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Hypertension: Effects of arterial stiffness and carotid intima-media thickness progression on blood glucose, insulin resistance, and blood lipids
Time of Update: 2022-02-19
Diabetes DiagnosisIn a study published in Hypertension, a leading cardiovascular journal, researchers investigated carotid-femoral pulse wave velocity (cfPWV), arterial stiffness, and carotid intima-media thickness (cIMT) progression with dysglycemia, insulin Time-causal longitudinal association between resistance and risk of dyslipidemia .
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CARDIOVASC DIABETOL: Fetuin A predicts risk of vascular complications in diabetes!
Time of Update: 2022-02-19
In short, in T2D patients, lower prediagnostic fetuin-A levels were associated with a higher risk of vascular complications, especially microvascular complications, independent of established cardiometabolic risk factors .
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Diabetes: Inhibition of Rapid Metabolic Decline in People at High Risk for Type 1 Diabetes within 3 Months of Teplizumab Treatment
Time of Update: 2022-02-19
To this end, in the TrialNet teplizumab trial, we assessed whether metabolic endpoints can be used to detect the effect of teplizumab on rapid beta-cell decline within 3 months of treatment in high-risk individuals .
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Hypertension: Attention - DPP4 inhibitors and ACEIs are prone to this side effect!
Time of Update: 2022-02-19
low blood sugar diabetesStudies have shown that DPP-4 inhibitors, as a new oral hypoglycemic drug, have a glucose concentration-dependent hypoglycemic mechanism, which can improve β-cells and protect the kidneys .
DPP4 (Dipeptidyl Peptidase-4) Inhibition Increases Catecholamines Without Increasing Blood Pressure During Sustained ACE (Angiotensin-Converting Enzyme) Inhibitor Treatment.
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JCEM: A causal relationship between endogenous dehydroepiandrosterone and lumbar spine bone mineral density and forearm fractures in women
Time of Update: 2022-02-19
A recent meta-analysis of four clinical trials showed that dehydroepiandrosterone (DHEA) treatment increased lumbar spine bone mineral density (LS-BMD) in women .
Objective: To determine whether circulating DHEAS is causally associated with lumbar spine bone mineral density (LS-BMD) and fracture risk in women .
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Diabetologia Shanghai Institute of Nutrition and Health, Chinese Academy of Sciences: Middle-aged and elderly people should pay attention to this indicator, or it may affect the incidence of diabetes
Time of Update: 2022-02-19
In conclusion, in the Chinese population, 8 GPLs, especially the PC related to the DNL pathway, were positively correlated with the occurrence of diabetes .
In conclusion, in the Chinese population, 8 GPLs, especially the PC related to the DNL pathway, were positively correlated with the occurrence of diabetes .
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Endocrinol Metab: Clinical and molecular features of a patient with PRKACA L206R mutant-producing cortisol adenomas
Time of Update: 2022-02-18
Analysis of differentially expressed genes (DEGs) between protein kinase camp-activated catalytic subunit alpha (PRKACA) L206R mutant and wild-type cortisol-producing adenomas (CPAs) (A) V volcano plot of DEGs with PRKACA L206R mutation on the x-axis The magnitude of the difference in gene expression between body and wild-type CPAs, and the y-axis is the statistical significance of the difference .
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FDA Issues Complete Response Letter (CRL) for Somatrogon for Growth Hormone Deficiency (GHD)
Time of Update: 2022-02-18
First-line results from the pivotal Phase III trial showed that weekly Somatrogon (hGH-CTP) administered subcutaneously was non-inferior to once-daily Genotropin (hGH) .
First-line results from the pivotal Phase III trial showed that weekly Somatrogon (hGH-CTP) administered subcutaneously was non-inferior to once-daily Genotropin (hGH) .
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Diabetes Obes Metab: Metformin reduces the risk of hospitalization and death in diabetic patients with COVID-19
Time of Update: 2022-02-18
COVID-19 diabetesIn a study published in Diabetes Obesity & Metabolism, a leading journal in the field of metabolic endocrine diseases, researchers compared the association between metformin use and COVID-19 outcomes in a cohort of 31,966 diabetic patients in Lombardy .
