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Drugs Articles

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R&D's 2022: Mo Dao's floating clouds end the day, and the harsh winter has bloomed spring buds

 Time of Update: 2023-02-03

Words written in front2022 is extraordinary. For Chinese, 2022 was an exceptionally difficult year, with the global economy continuing to decline under factors such as the coronavirus pandemic and geo
Look here! These experts were selected into the list of clinical external candidates for CDE's pediatric drug technical review

 Time of Update: 2023-02-03

docx In order to ensure the scientific fairness of children's drug review, study and solve key and difficult problems in children's drug research and development, and expand professional fields and expert strength, in accordance with the "Measures for the Management of External Experts of the Drug Evaluation Center" and with the consent of the State Medical Products Administration, our center organized and carried out the selection of clinical external experts for children's drug technical review.
Does China still need new crown oral drugs?

 Time of Update: 2023-02-03

The peak of severe disease is approaching, and it is difficult to find a new crown oral medicine. On the 26th, after verification and confirmation by a number of media, Beijing will soon distribute Pa
Domestic oncology NGS enterprises go overseas to find technological and commercial leaps

 Time of Update: 2023-02-03

On January 3, Burnstone Medical announced that its pan-cancer early screening products were recognized by the FDA as breakthrough therapies. On January 3, Burnstone Medical announced that its pan-cancer early screening products were recognized by the FDA as breakthrough therapies.
From the perspective of CDE guidelines, what are regulators focusing on in 2022?

 Time of Update: 2023-02-03

Compared with the ups and downs of the general environment, the drug regulatory policies in 2022 are generally stable. From the perspective of guiding principles, regulators pay more and more attentio
Academician Gao Fu bravely shoulders national responsibilities and actively promotes the development of China's bioeconomy and bioindustry

 Time of Update: 2023-02-03

Overview of the paperOverview of the paper The people of the country bravely shoulder the national responsibility and actively promote the development of China's bioeconomy and bioindustryThe people
Where is the innovation and transformation path for local pharmaceutical companies?

 Time of Update: 2023-02-03

From the sales of generic drugs in the past to the record high number of clinical applications for new drugs in recent years, "innovation transformation" has become an important proposition for the sustainable development of local pharmaceutical companies.
Overview of China's medical science and technology policies in 2022: comprehensive efforts to transform scientific and technological achievements

 Time of Update: 2023-02-03

In 2022, the situation at home and abroad will be complex and changeable, and the global economic development and scientific and technological exchanges will face major setbacks and challenges. Innova
$3.335 billion: Merck and Eli Lilly bet on PDC therapy

 Time of Update: 2023-02-03

235 billion Under this protocol, PeptiDream will utilize its proprietary Peptide Discovery Platform System ("PDPS") technology to identify high-affinity macrocyclic peptide ligands selected by Lilly for selected targets of interest, capable of delivering Lilly-conjugated payloads to certain cells and tissues of interest to Lilly.
Berkeley Lights acquires IsoPlexis and merges to create a state-of-the-art functional cell biology company

 Time of Update: 2023-02-03

com/berkeley-lights-to-acquire-isoplexis-in-57-8m-all-stock-deal/ Berkeley Headquartered in Emeryville, California, Lights is a leading digital cell biology company focused on single-cell functional characterization solutions. The merger to form a new company called PhenomeX (Nasdaq: CELL) will bring together innovative solutions from both companiesThe acquisition is expected to close in the first quarter of 2023.

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Zhuochuang Information: In 2023, the upstream and downstream profits of the pig industry may increase double

 Time of Update: 2023-02-03

uLr-，uLr-，In 2022, pig prices fell year-on-year, and the decline in breeding profits was largeuLr-，In 2022, pig prices fell year-on-year, and the decline in breeding profits was largeuLr-，uLr-，In 2022, the national average pig trading price showed a trend of rising first and then falling, the lowest point of the year was 11.
The first introduction of "high-rise pig farming" in central Guangzhou

 Time of Update: 2023-02-03

In recent years, as the largest central urban area in Guangzhou, Baiyun District has accelerated the construction of standardized pig breeding digital agriculture, changed the previous flat pig house layout, broke through the traditional flat land breeding method, replaced by a three-dimensional pig house, explored the intelligent breeding mode, and it is expected that the first batch of pigs will "move in" in the building early next year.
In 2022, the cost of pig breeding will fall to a low level and the profit period will come

 Time of Update: 2023-02-03

R9B-，R9B-，When the profit period comes, aquaculture enterprises may steadily extend downstreamR9B-，When the profit period comes, aquaculture enterprises may steadily extend downstreamR9B-，R9B-，In 2022, the cost of breeding continued to decline, compared with the pig cycle in previous years, the average weight of pig trading did not fall below 125 kg, and the lowest in the year was 125.
Soybean meal stocks have risen for five consecutive weeks, prices have risen and fallen, pig prices rarely fall before winter, and egg prices have fallen by 4 days

 Time of Update: 2023-02-03

; As the year closes approaching, pig prices and egg prices are falling, and raw soybean meal rises and falls, and remains at about 4600-4700 yuan / ton, how many people have made money this year, ho
Can the "chicken cycle" repeat the "strongest pig week."

 Time of Update: 2023-02-03

aQU-，aQU-，The amount of ancestral renewal has dropped significantly, and the introduction dilemma is difficult to solve the short-term overseas introduction gap, and it is expected that the annual introduction volume is much lower than the equilibrium requirement.
Last year, pig prices went from skyrocketing to stampede, and the pig market is in 2023

 Time of Update: 2023-02-03

"The decrease in small and medium-sized farmers, the increase in the proportion of group breeding, the large-scale process of the industry aggravates the fluctuation of pig prices, financial entities and information service entities intervene, market volatility increases, and the pig cycle during the year is more significant," Lin Guofa, research director of Brick Agricultural Products Collection, summarized the characteristics of the pig market in 2022 that are different from usual.
Egg prices fell rapidly, falling by 9.73% in only 4 days, affected by the epidemic

 Time of Update: 2023-02-03

; Recently, Shanghai Steel Union data shows that since December 22, the national egg price has entered a rapid decline channel. As of December 26, the average price of the main producing areas in the
Hong Kong suspended poultry imports from the United States, France, Poland and parts of Japan

 Time of Update: 2023-02-03

; On 3 January, the Centre for Food Safety of the Food and Environmental Hygiene Department of the HKSAR Government announced that the outbreak of highly pathogenic H5N1 avian influenza in parts of t
Affecting the pig breeding in 2022| reserve meat is put into multiple batches and building pig rearing

 Time of Update: 2023-02-03

P3Y-， In 2022, domestic pig prices have experienced a process of first falling and then rising, the industry's annual profit has become a foregone conclusion, the number of large-scale breeding enterprises has reached a record high, and the project that once pressed the pause button has resumed construction, and the haze shrouded at the bottom of the pig cycle has been swept away.
What kind of pig is an unhappy pig? A pig that doesn't eat or a sick pig? official

 Time of Update: 2023-02-03

gWz-，The merchant said that "unhappy pig" refers to pigs that do not eat, "eliminated pigs" are sows that can no longer give birth, are live pigs, generally bought by manufacturers to make ham sausages, these two pork are 3 yuan cheaper than the market price of one kilogram.

