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Nature destroys the MYC hollow ball and the cancer cells die
Time of Update: 2023-01-05
Hollow spheres protect sensitive DNA sitesThe researchers found that when cells in the lab were subjected to stress conditions similar to those of fast-growing tumor cells, the MYC protein in the nucleus rearranged in a dramatic way.
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[Cell Sub-Journal] New targets for pancreatic cancer microbiome and immune regulation
Time of Update: 2022-08-20
This article is original from Translational Medicine Network, please indicate the source for reprinting Author: TMZHIIntroduction: Different from other solid tumors, the stromal component of pancreati
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Chinese Academy of Sciences research team discovers archaeal transcription termination mechanism
Time of Update: 2022-01-25
The post-transcriptional regulation mechanism of ribosomal protein synthesis and assembly (Nucleic Acids Res, 2017); found that mRNA processing is important for low temperature adaptation in Methanogens (Environ Microbiol, 2021), and revealed the working mechanism of related nucleases (RNA Biol 2020; MolMicrobiol, 2017); discovered the first archaeal cold shock protein and its RNA chaperone function (PLoS Genet, 2019; Front Microbiol, 2017) .
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Chinese scientists deciphered the entire genome of ancient wheat from about 3800 years old
Time of Update: 2021-02-22
Chinese scientists have recently made great progress in the field of ancient wheat research, successfully measuring and analyzing the first full genome sequence of wheat dating back about 3800 years, proving the close relationship between ancient wheat and the existing local varieties of ordinary wheat in southwest China, and proposing the diffusion route of ordinary wheat from the edge of the Qinghai-Tibet Plateau to the Yangtze River basin.
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RNA Probes for the Analysis of Gene Expression
Time of Update: 2021-01-06
First, and in contrast to their cellular counterparts, the enzymes are single-chain proteins that were easily purified from phage-infected cells and are now produced by recombinantDNA technology.
Third, the enzymes are highly processive, allowing the efficient synthesis of very long transcripts from DNA templates.
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The Burton Assay for DNA
Time of Update: 2021-01-01
The Burton assay forDNA is a colorimetric procedure for measuring the deoxyribose moiety of DNA.
It is reasonably specific for deoxyribose, although very high concentrations of ribose (from RNA) or sucrose must be avoided.
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Electrophoretic Mobility Shift Assay Analysis of NFB Transcriptional Regulation by Nuclear IB
Time of Update: 2020-12-14
Using this protocol, we show that in human leukemia Hut-78 cells that exhibit high levels of NFκB DNA binding activity, MG132 induces nuclear translocation and accumulation of IκBα, which then specifically inhibits NFκB DNA binding.
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Optical Trapping and Unfolding of RNA
Time of Update: 2020-12-07
Optical tweezers have proven a useful tool for exploring the structure and function of individual molecules, such as proteins,DNA , and RNA.
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Computational Methods for Identification of DNA Transposons
Time of Update: 2020-11-19
DNA elements are structurally distinct from RNA elements and most of them have terminal inverted repeats (T IR s).
Among the DNA elements in plants, the most abundant type is the miniature inverted repeat transposable elements (MITEs).
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Hunting: A new mechanism for the diversity of transcripts
Time of Update: 2020-08-11
the study is the first to clarify the main way new variable shear sites are generated by TAM, and suggests that RNA diversity caused by TAM may provide another strategy for adaptive evolution of species.
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AML remission period first-line maintenance treatment of new drugs! TimeYUYCC-486 gets FDA priority review
Time of Update: 2020-05-30
This NDA is based on the efficacy and safety results of the key Phase III QUAZAR AML-001 study The study was conducted in a newly diagnosed AML patient who received remission after intensive induction