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Diabetes may be reversible!
Time of Update: 2022-02-18
In recent years, the team of Wang Wei , a professor at the Third Xiangya Hospital of Central South University and director of the Hunan Provincial Xenotransplantation Engineering Technology Research Center , has made a series of major breakthroughs in porcine islet transplantation .
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JCEM: Circulating microRNA-122 levels and liver fat response to weight loss interventions
Time of Update: 2022-02-18
CONCLUSIONS : Participants with higher serum miR-122 levels may have less benefit in reducing liver fat content due to dietary and physical activity interventions .
Participants with higher serum miR-122 levels may have less benefit in reducing liver fat content due to dietary and physical activity interventions .
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JAHA: Association between body mass index and cardiovascular outcomes in patients with stable coronary heart disease
Time of Update: 2022-02-18
diabetes hypertensionCONCLUSIONS: Cardiometabolic and inflammatory risk factors in patients with stable coronary heart disease gradually increased with BMI>25kg/m2 .
Body Mass Index and Association With Cardiovascular Outcomes in Patients With Stable Coronary Heart Disease – A STABILITY Substudy .
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PRMR: Thyroid Screening and Thyroid Radiation Dose Relationship
Time of Update: 2022-02-18
OBJECTIVE: To describe the status and results of screening for thyroid disease in a uterine cohort of 2,965 Belarusians exposed to Chornobyl fallout, and to assess the reliability of radioactive thyroid doses .
THYROID SCREENING AND RELIABILITY OF RADIATION THYROID DOSES FOR THE BELARUSIAN IN UTERO COHORT.
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How does sedentary life erode the vitality of diabetic patients a little bit?
Time of Update: 2022-02-18
After adjustment for other relevant clinical factors, taking the LST group as a reference, the adjusted mean changes of B-FAT, T-FAT, ASMI, LS-BMD, FN-BMD, H-BMD and T-BMD in the HST group were 2.
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JAHA: Effect of body mass index on postoperative atrial fibrillation in patients with hypertrophic cardiomyopathy undergoing septal myectomy
Time of Update: 2022-02-18
Blood vesselThe aim of this study was to determine the effect of body mass index (BMI) on the development of postoperative atrial fibrillation in patients with obstructive hypertrophic cardiomyopathy undergoing septal myectomy .
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International Journal of Obesity: You can lose weight by "lying flat"!
Time of Update: 2022-02-18
The research team found that after the PANX3 gene was knocked out in male mice, the body fat of the mice was reduced and the muscle mass was increased, which is equivalent to exercising 1 hour a day, 5 days a week, and lasting for 6 weeks .
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Diabetologia: What is the risk of developing cardiovascular disease within 10 years of being diagnosed with type 2 diabetes?
Time of Update: 2022-02-18
e. coronary heart disease and stroke) and risk prediction scores including atrial fibrillation and heart failure (CVD+) in patients with type 2 diabetes, experts from UK Health Data Research and the UCL Institute for Health Informatics A related study was carried out and the results were published in the journal Diabetologia .
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You can lose weight by "lying flat"!
Time of Update: 2022-02-18
The research team found that after the PANX3 gene was knocked out in male mice, the body fat of the mice was reduced and the muscle mass was increased, which is equivalent to exercising 1 hour a day, 5 days a week, and lasting for 6 weeks .
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BMJ sub-issue: Stop "lying flat"!
Time of Update: 2022-02-17
In conclusion, studies demonstrate a strong negative association between low physical fitness and multiple cardiometabolic factors, including obesity (both overall and abdominal), hypertension and metabolic syndrome, and use of cardioprotective medications .
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JAHA: Hyperglycemia, subsequent stroke risk, and efficacy of dual antiplatelet therapy
Time of Update: 2022-02-17
It is unclear whether higher blood glucose levels are associated with an increased risk of high-risk transient ischemic attack or recurrent stroke after mild ischemic stroke .
Hyperglycemia at presentation was associated with an increased risk of recurrent ischemic stroke following a high-risk transient ischemic attack or minor stroke .
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