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Drugs Articles

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Drug price monitoring has been implemented in many places, and retail pharmacies have ushered in major challenges

 Time of Update: 2022-09-26

In October last year, Shanghai Sunshine Pharmaceutical Procurement Network issued Notice No. 83 that drugs sold in designated pharmacies that belong to the "Shanghai Basic Medical Insurance, Work Injury Insurance and Maternity Insurance Drug Catalog" must upload retail price information through the Sunshine platform.
In order to optimize the allocation of resources, the pharmaceutical company is selling its hospitals one after another

 Time of Update: 2022-09-26

66 million, and intends to sell 10% of the equity of Kangzhi Hospital Company to Sichuan Jinxin Reproductive Medical Investment Management Co. 66 million, and intends to sell 10% of the equity of Kangzhi Hospital Company to Sichuan Jinxin Reproductive Medical Investment Management Co.
What is the difference between a vertical flow purification table and a horizontal flow table

 Time of Update: 2022-09-22

Vertical flow purification table and horizontal flow workbench where the difference is vertical purification workbench has been one of the main laboratory equipment in today's biological sciences, medicine, electronic science and other industries, scientists need to use the purification workbench when their equipment to provide a local dust-free clean space to protect the sample will not be polluted, but also to prevent dangerous samples from leaking into the surrounding environment, its appearance meets the user's field needs.
Liquid nitrogen tank YDS-10-50 (portable portable liquid nitrogen container) product details

 Time of Update: 2022-09-22

It is made of high-strength aluminum alloy, and the application of evacuation process and multi-layer insulation technology ensures a very low evaporation loss rate of liquid nitrogen, which greatly improves the economy of the product.
The latest | 2016-2020, the sales progress of medical insurance negotiations

 Time of Update: 2022-09-21

Among the 36 varieties successfully included in medical insurance, in 2013, the top 5 varieties of sales, in addition to erlotinib, which fell by 65%, the other 4 varieties all achieved positive growth after being included in medical insurance, and rituximab (Roche), trastuzumab (Genentech), bevacizumab (Roche) and radzumab (Novartis) increased from 1 billion yuan, 790 million yuan, 480 million yuan and 300 million yuan in 2016 before the negotiation to 1.
Is high-precision high and low temperature laboratory air conditioning the same as home air conditioning?

 Time of Update: 2022-09-21

2, due to the rapid change of environmental humidity, the generator set must often dehumidify, and high and low temperature air conditioning to choose a cold dehumidification method, so the provisions of the car air conditioning system can often start, the refrigeration unit regulations are very high; The central air conditioning refrigeration compressor can not be started frequently, and the refrigeration compressor is set to shut down for 5 minutes for maintenance.
Explosion-proof Industrial Small Weather Station - New Automatic Weather Station 2022 Updated (News/News)

 Time of Update: 2022-09-21

25%) ;( Beijing Meteorological Bureau calibration certificate)JD-CQXP explosion-proof industrial small weather station - new automatic weather station 2022 has been updated (news / dynamics), [Shandong Jingdao Optoelectronic Manufacturers] the temperature, relative humidity, precipitation data of the two sets of automatic weather stations, through the use of S S software and the continuity of the data value analysis, the consistency of the data of the new and old automatic weather stations was studied.
What are the key features and benefits of sanitary strainers?

 Time of Update: 2022-09-21

Advantages of sanitary pipe filter: 1, the use of multiple filter cartridge filtration, effective filtration area is large, pressure loss is small. Advantages of sanitary pipe filter: 1, the use of multiple filter cartridge filtration, effective filtration area is large, pressure loss is small.
Glass bottle cold and thermal shock strength meter - recommended

 Time of Update: 2022-09-21

Glass bottle cold and thermal shock strength meter - recommended first we to understand what is thermal shock, thermal shock refers to due to sharp heating or cooling, so that the object in a short pe
Fabric breathability tester test debugging and operation steps

 Time of Update: 2022-09-21

Select the specimen fixed value ring and install it on the instrument. Select the specimen fixed value ring and install it on the instrument. Select the specimen fixed value ring and install it on the instrument.

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Feed Industry News

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High temperature leads to water shortage in pig breeding Grassroots farmers have declined in the mood of supplementing fences

 Time of Update: 2022-09-27

XGJ China Feed Industry Information Network - based on feed, serving animal husbandry; "When I first started extreme heat and water shortage a few days ago, I didn't pay attention, and there were (pig) deaths, and as far as I know, many of our families have such a situation, which is particularly sad," Mr. Huang, the head of the southwest farm, told the Financial Associated Press reporter anxiously.
The impact of dry weather on major agricultural products around the world

 Time of Update: 2022-09-27

DSP China Feed Industry Information Network - based on feed, serving animal husbandry; Under the influence of extreme drought weather around the world, it is expected that the slight decline in domestic and foreign corn production and the reduction of ending stocks may cause the center of gravity of corn to shift up.
More than 6,000 pigs came in the building

 Time of Update: 2022-09-27

J56 China Feed Industry Information Network - Based on feed, serving animal husbandry Gao Yuanfei told Yan Finance that due to the lack of design standards, "building pig farms" are divided into two categories.
14 feed companies sold 38.55 million tons of feed in the first half of the year, but what is more worrying is the decline in gross profit of some companies

 Time of Update: 2022-09-15

6 billion yuan (with complete data)), today, the feed industry information network continued to conduct statistical analysis of feed production, feed income, gross profit margin and other indicators of 14 feed enterprises, as follows: PE6 China Feed Industry Information Network - based on feed, service animal husbandry34 agricultural and animal husbandry enterprises half-year performance, only one feed sales exceeded 10 million tons, the four major pig giants lost 18.
In August, pig enterprises sold 8.58 million pigs, and their income soared by 80%, and the production capacity of Makihara reached 75 million heads, accounting for 11% of the country

 Time of Update: 2022-09-14

; According to the monitoring of the Ministry of Agriculture and Rural Affairs, from August 29 to September 4, 2022, the average purchase price of pigs in pig designated slaughtering enterprises abov
32 of the world's top feed companies in China in 2021, accounting for 60% of the country's total feed volume

 Time of Update: 2022-09-14

UVr feed industry information network - based on feed, service animal husbandry (data source: WATT International Media, tabulation: feed industry information network) UVr feed industry information network - based on feed, service livestock From the number of countries on the list, China still ranks first with 32, 3 new from 2020, the United States ranks second with 27, followed by Brazil, Japan and Germany, with 8, 6 and 5 respectively.
China's grain imports have exceeded 100 million tons

 Time of Update: 2022-09-14

Be7 China Feed Industry Information Network - based on feed, serving animal husbandry Judging from this year's import situation, China's grain imports as a whole showed a decrease in volume and price, and the import amount increased by a quarter.
The price of eggs suddenly soared, and four problems appeared in a concentrated manner!