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Antitumor Therapy

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Endoscopic transnasal or transorbital approach for lesions in the petrous apex

 Time of Update: 2023-02-03

of the Department of Neurosurgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, South Korea, analyzed the efficacy of endoscopic transnasal (EEA) or transorbital approach (TOA) resection in patients with lesions in the rock apex area, and the results were published online in J Neurosurg in August 2021.
Molecular basis and treatment of high-grade glioma in children

 Time of Update: 2023-02-03

Conclusion of the study Finally, the authors note that the review explains the pathogenesis of high-grade gliomas in children from the perspective of genetic mutation and epigenetics; Taking specific mutations as the entry point for pHGG research can help improve clinical treatment decisions and is expected to realize individualized treatment of pHGG patients.
Endoscopic transorbital approach resection of intraaxial lesions in the medial temporal lobe

 Time of Update: 2023-02-03

Research methods The authors used 0° endoscopy to endoscopic dissection of four adult cadaver specimens to reach the medial temporal lobe region via orbital approach. Research methods The authors used 0° endoscopy to endoscopic dissection of four adult cadaver specimens to reach the medial temporal lobe region via orbital approach.
Choline kinase α2 acts as a protein kinase to promote the lipolysis of lipid droplets

 Time of Update: 2023-02-03

Study results Finally, the authors conducted experiments on cell biology and nude mice and found that the cytostatic effect induced by PLIN2/3 phosphorylation defects is the result of lipolysis and decreased fatty acid production, rather than lipid accumulation.
Relationship between body mass index and risk of glioma

 Time of Update: 2023-02-03

Conclusion of the study In summary, there may be a nonlinear association between BMI and the risk of glioma in male patients. Conclusion of the study In summary, there may be a nonlinear association between BMI and the risk of glioma in male patients.
The sickle meningiomas were removed posterior to the cerebral sickle approach after the anterior wedge of the interhemispheric corpus callosum

 Time of Update: 2023-02-03

Emrah Celtikci, Department of Neurosurgery, Pittsburgh Medical Center, Pennsylvania, USA, proposed another supratentorial approach for the resection of sickle meningioma, that is, the interhemispheric wedge anterior corpus callosum after the brain sickle approach through anatomical, imaging and clinical studies.
Construction of cerebellar white matter profiles of cognitive and motor deficits after tumor resection

 Time of Update: 2023-02-03

Study results The authors mapped the symptom maps of cognitive and motor deficits in children who survived cerebellar tumors to the structure map of cerebellar white matter, and observed that their cognitive, motor and executive dysfunction were associated with the superior foot nucleus (SCP), the deep cerebellar nucleus, including the intermediate nucleus (IN), the parietal nucleus (FN), the ventral medial dentate nucleus (DN), and the inferior vermis (VIIIa, VIIIB, IX, X cranial nerves).
Gliomas grow aggressively along the white matter tract

 Time of Update: 2023-02-03

Research methods Invasive growth of glioma cells is mostly distributed along some specific anatomical structures, including perivascular spaces and white matter nerve fibers, and some glioma cells can travel along white matter nerve fibers to brain tissue 3-5 cm from the glioma margin, and even enter the contralateral brain tissue through the corpus callosum.
Circulating miR-497 and miR-219 assist in the diagnostic grading of meningioma

 Time of Update: 2023-02-03

Research methods The authors collected serum samples from 74 patients with meningioma, including 25 WHO-I, 25 WHO-II, and 24 WHO-III, as well as 53 healthy controls, to evaluate the relationship between miR-497 levels in serum and exosomes and meningioma-grading diagnosis.
Long-term follow-up of boron neutron capture therapy for recurrent malignant meningioma

 Time of Update: 2023-02-03

Study results The researchers evaluated tumor size, overall survival (OS) and progression-free survival (PFS) after BNCT, and the reasons for treatment failure in 44 patients. Study results The researchers evaluated tumor size, overall survival (OS) and progression-free survival (PFS) after BNCT, and the reasons for treatment failure in 44 patients.

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Study of Nervous System

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Levodopa prodrug plus carbidopa prodrug significantly improves Parkinson's disease symptoms

 Time of Update: 2023-02-03

Copyright InformationThis article was translated, written or commissioned by Jiahui Medical Research and Education Group (J-Med) in collaboration with the New England Journal of Medicine (NEJM) for NEJM Medical Frontiers.
Progress in the study of the mechanism of new circuits of anxiety-like behavior in mice

 Time of Update: 2023-02-03

On December 3, 2022, Nature Communications published online the research group of Xu Xiaohong, a researcher at the Center for Excellence in Brain Science and Intelligent Technology (Institute of Neuroscience) and State Key Laboratory of Neuroscience, Chinese Academy of Sciences, entitled "A circuit from the ventral subiculum to anterior hypothalamic nucleus.
Vertigo that may be caused by a viral infection? Pay attention to the choice of treatment plan...

