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Drugs Articles

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In 2021, the trend of drug enterprise differentiation will become more and more obvious

 Time of Update: 2021-03-07

the trend of growth, of course, there are enterprises sales fell sharply. from the three-quarter reports issued by various pharmaceutical companies, special one pharmaceutical industry, guangzheng ophthalmology, Ha Sanlian, Zixin pharmaceutical
The most noteworthy antibody drug of 2021

 Time of Update: 2021-03-06

and children, including newborns born to mothers who test positive for the Ebola virus RT-PCR in Zaire, to treat infections caused by the Zaire Ebolavirus virus. Ebanga is the second Ebola treatment approved by the FDA after the regenerative
Time is ahead again! An Italian woman has been infected with the new coronavirus in November 2019

 Time of Update: 2021-03-06

An international research team led by the University of Milan in Italy found the genetic sequence of the new coronavirus from a biopsy sample taken by a young female dermatology patient in the country on November 10, 2019, an Italian media outlet
The first CAR-T in China is coming! Fosun Kate Aquilonsai injections are about to be approved

 Time of Update: 2021-03-06

From NMPA's official website, Aquilonsai Injection, codentag FKC876, Fosun Kate introduced YESCARTA (Axicabtagene Ciloleucel) technology from Kite Pharma in the United States and is authorized to localize the production of targeted CD19 self-contained CAR-T cell therapy products in China.
Authoritative Report: 2020 Global Health Investment and Financing Record China's performance?

 Time of Update: 2021-03-06

investment in all of the healthcare sub-sectors has broken records, with the venture capital-backed biopharma and diagnostic/tools industries performing well against the new crown pandemic.
Another exploration of the reform of the annual salary system of public hospitals!

 Time of Update: 2021-03-06

, the director of public hospitals, the annual salary system of health care to the country earlier to explore the reform of the annual salary system of deans, when the medical reform star province and city - Fujian Sanming.
The evolution of health care negotiations and the rise of local innovative drugs | year

 Time of Update: 2021-03-06

As 2020 passed, this year's memorabilia of the pharmaceutical industry was dominated by a sudden new crown outbreak, drawing a line under the national health-care negotiations that have boiled over the industry. the former created a lot
4 keywords and 7 key issues, interpretation of health care "14th Five-Year Plan" period tasks

 Time of Update: 2021-03-06

$20,000 (see table 1). with the gradual improvement of China's pre-rich old situation and the growing demand for healthy and long-lived consumption, China's total health expenditure and GDP ratio will also increase. In formulating the 14th
Medici partner Shengnoki "first-in-class" new drug up to III

 Time of Update: 2021-03-06

receptor (estrogen receptor, ER) has inhibition activity, since then, for masturbation amniotic acid in the pharmaceutical aspects of research has been carried out. Current studies of Acolatin's anti-tumor mechanisms have shown that it regulates
Koren, Yangzijiang... 57 new drugs reported clinically! Zhengda Qing the first inhaler class 1 new drug debut, Qilu's first oral dissolved membrane came

 Time of Update: 2021-03-06

(2020.12.26-2021.1.8) New drug listing application review status update domestic class 1 new drug Sovantini capsule was approved for market, the product is and Huang Pharmaceutical independently developed a new oral tyrosine kinase inhibitor, with anti-angiogenesic and immunomodulation dual activity.

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Shandong Chemical Park rectification into the "countdown", many problems, the status quo mixed. The road to the chemical park is not smooth!

 Time of Update: 2021-03-07

; Shandong Chemical Park rectification into the countdown with the situation of the epidemic improved, Shandong chemical parks suddenly busy up, "reform" "relocation" has become the local government and enterprises to discuss the most topic words
Jiangsu cracks down on "small chemical industry" that cracks down on illegality and violations

 Time of Update: 2021-03-07

production equipment. Thred is the undocumented or incomplete production of "small chemical industry", to resolutely implement the "four thorough" rectification, that is, completely cut off water and electricity, completely dismantle production
In May and June, the shipping company stopped shipping in large areas, container freight rates continued to rise! Ports, transportation industry continues to bear pressure!

 Time of Update: 2021-03-07

; As a result of the impact of the new crown outbreak on global trade, according to Alphaliner, as of May 11, there were 524 idle container ships and a total idle capacity of 2.65 million TEU.
Shut down 78! Stop approving 114 chemical projects! This area to step up efforts to rectify!

