2021-09-06
Text | SunshineOn July 13, Sanofi's recombinant human coagulation factor VIII Fc-von Willebrand factor-XTEN fusion protein (efanesoctocog alfa, rFVIIIFc-VWF-XTEN, BIVV001) for injection was awarded CDE's proposed breakthrough therapy and its proposed indications It is used for adults and children with hemophilia A: (1) Routine preventive treatment to reduce the frequency of bleeding; (2) On-demand treatment of bleeding; (3) Treatment of perioperative bleeding .
How to view and understand media reports on "growth hormone
Time of Update: 2021-08-27
On the 16th, the Financial Association learned how to view and understand media reports on "growth hormone"?
In fact, there were similar reports several years ago .
Anesthesia may affect the spread of tau protein in the brain and promote Alzheimer's disease
Time of Update: 2021-08-12
In order to see whether tau protein stimulates microglia to promote the development of Alzheimer's disease pathology, MGH researchers and their colleagues conducted experiments with an inhaled anesthetic called sevoflurane .
[Science Sub-Journal] How to improve the "quality of life" of vaccinators
Time of Update: 2021-08-08
The study comprehensively describes the antibody response of each virus, helping to identify the elevated characteristics and functions of survivors, which can be used as immune-related substances for vaccine-induced protection .
Transcription factors protect anti-cancer CAR-T cells from depletion
Time of Update: 2021-07-27
. The latest research results show that the transcription factor BATF plays a key role in the cellular pathway that triggers T cell failure, and shows how the increase in BATF levels with the help of another transcription factor IRF4 can improve the anti-cancer ability of these cells .
Professor Wang Jianxiang: The newly approved DRd/DVd combination therapy in China helps achieve the goal of "deep remission and longer survival" for the first relapse of MM
Time of Update: 2021-05-22
For the treatment of relapsed/refractory MM, the "Guidelines for the Diagnosis and Treatment of Multiple Myeloma in China (Revised in 2020)" clearly stated that the goal of the first relapse treatment is to obtain the greatest degree of remission and prolong progression-free survival.
Science Advances: Odontoblasts TRPC5 channel is a signal of tooth cold pain, which can be used as a new target for the treatment of toothache
Time of Update: 2021-04-13
The research team reported in Science Advances on March 26, 2021 that in mice and humans, tooth cells called odontoblasts contain cold-sensitive proteins that detect temperature drops.
Make you feel extraordinary pain!The research team tracked the location of the odontoblasts of TRPC5 between the pulp and dentin.
Scientists have found that a bacterium can prevent food allergies
Time of Update: 2021-02-06
food allergies are caused by the body's immune system overreacting, resulting in the production of special E antibodies (IgE ) in the blood.
Magic! Nature: Eating spicy food can mobilize your hematopoietic stem cells or help treat blood diseases
Time of Update: 2021-01-17
found that CGRP therapy significantly increased the number of HSCs mobilized by G-CSF, indicating that G-CSF-induced HSC mobilized neuropeptide CGRP regulation derived from injury nerves.