 Time of Update: 2023-02-03

Don't ignore this comorbidity!Check the diagnosis and treatment plan, how "6" is "Medical Knowledge Source"? Don't ignore this comorbidity!Vertigo and dizziness only considered vestibular lesions?
Nature Medicine: Professor Xu Yong antipsychotropic target receptor mediates the occurrence of obesity

 Time of Update: 2023-02-03

1038/s41591-022-02106-5The images in the article are from references13 rare mutations in the gene encoding the 5-HT 2C receptorFigure 2: F327L mutant mice promote obesity in miceFigure 2: F327L mutant mice promote obesity in miceAfter further knocking the 5-HT2CR-F327L mutant into mice (referred to as F327L mutant mice) through CRISPR-Cas9 technology, even after the ordinary diet, excessive feeding, weight gain, fat and fat increase.
2022 Neurology Clinical Foundation Good Article Summary|Year-end Inventory

 Time of Update: 2023-02-03

Year-end inventory ☟☟☟of the top 12 classic cases of neurology in 2022 to help you develop clinical thinkingIllustrated | 8 pictures teach you to master the basic skills➤Should know: The 5 most common central causes of dizzinessMultiple sclerosisMultiple sclerosisMultiple sclerosisMultiple sclerosis is a chronic, immune-mediated central nervous system disorder characterized by inflammation, demyelinating, and eventually axon loss.
Diabetes Care: SGLT2 inhibitors reduce the risk of dementia in people with type 2 diabetes

 Time of Update: 2023-02-03

▲Weighted Kaplan-Meier curves of subjects using SGLT2 and DPP-4 inhibitors (Image source: Reference [1])Overall, this large population-based cohort study showed a clinically significant association between SGLT2 inhibitor use and a lower risk of dementia at an average follow-up of 2.
Year-end inventory: GLP-1RA is used for progression of other diseases

 Time of Update: 2023-02-03

Polycystic ovary syndrome GLP-1RA treatment can simultaneously address various comorbidities of PCOS, such as improving insulin sensitivity, reducing the risk of cardiovascular disease (CVD), and controlling weight.
The team of Professor Tang Yamei of Sun Yat-sen University at Neuron discovered a new mechanism by which microglia infiltrate the brain parenchyma through chemotaxis peripheral CD8+ T cells

 Time of Update: 2023-02-03

On January 5, 2023, Professor Tang Yamei's team from the Brain Science Research Center of Sun Yat-sen Memorial Hospital of Sun Yat-sen University published a report entitled "Microglia drive transient insult-induced brain injury by chemotactic recruitment of CD8+T" on Nelon lymphocytes" research paper elucidates the mechanism by which microglia secrete chemokines CCL2 and CCL8 after radiation attract CD8+ T cells to infiltrate brain tissue and cause brain damage, and propose new intervention strategies for the treatment of radiation brain injury.
Pay attention to "orthostatic intolerance after stroke", these 4 points to know!

 Time of Update: 2023-02-03

Patient examination dataCase 783-year-old male, limb weakness, shaking for more than 1 month, symptoms appear when upright, lying flat can be relieved; History of previous hypertension and stroke, mRS score of 3 before admission.
Expert comment: NBT Li Yulong's laboratory has developed a new oxytocin fluorescent probe to reveal the spatiotemporal dynamic regulation of neuropeptides

 Time of Update: 2023-02-03

In summary, in this work, the authors developed a novel genetically encoded oxytocin fluorescent probe, which achieved high spatiotemporal resolution recording of extracellular oxytocin in vitro and in vivo, and reported the similarities and differences in the molecular mechanisms of oxytocin in the two release modes of neuronal axon terminals and somal dendrites, which provided a new reference for understanding the complexity of neuropeptide function.

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Immunology News

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CMI(IF=22) Shu Hongbing/Hu Mingming of Wuhan University collaborated to reveal the regulatory mechanism of epinephrine on innate antiviral response

 Time of Update: 2023-02-03

Viral infection downregulates epinephrine/norepinephrine and its receptors (Diagram from Cellular & Molecular Immunology) Studies have shown that adrenaline and norepinephrine secreted by the adrenal glands and nerve endings bind to the receptor ADRB1/2 and activate the downstream kinase PKA in the uninfected state 。 PKA phosphorylates the innate immune signaling protein VISA at the T54 site after RNA virus infection and MITA at the S241, S243, and T263 sites after DNA virus infection.
Vaccination and infection with Omicron once can prevent superinfection in the long term

 Time of Update: 2023-02-03

1016/S1473-3099(22) 00833-7 Open reprint, welcome to forward to Moments and WeChat groups Written byWang CongEditorWang DuoyuTypesettingWater writingOn January 5, 2023, researchers from the University of Lisbon in Portugal published a paper in The Lancet Infectious Diseases entitled Stability of hybrid versus vaccine immunity against BA.
Are rheumatologists afraid of pneumonia? Unafraid! Just do these things well

 Time of Update: 2023-02-03

China's vaccination of the new crown vaccine recommends rheumatic immunological drugs that need to adjust the treatment planIf the routine medication of rheumatology patients needs to be adjusted, the decision should be made after consultation with the doctor in charge, and the principle is: maintain the medication regimen that stabilizes the condition before infection to avoid mutations in disease activity and adverse consequences of aggravation of the disease.
Recent advances in the clinical application of CAR-Treg therapy in 8 autoimmune diseases

 Time of Update: 2023-02-03

In addition, multiple preclinical studies have shown that CAR-Tregs can inhibit the production of FVIII antibodies, and antigen-specific CAR-Tregs has proven to be a successful treatment for regulating coagulation factors related.
6 consecutive articles on Lancet RH, JAMA Netw Open, Sci Adv and STTT, making new progress in the research of rheumatoid arthritis and Sjogren's syndrome

 Time of Update: 2023-02-03

Facing clinical needs and focusing on the international frontier, Li Zhanguo's team from Peking University People's Hospital has published 6 papers on the mechanism and treatment of rheumatoid arthritis and Sjogren's syndrome in first-class journals such as Lancet RH, JAMA Network Open, and Science Advances.
How can rheumatism patients prevent and treat the new crown? Experts teach you these 8 tricks!

 Time of Update: 2023-02-03

*For medical professionals onlyRenji experts come to support!This article is | source Renji Hospital Affiliated to Shanghai Jiao Tong University School of MedicineResponsible Editor | cassetteCopyright statementThis article is reproduced Welcome to forward the circle of friends - End -* "Medical community" strives to publish the content professional and reliable, but does not promise the accuracy of the content; Relevant parties are requested to check separately when adopting or using it as a basis for decision-making.
2022 EULAR/ACR Conference highlights, one article inventory!

