Single-cell RNA sequencing reveals the evolution of the immune response in GBM progression
Time of Update: 2022-10-14
of Harvard Medical School in the United States used single-cell transcriptomics and flow cytometry to reveal large-scale comprehensive longitudinal changes in immune cell composition throughout tumor progression in a genetic mouse GBM model driven by epidermal growth factor receptors.
Adaptive immune resistance to AIR at tumor sites: mechanisms and future prospects
Time of Update: 2022-09-15
However, immunotherapy methods based on enhancing the T cell-mediated immune response against antigens (collectively referred to as "immune enhancers") often face similar problems to other conventional cancer treatments, such as limited efficacy and high toxicity 。 PD-1/PD-L1-blocked immunotherapy has been successfully applied to clinical patients, and since pembrolizumab and nivolumab were approved for advanced melanoma in 2014, the FDA has approved multiple indications for up to 20 solid tumors or hematologic malignancies of PD-1/PD-L1 monoclonal antibody.
Remote bile-pancreatic endoscopic laser tumor targeted therapy to start the "pancreatic defense war
Time of Update: 2022-09-07
After evaluating the patient's condition, Director Ling Hu Enqiang of the Department of Gastroenterology of the First Medical Center of the PLA General Hospital and Gu Ying, academician of the Chinese Academy of Sciences of the Laser Medicine Center of Hainan Hospital, decided to innovate the combination of bilecreatic endoscopy and laser tumor-targeted photodynamic therapy to achieve the removal of intrapancreatic lesions without excision of the pancreas.
eLife's breakthrough discovery of protein needed for muscle regeneration
Time of Update: 2021-12-25
The Kumar laboratory is investigating whether the recently developed highly specific drug activators IRE1 and XBP1 can improve skeletal muscle regeneration after acute injury and other muscle degenerative diseases .
Two pharmaceutical companies "marriage" to deepen their layout in the field of in vitro diagnostics
Time of Update: 2021-12-04
Public information shows that Zhongyuan Huiji is an enterprise specializing in the research and development, production, sales and technical services of in vitro diagnostic reagents and instruments.
China Heavy Pharmaceutical Holdings has been selling Zhongyuan Huiji's IVD products since 2019.
Shandong University found that Smek1 plays a protective role in demyelinating diseases
Time of Update: 2021-09-30
Csf1 + microglia in Smek1 -/- mice express IL-1β and chemokines at high levels, indicating that in the case of partial or complete loss of Smek1 function, this new cell may have a pre-activated phenotype, resulting in Neuroinflammation .
Tesla’s 100-year-old invention has long been “grown” in the shark’s gut
Time of Update: 2021-09-10
Tesla’s invention 100 years ago has long been “grown” in the shark’s intestines Tesla’s invention 100 years ago has long been "grown" in the shark intestines Tesla invention 100 yea
Genxi Biology and Mingji Biology collaborate to develop immune cell therapy for CLDN18.2 positive solid tumors
Time of Update: 2021-08-27
2 antibody, to further develop, produce and commercialize innovative immune cell therapy, which will benefit The majority of patients with CLDN18.
2 is regarded as one of the high-quality targets for the development of immune cell therapy, with broad potential for clinical benefit .
Another breakthrough in gene therapy: treatment of heart failure effectively improves heart function
Time of Update: 2021-08-06
AAV9-Sav-shRNA gene therapy improves heart function in pigs with myocardial infarction (Source: Science Translational Medicine)Three months after injection, the ejection fraction (a measure of left ventricular systolic function) of the pig heart treated with high-dose AAV9-Sav-shRNA increased by 14.
Drug financing can be administered repeatedly
Time of Update: 2021-08-04
Ring Therapeutics completed a US$117 million Series B financing this time, hoping to face these challenges by introducing a new gene therapy vector platform .
The company has discovered thousands of candidate vectors based on ring virus, and has the potential to achieve gene therapy and nucleic acid drugs in various diseases .
Roche's Evrysdi is about to be approved for listing in the EU and has been under review in China
Time of Update: 2021-04-28
Roche recently announced that the European Medicines Agency (EMA) Committee for Medicinal Products for Human Use (CHMP) has issued a positive review suggesting that Evrysdi (risdiplam) should be approved for the treatment of age ≥ 2 months and a clinical diagnosis of 1 Type 2 type/3 SMA or type 5q spinal muscular atrophy (SMA) with 1-4 copies of SMN2.
Nature Metabolism: Subverting cognition: The culprit of dizziness and mobility impairment after drinking is not alcohol, but its metabolite acetic acid
Time of Update: 2021-04-13
On March 22, 2021, the team of Professor Zhang Li from the National Institutes of Health (NIH) Institute of Alcohol Abuse and Alcoholism (NIAAA) published in the journal Nature Metabolism the title: Brain ethanol metabolism by astrocytic ALDH2 drives the behavioural effects of The research paper of ethanol intoxication, which was also selected as the cover paper of the current issue.
Radioimmunoassay for the Quantification of cGMP Levels in Cells and Tissues
Time of Update: 2021-03-07
Radioimmunoassay is an established method to determine the amount of a specific substance in a given cell or tissue sample.
Commercially available RIA or Elisa are very cost intensive.
Here, we describe the generation of radioactive c GMP tracer and the quantification of cGMP.
Aspects of Experimental Design for Plant Metabolomics Experiments and Guidelines for Growth of Plant Material
Time of Update: 2021-01-19
For this, each step from plant cultivation to data acquisition needs to be evaluated in order to identify the major sources of error and then an appropriate design can be produced, as with any other experimental approach.
Transformation of Plants Via the Shoot Apex
Time of Update: 2021-01-15
According to Cutter1 ), the apical meristem refers to only that portion of the shoot apex lying distal to the youngest leaf primordium.
True apical meristem culture of higher plants was first demonstrated by Smith and Murashige2 ).