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Extraordinary plasticity of glucocorticoid receptors
Time of Update: 2022-12-30
essayThe multivalency of the glucocorticoid receptor ligand-binding domain explains its manifold physiological activities The team's research revealed the enormous plasticity of the glucocorticoid receptor, which is able to form dimers, tetramers, and complexes with other proteins.
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【Pediatric anesthesia】Opioid use in infants and young children
Time of Update: 2022-11-01
Article from: Gregory's Pediatric AnesthesiaContributed by Wu YajunTypesetting/meat~Opioid use in infants and young children~Opioids are widely used to treat moderate to severe pain in infants and young children, especially in the early postoperative period.
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No more COVID-19 vaccinations! Multi-country joint study: two antibodies against all new coronavirus variants
Time of Update: 2022-10-03
The purpose of this study was to investigate the neutralization activity-specific breadth and structural basis of previously isolated mAbs. To identify previously isolated mAbs for RBD recognition of the new coronavirus, graduate students became RBD proteins that have been identified in Alpha, Beta, Gamma, Delta, and Omicron and tested eight mAbs that initially showed strong binding to wild-type strains of RBD.
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Neuron—A new molecular mechanism by which synaptic initiating proteins regulate ultrafast endocytosis
Time of Update: 2022-10-03
Written by - Wang Yalong Responsible Editor - Wang Sizhen Editor - Yang BinweiThe continuous neural activity of neurons requires the participation of a large number of synaptic vesicles, and the cell body cannot replenish the consumed vesicles in time, so a variety of vesicle circulation methods are formed within the synapses to ensure the rapid recovery of the membrane and protein components of the synaptic vesicles for reuse[1].
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Shanghai Jiaotong University Zhao Yilei's team found that a novel sulfur bond of sulfur-modified DNA has special significance in iodine cleavage reaction and SBD protein recognition
Time of Update: 2022-05-18
PNAS work elucidated that the super-strong "sulfur-iodine" halogen bond between the phosphorothioate modification site and the iodine molecule triggers a series of chemical reactions, resulting in DNA backbone cleavage or sulfur-oxygen conversion at the sulfur modification site, revealing that Molecular mechanism of highly selective splicing of sulfur-modified sites in deep sequencing by iodine cleavage .
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Li Xiaoliang's laboratory published a paper in JOURNAL OF VIROLOGY
Time of Update: 2022-01-10
078 )Authors: Xu, Jidong ; Mao, Junyong ; Han, Xiao ; Shi, Fushan ; Gao, Qin ; Wang, Tingjun ; Zhang, Zhenning ; Shan, Ying ; Fang, Weihuan ; Li, Xiaoliang* ()Source publication: JOURNAL OF VIROLOGYVolume 95, Issue 18, Literature Number e00853-21DOI10.
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Science: Omicron mutant strains are evolving new ways to evade antibodies and vaccines
Time of Update: 2021-12-28
The study predicted the future evolution strategy of SARS-CoV-2 and discovered several possible mutations that allow the virus to evade immune defenses, including natural immunity obtained through infection or vaccination, and antibody-based treatments .
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Nature Sub-Journal/Science/Hepatology Academician Tian Zhigang and other teams have made continuous progress in the field of immunology
Time of Update: 2021-10-01
In addition, on September 12, 2021, Peng Hui, Tian Zhigang and Sun Yan from the University of Science and Technology of China published a report entitled "Requirement of RORα for Maintenance and Anti-Tumor Immunity of Liver-Resident Natural Killer Cells/ILC1s" in Hepatology Online.
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β-Agonist Residue Analysis Technology
Time of Update: 2021-09-05
However, the recovery rate of fenoterol is only 32%; while the 10% sodium carbonate-acetonitrile solution is significantly better than the other two methods for extracting 9 drugs.
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"Good cholesterol" can protect the liver
Time of Update: 2021-07-27
Randolph, a professor of immunology at the University of Washington School of Medicine, one of the corresponding authors of the study, said that the study showed that increasing the level of this specific type of HDL, especially in the intestine, may have a protective effect on liver disease .
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Rongchang Bio-Tetacept was approved, the second new drug for systemic lupus erythematosus in 60 years
Time of Update: 2021-03-27
Overexpression of these factors is an important cause of systemic lupus erythematosus (SLE) and other autoimmune diseases related to B lymphocytes.
According to the key clinical research results published by Rongchang Biological, the systemic lupus erythematosus response index (SRI) of the high-dose Taltazep group for 48 weeks was significantly higher than that of the placebo control group (79.
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DNase I Footprinting of Small Molecule Binding Sites on DNA
Time of Update: 2021-02-27
Nuclease footprinting techniques were initially developed to investigate protein-deoxyribonucleic acid ( DNA ) interactions but these tools of molecular biology have also become instrumental for probing sequence-selective binding of small molecules to DNA.
DNase I is a convenient endonuclease for detecting and locating the position of actinomycin-binding sites within GC-rich sequences.
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The new method detects the presence of new coronavirus antibodies in the blood
Time of Update: 2021-02-18
Using plasma and serum samples from 16 new coronavirus-infected people, the team developed methods that observed all samples test positive for both versions of the pyrethroid protein.
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Measurement of Phosphatidylinositol and Phosphatidylcholine Binding and Transfer Activity of the Lipid Transport Protein PITP
Time of Update: 2021-01-03
Phosphatidylinositol transfer proteins (α and β) are lipid transport proteins that specifically bind phosphatidylinositol or phosphatidylcholine in their hydrophobic cavity and facilitate their transfer from one membrane compartment to another.
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Targeting the Purinome
Time of Update: 2020-12-04
A review of purine recognition in representatives of the various purine-binding protein families, as well as the challenges faced in targeting members of the purinome in drug discovery campaigns will also be given.