 Time of Update: 2022-09-14

s2e China Feed Industry Information Network - based on feed, serving animal husbandry; I believe that many friends have felt the price increase of this wave of eggs, which is really a bit surprising.
2022 global feed industry market data forecast analysis: China is the first

 Time of Update: 2022-09-10

; China Business Intelligence Network News: Feed refers to a safe and effective feedable substance that can provide the nutrients needed by animals, promote animal growth, production and health, and
Protect the "pig" battle! Pig prices soared 84% in half a year The national development and Reform Commission's big move began in September

 Time of Update: 2022-09-09

SR4 China Feed Industry Information Network - Based on feed, serving animal husbandry Take precautions to ensure the supply of pork market during the holiday season SR4 China Feed Industry Information Network - based on feed, serving animal husbandry The National Development and Reform Commission said that in the future, it will usher in a number of important festivals such as Mid-Autumn Festival, National Day, New Year's Day, Spring Festival, etc.

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2022 ESMO| Professor Tong Zhongsheng: Good safety, better liver safety, Darcily may be the preferred first-line treatment for HR+/HER2-advanced breast cancer

 Time of Update: 2022-09-21

Another blockbuster Phase III clinical study of Darsily, DAWNA-2, published interim analytical data (LBA16) in the form of an oral presentation at the 2022 European Society of Oncology (ESMO) congress, and after darcily combined with letrozole/Anastrozole first-line treatment, the median progression-free survival (PFS) of patients with HR+/HER2-advanced breast cancer was 30.
For the treatment of non-small cell lung cancer, the results of the first Phase 3 controlled trial of KRAS inhibitors were released

 Time of Update: 2022-09-21

▎ WuXi AppTec content team editorToday, at the annual meeting of the European Society of Oncology (ESMO), amgen's KRAS G12C inhibitor Lumakras (sotorasib) released the latest results of a Phase 3 clinical trial of CodeBreak 200 in patients with treated non-small cell lung cancer (NSCLC) with KRAS G12C mutations.
2022 ESMO| Professor Yueyin Pan: Based on the characteristics of Chinese population, dawnA-2 study provides a new first-line treatment strategy for HR+/HER2-advanced breast cancer

 Time of Update: 2022-09-21

In the DAWNA-2 study presented at the ESMO conference, Darcily has continued to perform well, combined with AI first-line treatment of PATIENTs with HR+/HER2-advanced breast cancer with excellent efficacy and controllable safety, easy management, and once again proved its liver safety characteristics.
Professor Ma Fei commented on the PHILA study: Pyrrolidinib started the battle to break the first-line treatment of her2-positive breast cancer in the advanced stage!

 Time of Update: 2022-09-21

Can the combination of large and small molecules change the current first-line treatment pattern of her2-positive breast cancer?Professor Ma Fei of the Cancer Hospital of the Chinese Academy of Medical Sciences is invited to analyze the eye-catching performance of pirroltinib in clinical translation as one of the innovative drug models independently developed in China through the interpretation of the research.
ESMO Live Strike Heavy Research! The results of the Phase II study of Avelumab for the second-line treatment of MSI-H/dMMR colorectal cancer were released

 Time of Update: 2022-09-21

Research backgroundThe SAMCO-PRODIGE 54 study is a national multicenter, open-label Phase II clinical trial designed to evaluate the efficacy and safety of Avelumab as a second-line treatment for patients with MSI-H/dMMR type mCRC compared to standard therapy for chemotherapy ± targeted therapy.
ESMO Field Direct Attack Late NSCLC Field: A Key Research Inventory of First-Line Immunization Combination Programs (Oral Presentation)

 Time of Update: 2022-09-21

At this year's ESMO conference, Professor Myung-Ju Ahn orally presented the results of an ongoing Phase 1b/2 study on the efficacy of the drug in combination with chemotherapy for first-line treatment of non-squamous NSCLC.
Professor Yan Min commented on the PHILA study: Pyrrolidinib writes a new chapter on small molecule anti-HER2-positive advanced breast cancer

 Time of Update: 2022-09-21

Professor Yan Min pointed out that the PHILA study released in the oral report of the recent ESMO annual meeting has been the third large-scale phase III study of pirroltinib, and its positive results add strength to the clinical application of pyrrolidinib in advanced breast cancer, and the THPy combination may provide a new choice for first-line treatment for patients with trastuzumab-sensitive HER2-positive advanced breast cancer.
NSCLC backline refractory? Sulfatinib is expected to break the dilemma or bring new dawn to patients| 2022 ESMO

 Time of Update: 2022-09-21

*For medical professionals only2022 ESMO Sulfatinib new attempts, results at a glance. Lung cancer is the leading cause of cancer death worldwide, and the treatment strategy for lung cancer depends pr
Professor Yang Hu Xichun deeply interpreted the results of the second interim analysis of the monarch 3 study total survival

 Time of Update: 2022-09-21

On the first day of the conference, the second interim analysis of the monarch 3 study overall survival (OS) was published in the form of LBA, and the results showed that the OS clinical benefit of Abexili combined with nonsteroidal aromatase inhibitors (NSAI) in the first-line treatment of HR+/HER2- advanced breast cancer was more than 1 year, and the benefits were consistent across the preset subgroups, both in the intended treatment (ITT) population and the visceral metastase subgroup.
ESMO Voice of China| furuquintinib combined with sindilimonumab applied to the phase II study of colorectal cancer patients in China

 Time of Update: 2022-09-21

Research backgroundAnti-angiogenic therapy combined with immune checkpoint inhibitors is expected to enhance the clinical benefits of mismatch repair of normal/microsatellite-stabilized (pMMR/MSS) refractory metastatic colorectal cancer (mCRC). Research backgroundAnti-angiogenic therapy combined with immune checkpoint inhibitors is expected to enhance the clinical benefits of mismatch repair of normal/microsatellite-stabilized (pMMR/MSS) refractory metastatic colorectal cancer (mCRC).

