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Nat Immunol Qi Hai/Wang Jianbin of Tsinghua University collaborated to reveal plasma cell responses to immunity, autoantigens and microbiota
Time of Update: 2022-11-04
On October 31, 2022, Qi Hai of Tsinghua University and Wang Jianbin jointly published a joint newsletter entitled "Heterogeneous plasma cells and long-lived subsets in response to immunization, autoantigen and microbiota" online in the journal Nature Immunology Through single-cell mRNA sequencing, cytology, and genetic pulse-chasing mouse models, the study found that IgG and IgM LLPCs showed the EpCAM hi CXCR3- phenotype, while IgA LLPCs were Ly6AhiTigit-.
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Unexpectedly, the human dendritic cells turned out to be Zika virus processing plants
Time of Update: 2022-09-21
SREBP2-dependent lipid gene transcription enhances the infection of human dendritic cells by Zika virus Zika virus transmission electron microscopy image (red).
SREBP2-dependent lipid gene transcription enhances the infection of human dendritic cells by Zika virus Zika virus transmission electron microscopy image (red).
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Co-stimulation effect and research progress of humanized monoclonal antibody CD28
Time of Update: 2022-09-14
The co-stimulation process in which CD28 is involved can produce a number of important molecular effects:Induces the expression of IL-2R (interleukin-2 receptor) on the surface of T cells, thus allowing cells to receive a third signal;2.
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The innovation of biopharmaceutical companies accelerated, and more than 90 companies completed financing in the first quarter
Time of Update: 2022-08-10
Recently, many pharmaceutical companies have announced the completion of financing, which will be used for new drug research and development, promotion, At present, from the perspective of the industry as a whole, this wave of financing is still continuing.
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The first review
Time of Update: 2022-05-19
Sales of terminal piracetam injections in Chinese public medical institutions (unit: 10,000 yuan) Source: Minet.
hospital hospital hospital Sales of terminal piracetam injections in Chinese public medical institutions (unit: 10,000 yuan) Source: Minet.
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Diabetologia: genetic control of postprandial blood glucose and insulin secretion by blunting DPP4 in prediabetes
Time of Update: 2022-04-19
(d, e) Quantitative trait locus analysis map of 33 SNPs in the DPP4 gene region, detecting (D) blood glucose AUC and (E) C in (D) NGT participants (blue circles) and prediabetic participants (orange circles) Correlation of peptide AUC (0-120 min) levels .
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Youchao Beichun - TAA Tongen Medical's first domestic functional medicine concept product launched
Time of Update: 2021-10-11
Functional medicine, with its strong advantages in the field of chronic disease prevention and health management, has gradually played an increasingly important role in helping the "Healthy China 2030" strategy .
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Research funding of 45 million
Time of Update: 2021-08-12
On May 14, 2021, the launching ceremony of the "Innovation Research Institute Establishment and Academician Expert Workstation Unveiling" organized by Shanghai Zhongke New Life Biotechnology Co. , Ltd
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JCEM: The efficacy of zoledronic acid in the treatment of glucocorticoid-induced osteoporosis
Time of Update: 2021-08-03
The study aims to clarify that intravenous (IV) zoledronic acid (ZA) is compared with placebo in the treatment of GC-induced Efficacy and safety of osteoporosis (GIO) .
Zoledronic acid versus placebo in pediatric glucocorticoid-induced osteoporosis: A randomized double-blind phase 3 trial .
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21 kinds of hypoglycemic drugs-blood pressure, weight loss "super power" ranking
Time of Update: 2021-06-30
Table 3 Effect of hypoglycemic drugs on diastolic blood pressure (compared to placebo) Figure 3 Network meta-analysis: Effect of hypoglycemic drugs on diastolic blood pressure (mmHg, compared to placebo) Summary There is medium and high-level evidence that GLP-1RAs—— Simeglutide (subcutaneous administration), simeglutide (oral), exenatide (2 times a day) and liraglutide have the best "efficacy" in weight loss, followed by four SGLT-2i-Enpagliflozin, canagliflozin, dapagliflozin, and atogliflozin .
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Identify the causative gene of premature amyotrophic chordosclerosis | "Nature-Medical" paper
Time of Update: 2021-06-04
A clinical discovery report published in Nature-Medical this week, Childhood amyotrophic lateral sclerosis caused by excess sphingolipid synthesis, found that children with severe early-onset amyotrophic lateral sclerosis (ALS) have a rare type of SPTLC1 gene Mutations, this gene encodes a key metabolic molecule responsible for the production of a class of lipids called sphingolipids.
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The "magic drug" metformin exposes HIV weaknesses and can be used as an adjuvant treatment to enhance the immunity of AIDS patients
Time of Update: 2021-04-19
The study found that metformin can act on mitochondrial respiratory chain complex I, inhibit the oxidative phosphorylation (OXPHOS) pathway, and thereby inhibit the replication of human CD4+ T cells and HIV-1 virus in humanized mouse models.
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Nat Chem Biol: Fbxo48 inhibitors reduce insulin resistance by preventing pAMPK alpha degradation
Time of Update: 2021-02-02
in the recent study "A Fbxo48 inhibitor prevents pAMPK alpha degradation and ameliorates insulin resistance", researchers say they have identified an orphan Ubithin E3 connective enzyme sub-unit protein Fbxo48 that targets the active phosphorylated AMPK alpha (pAmpk alpha) and induces its multi-ubiction, which in turn is degraded by ponase.
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JCEM: Long-term outcomes and treatment of persistent and transient congenital high insulinemia
Time of Update: 2021-02-01
0% and 84% of these patients had diabetes, respectively, while 23% and 58% had clinical pancreatic exocrine dysfunction.
, however, the incidence of diabetes and pancreatic exocrine dysfunction was higher in patients with post-P-CHI neurodevelopment than in patients with P-CHI before 2000.
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Effects of Sterols on the Development and Aging of Caenorhabditis elegans
Time of Update: 2021-01-05
elegans to form certain sterols of unknown function.
elegans differs from that in other species, such as mammals and yeast, it is important to examine how sterols regulate worm physiology.
To examine the functions of sterols inC.
