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Materials Today Bio: Liu Gang's team at Huazhong University of Science and Technology develops black technology for gene therapy and rapid quantitative detection of vaccine vectors
Time of Update: 2022-10-12
Gene therapy can fundamentally supplement or repair defective genes and restore the normal biological functions of healthy genes, which has incomparable therapeutic advantages. Adenoviruses or adeno-a
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Facing the epidemic: it is necessary to establish a new understanding that milk has dual nutritional functions
Time of Update: 2022-09-10
, American Journal of Respiratory Cell and Molecular Biology, 2011 )Therefore, in the process of human beings fighting against epidemic diseases, it is necessary to not only exert the basic nutritional function of milk, but also give full play to the active nutritional function of milk.
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Science Sub-Journal: What causes intestinal disorders in premature infants
Time of Update: 2021-09-29
Researchers have shown that the loss of enteric glial-supporting specialized nerve cells in the small intestine causes intestinal motility disorders-a condition where the gastrointestinal tract is incapable of food and other materials (called peristalsis), this malfunction is NEC's A key element of origin .
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Research finds that "variable" immune cells may help develop new crown vaccines
Time of Update: 2021-09-03
Xinhua News Agency, Sydney, August 24 (Reporter Hao Yalin) A new study by an Australian research team found that tissue-resident memory T cells (TRM cells) have different molecular characteristics and behaviors in different tissue environments of the human body.
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Nat Commun Ji Jing's team discovered a new mechanism for prodynein to regulate neuronal death after traumatic brain injury
Time of Update: 2021-08-08
Figure 1 In summary, the team revealed the protective effect of Prok2 on neurons after traumatic brain injury, and further explained the importance of the Prok2-Fbxo10-Acsl4 regulatory axis in inhibiting neuronal iron death and the accompanying lipid peroxidation.
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Merck's TGF-β/PD-L1 dual-targeted therapy for cholangiocarcinoma shows therapeutic potential
Time of Update: 2021-04-28
The study was carried out in patients with locally advanced or metastatic cholangiocarcinoma (BTC) who had failed or intolerated first-line platinum-containing chemotherapy, and evaluated bintrafusp alfa (M7824) as a monotherapy for second-line treatment.
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Small cells, big impact: RNA-protein complexes in cyanobacteria
Time of Update: 2021-03-25
Scientific question: What are the RNA-binding proteins involved in important post-transcriptional regulation processes in cyanobacteria that have not been clearly studied in other bacteria?
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Chinese scholars have discovered the apoptosis mechanism of inflammatory macrophages
Time of Update: 2021-03-05
The team identified the metal ion transport protein SLC39A10 mediated macrophage zinc ion intake through the gene knock-out mouse model, and found that in the inflammatory state, the mortality rate of gene knock-out mice decreased significantly, liver damage and blood inflammatory factor levels were significantly reduced.
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Stress Detection Using Bioluminescent Reporters of the Heat-Shock Response
Time of Update: 2020-12-24
The heat-shock response is the coordinated induction of a set of protems in response to a variety of cellular stresses, including elevated temperature ( 1 ).
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Science: Reveals protein NRLP1 specific identification of double-stranded RNA to detect viral infection mechanisms
Time of Update: 2020-12-21
Nov 29, 2020 /--- In a new study, Veit Hornung of the University of Munich in Germany and his team confirmed that a protein found in skin cells called NRLP1 identifies specific nucleic acid intermediates formed during virus replication.
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Isolation of an mRNA-Binding Protein Involved in C-to-U Editing
Time of Update: 2020-12-16
Here we outline a protocol for purifying Apobec-1 complementation factor (ACF), the RNA-binding subunit of the apolipoprotein-B (apo-B) mRNA-editing enzyme.
ACF was purified using synthetic wild-type and mutant apo-B RNAs, which were coupled to cyanogen bromide (CNBr)-activated Sepharose.
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Nat Commun:c-Myc activates the pan-cancer expression lncRNA MILIP inactivated p53 and induces cancer
Time of Update: 2020-10-28
Previous studies have shown that the protocancer protein c-Myc and tumor suppressor p53 are inextricable relationships in regulating normal cell survival and proliferation, and that their function also maintains a steady state of tissue: c-Myc can induce The expression of ARF tumor inhibitors, which then bind and inhibit the expression of MDM2, eventually causes the activation of p53, which inhibits c-Myc through a variety of mechanisms, including transcriptional inactivation and microRNA-mediated inhibition.
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Determination of the activity of superoxide disambiguation enzyme (SOD
Time of Update: 2020-10-17
type: the total activity of SOD is U/gFW, which represents the light absorption value of ACK as a control cup (light) in U/mg protein than the unit of vitality; AE is the light absorption value of the sample; V is the total volume of the sample fluid, V1 is the sample amount at the time of determination, and W is the sample weight g..
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Cell Death Differ: TRIM22 activates the NF-B signal by accelerating I-B alpha degradation
Time of Update: 2020-09-23
trim protein family, a sub-family of RENING-type E3 ubiquitin connective enzymes, can act as a key regulatory factor in the development of a variety of cancers, including GBM, by regulating the transcriptional activity of NF-B.
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The T-cell-function TIDE algorithm predicts the efficacy of immunotherapy
Time of Update: 2020-08-07
Pancreatic cancer formed by the -inflame cell line is also CD8-T cell immersion, expressing Tim, CTLA4, PD1, Lag3 and other ICB sensitive markers; metabolism and immunotherapy (1) Tumor microenvironment promotes tumor growth, inhibits immunity, and affects the efficacy of immunotherapy.