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Study of Nervous System

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Ultra processed foods or brain damage! A 10-year study of 70,000 people by a team at Tianjin Medical University found for the first time that higher intakes of ultra-processed foods were associated with an increased risk of dementia

 Time of Update: 2022-09-22

So, does UPF have an impact on human brain health?Recently, a research team led by Professor Wang Yaogang of the School of Public Health of Tianjin Medical University published important research results in the journal Neurology [1]: Higher UPF intake was significantly associated with a higher risk of dementia, while unprocessed or microprocessed foods were closely related to a lower risk of dementia compared with UPF intake.
Large-scale studies have shown that people with blood type A have a higher risk of stroke before the age of 60

 Time of Update: 2022-09-22

On August 31, 2022, a new study published in the journal Neurology linked a person's blood type to the risk of early stroke. On August 31, 2022, a new study published in the journal Neurology linked a person's blood type to the risk of early stroke.
Acyclovir in the treatment of shingles requires attention to these compatibility contraindications

 Time of Update: 2022-09-22

When is it time to be wary of acyclovir causing AKI?Today, we're going to take a look at Dr. Abdullah's article in the journal Saudi Pharm J to see the incidence, patterns, and associated risk factors of AKI after intravenous acyclovir injection.
The "preference" of experimental mice for women and the "dislike" of men directly affected the results of drug development experiments

 Time of Update: 2022-09-22

Next, the researchers assessed the effect of the experimenter's sex on the mice's response to ketamine administration. Next, the researchers assessed the effect of the experimenter's sex on the mice's response to ketamine administration.
How to choose insomnia medication correctly? These 5 points to know!

 Time of Update: 2022-09-22

*For medical professionals onlyFull of dry goods!Clinically often encounter many patients have difficulty falling asleep, early awakening, dreams and other symptoms, how to correctly choose insomnia drugs to become the basic ability of clinicians, the author consulted the insomnia drugs related literature, summarized as follows, hope to bring certain help to peers.
Classification, diagnosis and treatment of cerebral hemorrhage, this article clarifies!

 Time of Update: 2022-09-22

(4) For high-risk patients prone to DVT (excluding cerebral hemorrhage caused by coagulation dysfunction), after hematoma stabilization, subcutaneous injection of low-molecular-weight heparin or unfractionated heparin 1 to 4 days after the onset of the disease can be considered to prevent DVT, but the risk of bleeding should be noted (grade II recommendation, grade B evidence).
Nat Neurosci is more popular with women! Experimental mice "favor" for women and "dislike" for men will directly affect the effect of the drug

 Time of Update: 2022-09-21

Further studies of human experimenters' sex-influenced mouse responses to KET (from Nature Neuroscience) found that this aversion and stress sensitivity caused by human-male odor was mediated by activation of corticotropin-releasing factor (CRF) neurons projected into the endophrapist cortex of CA1 in the hippocampus.
Xuanwu Hospital team finds specific metabolic markers for peripheral blood AD!

 Time of Update: 2022-09-21

RoC analysis results show that the changing combination of metabolites in these 11 can effectively distinguish between AD and control groups (Figure A below), AD and non-AD (Figure B below), as well as AD and other types of dementia (Figure C below).
Using coffee to "refresh the mind" and "continue to live", but there are only 2 kinds of real effectiveness

 Time of Update: 2022-09-21

5 to 3 cups of coffee a day has certain benefits for heart health, and also helps reduce the risk of all-cause death, cardiovascular disease death and stroke, in addition, the researchers also found that the type of coffee has a certain association with health benefits, such as freshly ground coffee can bring certain health benefits, while instant coffee can not.
Often dizzy, don't forget ta! 4 key points to help you avoid the "pit" of misdiagnosis

 Time of Update: 2022-09-21

. Considering the doctors, for recurrent transient vertigo, which disease does the following four clues point to?Clue one: at least 10 spontaneous spin or non-rotational episodes of vertigo;Clue 2: the duration of symptom onset < 1 minute;Clue three: carbamazepine and oxcarbazepine treatment is effective;Clue four: can not be better explained with other diagnoses.

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Immunology News

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Cell Sub-Journal: Simulated fasting can reshape the body's immunity and improve the effect of cancer immunotherapy

 Time of Update: 2022-09-22

Compared with other experimental groups, fasting simulated diet combined with immunotherapy also increased the expression of cytotoxic activity-related genes and CD8 T cell activation percentage in tumor immune infiltration.
Sci Immuno iNKT cells help fight cancer

 Time of Update: 2022-09-22

In 2022, the Giulia Casorati and Paolo Dellabona research group from Milan, Italy, presented a presentation in Science Immunology titled TCR-engineered iNKT cells induce robust antitumor response by dual targeting cancer and The suppressive myeloid cells article provides an in-depth study of the anti-tumor effects and mechanisms of iNKT cells.
AdTp: elastin-like polypeptide enhancement adeno-associated virus in Zongchao Han's research group at the University of North Carolina is expressed under pre-storage neutralizing antibody conditions

 Time of Update: 2022-09-21

In view of this, the above immunogenic residues can be avoided by various ways to avoid the human immune response may improve the efficiency of gene therapy for some genetic diseases.
The team of Fan Xiaoyong of MedComm Fudan University published an article: A review of the yin-yang balance of trained immunity and its application prospects

 Time of Update: 2022-09-21

A team of researchers fan Xiaoyong of Shanghai Public Health Clinical Center affiliated to Fudan University published a review entitled Trained immunity: A Yin‐Yang balance in MedComm issued by Wiley, which systematically summarized the discovery process, research model, induction process and regulatory mechanism of training immunity, and proposed for the first time that the impact of training immunity on human health is in line with the ancient Chinese philosophical idea "Yin and Yang Theory".
First reported: Sjogren's syndrome coexists with such conditions, and this test is key to diagnosis

