Zhang Haitao's research group at the School of Pharmacy of Zhejiang University reported in Nature Communications that the drug target histamine H3
Time of Update: 2022-10-31
In this study, the crystal structure of the complex of human histamine receptor H3R and antagonist PF-03654746 was analyzed by protein crystallography, and the antagonist PF-03654746 was systematically elucidated by combining computational and functional experimental results The unique binding mode of allosteric regulation of molecular cholesterol and the conserved binding mode of different antagonists provide a structural basis for the design of H3R-based drugs.
Rheumatism patients with immunosuppressive drugs undergo surgery, preoperative medication management recommendations at a glance
Time of Update: 2022-10-03
Compiled and sorted out, please do not reprint without authorization. The increasing complexity of patients undergoing surgery makes perioperative medication management challenging. Some patients with
Hefei Research Institute has developed a new type of tropomyosin receptor kinase inhibitor
Time of Update: 2022-06-22
NTRK gene fusion occurs in a variety of solid tumors in adults and children, including breast cancer, colorectal cancer, non-small cell lung cancer, and various sarcomas .
AI pharmaceutical has become a trend, attracting domestic and foreign pharmaceutical companies to compete for layout
Time of Update: 2022-03-02
On January 11 this year, after Fosun Pharma and Insilicon announced their "marriage", on February 17, the two parties announced that they had nominated the preclinical candidate compound ISM004-1057D for the cooperation project for new tumor immunotherapy .
Express targets a variety of solid tumors, and clinical trials of allogeneic CAR-T therapy have been approved by the FDA
Time of Update: 2021-12-28
▎ WuXi AppTec content team editor today, Poseida Therapeutics announced that the US FDA has approved a new drug clinical trial application (IND) for the allogeneic CAR-T cell therapy P-MUC1C-ALLO1 to treat multiple solid tumor indications .
Summary of treatment options for renal cell carcinoma: what is the current situation and what is the future
Time of Update: 2021-08-08
Rapalogs (analogs of rapamycin), everolimus and temsirolimus are the most common mTOR inhibitors and have been shown to have potent anticancer activity against several tumor types including RCC (Figure 2b) .
VEGFR signaling and mTOR are important targets, and several approved drugs have significantly improved the survival rate of RCC patients .
Notice on the implementation of guardian management of standard varieties of pharmaceutical packaging materials in the "Chinese Pharmacopoeia
Time of Update: 2021-07-28
cn Attachment: Contact Information of "Variety Guardian" in the "Chinese Pharmacopoeia" drug packaging standard National Pharmacopoeia Committee April 9, 2021 annex Contact information of "Variety Guardian" in the "Chinese Pharmacopoeia" drug packaging material standard standard name Responsible unit contact number Contact Email 4001 121℃ Determination of water resistance of glass particles China Institute of Food and Drug test 010-67095110 rayradix@126.
FDA solicits comments on considerations for clinical pharmacology evaluation of peptides
Time of Update: 2021-05-23
Although the FDA has been monitoring peptides for decades, there is a growing need to design and perform clinical pharmacology studies to evaluate peptide-specific considerations, for example, studies designed to assess organ dysfunction or drug interactions.
Yiyi Biotech submitted Ryzneuta(TM) Biological Products License Application (BLA) to the US FDA
Time of Update: 2021-04-14
Following the completion of the global phase III clinical trial of chemotherapy-induced neutropenia for breast cancer patients, Yiyi Biotech submitted the relevant BLA application to the US FDA .
Qilu anti-tumor drug first imitation, injection first over-evaluation, 700 million varieties of the third domestic
Time of Update: 2021-01-14
Table 1: Declaration of hydrochloric acid Fashudir injection consistency evaluation supplementary application of the enterprise situation Source: Minet MED2.0 China Drug Review Database At present, in addition to Qilu's first review, the enterprises reporting the hydrochloric acid Fashudir injection consistency evaluation supplementary application also have Yangzijiang, Yuandong, Bert, Red Day and other 5, Abao Pharmaceuticals according to the new classification declaration is also under review and approval.
Purification, Functionalization, and Bioconjugation of Carbon Nanotubes
Time of Update: 2020-12-04
Bioconjugation of carbon nanotubes (CNTs) with biomolecules promises exciting applications such as biosensing, nanobiocomposite formulation, design of drug vector systems, and probing protein interactions.
Both noncovalent and covalent procedures can be used to conjugate CNTs with a target biomolecule for a specific bioapplication.
Cancer targeted therapy research and development and trading "front wave" unexplied "back wave" hit again
Time of Update: 2020-10-30
The largest change in tumor size in patients with different types of tumors in La Lotini clinical trials: NEJM, China Kang Industrial Capital Research Center In May this year, Lilly's acquisition of Loxo Oncology was re-rewarded and the FDA approved the first RET inhibitor, Retevmo ( selpercatinib) for the treatment of lung or thyroid cancer with RET gene mutations or fusions.
The takeaway platform caused controversy by buying Starbucks on its behalf
Time of Update: 2020-10-01
"We started buying black hands from last year, only hungry, a day can probably send twenty or thirty orders." sets of Starbucks qualification for the distribution of purchasing companies Yesterday afternoon, the North Qing newspaper reporters through the United States group takeaway platform search "Starbucks", you can see the nearby Starbucks coffee shop, two stores, three stores a total of three takeaways.
New drugs that are not on the market are available here
Time of Update: 2020-09-23
The Program proposes to comprehensively implement the reform of "minimal approval", the free and convenient trade in licensed pharmaceuticals, the freedom of investment, the convenience of cross-bord
Just! The latest version of the new crown diagnosis and treatment program released: even flowers clear plague, fennel positive gas, blood must be net
Time of Update: 2020-08-31
According to the plan, the new crown pneumonia belongs to the category of Chinese medicine "epidemic" disease, the disease because of the feeling of "epidemic" gas, according to the disease, local cl