The diagnostic history of a case of T-cell large granular lymphocytic leukemia
Time of Update: 2022-10-25
Hemomyeloid image: the proportion of T lymphocytes in the bone marrow is increased, combined with flow cytometry immunophenotyping can not exclude T-cell lymphoma (large granular T lymphocytic leukemia), but please rule out reactive changes first, please combine clinical, bone marrow smear and other examinations, and do TCR rearrangement examination.
New Cell Insights: New signals that trigger the body's immune response
Time of Update: 2022-10-03
essayActin Cytoskeleton Remodeling Primes RIG-I-like Receptor Activation Image: Researchers at the Cleveland Clinic's Florida Center for Research and Innovation have found that the destruction of cellular structures known as actin cytoskeletons is a "start-up signal" for the body to respond to the virus.
Cell Wrote textbook discoveries! This neglected organ may directly affect brain functions such as memory, sleep, and mood
Time of Update: 2022-09-21
The researchers used cilia-targeted serotonin sensors, showing that when neurons extending out of the brainstem release the chemical signaling molecule Serotonin from axons, receptors on the cilia receive signals that trigger a series of biochemical reactions within the cell, ultimately altering the genomic material in the nucleus, especially epigenetic states.
J Autoimmun: Phosphatase controls cytokine-mediated overproduction of galactose-deficient IgA1 ( the main autoantigen for IgA nephropathy
Time of Update: 2022-09-07
SiRNA knockdown of SOCS1 and associated SOCS3 increases Gd-IgA1 production in cells from healthy control PBMCs, indicating the role of these regulators in abnormal cytokine signaling and Gd-IgA1 overproduction.
2021 Top Ten Innovative Products in Life Science Announced
Time of Update: 2022-02-22
The emergence and breakthrough of technologies such as genome editing, microscopic imaging, single-cell analysis, and spatial transcriptomics have enabled the field of life science to develop higher, faster, and stronger, and have also enabled scientists to better answer questions related to health and disease.
Cell heavyweight: Liu Ruqian develops a new virus-like vector for safe and efficient in vivo gene editing
Time of Update: 2022-02-18
When it comes to Liu Ruqian, the first thing that comes to our mind are new gene editing tools such as Base Editor and Prime Editor . Different from CRISPR-Cas9 gene editing, a series of precise gene
eNeuro: withdrawal from psychostimulants will rebuild the functional structure of the brain
Time of Update: 2021-10-11
"We found that cocaine, methamphetamine, and nicotine withdrawal symptoms produced a major reshuffle of the brain area with an increase in the main functional connectivity in the whole brain control (saline) mice compared to," George said, "with a decrease in modular structure The strongest of the brain is methamphetamine, cocaine, and nicotine .
Scientists have developed a new agricultural research management framework based on ecological functions
Time of Update: 2021-08-17
Mane Isaac, the research chair in the field of agricultural ecosystems and development in Canada and an associate professor at the University of Toronto Scarborough, said that the focus of the study of ecological functional traits is on the response and impact of plants to environmental changes, not just analyzing their genetic characteristics or Measure its output .
Pay attention to the precise diagnosis and treatment of rare mutations, and start a new journey of integrated diagnosis and treatment in the targeted outpatient clinics
Time of Update: 2021-06-22
With the support of the hospital, the Lung Cancer Rare Mutation Targeted Clinic will be opened on March 18, 2021, so that patients can receive scientific treatment guidance and precise treatment services .
Researchers establish a patient typing model based on epigenetic heterogeneity of lung adenocarcinoma
Time of Update: 2021-06-05
In order to explore whether this apparent group-based lung adenocarcinoma typing model can be applied to other patients, the researchers used the respective feature gene sets of the two subgroups to divide the lung adenocarcinoma patients in the TCGA database into G I-like and G II-like two groups, and found that they have significantly different survival times, and G II-like patients generally have a higher tumor mutation burden and more tumor suppressor gene mutations.
The best biomarkers for targeted therapy of ovarian cancer
Time of Update: 2021-05-21
The latest SOLO-1 data shows that for newly diagnosed ovarian cancer patients with BRCA mutations, the benefits of maintenance therapy with the PRAP inhibitor olaparib for 2 years can continue until the end of the treatment, and nearly half of the patients will be treated after 5 years.
Time of Update: 2021-03-16
In acidic and moist conifer woodlands, this species grows in large areas and is often mixed with gray or white-haired plants.
blond hairs include 1 21 genus, distributed around the world, the number of chromosomes is more than n- 7 , 14 or 21 .
Japan has cultivated mysterious single-celled microorganisms
Time of Update: 2021-03-04
a single-celled pro-nuclear biome, the newly discovered Asgard bacteria, believed to be the ancestors of more complex egos.
Further analysis revealed that the genome of "P.syntrophicum" contained a high proportion of celebular cell-like genes, confirming previous DNA analysis.
Scientists crack the code of origin of land plants
Time of Update: 2021-02-28
Viride is the oldest known single-celled algae, with information on its genome, transcription and observational groups, and is a key node in revealing the origin and evolution of the entire plant, which is important for explaining the evolutionary history of life on Earth and the early differentiation of plants about 1 billion years ago.
Single-Cell Gel Electrophoresis or Comet Assay of Intestinal Epithelial Cells Using Manual Scoring and Ridit Analysis
Time of Update: 2021-02-24
The single-cell gel electrophoresis or comet assay was initially reported in 1984 as a novel technique to directly visualize DNA damage in individual cells ( 1 ).