 Time of Update: 2022-09-21

Magnetic resonance angiography (MRA) does not see the common carotid artery, sees collateral vessels, these results are consistent with TAK; Therefore, FDG-PET/CT examination shows that the blood accumulation of the ascending aorta to the descending aorta is increased, and the descending aortic stenosis is found.
Dysbiosis of the gut microbiota can trigger autoimmune diseases, and the tonsil flora is no exception

 Time of Update: 2022-09-21

In conclusion, the study reveals the immunomodulatory role of Salivaricin in autoimmune diseases, demonstrating that it beneficially regulates host immunity by directly binding to and inhibiting IL-6 and IL-21 receptors.
From "fighting alone" to "fighting together", traditional medicines synergize

 Time of Update: 2022-09-21

Efficacy and safety comparison of Ellamod or leflunomide combined with methotrexate in the treatment of active rheumatoid arthritis: a multicenter, randomized, double-blind, double-analog-controlled clinical study[J]. Efficacy and safety comparison of Ellamod or leflunomide combined with methotrexate in the treatment of active rheumatoid arthritis: a multicenter, randomized, double-blind, double-analog-controlled clinical study[J].
Want to predict lymphoma risk in patients with Sjogren's syndrome? This indicator is important!

 Time of Update: 2022-09-21

Download the Doctor Station App and subscribe anytime, anywhere*For medical professionals onlyClinical information, 1s reach ▎ Clinical question: Can accurate records of parotid swelling (PSW) predict non-Hodgkin lymphoma (NHL) in primary Sjögren syndrome (pSS)?
Directly attack the clinical pain points of SpA, improve the level of diagnosis and treatment, and "go to the future" together!

 Time of Update: 2022-09-21

”A three-pronged approach to improving the status quoTowards the future plan will be in view of the pain points and difficulties in the clinical diagnosis and treatment of SpA in China, Professor Zeng Xiaofeng said that the "To the Future" project mainly carries out three major sections of work:Establish a standardized diagnosis and treatment center to promote the development of standardized diagnosis and treatment of rheumatology and immunology in the country.
The Nature retrofit element Lx9 regulates the immune response to viral infections

 Time of Update: 2022-09-21

Next, the researchers used CRISPR-Cas9 to construct a usable mouse model of Lx9c11 deletion, and on the fourth day after CVB4 infection, RNA-seq analysis confirmed a reduction in host transcription in Lx9c11-/-mice, and reduced expression of L1_Mus3 on nearby LINE-1, or chromosome 11.

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Infection

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A world first!

 Time of Update: 2022-09-25

Original source:First case of monkeypox virus, SARS-CoV-2 and HIV co-infection, #%20 While the global outbreak of COVID-19 (also known as the new crown) has not yet ended, monkeypox (Monkeypox) has also been included in the World Health Organization (WHO) "Public Health Emergency" (PHEIC) list .
Ma Liu Consensus: Flow chart of empiric Hp eradication treatment

 Time of Update: 2022-09-22

The 6th Edition Maastricht/Florence Consensus 2021 report covers advances in the management of Helicobacter pylori (Hp) infection, providing guidance on the management of Hp infection and recommending eradication therapies for treatment of Hp infection.
Covid-19 Vaccines – A Review of Immunization, Variants, and Boosters NEJM

 Time of Update: 2022-09-21

Last week, the New England Journal of Medicine (NEJM) published a review online titled "Covid-19 Vaccines – Immunity, Variants, Boosters," summarizing the current understanding of the various COVID-19 vaccine-induced immune responses and the importance of humoral and cellular immunity for the long-term prevention of severe disease.
WHO guidelines are heavily updated, and new initiatives are being taken to treat Cryptococcus meningitis in HIV-infected patients

 Time of Update: 2022-09-21

A single high dose of amphotericin B liposomes (L-AmB) is strongly recommended in this update as a component of the preferred induction regimen for the treatment of Cryptococcus meningitis (CM) in HIV-infected patients [10 mg/kg L-AmB+5-FC (100 mg/kg·d*14d)+FLU (1200 mg/day*14d)].
Rare complications of brucellosis | case sharing

 Time of Update: 2022-09-21

After surgical consultation, conservative treatment of splenic rupture is considered, and patients undergo intravenous fluids, blood transfusions, and clinical and biochemical monitoring, and begin to receive a combination of rifampicin, doxycycline, and streptomycin for brucellosis.
Classic summary of adverse reactions of ten major categories of antibacterial drugs!

 Time of Update: 2022-09-21

*For medical professionals onlyFocus on clinical rational use! Antibacterial drugs refer to drugs with bactericidal or bacteriostatic activities, including various antibiotics, sulfonamides, imidazole
Monkeypox: epidemiology, host immunity, and clinical interventions

 Time of Update: 2022-09-21

Of the 5 vaccinated individuals who subsequently became infected with MXV, 2 did not detect positive pox virus-specific CD4+ and CD8+ T cells throughout the recovery period.
Is Tebipenem Pivoxil Hydrobromide's efficacy in the treatment of complex urinary tract infections inferior to intravenous ertapenem? - Cutting-edge research

 Time of Update: 2022-09-21

This International Phase 3 trial (ADAPT-PO) aims to evaluate the efficacy of oral Tebipenem Pivoxil Hydrobromide with intravenous ertapenem in hospitalized patients with complicated urinary tract infections or acute pyelonephritis.
The Pfizer vaccine has been recognized by the FDA as a breakthrough therapy, and pregnancy vaccination can benefit both mother and baby

 Time of Update: 2022-09-21

▎ WuXi AppTec content team editorNot long ago, Pfizer announced that its research streptococcal b vaccine candidate, GBS6 (PF-06760805), has been recognized as a breakthrough therapy by the US FDA to prevent invasive streptococcus b (GBS) infection in newborns and young children by vaccinates pregnant women during pregnancy.
"Lancet" sub-issue: domestic bivalent HPV vaccine can be fought! The results of the first domestic divalent HPV vaccine 5.5 years follow-up were released, the protection rate was 100%, and the clinical discovery of good safety was good

 Time of Update: 2022-09-21

Overall, the 5-and-a-half-year follow-up results confirmed that the first domestic bivalent HPV vaccine was effective and safe, and could be used to prevent HPV16/18-related precancerous lesions and persistent infections in women aged 18-45 years.

