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J Clin Oncol: Long-term efficacy of B-cell maturation antigen and CD19 chimeric antigen receptor T-cell combination therapy in multiple myeloma
Time of Update: 2022-04-24
Combination of anti-B-cell maturation antigen and anti-CD19 chimeric antigen receptor T cells induces durable remission in patients with refractory or relapsed multiple myeloma, with a median progression-free survival of 18.
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Leuk Res: Docepastat (DSTAT), a CXCL12/CXCR4 inhibitor, in combination with azacitidine for the treatment of hypomethylating agent-refractory AML and MDS
Time of Update: 2022-01-23
A research team conducted a pilot study of adding DSTAT to azacitidine in patients with AML or MDS who had not responded to or had relapsed to prior hypomethylating drug therapy, hypothesizing that DSTAT might improve response rates .
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Lancet Oncol: Maintenance therapy with daratumumab can significantly reduce the risk of disease progression and death in patients with multiple myeloma
Time of Update: 2021-09-29
The results of Part 1 of the CASSIOPEIA study showed that newly diagnosed multiple myeloma patients who are eligible for autologous stem cell transplantation (ASCT) were treated with daretuzumab, bortezomib, thalidomide, and dexamethasone (D- The depth of remission and progression-free survival of the VTd) regimen as an induction and consolidation treatment were significantly better than those of bortezomib, thalidomide, and dexamethasone (VTd) regimens .
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Science Immunology: Memory killer T cells are injected into the spleen during influenza infection
Time of Update: 2021-09-18
"UAB researchers used a mouse/influenza virus infection model and found that the initiation in the spleen is completed by a part of migrating lung dendritic cells, which leave the lymph nodes, enter the bloodstream, and return to the spleen .
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J Clin Oncol: Avoiding the hippocampus during preventive brain radiotherapy can protect cognitive function without reducing the prognosis
Time of Update: 2021-08-26
The main goal is delayed free recall (DFR) in the free and prompt selective reminder test (FCSRT) at month 3; a drop of ≥3 points from baseline is considered a decrease in neurocognitive function .
Compared with the PCI treatment group, the HA-PCI treatment group had a smaller decrease in DFR from baseline to month 3 (23.
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Telomere Terminal G/C Strand Synthesis: Measuring Telomerase Action and C-Rich Fill
Time of Update: 2021-03-02
By combining a series of cell biological and biochemical approaches, and taking advantage of the enzyme DSN that specifically cuts double-stranded DNA and releases the telomeric overhangs, we have developed a method to monitor telomerase action during one cell cycle.
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Human Intestinal Dendritic Cell Isolation
Time of Update: 2021-01-26
The isolation of dendritic (DC) cells from human intestinal tissue is associated with many of the problems encountered in the mouse, for example, low cell numbers and the paucity of specific cell surface markers.
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Genetic and Phenotypic Analysis of Shoot Apical and Floral Meristem Development
Time of Update: 2020-11-15
The shoot apical and floral meristems (SAM and FM, respectively) ofArabidopsis thaliana contain reservoirs of self-renewing stem cells that function as sources of progenitor cells for organ formation during development.
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Boya submitted the country's first CRISPR gene editing therapy clinical trial application
Time of Update: 2020-11-11
On October 27th, Boya announced that the Drug Review Center of the State Drug Administration had accepted its clinical trial application for a gene-editing therapy product for transfusion-dependent β thalassemia, ET-01, or CRISPR/Cas9 gene-modified self-made CD34 plus hematocyte injection of BCL11A red line enhancers.
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Key genes for thickening tomato stalks have been found
Time of Update: 2020-09-10
11-bp insertion of missing (indel_11) in the SD1 promoter is completely interlocked with the tomato stem, and the mutation of the bit affects the expression of the gene, which in turn regulates the development of the tomato stalk.
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BMI1: Overcome the apoptosis that occurs in adifferent embryos with human pluripotent stem cells
Time of Update: 2020-08-06
Pan Guangjin of the Guangzhou Institute of Biomedicine and Health of the Chinese Academy of Sciences made new progress in the study of human pluristem stem heterogeneous, with the results of the BMI1 enablessss sie chimerism with human pluripotent cells published on November 7 in the academic journal Nature Communications.
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Neuron: Human Star-shaped glial cell "killer" nature proves for the first time
Time of Update: 2020-06-05
In view of the key role of human astrocytes in the central nervous system, we urgently need to study new methods of human astrocytes recently, researchers have discovered that CD49f is a new type
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Nat Neurosci: Zhang Guo/Cai Dongsheng/Li Juxue Team Finds That Inhibiting Tak1 Reverses Obesity-Related Cerebrovascular Disorder
Time of Update: 2020-05-29
Long-term obesity is associated with cerebrovascular dysfunction, however, our basic mechanisms are still unclear in a recent study using a long-term obese mouse model with basal artery (BA) abno
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Orthopedic market segment ranking open! Involving Johnson & Johnson, Medtronic, and Stryker
Time of Update: 2019-11-05
On the whole, the concentration of each segment industry is quite high, and the listed enterprises basically account for 80% - 90% of the share of each segment field; especially the top enterprises, w
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A number of Listed Companies in the biomedical industry accept centralized research
Time of Update: 2019-07-01
[industry trends of pharmaceutical Station] with the transformation of technology experience medicine such as gene detection and targeted therapy to medicine, the research and development of biomedica