 Time of Update: 2021-03-07

the approval of 114 chemical construction projects. In the chemical industry special three-year action plan, Shijiazhuang City plans to close this year to ban more than 20 small-scale, poor conditions of dangerous chemical enterprises
Jiangsu to promote the safety of dangerous chemicals safety production special rectification, to fight the hidden dangers of the problem "annihilation war"

 Time of Update: 2021-03-07

Security Commission office responsible person said that this time will take a centralized meeting, centralized training, centralized inspection, centralized supervision, centralized exposure, centralized exercise work measures, the city and the district
Capital, logistics, exports, front-line staff seriously inadequate! Small and medium-sized enterprises face four major problems

 Time of Update: 2021-03-07

pressure, many enterprises appear a funding gap, cash flow is insufficient, at any time to face the risk of broken capital chain. jiangyin Chengxing Industrial Group Co. , Ltd. said that due to product inventory backlog, capital turnover
Corn prices are breaking records! Usher in the era of 1.5 yuan / catty!

 Time of Update: 2021-03-06

More than 1.5 yuan per catty (3000 yuan per ton) domestic corn ushered in a new era Shandong corn officially more than 1.5 yuan per catty, the latest price of 1.515 yuan per catty, representing the first time China's corn price more than a piece
The global soybean market has changed dramaticly, and the domestic soybean market is no exception

 Time of Update: 2021-03-06

, Brazil's 2020 soybean cultivation cannot be advanced because of "gods" - the pace of soybean cultivation in Brazil has fallen to its lowest level in a decade due to dry weather in September and early October 2020, leading to fears that the harvest
New Hope launched its biggest equity incentive in 22 years, benefiting 4,000 employees and raising pigs in 2023

 Time of Update: 2021-03-06

/> to the chairman of Yongsheng, Chang and the new hope colleagues to my tolerance. I always agree with Chang, she is one of the few young business leaders of our time, and will continue to be an example for me to follow in the future." <br
Break through 3000 yuan / ton, corn after the opening of the price increase of about 15%, feed with the rise

 Time of Update: 2021-03-05

companies, Mr Chen said, "Normal conditions change every two Mondays, but when market conditions are adjusted more frequently, it becomes a weekly adjustment." " raw material prices, feed enterprises can afford it? What's the response

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10 domestic 1 class of new drugs "on the market take off"! It's sunny, Hengrui, Howson bright...

 Time of Update: 2021-03-07

(referred to as China's public medical institutions) terminal and Sales of physical pharmacies terminals in Chinese cities focus on the 10 domestic innovative drugs that quickly "take off" after the listing, including the three PD-1 mono-resistance
East China Medicine heavy-handedly hit the medical U.S. track, the future transformation depends on it?

 Time of Update: 2021-03-07

, as early as 2013, East China Medicine took the chinese rights and interests of Uric acid Yiwan to enter the field of medical beauty, began a new layout.
(..)

 Time of Update: 2021-03-07

to study the relationship between the use of glucose by tumor cells and the response to immunotherapy, the researchers used a highly sugar-ionized mouse model of breast cancer --- which means it uses a lot of sugar to grow.
Nat Metabol: Scientists hope to develop a new potential treatment for malignant non-small cell lung cancer

 Time of Update: 2021-03-06

January 11, 2021 // -- In a recent study published in the international journal Nature Metabolism, scientists from the University of Texas Southwestern Medical Center and other institutions discovered a new metabolism in a highly invasive form
The response of super mutant gliomas to immuno-checkpoint inhibitors is heterogeneic

 Time of Update: 2021-03-06

divided into the ICB Reaction (ICB R) group and the ICB Non-Response (ICB NR) group. d26 to take IB R and IB NR group mouse tumors for exon sequencing. used imaging histology to evaluate ICC reaction and false progress. mice MRI
Postoperative ancillary treatment of esophageal cancer/gastroesophageal cancer! Pepsi Opdivo receives FDA Priority Review: Significantly Extending Disease-Free Survival!

 Time of Update: 2021-03-06

) and a centralized review process has been initiated. application is based on the results of Phase 3 CheckMate-577 trials. data show that opdivo-assisted therapy doubled the patient's disease-free survival (DFS) (median DFS: 22.4 months vs
JAMA Network Open: Chinese scientists have developed a new deep learning technique that promises to successfully predict hidden peritometrial metastasis in patients with stomach cancer!