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Digestive System Information

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Professor Liu Min's team: Countdown to eliminating hepatitis B in 2030! The global trend of hepatitis B-related liver disease burden is revealed

 Time of Update: 2022-09-21

The results showed that HBV infection remained a global health problem, with HBV-associated cirrhosis and other chronic liver diseases in low, low-to-moderate sociopolymerological index (SDI) areas showing an increasing trend, and HBV-associated liver cancer in high SDI areas.
China's first consensus on the diagnosis and treatment of intrahepatic bile duct carcinoma 16 key recommendations to open a new journey of standardized diagnosis and treatment of intrahepatic cholangiocarcinoma

 Time of Update: 2022-09-21

Professor Shen Feng accelerated the standardization process of intrahepatic cholangiocarcinomaProfessor Shen Feng, a representative of the Consensus Editorial Board and Shanghai Oriental Hepatobiliary Surgery Hospital, said that the incidence of ICC has increased significantly nationwide, and the mortality rate is extremely high, and it is necessary to formulate a diagnosis and treatment specification for bile duct cancer that is suitable for China's national conditions.
In the first-line treatment of liver cancer, Hengrui Pharmaceutical and BeiGene released the latest clinical trial results of ESMO

 Time of Update: 2022-09-21

Efficacy results of carellizumab/apatinib (C+R) (Image source: Reference[2])The researchers said this result showed that the carrelizumab/apatinib combination significantly prolonged progression-free survival and overall survival in patients with unresectable hepatocellular carcinoma compared with the active control.
"Lean fatty liver" can not be ignored - how to identify and treat? Expert perspective

 Time of Update: 2022-09-21

Q3How to treat patients with lean NAFLD?For patients with lean NAFLD, lifestyle interventions (including dietary adjustments and exercise) are recommended to achieve moderate weight loss of 3% to 5%. For patients with lean NAFLD, lifestyle interventions (including dietary adjustments and exercise) are recommended to achieve moderate weight loss of 3% to 5%.
New Knowledge: Occasional Constipation Expert Consensus!

 Time of Update: 2022-09-21

Therefore, this expert consensus recommends a practical definition of OC:“Intermittent or occasional symptomatic changes in bowel habits, including a decrease in annoying frequency and/or difficulty defecating, but without "alarm signs".
Milestone! NASH new drugs can take effect in less than half a year, what does the pharmaceutical industry think?

 Time of Update: 2022-09-21

▲If you have any business needs, please long press to scan the QR code above, or▎ WuXi AppTec content team editor"We believe the results of today's HARMONY trial are an important milestone for Akerero and the entire population of non-alcoholic steatohepatitis (NASH) patients!"—Dr. Andrew Cheng, President and CEO of AkeroToday, there is a big news in the industry.
Treatment of "chronic pancreatitis", the latest Japanese guidelines give these recommendations (Part 2)

 Time of Update: 2022-09-21

Recommended intensity: weak, level of evidence: DIs pancreatic enzyme replacement therapy recommended for pain?Pancreatic enzyme replacement therapy is not recommended for the treatment of pain in cp patients.
How to manage non-alcoholic fatty liver disease in primary care institutions?

 Time of Update: 2022-09-21

Diagnosis, evaluation, and treatment of NAFLDNAFLD is common in patients with metabolic risk factors such as diabetes mellitus and obesity, and is diagnosed based on testing for liver steatosis and excluding other liver disease, excessive alcohol consumption (30 g/day≥ ≥ in men and 20 g/day in women), and secondary causes of fatty liver disease (e.
Professor Chin Lun Xiu: Evidence-based and comprehensive layout, the cornerstone of the treatment of liver cancer by lenvatinib is solid

 Time of Update: 2022-09-21

Professor Qin Lunxiu said that in clinical practice, lenvatinib shows more advantages, and its ORR and other efficacy results are better, therefore, lenvatinib has now become the preferred drug for the first-line treatment of advanced HCC, and has been unanimously recognized by the majority of clinicians.
Professor Xing Baocai, | of the new life of the intestinal tract: A multi-dimensional discussion on the translational treatment of liver metastasis of colorectal cancer

 Time of Update: 2022-09-21

Hot Spots and Controversies: Translational Treatment Strategies for Patients with Multiple CRLMProfessor Xing introduced that surgical resection after non-resectable liver metastases and conversion therapy helps to prolong the survival of patients, and a small number of patients can even achieve cure.

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JAMA sub-journal: Middle-aged and elderly people need to be more vigilant about "beer belly"! Nearly 60,000 Chinese 4 years of follow-up data suggest that people who lost weight but increased waist circumference were associated with a 69% increased risk of death

 Time of Update: 2022-09-22

In addition, middle-aged and older adults who lost weight but increased waist circumference were associated with a 69% increased risk of death compared with participants with stable weight and waist circumference.
1 Table reading, painless thyroiditis vs subacute thyroiditis, how to distinguish?

 Time of Update: 2022-09-21

cn Click "Read the original article" for a guide to the diagnosisFor medical professionals onlyDiagnosis is no small matter Where to see more endocrine clinical knowledge? cn Click "Read the original article" for a guide to the diagnosisFor medical professionals onlyDiagnosis is no small matter Where to see more endocrine clinical knowledge?
Gathering? Epidemic situation? Double background blessing, how to choose insulin clinically?