 Time of Update: 2023-02-03

So, what role does vitamin D play in rheumatic immune diseases that are closely related to immunity?Many scholars have conducted in-depth research on the topic of vitamin D and rheumatism, and shared the following latest progress at the EULAR 2022 Annual Conference:Low 25-hydroxyvitamin D levels and VDR (FokI) gene polymorphisms are independent risk factors for osteoporosis in postmenopausal rheumatoid arthritis (RA) patients.
Glucosamine for osteoarthritis, 5 precautions!

 Time of Update: 2023-02-03

5g (based on glucosamine sulfate)] at a time, once a day (better effect when taking with meals), take continuously for 3 months, and can be reused with an interval of 2 months 。 5 major considerations★ (1) This product should be taken during or after meals, which can reduce gastrointestinal discomfort, especially for patients with gastric ulcers.
The first article of Cao Xuetao's team in 2023

 Time of Update: 2023-02-03

iNatureAutoimmune and autoinflammatory responses result from abnormal immune and inflammatory responses to their own components and contribute to various autoimmune and autoinflammatory diseases. RNA-
Looking forward to the future, RA treatment has entered the era of precise targeting

 Time of Update: 2023-02-03

Based on clinical practice, looking forward to the future prospects of the departmentThe Department of Rheumatology and Immunology of the Third Hospital of Beijing Medical University, established in October 2006, as a discipline leader, when asked why he decided to become a rheumatologist in the first place, both professors said that this was an accidental and inevitable result.

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Infection

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How effective is the new crown "special drug"?

 Time of Update: 2023-02-03

As the name suggests, this is a randomized, double-blind, placebo-controlled clinical trial in a high-risk population (HR) that included 2246 adult patients, none of whom had been vaccinated, and who had ≥ 1 risk factor for progressing to severe disease 。 The primary endpoint of the study was the proportion of patients hospitalised for coronavirus infection or death from any cause when treated within 28 days of treatment in the modified intention-to-treat (mITT) population (i.
Domestic new crown drugs top NEJM: the efficacy is not inferior to Paxlovid, and it is safer Ding Jian, Cao Bin commented

 Time of Update: 2023-02-03

Early this morning, Beijing time, the New England Journal of Medicine (NEJM) published a phase 3 randomized controlled trial of non-inferiority in China, the results of which showed that for adult patients with mild to moderate Covid-19 with high-risk factors, domestic VV116 was not inferior to Paxlovid (4 days) in terms of continuous clinical recovery time vs.
What are the risk factors for Klebsiella pneumoniae infection? How can it be prevented and treated? —One-article answer

 Time of Update: 2023-02-03

Klebsiella pneumoniae (KP) belongs to the Enterobacteriaceae genus Klebsiella, and its diseases rank first in the genus Klebsiella, which can cause community and hospital-acquired pneumonia, sepsis, m
ARDS+ septic shock "kills"! See how experts "reverse"

 Time of Update: 2023-02-03

After 7 days, the patient'sventilatorFiO2 had been adjusted down to 50%, PEEP 10cmH2O, lung compliance 35ml/cmH2O, prone oxygenation index maintained at 200mmHg, and 180mmHg remained in the supine position for 4 hours, so prone ventilation and sedation were stopped.
It is not only vaccines that can reduce the risk of new crown pneumonia sequelae!

 Time of Update: 2023-02-03

STOIC research published in The Lancet Respiratory Medicine suggests that short-term inhaled corticosteroids, budesonide, may be an effective treatment for COVID-19 in early adulthood [3]. STOIC research published in The Lancet Respiratory Medicine suggests that short-term inhaled corticosteroids, budesonide, may be an effective treatment for COVID-19 in early adulthood [3].
Heavy! Union Medical College Hospital Releases "New Crown Diagnosis and Treatment Reference Plan"

 Time of Update: 2023-02-03

For medical professionals onlyDiagnose and treat big and small problems, see what the guidelines say In order to enhance physicians' understanding of the novel coronavirus infection and its critical diseases, provide a basis for clinical decision-making, promote standardized diagnosis and treatment, and improve the level of patient treatment, Peking Union Medical College Hospital issued the "Reference Plan for the Diagnosis and Treatment of New Coronary Pneumonia in the Department of Respiratory and Critical Care Medicine (December 2022 Edition)".
Long-term "healthy" knowledge: promote the prevention and treatment of infectious diseases, focusing on early screening and early diagnosis

 Time of Update: 2023-02-03

For medical professionals onlyThe 7th Seminar on New Progress in Laboratory Diagnosis of STDs and AIDS and the 7th Workshop on Laboratory Diagnosis of Liver Disease Related to Liver Disease have been
The heart muscle damage of BA.5 is the same as Delta! Strenuous exercise is deadly? NEJM: Myocarditis in new crown hospitalized patients increased by 16 times! BMJ tells you how to exercise after Yangkang

 Time of Update: 2023-02-03

Wang Dezhao, director of the Cardiovascular Center and chief physician of the Department of Cardiology at Beijing United Family Hospital, also said that on December 27 alone, 18 "Yangkang" patients came to make an appointment, they had varying degrees of fatigue, and they had symptoms such as palpitation, chest tightness, and chest compression, and they were afraid that fulminant myocarditis would appear as reported in the news, so they all came to check their hearts.
Do people with COVID-19 need to take zinc preparations?

 Time of Update: 2023-02-03

This article is from NEJM Journal WatchZinc for Patients with COVID-19?Do people with COVID-19 need to take zinc preparations?Reviewed by Daniel Kaul, MDIn a randomized, blinded, multicentre study in Tunisia, oral zinc formulations appeared to be beneficial in reducing COVID-19 progression, particularly in critically ill hospitalized patients.
"Nature" sub-journal: Scientists have confirmed for the first time that there is an association between new crown vaccination and orthostatic orthostatic tachycardia syndrome, but the increased risk level is much lower than that of new crown infection

 Time of Update: 2023-02-03

Yesterday, a colleague also said that it is easy to increase the heart rate after infection, I wonder if you have similar symptoms?Recently, Nature Cardiovascular Research published a data analysis in the form of a cover study, using data from 300,000 people in the Los Angeles area to discuss the possibility of postural orthostatic tachycardia syndrome (POTS) after the new crown vaccination.

