December neurology guidelines and consensus, one article included in the guideline consensus
Time of Update: 2023-02-03
cn/guideline/27616Recommended reading ☟☟☟January| February| March| April| May| June| July| August| September| October|November03Consensuson the diagnosis, treatment and management of cognitive impairment after noveland spread of coronavirus disease 2019 (COVID-19) (referred to as "new coronary pneumonia") around the world has had a huge impact on the physical and mental health of the people, especially the elderly, about 80% Patients infected with COVID have one or more long-term symptoms (level I evidence).
Sinovac Pharmaceutical joined hands with Tonghua Dongbao to accelerate the overseas expansion of domestic diabetes products
Time of Update: 2023-01-01
The cooperation between Sinovac and Tonghua Dongbao is an important step for the two companies to focus on high-quality biological drugs, give full play to their respective experience advantages, and achieve global commercialization of domestic diabetes products liraglutide.
Current gastric cancer treatment methods and new developments
Time of Update: 2022-11-05
6 months, and the survival status of patients was almost equivalent to that of second-line therapy 。 On June 9, 2021, Remegen's HER2-targeted ADC drug vedicitumab (RC48) was approved for marketing in China for the treatment of patients with HER2 overexpression locally advanced or metastatic gastric cancer (including gastroesophageal junction adenocarcinoma) who have received at least 2 systemic chemotherapy, breaking the situation that there are no original domestic new drugs in the field of ADC drugs, which is a milestone.
Nature Communications: Zhejiang University Ye Zhaoming's team reveals the mechanism by which chemotherapy leads to tumor immune escape
Time of Update: 2022-10-31
On October 23, 2022, Professor Ye Zhaoming's team from the Second Affiliated Hospital of Zhejiang University School of Medicine published a paper in Nature Communications entitled "Metabolic control of CD47 expression through LAT2-mediated amino acid uptake promotes tumor immune" Evasion's research paper.
Cancer Cell: A new mechanism of acquired chemotherapy resistance for bladder cancer offers new ideas for differentiated treatment
Time of Update: 2022-10-03
bladder cancer, found that semi-squamous differentiation is a new feature of chemotherapy resistance for bladder cancer, and then proposed a differentiated treatment strategy that targeted histoproteinase (Cathepsin H, CTSH) to promote the terminal differentiation of drug-resistant tumor cells, providing a new idea for the differentiation therapy of solid tumors.
Announcement of the State Food and Drug Administration on the cancellation of 34 drug registration certificates such as mercury bromine red solution (No. 132 [2021
Time of Update: 2022-10-01
docx to Announcement No. 132  of the State Drug Administration In accordance with the relevant provisions of the Regulations on the Implementation of the Drug Administration Law of the People's Republic of China and the Measures for the Administration of Drug Registration, the State Drug Administration decided to cancel 34 drug registration certificates such as mercury bromine red solution.
Top Journals and National Nature's Preference: How Can Organoids Publish Top Journals of Oncology with 3 Pictures? Smooth application country natural
Time of Update: 2022-09-30
flow chart Third, the content of the study Figure 1-2: Construct organoids and characterize and identify their features To determine whether the constructed organoids can represent molecular subtypes of different pancreatic cancers, the authors performed immunohistochemical identification of 4 biopsy tissues and 6 organoids, transcriptomics detected in 9 organoids, and compared the molecular subtypes of RNA-seq data from PDOs using two algorithms (Figure2A).
Status quo and prospect of intravenous thrombolytic therapy for acute ischemic stroke
Time of Update: 2022-09-30
The Chinese Guidelines for the Endovascular Treatment of Acute Ischemic Stroke point out that for patients with cerebral infarction within 6 h of onset, intra-arterial thrombolysis therapy can be considered in experienced and conditional situations.
Professor Zhu Kui/Academician Shen Jianzhong's team: Advances in host-directed antimicrobials Cell Press Paper Express
Time of Update: 2022-03-08
In the past nearly 100 years, researchers have targeted pathogenic bacteria and obtained a large number of antibacterial molecules through the screening of natural products or artificial synthesis .
The latest exploration and research progress on host-acting antibacterial compounds (HACs) .
CanSino Bio's tetravalent meningococcal conjugate vaccine is approved for marketing in China
Time of Update: 2022-01-09
Retrieved Dec 29, 2020, from https://  CanSinoBio's first domestic tetravalent meningococcal conjugate vaccine new drug registration application has been given priority review.
com/s/Sg0-o1e0ctAgx8UVKgaevgCanSinoBio and Pfizer signed a promotion service agreement for a tetravalent meningococcal conjugate vaccine that is expected to be approved.
The new Tibetan medicine research and development discipline group has made new progress in the study of free radical inhibitors of Saxifraga
Time of Update: 2022-01-07
The Tibetan Medicine New Drug Research and Development Discipline Group of the Northwest Plateau Institute of Biology, Chinese Academy of Sciences found that the components of Saxifraga have excellent free radical scavenging activity in vitro, but it is not clear about the exogenous free radical suppression contained in it.
Nature anti-HER2 and PD-1 dual-pronged treatment of gastric cancer
Time of Update: 2021-12-28
A few years ago, the combined intervention of anti-HER2 antibody drug trastuzumab (trastuzumab) and chemotherapy has become clinically the first-line treatment for gastric cancer  .
The world's first oral anti-coronavirus specific drug was approved. Merck uses biocatalytic synthesis to increase the yield by 7 times
Time of Update: 2021-11-14
The research achieved a new synthetic route for Molnupiravir through a biocatalytic cascade reaction with engineered ribosyl-1 kinase and uridine phosphorylase, these engineered enzymes and pyruvate oxidase enabled phosphate recovery strategy Working together, compared with the original synthetic route, the new synthetic route is shortened by 70%, and the total yield is increased by 7 times .
[Clinical Tumor Research] Issues to be considered in PFS analysis
Time of Update: 2021-11-14
If the research is for new drug marketing approval, the regulatory agency should reach an agreement with the investigator in advance on the following aspects: research design; definition of disease progression; data recorded on the clinical trial observation form (CRF); statistical analysis plan; Methods of handling missing data and data censorship; if applicable, the operating procedures of the Independent Endpoint Review Committee (IRC) .
Innovent's FGFR small molecule inhibitor Pemigatinib was approved in the Taiwan market
Time of Update: 2021-09-07
Today, Cinda Biotech announced that pemigatinib has been approved by the Food and Drug Administration (TFDA) of the Ministry of Health and Welfare of Taiwan for the treatment of adults who have received systemic drug therapy and tumors with fibroblast growth factor receptor 2 (FGFR2) Locally advanced or metastatic cholangiocarcinoma that is fused or rearranged and cannot be resected .