Advanced Science Peking University Li Zhanguo's research group discovered the molecular mechanism of tonsillar flora regulating the pathogenesis of rheumatoid arthritis
Time of Update: 2022-09-08
Thus, this study discovered the important role of tonsillar flora in maintaining immune balance, and the immunomodulatory mechanism of the antimicrobial peptide salivaricin in the pathogenesis of rheumatoid arthritis .
Xie Yuli: The development trend of new biomedical technologies
Time of Update: 2022-09-07
Although China's biomedical industry has made great strides in development in recent years, and some achievements have been made in the production of new drugs, but compared with the United States, especially in the cutting-edge, revolutionary field, there is still a big gap, take these biophase transformation companies, when they were first established, we did not know what they were doing, and they knew nothing about their targets and pharmaceutical methods.
Research frontiers Because of it, nearly half of prostate cancer patients may avoid excessive biopsy
Time of Update: 2022-09-07
GuideProstate-specific antigen (PSA) has been widely used in the diagnosis of prostate cancer (PCa), but because of its poor specificity, the number of unnecessary prostate puncture biopsies has also increased during application, resulting in over-diagnosis and over-treatment of low-risk PCa. The use of non-invasive biomarker testing may help improve the situation.
Time of Update: 2022-06-10
Thin layer plate silica gel GF254Eluent, dichloromethane - ethyl acetate - acetic acid (80:1:1)Inspection of 2,4-dinitrophenylhydrazine solution, observation under sunlight and ultraviolet light (254nm)2.
Thin layer plate silica gel GF254Developing agent toluene-ethyl acetate (19:1)Inspection of 2,4-dinitrophenylhydrazine solution, observation under sunlight and ultraviolet light (254nm)Gas chromatographyColumn AB-INNOWAX capillary column, 0.
Time of Update: 2022-05-28
Thin layer plate silica gel GDeveloping agent petroleum ether (60～90℃) -ethyl acetate (10:1)Check 10% sulfuric acid ethanol solution, heat at 105℃ until the spots are clear, check under sunlightHigh performance liquid chromatographyColumn HIQ-silC 18 , 5pm (4.
Express prolongs the life of patients with advanced breast cancer by nearly 16 months, and the long-term clinical results of Novartis CDK4/6 inhibitor are positive
Time of Update: 2022-05-27
▎WuXi AppTec Content Team Editor Today, Novartis announced that its CDK4/6 inhibitor Kisqali (ribociclib) in combination with fulvestrant as first-line therapy in postmenopausal patients with HR+/HER2- advanced or metastatic breast cancer In the phase 3 clinical trial of fulvestrant, the overall survival of patients was extended by nearly 16 months .
Under the normal situation that pharmaceutical companies have joined forces, the amount of cooperation is continuing to grow
Time of Update: 2022-05-08
[Pharmaceutical Network Industry News] In recent years, affected by the changes in the pharmaceutical industry, in order to respond to more and more market challenges and accelerate the development and commercialization of innovative drugs, the cooperation between pharmaceutical companies is becoming more and more frequent .
Time of Update: 2022-04-28
OlympiA trial results have shown that, The identification of BRCA1/2 mutations in women with high-risk disease gives them an additional option for treatment with olaparib, which reduces the risk of recurrence and improves survival in these breast cancer patients .
How will cancer change in China in 2022
Time of Update: 2022-04-27
21 million deaths; the burden of liver, gastric and esophageal cancer in China will decrease, but lung, colorectal, breast and Increased burden on the prostate; advances in cancer prevention and care, as well as aggressive responses to population aging, may help reduce cancer burden in China .
Br J Cancer: Effects of BRAF, KRAS and MSI on cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) in patients with metastatic colorectal cancer (mCRC) with peritoneal
Time of Update: 2022-04-23
Metastatic with BRAF (mutBRAF) or KRAS mutation (mutKRAS)Colorectal cancer (mCRC) patients have poor prognosis after liver or lung surgery, while the prognostic role of cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) in patients with peritoneal metastases (PM) is unclear .
Latest study: Inhibition of kinase GCN2 improves liver lipid deposition in obese mice
Time of Update: 2022-01-10
2021 Nian 12 Yue 23 days, College of Life magazine Lu Zhongbing research group in the field of oxidative stress and free radicals authority Redox Biology Online published an article Title ldquo &; Inhibition of hepatic steatosis and GCN2 alleviates oxidative Stress in the MICE Obese: Involvement of NRF2 The research paper of regulation ” reveals the molecular mechanism of inhibiting the kinase GCN2 to improve liver lipid deposition and oxidative stress in obese mice .
This article sorts out what treatment changes the new generation of ADC drugs bring to HER2-positive breast cancer
Time of Update: 2021-12-30
DS-8201 showed unprecedented activity in the phase II DESTINY-Breast01 clinical trial for patients with advanced HER2-positive breast cancer who had previously received multiple lines of treatment .
Fudan University "Cancer Research" published a paper: Cancer stem cell markers promote breast cancer by reshaping the immune microenvironment
Time of Update: 2021-12-25
The remodeling and tumor-promoting effects of breast cancer immune microenvironment and its specific molecular mechanisms help us better clarify the influence of BCSC marker ALDH1A1 on the occurrence and development of breast tumors, and provide new ideas for the clinical treatment of malignant breast cancer .
Eur Urol: Differential Response Analysis of Different Molecular Subtypes of Urothelial Carcinoma to Neoadjuvant Chemotherapy
Time of Update: 2021-12-24
Recently, researchers from Sweden published an article on the "Eur Urol" magazine, investigated how different molecular subtypes influence pathological response and students before preoperative chemotherapy of cisplatin deposit rate .
Among the predetermined molecular subtypes, the researchers compared the complete pathological response (ypT0N0) and survival rates of cystectomy samples .
Consensus on the latest guidelines of the 6 liver disease departments, one article is included in the bag
Time of Update: 2021-12-05
This article summarizes the recently released domestic and foreign liver disease related guidelines for everyone to read and download! 2021 AGA Clinical Practice Guidelines: Management of coagulopath