 Time of Update: 2022-09-21

The reduction in insulin prices will benefit more diabetic patients, and patients who can only use animal insulin and human insulin before collection due to drug prices can be treated with the latest three generations of insulin - insulin analogues, which greatly improves the accessibility of insulin and helps reduce the risk of hypoglycemia and weight gain.
Medical Pulse Interview | talk about the new STRATEGY of T2D related CKD management, and take multiple measures to help win-win results

 Time of Update: 2022-09-21

This time, Yimaitong had the honor to invite Professor Wang Rong of Shandong Provincial Hospital, Professor He Qiang of Zhejiang Provincial Hospital of Traditional Chinese Medicine and Professor Lu Chen of the First Affiliated Hospital of Xinjiang Medical University to share expert views on how to explore and improve the multidisciplinary management model of T2D-related CKD, and what significance and value the approval of the innovative drug nonelidone in China will bring to the upgrading of disease treatment strategies.
Science Bulletin Advances in Diabetes and Intestinal Microbiota

 Time of Update: 2022-09-21

Click "Read the original article" below to learn more about the studyThe gut microbiome has been recognized as one of the key factors regulating host health and plays an important role in a variety of chronic diseases, including diabetes.
"Guide to Avoiding Pits" - The 8 most common mistakes made in interpreting the Jia Gong report

 Time of Update: 2022-09-21

In recent years, the prevalence of thyroid diseases in China has shown a significant upward trend, and has now become the second largest endocrine disease after diabetes, and "nail function examinatio
Be wary of these "pits" in the clinic, "hypoglycemia" is easy to confuse with these three diseases

 Time of Update: 2022-09-21

Misdiagnosis of hypoglycemia as "mental illness"Some patients have a long history of diabetes or autonomic neuropathy, or take adrenergic receptor blockers, resulting in a sluggish sympathetic and adrenal medullary response, hypoglycemia without sympathetic involvement symptoms, but manifested as central nervous system dysfunction, convulsions, clinically easy to misdiagnose epilepsy and take antiepileptic drugs, causing pain and unnecessary economic burden to patients.
Regarding levothyroxine tablets, you should at least know these nine points!

 Time of Update: 2022-09-21

4Optimal time to take the drug▎Recommended manual:Levothyroxine sodium tablets should be taken on an empty stomach with a one-day dose of the appropriate liquid (e. 4Optimal time to take the drug▎Recommended manual:Levothyroxine sodium tablets should be taken on an empty stomach with a one-day dose of the appropriate liquid (e.
100 years of biguanide, multiple benefits open a new era of diabetes treatment!

 Time of Update: 2022-09-21

In addition to reducing sugar, metformin brings surprisesIn addition to hypoglycemicity, metformin in recent years in various clinical studies, showing pleiotropic benefits, taking the more concerned polycystic ovary syndrome (PCOS) as an example, Professor Li Xiaoying pointed out that metformin by improving insulin resistance in PCOS patients, improving insulin sensitivity, improving menstrual cycle, improving conception rate, its pleiotropic effect is worthy of in-depth study.
"Nature Metabolism": Basking in the sun will make men fat! Scientists have found that ultraviolet exposure causes increased ghrelin levels, increased appetite, and weight gain in men

 Time of Update: 2022-09-21

*For medical professionals onlyp53, the famous cancer-related genes, we can often see it appear in bowel cancer, lung cancer, liver cancer and other related literature, cancer inhibition and cancer pr

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FDA approves ibrutinib for children with chronic GVHD

 Time of Update: 2022-09-24

ly/3cgRdJ8 Based on the results of the Phase 1/2 iMAGINE trial, the FDA has approved ibrutinib for patients with chronic graft-versus-host disease in children . ly/3cgRdJ8 Based on the results of the Phase 1/2 iMAGINE trial, the FDA has approved ibrutinib for patients with chronic graft-versus-host disease in children .
EU approves bispecific antibody Tecvayli (teclistamab) for the treatment of adults with relapsed/refractory multiple myeloma (RRMM)

 Time of Update: 2022-09-24

Janssen announced today that the European Commission (EC) has approved the conditional marketing of Tecvayli (teclistamab), a bispecific antibody targeting B cell maturation antigen (BCMA), for the treatment of adults with relapsed/refractory multiple myeloma (RRMM).
Researchers have discovered a rare inherited blood disease HLH new pathogenic gene

 Time of Update: 2022-09-22

A hypothetical model of NBAS gene defects causing HLH to occurSource: Beijing Institute of Genomics, Chinese Academy of SciencesHemophagocytic syndrome (HLH) is a severely life-threatening rare blood disease with an incidence of only one in a million, named after the phenomenon of phagocytes commonly found in the bone marrow of patients.
Preliminary clinical results of ESMO field direct-attack anti-CD47 monoclonal antibody Lemzoparlimab combined with azacytidine in the treatment of newly diagnosed patients with HR-MDS

 Time of Update: 2022-09-21

Figure 1Among the 29 patients with assessable efficacy ≥ 4 months of initial treatment, the overall response rate (ORR) was 86. Figure 1Among the 29 patients with assessable efficacy ≥ 4 months of initial treatment, the overall response rate (ORR) was 86.
Unprecedented and exciting! The 18th National Conference on Red Blood Cell Disease (Anemia) of the Chinese Medical Association was grandly opened

 Time of Update: 2022-09-21

The 18th National Conference on Red Blood Cell Disease (Anemia), sponsored by the Chinese Medical Association and the Hematology Branch of the Chinese Medical Association, undertaken by the Henan Medi
JHO (IF=23) In a multi-unit collaboration with Xiamen University, Xu Bing/Li Zhiming/He Xuhua revealed the evolution of the tumor immune microenvironment in follicular lymphoma patients over a 24-month period

 Time of Update: 2022-09-21

Patients with follicular lymphoma have a poor prognosis if they experience disease progression (POD24) within 24 months. Patients with follicular lymphoma have a poor prognosis if they experience disease progression (POD24) within 24 months.
ESMO Direct Hit ORR 42.2% and DCR 75.6%! Preliminary results of a Phase I study on the treatment of relapsed refractory B-NHL by TRS005 were published

 Time of Update: 2022-09-21

Professor Shi Yuankai's team at the Cancer Hospital of the Chinese Academy of Medical Sciences conducted a Phase I dose escalation and extension study (CTR20182204) to explore the safety, pharmacokinetics and preliminary efficacy of TRS005 in patients with CD20+ relapsed or refractory B-cell non-Hodgkin lymphoma (NHL).
Ke Xiaoyan and Professor Hu Kai's team: The provider CD7 CAR-T treatment of recurrent T-ALL/LBL after allogeneic hematopoietic stem cell transplantation is safe and has a high remission rate, which is worth looking forward to

 Time of Update: 2022-09-21

As the efficacy of CAR-T therapy in B-cell lymphoma is becoming recognized, several studies have focused on patients with refractory/relapsing T-ALL/LBL. It is well known that refractory/relapsing T-A
Professor Sun Zhiqiang: The fire of innovation, casting the blade of treatment, from the real drug use of Rotxip and core research β- the future treatment trend of local poverty