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Digestive System Information

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Read the rare liver disease - Budd-Chiari syndrome clinical necessity

 Time of Update: 2023-02-03

Treatment – management of acute, subacute, or chronic BCS The preferred approach for patients with BCS in the West is gradual management, including medical therapy, angioplasty, TIPS, or liver transplantation; Patients with BCS in Asia often have short segments of thrombosis or narrowing of the vascular opening, and angioplasty is the preferred invasive treatment.
Professor Xu Ruihua: 2022 Top 10 Digestive Tract Tumor Clinical Research Progress and Outstanding Problems

 Time of Update: 2023-02-03

The ASTRUM-007 study is a randomized, controlled, double-blind, multicenter phase 3 clinical trial led by Professor Huang Jing of Cancer Hospital of the Chinese Academy of Medical Sciences, which explores the efficacy and safety of domestic PD-1 monoclonal antibody serplulimab combined with chemotherapy alone for the first-line treatment of PD-L1-positive (comprehensive positive score [CPS]≥1) locally advanced/metastatic unresectable esophageal squamous cell carcinoma.
Working together to overcome the difficulties Professor Zhang Jun| Professor Zhang Jun: In case of "yang" in bowel cancer patients, the guideline consensus recommends what we do?

 Time of Update: 2023-02-03

*For medical professionals onlyThe new crown virus is impossible to prevent, and domestic and foreign guidelines and consensus recommend treatment recommendations for people with small "yang" tumors.
The risk of fatty liver progression to liver cancer is as high as 23%! The sub-issue of "Nature" takes stock of 3 major developments

 Time of Update: 2023-02-03

Screenshot credit: Nature ReviewsGastroenterology & HepatologyFocus on research progressFirst, artificial intelligence can quantitatively evaluate liver fibrosis after anti-NAFLD treatment through second harmonic (SHG)/two-photon excitation fluorescence (TPEF) microscopic imaging technology.
Acetaminophen: hepatotoxicity and treatment methods Director talks about liver disease

 Time of Update: 2023-02-03

6Grade III (confusion and lethargy) or grade IV (retardation and coma) hepatic encephalopathyhypoglycemiaThrombocytopeniaAcute paracetamol poisoning with cirrhosissummaryMild aminotransferase elevations that occur during acetaminophen treatment are rarely symptomatic, usually undetected, disappear quickly after discontinuation of acetaminophen, and sometimes even continue at the same dose.
Professor Li Jie: When chronic HBV infection encounters hepatic steatories

 Time of Update: 2023-02-03

Table 1 Influencing factors of CHB combined with hepatic steatosisSeveral studies have explored the interaction between CHB and NAFLD:A 2019 retrospective study in Israel enrolled 524 patients with treatment-naïve CHB with an average follow-up of 6 years, and both ultrasound and liver puncture diagnosis showed that HBV DNA load was inversely correlated with the degree of fatty liver change.
This new crown common drug may increase gastrointestinal risk! Pay attention to these 8 points with medication!

 Time of Update: 2023-02-03

As a non-steroidal anti-inflammatory drug with fewer adverse reactions, it is currently the preferred antipyretic analgesic, but it may also increase gastrointestinal risks, let's take a look at the 8 major medication precautions pointed out by "Clinical Decision Assistant-Evidence-Based Medicine"!Gastrointestinal risksNSAIDs increase the risk of serious gastrointestinal adverse events, including bleeding, ulceration, and perforation of the stomach or intestines, which can be fatal.
Use with caution in patients with peptic ulcer! Did you use this cough medicine correctly after "yang"?

 Time of Update: 2023-02-03

What is the difference between the use of ambroxol in different dosage forms?What cough drugs should be used with caution for peptic ulcer?Where to see more common drugs in gastroenterology?Open "Clinical Decision Assistants - Evidence-Based Medicine"Search for related disease names/drug names, one click direct!
An article summarizing anti-HER2 therapy for gastroesophageal adenocarcinoma

 Time of Update: 2023-02-03

Among them, the single-arm study PANTHERA trial has achieved exciting results, which explored the efficacy of pembrolizumab + trastuzumab + chemotherapy in patients with HER2-positive advanced GEA, and showed that 6 of the 43 patients had no disease progression after 2 years of treatment, with an objective response rate (ORR) of 76.
"2022 China Helicobacter pylori infection treatment guide" released!

 Time of Update: 2023-02-03

pylori infection?Recommendations: It is recommended that bismuth quadruple regimen be considered in combination with certain traditional Chinese medicine treatment (conditional recommendation, low quality) in the following situations:(1) empirical treatment should be implemented in areas with low eradication rates of bismuth quadruple regimen; (2) The patient has refractory H.

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Endocrine System

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Regarding the relationship between drinking and weight loss, this article makes it clear!

 Time of Update: 2023-02-03

, and a large amount of heat will be generated in the body during the process of alcohol metabolism(if there is excess calories, about 3%-5% of alcohol will eventually be converted into fat。。 Things you didn't know about losing weight and drinking alcoholIn a survey of 2,000 adults conducted by the health department in 2010, the results showed that 4 in 10 people admitted that they were unaware of the fact that alcoholic beverages contain higher calories.
How to use medication after diabetic patients are positive? What are the precautions?

 Time of Update: 2023-02-03

*For medical professionals onlyHurry up and collect!AuthorLv XiongOn December 10, the State Council Joint Prevention and Control Mechanism press conference reported that the elderly over 60 years old and patients with underlying diseases are at risk of severe disease after infection with the new crown virus, and diabetes is one of the underlying diseases.
【Nature】The "breakthrough" obesity drug that stunned researchers!

 Time of Update: 2023-02-03

Weight loss lasts for a year or two 03 03 Historically, it has not been possible to safely reduce body weight by more than 10 percent by pharmacological methods, and Timo Müller, biologist and director of the Helmholtz Institute for Diabetes and Obesity in Munich, also believes that new treatments improve cardiovascular health.
Uncover the truth of β cell damage, 4 points to solve the problem of T2DM patients from the source!

 Time of Update: 2023-02-03

*For medical professionals onlyStep into the world of β cellsThe web version of the doctor station is online, please scan the QR code below or click to read the original articleNo need to download to
If you have thyroid cancer, should I have surgery?