 Time of Update: 2021-03-06

January 11, 2021 // -- Stomach cancer is a common gastrointestinal malignancies that often occur in most patients with advanced stomach cancer, which is considered an invasive cancer and often has a poor prognosis. patients with peritina
18F-FET PET identifies the value of glioma progression

 Time of Update: 2021-03-06

October 2017 MRI-T2 axle (A.left) and T1 enhanced axon (A.right); November 18, 2017 F-FET PET (B); and November 2017 biopsy sample histology (Sumu-Ihong (C) and immunologic chemistry (IDH1_R132H, arrows indicating IDH1_R132H positive tumor cells) (D).
A study of the heavyweight highlights that Nature had to look at in January

 Time of Update: 2021-03-05

doi:10.1038/s41586-020-03057-ydoi:10.1038/d41586-020-03577-In a recent study published in the international journal Nature, scientists from institutions such as the Albert Einstein College of Medicine found that pain nerves in the body's bone marrow may help regulate the mobilization of hematopoietic stem cells.
How scientists have succeeded in mapping what promises to improve the study of many human diseases!

 Time of Update: 2021-03-05

: Eviatar Yemini 1 Cell: Heavy! Scientists have developed a new coloring technique to successfully map the brain! doi:10.1016/j.cell.2020.12.012 The human brain contains about 86 billion neuron cells, woven together by about 100 trillion synhapal

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Immunology News

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Science | first human trial Phase II clinical conclusion...

 Time of Update: 2021-03-07

Recently, researchers at upMC Hillman Cancer Center and the U.S. National Cancer Institute demonstrated that changing the gut microbiome can turn patients with advanced melanoma who do not respond to immunotherapy into responders.
Immunome announces discovery of new coronavirus variant first in ...

 Time of Update: 2021-03-07

the expression of a fake virus specific to the South African mutant strain B.1.351. recent literature suggests that the South African mutant strain weakens the efficacy of vaccines and some existing antibody therapies. , chief executive
NovarceEntresto's treatment of HFpEE heart failure has been approved

 Time of Update: 2021-03-07

approved the emergency use of the New Crown Vaccine in Hong Kong in accordance with the Prevention and Control of Disease (Use of Vaccines) Regulations. information provided by vaccine suppliers, the first batch of about 1 million doses
3 days 3 changes - in more than 2.8 billion traditional pharmaceutical giant innovation turn...

 Time of Update: 2021-03-07

February 16, Qilu Pharmaceuticals signed a cooperation agreement with Cend Therapeutics, a U.S. biotech company, to obtain an exclusive interest in Cend's new cancer drug in Greater China for up to $235 million.
External JAK inhibitor to treat eczema Incyte using priority review vouchers submitted...

 Time of Update: 2021-03-07

Retrieved February 19, 2021, from Ruxolitinib Cream: Phase 3 Data in Atopic Dermatitis.
The application for the listing of regenerant biology Terripley single anti-new anti-adhesive disease was accepted

 Time of Update: 2021-03-07

On February 18, Junshi Bio announced that the company had received a "notice of acceptance" approved by the State Drug Administration, and that the new adaptation application for Ripley monoantithermal combination chemotherapy for advanced first-line
New research reveals new mechanisms to root out cancer cells by bypassing the mutated anti-cancer gene

 Time of Update: 2021-03-07

/> That is, mtp53 induces congenital immune signal infusion, alters the production of cytokines, and causes immune escape; Overall, the study found a new mechanism, mtp53, that inhibits cellular autonomy and non-cellular signaling by interfering
Cell Rep: Reveals a new molecular mechanism by which malignant prostate cancer subtypes are resistant to therapy

 Time of Update: 2021-03-07

prostate cancer) in the body after hormone therapy. Photo Source: The Hospital Research Foundation is well known that some tumors exhibit increased cell plasticity under new or stressful conditions, such as cancer therapy, which may promote
Global Pharmaceutical CEO Compensation PK: AZ annual salary of 140 million yuan Roche down salary ...

 Time of Update: 2021-03-07

02 Roche/Novarter CEO's annual salary doubles, a year-end award for the base salary 2020 new crown pandemic raging around the world, seriously affecting global economic growth, most companies are struggling, layoffs and pay cuts.
Cutting-edge | Anti-APOE antibodies effectively remove amyloid deposition

 Time of Update: 2021-03-07

a new pathway by targeting APOE. it appears to effectively remove amyloid protein from brain tissue and blood vessels while avoiding this potentially dangerous side effect. : This article is intended to introduce medical and health research

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NovartEntresto treats HFpEE heart failure...

 Time of Update: 2021-03-07

/> December, Novaral announced that the FDA's Advisory Committee on Cardiovascular and Kidney Medicines (CRDAC) had voted 12 to 1 in support of the use of Entersto to treat HFpEF. Entresto is a cocrystalline complex of sodium salts combined
Koren, East Sunshine Medicine, It's Sunny... The 12 heavyweights will be approved

 Time of Update: 2021-03-07

for listing by the FDA in October 2010 and entered the domestic market in January 2019, with global sales of 189.5 billion yen in 2019 and 194.2 billion yen in 2020. Table 12: New classification of hydrochloric acid lulassin ketone tablets reported
Anticipate the future | 13 clinical emergencies expected to be approved for listing in China in 2021...

