10x Genomics Announces New Product: First Visium Instrument CytAssist
Time of Update: 2022-08-30
In order to solve the problem of serious degradation of FFPE samples, 10x Genomics launched the first-generation product of Visium FFPE gene expression solution in 2021, which can analyze the whole transcriptome of long-term preserved FFPE tissue samples, and has complete tissue coverage, which can be reproduced Analyze long-term stored biobank samples for biomarker discovery, or perform retrospective and longitudinal studies .
Who is more likely to develop Alzheimer's disease
Time of Update: 2022-08-20
A molecular analysis of human microglia by researchers at the Mount Sinai School of Medicine in New York has identified 21 genetic loci associated with Alzheimer's disease risk .
China University of Science and Technology Liu Qiang's team has made important progress in the field of Alzheimer's disease research
Time of Update: 2022-01-25
On January 26, 2021, Liu Qiang's team from the University of Science and Technology of China published a research paper titled " Astrocytic ApoE reprograms neuronal cholesterol metabolism and histone-acetylation-mediated memory " in the journal Neuron , revealing the effect of ApoE on neuronal cholesterol The mechanism of metabolic reprogramming and the impact of this metabolic regulation on neuronal function, especially learning and memory processes, also revealed a new mechanism by which ApoE4 causes Alzheimer's disease .
Secondary deletion of miR-3607 reduces expansion of cortical progenitors during rodent evolution
Time of Update: 2022-01-24
Therefore, the loss of endogenousMir 3607Proliferation of RGCs is reduced in ferrets, whereas overexpression of human brain organoids promotes VZ expansion .
Our findings identify a gene that was selected during mammalian evolution to limit RGC expansion and possibly cortical size in rodents .
Baylor College of Medicine discovers new target for triple-negative breast cancer: MAPK4
Time of Update: 2022-01-21
In a study published today in Nature Communications, scientists at Baylor College of Medicine and other institutions report that MAPK4 appears to play an important role in triple-negative breast cancer .
MAPK4 promotes triple negative breast cancer growth and reduces tumor sensitivity to PI3K blockade.
The mechanism of fruit maturation obstacles in banana fruit caused by low temperature stress is revealed
Time of Update: 2021-12-02
This study reveals the molecular mechanism of the interaction between the ethylene F-box protein EBF1 and the transcription factor ABI5-like to regulate the low temperature stress causing the ripening obstacle of the banana fruit, which provides a theoretical basis for improving the storage and preservation technology of the banana fruit .
Cell 820,000 GWAS meta analysis reveals the genetic risk of osteoarthritis and new drug targets
Time of Update: 2021-10-02
The GWAS meta-analysis of the cohort emphasized the influence of joint location types on the characteristics of genetic risk variation and the link between osteoarthritis genetics and pain-related phenotypes, and pointed out potential targets for therapeutic intervention .
Nature's in-depth review: Where will the new generation of mRNA therapy go
Time of Update: 2021-09-13
A few days ago, a review published by Nature Reviews Materials made a detailed inventory of the development of LNP technology for mRNA delivery, and discussed the broad clinical application prospects and challenges that need to be solved for this technology in addition to infectious disease vaccines.
Microfluidic thermophoresis biosensing research has made progress
Time of Update: 2021-08-07
This DNA tetrahedron-based thermophoretic assay (DTTA) detects the detection limit of prostate specific antigen (PSA) in serum EVs by extracting ribonucleic acid and enzymatic amplification.
Recently, the research team published this research in the "Nano Today" magazine, entitled "Ultrasensitive detection of mRNA in extracellular vesicles using DNA tetrahedron-based thermophoretic assay" .
Which is better for analyzing bulk RNA-seq data
Time of Update: 2021-08-04
Researchers at the University of Queensland have recently identified a powerful tool that can be used for the analysis of large-scale patient data sets .
Therefore, researchers at the University of Queensland, led by Professor Di Yu, compared four different mainstream tools: PCA, MDS, t-SNE and UMAP .
The human brain is bigger than the ape brain, the first explanation
Time of Update: 2021-04-08
In the latest study, a team led by Madeleine Lancaster, the Molecular Biology Laboratory of the Cambridge Medical Research Council, compared "brain organoids" grown from stem cells from humans, gorillas and chimpanzees.
Chinese and American researchers work together to lift the veil of corn leaves
Time of Update: 2021-03-13
Xinhua News Agency, Jinan, October 12 (Reporter Xiao Haichuan) reporter from Shandong Agricultural University was informed that the school researchers and a number of research institutes to cooperate in research, the use of high-volume research corn transcription factor control site technology, with the help of large-scale transcription factor data reconstruction of corn leaf gene expression control network.
Chromatin Immunoprecipitation to Verify or to Identify In Vivo ProteinDNA Interactions
Time of Update: 2021-03-12
ChIP may also be used to discover new targets, and when combined with high-throughput approaches to identify DNA fragments associated with a transcription factor, it may provide a tool to study the gene regulatory networks active during plant development and/or response to the environment.
Time-Lapse Imaging of Developing Meristems Using Confocal Laser Scanning Microscope
Time of Update: 2021-03-09
Here we describe in detail how to prepare shoot apices of both Arabidopsis and tomato, in order to image them over time using a confocal microscope equipped with a long-distance water-dipping lens.
Transient and Inducible Expression of Vaccinia/T7 Recombinant Viruses
Time of Update: 2021-02-22
Transient expression can then be achieved either by transfecting this plasmid into cells infected with the recombinant vaccinia virus expressing T7 RNA polymerase, vTF7-3 or by crossing this plasmid into the vaccinia virus genome and coinfecting cells with both viruses.