You Han's team at Xiamen University discovered that acetylation modifications dynamically regulate the nucleoplasmic localization of oncogenigens and the molecular mechanism of tumor invasion
Time of Update: 2022-11-04
On October 26, 2022, the team of You Han of Xiamen University published a research paper entitled "METTL3 acetylation impedes cancer metastasis via fine-tuning its nuclear and cytosolic functions" in Nature Communications 。 The study identified an acetylation-dependent regulatory mechanism that determines METTL3 subcellular localization, which may provide mechanistic clues for the development of therapeutic strategies against breast cancer metastasis.
Single-cell multi-omics analysis provides an in-depth analysis of the tumor microenvironment of pancreatic cancer
Time of Update: 2022-09-30
They paid particular attention to cells that express acinar markers, as one theory suggests that pancreatic ductal adenocarcinoma originates from acinar cells that undergo acinar-duct metaplasia (ADM).
U.S. Environmental Protection Organization: Strawberry ranks first with the worst pesticide residues
Time of Update: 2022-03-21
The Environmental Working Group (EWG), a non-profit environmental organization in the United States, stated that federal officials have detected pesticide residues in approximately 98% of "traditional" strawberry samples .
Since 2004, EWG has published a list of the “Twelve Contaminated Fruits and Vegetables” every year.
New drug combination effective for patients with advanced ovarian cancer
Time of Update: 2022-03-06
"With the limited number of effective combinations currently available to treat patients, new treatments for recurrent ovarian cancer are urgently needed .
The results of this study suggest that a drug combination may be an effective treatment for this type of ovarian cancer, " said Alessandro Santin, M.
The effectiveness of chemotherapy may vary over time
Time of Update: 2022-02-18
William Walker, a researcher at West Virginia University School of Medicine, is investigating whether the blood-brain barrier is more susceptible to chemotherapy drugs at different times of the day .
Nature Cancer: Let cancer cells "stay awake
Time of Update: 2022-01-23
Comparison of collagen types between T-HEp3 (proliferating tumor) and D-HEp3 (dormant tumor) (Image source: Nature Cancer)Next, the researchers used a human-mouse xenograft system to further determine the relative contribution of tumor cells (human protein sequences) and stromal cells (mouse protein sequences) to matrix body production .
Int J Cancer: Hypothyroidism is a better predictor of anti-tumor efficacy of PD-1 inhibitors in liver cancer
Time of Update: 2021-11-02
(A) PFS in hypothyroidism and non-hypothyroidism patients; (B) PFS in hypothyroidism patients and non-hypothyroidism patients before immunotherapy; (C) PFS in TKI patients and non-TKI patients; (D) Using different PD-1 PFS of patients with inhibitors; (E) PFS stratified by liver function at first diagnosis; (F) PFS stratified by GGT before immunotherapyFigure: Survival analysis of patients receiving anti-PD-1 therapy .
Genetic analysis reveals differences in mate selection between wild coho salmon and hatched coho salmon
Time of Update: 2021-10-22
A new study on the genetic profiles of wild coho salmon and hatched coho salmon shows that there are important differences in how the two species of fish form mating pairs .
Weigh cancer cells
Time of Update: 2021-10-21
In recent years, Manalis and Ligon have been working on a new method of predicting patient response based on measuring the response of tumor cells to treatment rather than genomic characteristics .
Hengrui's clinical application for 3 new drugs has been accepted
Time of Update: 2021-10-11
Famitinib Malate Capsules is a small molecule multi-target tyrosine kinase inhibitor independently developed by Hengrui.
SHR-1802 is a monoclonal antibody targeting lymphocyte activation gene 3 protein (LAG3) .
NEJM: MRI targeting vs standard prostate biopsy for prostate cancer screening in the general population
Time of Update: 2021-09-11
In patients with suspected prostate cancer with elevated PSA levels, the detection rate of malignant diseases in prostate biopsy guided by MRI is high, while the rate of non-essential biopsy is reduced .
Research reveals the relationship between the genome, three-dimensional genome and transcriptome of clinical samples of lung cancer
Time of Update: 2021-08-10
▲Figure 1: Comparison of TAD detection in Hi-C experiments with different cell amounts in A549 cell line and 5534T clinical samples (Image source: Contributed by Professor Li Cheng's research group)Through multi-omics data integration and analysis of genomic changes at different levels, we found:(1) The topological domains (TADs) and chromatin loops (loops) structure in clinical lung cancer samples have undergone significant changes .
Eur J Cancer: Efficacy and safety of the combination of pabocinil, pembrolizumab and letrozole in the treatment of HR+ metastatic breast cancer
Time of Update: 2021-08-02
The combined regimen of Pabocinil, Pembrolizumab and Letrozole is well tolerated in patients with HR+ metastatic breast cancer, and the complete remission rate can be as high as 31%.
Phase I/II trial of palbociclib, pembrolizumab?and letrozole in patients with hormone receptor-positive metastatic breast cancer .
2021 EHA Big Coffee Interview Professor Cao Xinxin: Interpretation of Research Progress in Light Chain Amyloidosis
Time of Update: 2021-06-22
In all previous studies of daratumumab, almost no patients in Mayo2004 phase IIIb were enrolled, so for these ultra-high-risk AL amyloidosis patients, how to choose daratumumab and which drugs should be combined for treatment , Is the current clinical problem that needs to be solved urgently .
The latest recommendations for colorectal cancer screening by the US Preventive Services Task Force (USPSTF
Time of Update: 2021-06-22
Schwenk, MD, US Preventive Services Task Force (USPSTF) with moderate Deterministically, it is concluded that screening from the age of 45 has moderate benefits for patients at general risk.