 Time of Update: 2023-02-03

*For medical professionals only, these points can be met without surgeryAuthorNanzhong Endocrinology Chen XiaotianWith the continuous development and progress of the economy, people's living standards
Inventory 2022 Professor Chen Jie: 2022 Neuroendocrine Tumor Drug Treatment Progress Inventory

 Time of Update: 2023-02-03

7 months [9], overall, Targeted drugs have not yet shown satisfactory efficacy in high-level NETs and NECs. 03 chemotherapyThe final results of the prospective Phase II ECOG-ACRIN E2211 clinical trial comparing the efficacy of temozolomide monotherapy and temozolomide + capecitabine combination regimen in advanced pancreatic NET were presented at the 2022 ASCO Annual Meeting, which included a total of 144 metastatic/unresectable G1/G2 grade pancreatic NETs, with overall survival OS time and ORR of 53.
10 points to note about taking azvudine for diabetics! Favorites are recommended

 Time of Update: 2023-02-03

The "Recommendations and Appropriate Technologies for Primary Diagnosis and Treatment of Novel Coronavirus Infection in Peking Union Medical College Hospital" [3] mentions that high-risk groups with poorly controlled primary diseases such as diabetes and diabetes complications may require antiviral therapy, and from the perspective of clinical benefit, it is taken in the early stage of infection (within 3-5 days) and the rapid replication of the virus.
Are women with diabetes at higher risk of venous thromboembolism than men? But it has attracted attention...

 Time of Update: 2023-02-03

Study screenshotsstatus quoCarola Deischinger, MD, Department of Endocrinology and Metabolism, Medical University of Vienna, said:Type 2 diabetes is a chronic blood sugar disorder that affects more than 8% of the global population and is associated with a variety of microvascular and macrovascular complications.
A new start for diabetes management, interpreting diabetes mitigation strategies from multiple aspects

 Time of Update: 2023-02-03

The web version of the doctor station is online, please scan the QR code below or click to read the original articleNo need to download to view more endocrine frontiers- End -"This article is for scientific information provided only to healthcare professionals and does not represent the position of the platform"*For medical professionals onlyLearn many things about diabetes relief from your doctor's discussions.
The latest progress of "diabetic eye disease"! Discovery of new targets for DR therapy

 Time of Update: 2023-02-03

Recently, research published in the journal Theranotics showed that by restoring the function of ADAM10, a major exfoliative protein, the formation of abnormal blood vessels can be controlled in preclinical models, and ADAM10 may be a potential new target for the treatment of DR.

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Annual Inventory 2022 Multiple Myeloma Progress Summary (Part I) – Voice of Experts

 Time of Update: 2023-02-03

Multiple myeloma (MM) is a malignant plasma cell disease, accounting for about 10% of hematologic malignancies, second only to non-Hodgkin lymphoma, and more likely to occur in middle-aged and elderly
2022 ASH Expert Interview | Professor Jorge Castillo: Exploration and prospect of targeted therapy for Waldenstrom macroglobulinemia

 Time of Update: 2023-02-03

Table 2The results confirmed that the combination of the two drugs was very effective, however, the incidence of ventricular arrhythmias was higher than expected, which prompted the discontinuation of the study treatment, based on complications, which cannot be recommended for clinical use at this time, and I think future trials can also choose different drugs or low-toxicity drug combination therapy to develop treatment options.
Interim PET results identify aggressive NHL patients who would benefit from intensive therapy

 Time of Update: 2023-02-03

The researchers who performed post-hoc analysis of the PETAL trial first used the PET data of the PETAL test to investigate whether the average FDG uptake value of lymphoma lesions predicted the patient's time to progression (TTP); Second, it investigated whether comprehensive iPET analysis could identify subgroups of patients who would benefit from intensive therapy.
Annual inventory of new drugs and new protocols approved by the FDA for hematologic malignancies in 2022

 Time of Update: 2023-02-03

The approval is based on the AG120-C-009 study, details of which can be stamped: FDA Update | Approval of ivosnib in combination with azacitidine for the treatment of newly diagnosed patients with acute myeloid leukemiaThe recommended dose of ivoranib is 500 mg orally once daily, with or without food, until disease progression or intolerable toxicity.
International perspective| progress in the treatment of high-risk myelodysplastic syndrome

 Time of Update: 2023-02-03

Compared with single-agent HMA, the ORR and CR rates in the combination group were 57% and 20%, respectively, with no significant improvement, but there were good results in duration of response (DOR), objective response and CR duration were 17 and 19 months, respectively, and patients with high-risk MDS, including TP53 mutations, also achieved good efficacy, with a DOR of 21.
"Wan" is in the spotlight, "moving" road follows, domestic melphalon helps China's transplant field to flourish - Wanjia ® melphalon hydrochloride hydrochloride cloud summit forum for injection was successfully held!

 Time of Update: 2023-02-03

Wanjia ® (melphalan hydrochloride for injection) was approved on August 23, 2022 by the original drug Alkeran® (50mg lyophilized powder needle propylene glycol solubilization) as the standard copy, an
Ji Chunyan and Professor Wang Xin | Season 2: How to grasp the timing of 1L DLBCL treatment? Verptozumab focuses on clinical and value needs, steadily improving the "happiness" of treatment-naïve patients

 Time of Update: 2023-02-03

FIGURE 8 THE POLARIX STUDY ESTIMATES THE NUMBER OF PATIENTS RECEIVING SECOND-LINE THERAPY FROM 2023 TO 2033The above research data shows that Pola-R-CHP regimen brings all-round benefits to treatment-naïve DLBCL patients, especially in the early stage of treatment, reducing the treatment burden of patients, helping to improve patients' "happiness", and bringing new choices and new hopes to the elderly and high-risk patient groups.
HEMA Perspective Professor Ou Jinping: Life is endless, exploration is endless, and the diagnosis and treatment of gastrointestinal lymphoma is continuously optimized

 Time of Update: 2023-02-03

Professor Ou JinpingOur center has cooperated with a number of well-known domestic lymphoma diagnosis and treatment centers to carry out PGIL-related research, among which, the retrospective study for PGIL patients not only discusses the factors affecting the survival of patients and the optimization of treatment plans, but also discusses the relationship between complications such as gastrointestinal obstruction, bleeding, and perforation and the prognosis of patients [1-2].
Ruichuang Biologics was approved for IND for the new indication of universal DNT cell therapy

 Time of Update: 2023-02-03

January 8, 2023 / eMedClub News / -- January 6, 2023, Guangdong Ruishun Biotech Co. , Ltd. (hereinafter referred to as "Wyze Biotech CO. , Ltd. "), a biopharmaceutical company focusing on the R&D and
Cell therapy for multiple myeloma: "what is now" and "what is next"

 Time of Update: 2023-02-03

Major clinical studies of BCMA-targeted CAR T cell therapy in RRMM"What is next", how to further improve the therapeutic effect of cell therapyDespite the impressive clinical results achieved by cell therapy, no changes have been seen in the survival curve, and relapses occur frequently.