 Time of Update: 2022-09-21

For the treatment of β-thalassemia (hereinafter referred to as "β-ground poverty"), the previous means were more limited. Some patients rely on long-term blood transfusions and face multiple dilemmas
Professor Huang Huiqiang: Pola sends charcoal in the snow to help patients with non-transplantable R/R DLBCL to rekindle hope

 Time of Update: 2022-09-21

GuideThe opening of every unknown world has been bravely foreseen by pioneers; Every journey of stealth in the dark of night, there are lighters fearlessly leading the way. The series of reports on "S

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【Friday. Impaired automodulation of cerebrovascular vessels and delayed neurocognitive recovery in large tumor surgery: a secondary analysis of pooled data

 Time of Update: 2022-09-21

Intraoperative impaired cerebrovascular autoregulation and delayed neurocognitive recovery after major oncologic surgery: a secondary analysis of pooled dataImpaired automodulation of cerebral vessels and delayed neurocognitive recovery in large tumors: a secondary analysis of pooled dataCerebral blood flow is strictly regulated by cerebrovascular autoregulation (CVA), and intraoperative CVA injury is associated with perioperative neurocognitive disorders (PND).
Anesthesia Care Column - Let's Know About World Patient Safety Day

 Time of Update: 2022-09-21

Raise global awareness of the high burden of drug use harm caused by medication errors and unsafe medication practices, and advocate for urgent action to enhance medication safety.
【Pediatric Anesthesia】Lung interaction in congenital heart disease surgery center

 Time of Update: 2022-09-21

Although low peak inspiratory pressure, shorter inspiratory times, increased intermittent forced frequencies, and low-level PEEP ventilation strategies are recommended in patients with limited RV physiological function, the small tidal volume of this ventilation mode (e.
【Pediatric Anesthesia】Reflections on the anesthesia plan of tracheoscopy surgery

 Time of Update: 2022-09-21

ps Chinese Doctor 👩 ⚕️👨 ⚕️ was releasedEveryone has time to moveIntroduction to keep LOOKING FORWARD TO GOING Children 16 days 3. ps Chinese Doctor 👩 ⚕️👨 ⚕️ was releasedEveryone has time to moveIntroduction to keep LOOKING FORWARD TO GOING Children 16 days 3.
Pain: The relationship between physical activity and chronic pain

 Time of Update: 2022-09-20

Consistent pattern between physical activity measures and chronic pain levels: the Tromsø Study 2015-2016. Consistent pattern between physical activity measures and chronic pain levels: the Tromsø Study 2015-2016. Consistent pattern between physical activity measures and chronic pain levels: the Tromsø Study 2015-2016.
【Anesthesia hotspot】Blood transfusion threshold and intraoperative coagulation abnormalities

 Time of Update: 2022-09-15

Oxygen saturation at the start of surgery is 97%, heart rate is 68 beats per minute, MAP 71 mmHg. Based on the fact that the patient has stable ischemic heart disease, the minimum Hb is set to 80 g/L, and the anesthesiologist calculates the patient's maximum allowable blood loss (MABL), using the following formula:MABL =[(Preoperative Hb- lowest acceptable Hb)/preoperative Hb]× body weight (kg) × blood volume (ml/kg)[（12.
Sugar, not necessarily sweet~

 Time of Update: 2022-09-14

Welcome to actively submit "v draft" (vlog draft)01Purpose of the activityWe are determined to continue to provide "quality content and services" to people all over the country and even people around the world (including but not limited to anesthesiologists, physicians and surgeons, dentists and other doctors, patients, ordinary people, insiders and professionals who are interested in this), but at the same time we do not want to be "behind closed doors".
Effect of pathophysiology of the liver on anesthesia in liver transplant patients

 Time of Update: 2022-09-14

In addition, thrombocytopenia is common in patients with liver failure due to decreased thrombopoietin produced by the liver and the isolation of platelets by the spleen in the presence of portal hypertension.
Yao's Anesthesiology Reading Notes Day2

 Time of Update: 2022-09-14

How to deal with hypoxemia in single lung ventilation?OK that's itNext week's mission is comingHello Hello Everyone have a good weekend ~~It's time to summarize the cases againThe cases this week were shortThis case mainly discusses three problemsPoints of preoperative assessment, physiological changes, and intraoperative management of thoracic surgerySome management strategies for longitudinal and tracheoscopy are also involvedKey points of the question includeB1、C2、C5、C8、C11、C14How's it going?
Ibrain ultrasound-guided peripheral trunk block technology: a new approach that is gradually taking the stage of clinical anesthesia

 Time of Update: 2022-09-08

With the continuous development and validation of new visualization techniques, ultrasound-guided peripheral trunk block has become more mature and the scope of implementation in clinical anesthesia has become more extensive.

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42% lower risk of death! The team of Ye Dingwei of Fudan University released the first Chinese plan for the treatment of metastatic hormone-sensitive prostate cancer

 Time of Update: 2022-09-21

On September 5, 2022, the team of Ye Dingwei of the Department of Urology of the Affiliated Cancer Hospital of Fudan University published a research paper in the journal Lancet Oncology, which lasted more than 4 years, comparing the efficacy and safety of "revirutrum combined castration therapy" and the classic "bicalutamide combined castration therapy" in patients with high tumor load metastatic hormone-sensitive prostate cancer, confirming the first new second-generation anti-male drug "revirutamine" independently developed by China.
ESMO pre-"research" news The development of domestic anti-PD-1 monoclonal antibodies is eye-catching, and the results of the phase II trial of paimpril combined with allotinib are outstanding

 Time of Update: 2022-09-21

GuideThe 2022 Annual Meeting of the European Society of Oncology (ESMO) was held in Paris from September 9 to 13, local time. As one of the most influential academic conferences in the field of oncolo
ESMO Preview Carellizumab plus albumin paclitaxel, positive results of Phase 2 clinical trials are announced

 Time of Update: 2022-09-21

Immune checkpoint inhibitors (ICIs) have brought new changes to the treatment of urothelial carcinoma after the failure of platinum-containing chemotherapy, and the results of a Phase II trial of carellizumab combined with albumin paclitaxel in the treatment of advanced urinary intestinal carcinoma (aUC) will be released at this ESMO conference.
Research frontiers: Selection of hypospadias repair modality and risk factors for postoperative complications

