The application of T cell sorting in car-T cell preparation and its future development trend are discussed
Time of Update: 2022-09-14
： ， 。 Video Applet Like, double tap to cancel Like in Watch, tap twice to cancel Watch Importance in cell therapy for bead sortingSince Emily Whitehead brought new hope for cancer cures, CAR-T cell therapy has once again cemented its central position in the field of immune cell therapy.
Cell Res Tsinghua University Wang Gelin/Tang Yefeng developed a small molecule activator of nicotinamide phosphoribosyltransferase, laying the foundation for the development of new anti
Time of Update: 2022-06-08
Discovery and development of potent activators (NATs) of nicotinamide phosphoribosyltransferase (NAMPT), a rate-limiting enzyme in the NAD salvage pathway .
Here, we report the discovery of a chemical-like NAMPT activator (NAT) that promotes neural stem cell proliferation in vitro and exhibits neuroprotection in a preclinical mouse model of chemotherapy-induced peripheral neuropathy (CIPN) efficacy .
Science: Using CRISPR to build a melanoma model from scratch
Time of Update: 2022-05-11
The work is the first time scientists have used precisely controlled genetic engineering to create a human cancer model from fully differentiated or specialized cells, rather than stem cells, said Eran Hodis, first author and one of the corresponding authors of the study .
The biochemical "switch" that controls the development of regulatory T cells found
Time of Update: 2022-01-08
The researchers discovered a biochemical process consisting of three steps in mouse T cells: first, precursor cells receive guidance signals and initiate the development of regulatory T cells; then, a table called histone acetylation The genetic mechanism acts as a switch to turn on the expression of Foxp3, just like a battery starts an engine .
Zhong Nanshan's team: the origin, intermediate host and sensitization characteristics and hypotheses of SARS-CoV-2｜MDPI Healthcare
Time of Update: 2021-12-02
Research process and methods This research conducted a comprehensive amino acid sequence analysis of the sliding sequence fragments of the spike protein of the new virus, and confirmed that bats are the natural hosts of the new coronavirus SARS-CoV-2, which are then transmitted to humans through rodents .
Cell Metabolism Chill stimulates the immune system and relieves inflammation of the nervous system
Time of Update: 2021-11-14
On this basis, the authors found that cold exposure reduces the expression of MHCII in mouse Ly6Chi monocytes, but does not affect other immune cell populations .
Chinese Academy of Sciences scholar Advanced Science published a paper: Oncogene NEAT1 inhibits the occurrence and development of leukemia
Time of Update: 2021-10-20
The researchers found that NEAT1 located in the side spots shuttles from the nucleus to the cytoplasm, and binds to the Wnt pathway linker protein DVL2 and E3 ubiquitination ligase Trim56, which promotes the degradation of DVL2 and inhibits the Wnt signaling pathway, thereby inhibiting the self-renewal of AML stem cells.
The calorie is the same, just eat three meals within 10 hours, can not only lose weight but also lower blood sugar
Time of Update: 2021-10-11
At this year’s 2021 European Association for the Study of Diabetes (EASD) Annual Meeting According to research conducted by Charlotte Andriessen of Maastricht University in New Zealand, a three-week limited time of eating can improve fasting blood sugar levels in patients with type 2 diabetes, and may have a positive effect on the body’s metabolic health .
Maoming Petrochemical Hydrogen Fuel Cell Hydrogen Supply Project Starts Construction
Time of Update: 2021-09-19
44 million yuan, including a newly built hydrogen purification device with a design scale of 3000 standard cubic meters per hour, and a hydrogen refueling mother station with a hydrogen supply capacity of 500 kg/h .
No antibodies required
Time of Update: 2021-08-15
The tool is called PROPER-seq (protein-protein interaction sequencing) and allows researchers to map PPI networks from their cells of interest within a few weeks without the need for any specialized resources, such as antibodies or prefabricated gene banks .
Diet, exercise, and sleep can affect heart health, but why
Time of Update: 2021-08-14
He said that current and ongoing research is seeking to reveal the mechanisms by which these factors "change tissues at the cellular and molecular level," with a focus on "communication between organs .
What are the toxic effects after taking dragasemide
Time of Update: 2021-07-07
The symptom that appears is to avoid taking medicines to cause toxins to deposit in the body, which may cause other What are the toxic effects after taking dragasemide ?
Cell: Who said that pressure is motivation
Time of Update: 2021-04-23
The study showed that stress-induced hormones (glucocorticoids) can weaken the anti-cancer ability of innate-like T cells, leading to accelerated development and spread of cancer cells.
However, this study by Cell Reports shows that congenital T cells do not actually die due to chronic stress, but their anti-cancer ability is greatly impaired by stress-induced hormones (glucocorticoids).
The same signal, different fates, the root of the difference between CD28 CAR-T and 4-1BB CAR-T
Time of Update: 2021-04-14
The research results show that CD28 and 4-1BB use the same signal pathway, but the phosphorylation level caused by CD28 activation is significantly higher than that of 4-1BB, and therefore produces a higher level of effector molecules, so CD28CAR-T has a stronger cell effect function .
Nature: Bacterial peptides on the surface of tumor cells are expected to become a new target for cancer immunotherapy
Time of Update: 2021-03-27
com" target="_blank">/---Cancer immunotherapy may be promoted in an unexpected direction: bacteria residing in tumor cells.
com/course/tags/%E7%BB%86%E8%83%9E%E7%94%9F%E7%89%A9%E5%AD%A6/">Cell Biology at the Weizmann Institute of Science has studied molecular "markers"-protein fragments on the cell surface, or peptides, which can mark cancer cells as foreign and may therefore become immunotherapy.