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Anesthesia Topics

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【Anesthesia practice】How to minimize the physiological response during tracheal extubation

 Time of Update: 2023-02-03

BaileyThe Bailey manoeuvre (replacing ETT with SGA while the patient is still under deep anesthesia) is an alternative to deep extubation and, if successful, maintains airway control.
Hands-on teaching ~ Anesthesiology pre-anesthesia preparation (Part II)

 Time of Update: 2023-02-01

Welcome to actively submit "vlog" (vlog)01Purpose of the activityWe aspire to continue to provide "high-quality content and services" to people all over the country and even the world (including but not limited to anesthesiologists, physicians and surgeons, dentists and other doctors, patients, ordinary people, and insiders who are interested in it), but at the same time, we do not want to be "behind closed doors".
【Pediatric anesthesia】Selection of single-lung ventilation equipment for children

 Time of Update: 2023-02-01

1. Endobronchial intubationThe simplest technique of lung isolation is to insert the ordinary endotracheal tube (ETT) across the ridge into the desired main bronchi. 1. Endobronchial intubationThe simplest technique of lung isolation is to insert the ordinary endotracheal tube (ETT) across the ridge into the desired main bronchi.
【Pain topic】Ropivacaine is used for half the effective dose of pediatric ultrasound-guided median nerve block

 Time of Update: 2023-01-06

Conclusion: A single dose of ropivacaine is an effective drug for trigger thumb opening surgery in children requiring ultrasound-guided median nerve block in the forearm. Conclusion: A single dose of ropivacaine is an effective drug for trigger thumb opening surgery in children requiring ultrasound-guided median nerve block in the forearm.
【Quick Collection~】Mind Map Read Chapter 1~4 of "Anesthesiology Nursing" Related concepts and common drugs in the perioperative period

 Time of Update: 2023-01-06

Thank you Mr. TuThank you to the teachers of the School of Nursing, Xuzhou Medical UniversityFrom today it will be updated every two weeksLet's read the book more thoroughly~ ღ( ́・ᴗ・' ) than the heart
【Literature Reading】Efficacy and safety study of HSK3486 in induction and maintenance of general anesthesia in patients undergoing elective surgery

 Time of Update: 2023-01-06

Fig. 1 Trial flow chart, Fig. 2 Changes in BIS values during anesthesia induction and maintenance Table 1: Baseline characteristics, Table 2, Effectiveness outcome table, Table 3 Adverse events To evaluate the efficacy and safety of HSK3486 for the induction and maintenance of general anesthesia in elective surgical patients, but excluding emergency, cardiothoracic, cerebral and endoscopic sinus cases.
【Quick Collection~】Mind Map Read Chapter 1~4 of "Anesthesiology Nursing" Related concepts and common drugs in the perioperative period

 Time of Update: 2023-01-06

Thank you Mr. TuThank you to the teachers of the School of Nursing, Xuzhou Medical UniversityFrom today it will be updated every two weeksLet's read the book more thoroughly~ ღ( ́・ᴗ・' ) than the heart
【Pain topic】Ropivacaine is used for half the effective dose of pediatric ultrasound-guided median nerve block

 Time of Update: 2023-01-06

Conclusion: A single dose of ropivacaine is an effective drug for trigger thumb opening surgery in children requiring ultrasound-guided median nerve block in the forearm. Conclusion: A single dose of ropivacaine is an effective drug for trigger thumb opening surgery in children requiring ultrasound-guided median nerve block in the forearm.
【Literature Reading】Efficacy and safety study of HSK3486 in induction and maintenance of general anesthesia in patients undergoing elective surgery

 Time of Update: 2023-01-06

Fig. 1 Trial flow chart, Fig. 2 Changes in BIS values during anesthesia induction and maintenance Table 1: Baseline characteristics, Table 2, Effectiveness outcome table, Table 3 Adverse events To evaluate the efficacy and safety of HSK3486 for the induction and maintenance of general anesthesia in elective surgical patients, but excluding emergency, cardiothoracic, cerebral and endoscopic sinus cases.
What is a CPAP breathing pattern?

 Time of Update: 2023-01-05

02Expand the alveoli and increase the functional residual gas volumeCPAP maintains positive alveolar pressure at the end of breathing, keeps the alveoli dilated, avoids alveolar collapse, increases functional residual air, increases alveolar area, improves lung compliance, reduces intrapulmonary shuntage, and improves oxygenation.

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Urinary System

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One picture to read and adhere to follow-up - double standard parallel, heal the anterior gland

 Time of Update: 2023-02-03

Execution: RudolfThis platform is designed to deliver more medical information to healthcare professionals. Execution: RudolfThis platform is designed to deliver more medical information to healthcare professionals. Execution: RudolfRudolfThis platform is designed to deliver more medical information to healthcare professionals.
CUA 2022|Professor Yao Yousheng: Current status of diagnosis and treatment of male urinary incontinence

 Time of Update: 2023-02-03

prefaceOn December 9-11, 2022, the 29th National Urology Conference (CUA 2022), hosted by the Chinese Medical Association and the Urology Branch of the Chinese Medical Association, was held online. Ad
Research Frontiers The mental health problems of urolithiasis patients cannot be ignored

 Time of Update: 2023-02-03

Fig. 2 Meta-analysis of urolithiasis and anxietyconclusionStudies have shown that there is a moderate and significant positive correlation between anxiety and urolithiasis, and that more people with urolithiasis experience psychological distress than expected, and researchers recommend that urological treatment teams treat urolithiasis patients in time to prevent unnecessary psychological distress.
Research Frontiers Can male grip strength reflect sperm quality?