 Time of Update: 2022-09-21

A multicenter study on surgical procedure selection and risk factor analysis of postoperative complications after TIP and Duckett hypospadias repair. A multicenter study on surgical procedure selection and risk factor analysis of postoperative complications after TIP and Duckett hypospadias repair.
First-line treatment for bladder cancer, with a combined ADC/Keytruda response rate of 64.5% ESMO

 Time of Update: 2022-09-21

The purpose of this trial was to test the efficacy and safety of the antibody-conjugated drug Padcev (enfortumab vedotin) and the PD-1 antibody Keytruda (pembrolizumab) as first-line therapy for patients with local unresectable advanced or metastatic urothelial carcinoma (la/mUC).
ESMO Pre-"Research" Newsletter Atenolizumab: New Advances in the Field of Urinary Tumors

 Time of Update: 2022-09-21

Abstract number: 1742P：Phase 2 study of rucaparib and atezolizumab (ARIANES): Results in patients (pts) with platinum-sensitive metastatic urothelial cancer (mUC) and metastatic castration-resistant prostate cancer (mCRPC)Research backgroundPolyADP ribose polymerase inhibitors (PARPi) modulate immunity by activating the innate immune pathway of cGAS/STING and inducing PD-L1 expression.
ESMO Pre-"Research" Newsletter Radioactive Ligand Therapy in mCRPC

 Time of Update: 2022-09-21

This study aimed to evaluate the safety and efficacy of treatment with 177 patients with metastatic castration-resistant prostate cancer (mCRPC) in the RALU study after using 233Ra with 177Lu-PSMA.
ESMO pre-"research" news Averumab first-line maintenance therapy for the long-term results of advanced urinary urothelial carcinoma, worth paying attention to!

 Time of Update: 2022-09-21

GuideThe 2022 Annual Meeting of the European Society of Oncology (ESMO) was held in Paris from September 9 to 13, local time. As one of the most influential academic conferences in the field of oncolo
Lancet Sub-Journal (IF=54) Reduces Risk of Death by 42%! Fudan University Ye Dingwei's team first launched the "Chinese plan" for the treatment of metastatic hormone-sensitive prostate cancer

 Time of Update: 2022-09-21

iNatureProstate cancer is a malignant tumor with a very high incidence, ranking second in the world in the incidence of malignant tumors in men, after lung cancer. About 70% of Chinese prostate cancer
How effective is neoadjuvant radiation-immunotherapy in patients with locally advanced bladder cancer?

 Time of Update: 2022-09-21

conclusionThe RACE IT trial reached the primary endpoint and confirmed that neoadjuvant radio-immunotherapy prior to radical cystectomy is feasible and safe in patients with locally advanced bladder cancer.

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Diagnostic Test

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The official Creaform form created peel 3 and peel

 Time of Update: 2022-09-20

OS； as well as a fully integrated 3D scanning solution for reverse engineering, peel 3 CAD with peel 3D scanner and peel. OS； as well as a fully integrated 3D scanning solution for reverse engineering, peel 3 CAD with peel 3D scanner and peel.
One of the world's largest auto parts suppliers, their secret to improving efficiency is...

 Time of Update: 2022-09-14

Today we learn more about the Hilschvogel Group's secret to efficient and high-quality work by understanding the quality inspection of wheels, one of the many components produced by the Hirschvogel Group: the atos ScanBox 4105 and the gom software in the work.
Empower innovation in education See how ACADEMIA's 3D scanning solutions look

 Time of Update: 2022-09-14

Creaform ACADEMIA is an affordable suite of educational solutions from Tron as a company that includes a range of 3D measurement technology products for many different areas of study, including science and engineering, applied science, industrial design, natural sciences, archaeology, as well as research projects and university service centers.
Company team building - we are together is the life we yearn for

 Time of Update: 2022-08-19

The summer wind softens the whole village Mist pours into the mountains and turns into a painting of blue, naturally the most poetic ink painter Life is not only about the hustle and bustle in front of you, but also poetry and distant fields .
Empowering the automotive aftermarket Ryco Filters uses Creaf

 Time of Update: 2022-08-19

Long press the following QR code to contact technical experts In the automotive aftermarket in Australia and New Zealand, it is safe to say that Ryco Filters is well known .
Unilink Technology and you focus on the integrated die-casting molding process - 2022 National Die-casting Annual Conference and the 17th

 Time of Update: 2022-08-15

Invitation to visit With the theme of "Technological Innovation and Industrial Development led by Large-scale Integrated Die Casting", this conference will bring 20+ wonderful technical speeches, theme workshops, special brand displays, dialogues with industry experts, casting company visits, and many exchange activities.
Spreadtrum PolyWorks Shanghai will attend the 8th Dimension

 Time of Update: 2022-08-15

At that time, Chen Yu, a technical application expert from PolyWorks Shanghai, will also give a speech on " PolyWorks helps you optimize manufacturing processes and gradually realize digital 3D transformation " ( July 28, 2022, Beijing time, 15:00-15:30 pm ), as The exhibitors this time, during the two-day exhibition, PolyWorks Shanghai will also bring the overall solution of PolyWorks® in the exhibition area .
VisiConsult acquires majority stake in CT specialist diondo

 Time of Update: 2022-08-15

Our strengths are complementary, and use this opportunity to bring greater value to the company's operations and products" Jason Robbins, Head of Sales at VisiConsult, puts it bluntly from the customer's perspective: "diondo's CT technology is the perfect complement to our own extensive product portfolio .
The smart production method of many famous German companies of BSH and Funke

 Time of Update: 2022-08-15

" - Florian Topp, Wilhelm Funke Metal Casting Quality Manager > Read the full Funke case story For many companies, the requirements for production quality control are increasing: high throughput and repeatability of inspections, precise proof of part accuracy, flexibility to measure different parts and molds.
Enabling racing technology Inspection, control and digital archiving of racing carbon fiber components

 Time of Update: 2022-08-15

As we all know, the technical content of racing cars is very high, and so are the requirements for the quality of components . This also places strict demands on the entire development, design and pr

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