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First-line treatment prolongs the lives of gastric cancer patients, and the potential "first-in-class" therapy has been clinically validated for the first time in Phase 3
Time of Update: 2023-01-06
Looking forward to the new year, in order to have a more comprehensive understanding of the views and insights of friends in the biomedical industry on the development of the industry, we invite you to spend 1 minute in your busy schedule to fill out this questionnaire (long press to scan the code, or▎WuXi AppTec content team editor On November 17, Astellas Pharma announced that zolbetuximab, an investigational antibody therapy targeting Claudin18.
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First-line treatment prolongs the lives of gastric cancer patients, and the potential "first-in-class" therapy has been clinically validated for the first time in Phase 3
Time of Update: 2023-01-06
Looking forward to the new year, in order to have a more comprehensive understanding of the views and insights of friends in the biomedical industry on the development of the industry, we invite you to spend 1 minute in your busy schedule to fill out this questionnaire (long press to scan the code, or▎WuXi AppTec content team editor On November 17, Astellas Pharma announced that zolbetuximab, an investigational antibody therapy targeting Claudin18.
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Breast cancer survival rate doubles
Time of Update: 2022-11-15
"So Kirkham, in collaboration with oncologist Katarzyna Jerzak at Sunnybrook Odette Cancer Center and an assistant professor in the Department of Medicine at Temerty School of Medicine at T University, began a new study to determine the latest estimate of the prevalence of breast cancer survivors in Canada in 2022, using the Canadian Cancer Society's annual Cancer Statistics Report.
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Immunity angels turn demons – Li Ming's team revealed that tumor-associated macrophages use IRF8 to promote T cell depletion
Time of Update: 2022-11-15
The authors first detected changes in the mononuclear phagocyte system in the MMTV-PyMT (PyMT) breast cancer model, and found that the number of tumor-associated macrophages residing in tumor tissues increased, while the proportion of DC1 decreased, and DC2 did not change significantly。 Most DC1 expresses CD103, a marker associated with maturation and migration to secondary lymph nodes.
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Science sub-journal discovered drug targets for the treatment of rare, deadly neurocarcinoma MPNST
Time of Update: 2022-11-15
essaySingle-cell multi-omics identifies clinically relevant mesenchymal stem-like cells and key regulators for MPNST malignancy Image: Using Slingshot to infer the trajectory of tumor cell states from NF to MPNST.
Image credit: Cincinnati Center for Children and Scientific ProgressImage: Using Slingshot to infer the trajectory of tumor cell states from NF to MPNST.
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Radiation therapy for high-risk, asymptomatic bone metastases can prevent pain and prolong life
Time of Update: 2022-10-25
A phase II clinical trial showed that treating high-risk, asymptomatic bone metastases with radiation therapy may reduce painful complications and hospitalizations, and may prolong overall survival in patients whose cancer has spread to multiple sites.
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EBioMedicine: Baseline host determinant of human HIV-1 vaccine-induced immune response
Time of Update: 2022-10-25
9% of participants were classified as high responders to gp120 IgG, gp140 IgG, gp41 IgG, and Env-specific CD4+ T-cell vaccine-induced responses, respectively 。 When all baseline features were included, the classification of the high responder state bound to antibody response was moderate, with a cross-validation area (CV-AUC) of 0.
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BMJ: Effects of low-dose CT screening on disease staging and survival in patients with lung cancer
Time of Update: 2022-04-23
The study found that for people aged 55-80 years, the proportion of patients with stage I NSCLC did not change significantly between 2010-13 (27.
Studies have shown that the low-dose CT lung cancer screening program has greatly increased the proportion of patients with stage I NSCLC and prolonged patient survival .
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Eur Urol Oncol: Immune milieu and differentiation signatures predict bladder cancer outcome
Time of Update: 2022-04-23
Determined whether immune cell subsets and cancer cell intrinsic characteristics are associated with BC outcome and response to first-line chemotherapyThe researchers used multiplex immunofluorescence (CD3, CD8, FOXP3, CD20, CD68, CD163 and MHC-I) and immunohistochemistry (pancytokeratin, CK5/6, GATA3, PD-1 and PD-L1) on 785 BC patients ( Ta-T4b) primary tumor tissue was examined, and the staining results of the cancerous and stromal portions of the tumor were quantified by digital image analysis .
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Molecular Cancer Wang Fubing's team from Zhongnan Hospital of Wuhan University: Engineered exosomes as dendritic cell in situ vaccines enhance anti-tumor immunity of breast cancer
Time of Update: 2022-03-06
On February 11, 2022, Wang Fubing, Zhongnan Hospital of Wuhan University, and Yuan Chunhui's team of Wuhan Women and Children's Health Care Center published online at Molecular Cancer (IF=27) entitled "Engineered exosomes as an in situ DC-primed vaccine to boost antitumor immunity in breast cancer”, which loaded the immunogenic cell death (ICD) inducers human neutrophil elastase (ELANE) and Hiltonol (a TLR3 agonist) into engineered α-lactalbumin (α-LA) breast cancer-derived exosomes to form an in situ DC vaccine (HELA-Exos) .
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Fallopian tube organoids show how BRCA1 mutant women with ovarian cancer start
Time of Update: 2022-01-08
Stem cell scientists at Cedars-Sinai Medical Center have revealed the origin of a common ovarian cancer by establishing a fallopian tube tissue model .
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FDA Rheumatism News: 3 new drugs have been approved, and 2 drugs have been "warned
Time of Update: 2021-12-05
In this issue, Wang Yuhua, director of the Department of Rheumatology and Immunology, Beijing Shijitan Hospital, Capital Medical University, took us into ACR 2021 and shared the latest news of the FDA on the safety of rheumatism treatment .
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Bacteria and fungi interact more frequently than previously thought
Time of Update: 2021-11-02
"This research contributes to a new understanding of the fungal flora, that is, the presence of bacteria in and closely related to the fungal host, in order to more closely study the interaction and link the research to issues such as ecosystem functions and the impact of climate change.
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Nature: Seeing through the "trick" of cancer cells brings new hope to patients with colorectal cancer
Time of Update: 2021-06-16
Therefore, in order to explore the interaction between cancer-promoting mutant cells and normal neighboring cells, researchers at the Cambridge Stem Cell Institute developed a microscopy technique that uses multicolor labeling technology to track the trajectories of single mutant genes Kras and Pik3ca , Studies have found that mutated cancer stem cells can secrete specific cytokines and inhibit the activity of surrounding healthy intestinal stem cells .
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Professor Wang Liwei: Progress in medical treatment of liver cancer
Time of Update: 2021-03-22
02 During the 2020 ASCO conference, a phase III study of apatinib versus placebo in the second-line treatment of Chinese patients with advanced liver cancer was announced.