 Time of Update: 2023-02-03

Table 1 General demographic characteristics and sperm quality of participants stratified by quartile of grip strengthAfter adjusting for confounding factors, both the mixed-effects model (Table 2) and the restriction cubic spline model (Figure 1) showed that grip strength was positively correlated with semen volume, sperm density, forward motility sperm rate, total sperm motility, and total count (P 。 Compared with men in the lower quartile of grip strength, men in the upper quartile had 14.
CUA 2022 Professor Liu Zhuowei: Treatment strategies for high-risk NMIBC

 Time of Update: 2023-02-03

Subsequently, Professor Liu Zhuowei's team conducted a prospective study to compare the efficacy of T1 high-grade bladder cancer, arterial chemotherapy and BCG bladder instillation, with the primary endpoint of 2-year recurrence-free survival (RFS) and secondary endpoints of PFS, CSS, and bladder preservation rate.
CUA 2022|Professor Qiao Ludong: 2022 "Guidelines for the Diagnosis and Treatment of Urinary Tract Infections" update points

 Time of Update: 2023-02-03

The 2022 edition of CUA "Guidelines for the Diagnosis and Treatment of Urinary Tract Infections" has been officially published, on the occasion of this annual academic event, Professor Qiao Ludong of Beijing Tongren Hospital affiliated to Capital Medical University introduced the new developments and guidelines update highlights of urinary tract infections at home and abroad.
Focus on the "chicken and egg problem" - the relationship between kidney stones and recurrent urinary tract infections

 Time of Update: 2023-02-03

Table 1 KSD intervention modalities and UTI resultsThe results of a prospective cohort study in the UK showed that stone clearance (SFR) and infection clearance (IFR) at 3, 6, and 12 months postoperative in patients treated with URS were 96% vs 88%, 90% vs 86%, and 82% vs 71% (P), respectively, indicating a strong association between SFR and IFR.
TITAN Asian population data was released, and the deep decline of apatamide PSA was better than the global population

 Time of Update: 2023-02-03

1]Apatamide regimens help Asian patients achieve this"Better PSA Deep Descent"The TITAN study[2] is undoubtedly a "milestone" in prostate cancer drug treatment. 1]Apatamide regimens help Asian patients achieve this"Better PSA Deep Descent"The TITAN study[2] is undoubtedly a "milestone" in prostate cancer drug treatment.
CUA 2022| Professor Liu Zhuowei: Treatment strategies for high-risk NMIBC

 Time of Update: 2023-02-03

Subsequently, Professor Liu Zhuowei's team conducted a prospective study to compare the efficacy of T1 high-grade bladder cancer, arterial chemotherapy and BCG bladder instillation, with the primary endpoint of 2-year recurrence-free survival (RFS) and secondary endpoints of PFS, CSS, and bladder preservation rate.
Clinical necessity Interstitial cystitis Chinese and Western medicine treatment

 Time of Update: 2023-02-02

GuideInterstitial cystitis (IC) is a chronic inflammatory disease of the bladder characterized by chronic pelvic pain, urgency, frequency, routine urine examination and negative bacterial culture, which has a significant impact on the patient's quality of life and psychopsy.

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Diagnostic Test

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A digital microscope DSX1000 was used to verify the power battery pole slitting process

 Time of Update: 2023-02-02

After slitting, the pole piece can be burred with the help of the DSX1000 digital microscope to verify that the mechanical die-cutting process meets the requirements. After slitting, the pole piece can be burred with the help of the DSX1000 digital microscope to verify that the mechanical die-cutting process meets the requirements.
When industrial endoscopes plug in the wings of digitalization

 Time of Update: 2023-02-02

Offline mode of the software In order to cope with the situation that there is no network in remote areas, we provide customers with offline operation mode, engineers can run services from any location, perform fast image transmission processing, editing, measurement and report generation, and wait for network conditions to allow, inspection items can be uploaded to the cloud with one click, and shared with people who want to view reports in time.
How to become a trusted service provider for Boeing and Airbus?

 Time of Update: 2023-02-02

APU: Auxiliary Power Unit Precision and efficiency are indispensable EPCOR had two main troubles before choosing ScanBox. One is that the current annual maintenance of APU is more than 300, the future production capacity will also reach 600, we know the aerospace industry, safety above all, there is a strict quality control system, so in the production capacity increase at the same time, how to ensure the accuracy of part size inspection?
The profit of the equipment manufacturing industry in the first 10 months rebounded significantly (new data, new highlights)

 Time of Update: 2023-02-02

This article is transferred from [People's Daily]; Beijing, 22 Dec (Reporter Lu Yanan) -- The National Bureau of Statistics recently released data showing that from January to October, the profit of the equipment manufacturing industry increased by 3.
【Q&A】How do AI technology and industrial endoscopes work together?

 Time of Update: 2023-02-02

Of course, the blade counting function can actually automatically add and subtract according to the engineer's rotation direction, without manual intervention, and there are functions such as pause/start/end/hide in the software, which can be realized with one click.
Delang technology products five soul torture! You are trustworthy!

 Time of Update: 2023-02-01

Delan Technology Products Soul Torture 3 How is the quality The hero said: It's good or not, the user says We maintain continuous R&D investment in new products every year, through continuous R&D investment, product iterative upgrades, and self-renewal to better provide customers with the best quality products and services.
New Year Benefits 2023, looking forward to walking with you all the way!

 Time of Update: 2023-02-01

Please specify by email: 2023 calendar Please specify the content of the email: your name, mobile phone number, address 2022, thanks for having you. Please specify by email: 2023 calendar Please specify the content of the email: your name, mobile phone number, address Send an email to: marketing.
Hangzhou Hongshen was invited to participate in the China Industrial Software Development Conference, Software Empowerment∙

 Time of Update: 2023-01-05

Automated 3D online inspection system With self-developed 3D digital inspection software as the core, driven by artificial intelligence technology, with "lightweight and high-precision" intelligent robotic arm and 3D laser scanner as the carrier, one-key start, offline programming, and highly compatible software can be operated freely regardless of the user's professional level.
Efficiently linking supply and demand, opening a new chapter in intelligent manufacturing, the 2022 South China Laser Exhibition was successfully concluded

 Time of Update: 2023-01-05

On November 17th, the 24th China International High-tech Fair Member Exhibition - 2022 South China International Intelligent Manufacturing, Advanced Electronics and Laser Technology Expo (LEAP Expo)
Vehicle Digitalization Innovative 3D scanners empower automotive design practitioners with a competitive edge

 Time of Update: 2023-01-05

Efficient 3D measurement systems drive innovation The combination of Creaform's portable 3D scanner and the scan-to-CAD software module VXmodel opens up a whole new digital world in automotive design.

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