 Time of Update: 2021-03-07

-IIIA and phase IIIB phase NSCLC. 13, Drug Name: Vinacaran Injection Company hydrochloric acid: Cardiome Pharmaceutical Mechanism: Sodium/Potassium Channel Blocker Adaptation: Atrial Fibrillation Hydrochloride Injection (vernakalant hydrochloride
A number of medical devices were named by the State Drug Administration

 Time of Update: 2021-03-07

of innovative medical devices in China. By November 2018, the State Drug Administration revised and issued the Special Review Procedure for Innovative Medical Devices, which improves the application situation, refines the application process
FDA responds to criticism of Alzheimer's drug review process by refusing to pre-declaration and claim...

 Time of Update: 2021-03-07

, Public Citizen, a consumer advocacy group, issued a scathing letter of criticism about the FDA's review process for Biogen's controversial Aducanumab listing, saying that Billy Dunn, director of the Office of Neuroscience, and other reviewers had
Big discovery! The psychiatric drug lipeone may be a boon for stuttering patients

 Time of Update: 2021-03-07

libido, previously earmarked for schizophrenia and bipolar disorder, may have some effect on stuttering, and that its function may be related to astrocytes in the brain streatum. 2019, PNAS published a study entitled Human GNPTAB Stuttering
The Spring Festival special | Professor Wang Li explains interstate-charged stem cells and reproductive health

 Time of Update: 2021-03-07

in the field of reproductive health, a number of clinical research projects related to ovarian premature aging and endometrial injury have been completed in China, most of which use interstittal-filled stem cells from fetal appendage tissue sources.
People's Daily: The after-effects of the new crown appear hair loss, loss of taste, memory impairment....

 Time of Update: 2021-03-07

that some patients said that after the diagnosis of neo-coronary pneumonia, thought they were mild patients, the condition will soon improve, but for a long time continued to endure burnout, hair loss, loss of taste and smell and other sequelae
Advances have been made in the study of the regulatory mechanism of subsymulated ratios of different glutamate ligates

 Time of Update: 2021-03-06

this study reveals the direct role of the post-synact cAMP signal path in regulating the glutamate-like subtype balance associated with synhaplic plasticity, which makes people have a deep understanding of the molecular regulatory mechanism of synhaplic plasticity.
The study found that different myelin-like cell reactions mediate damage and repair after cerebrovascular damage

 Time of Update: 2021-03-06

that cerebrovascular damage can lead to severe edema and inflammation, adversely affecting human health.

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Infection

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Science Paper Interpretation! Changes in metabolic state make bacteria resistant to antibiotics...

 Time of Update: 2021-03-07

a new study, researchers at the Massachusetts Institute of Technology in the United States have now identified another type of mutation that helps bacteria develop resistance.
National mining press the accelerator key, where does generic drugs go from here?

 Time of Update: 2021-03-07

, developing drug combination therapies, and expanding new adaptive disorders. the core of the modified new drug is that it has a "clear clinical advantage" over the reference drug that has been marketed, rather than the early "three-change" varieties
Sanofi injects 2...

 Time of Update: 2021-03-07

NOVA, disease modeling and clinical trial simulation are increasingly being used in drug development to support decision-making.
Henan an overseas import asymptomatic

 Time of Update: 2021-03-07

acid testing and centralized isolation medical observation (returning staff and 120 ambulance drivers wearing protective clothing and operating according to procedures), 16 nucleic acid test results positive, comprehensive determination for overseas
Howson introduced first in class oral antifellar drugs

 Time of Update: 2021-03-07

Scynexis has submitted to the FDA a listing application for Ibrexafungerp oral preparations for the treatment of VVV candida disease (vaginal yeast infection), with PDUFA scheduled for approval on June 1, 2021.
Fda Cancer Center of Excellence 2020 Report focuses on cancer patients in the outbreak

 Time of Update: 2021-03-07

these two initiatives are designed to complement OCE's existing diversity and inclusion, including Project Community, which aims to increase minority participation in clinical trials and genetic database knowledge.
Let healthy people

 Time of Update: 2021-03-07

A number of foreign media reported that the British government issued a statement on the 17th local time, the country's clinical trial ethics agency has approved a new coronavirus human trial, 90 adult volunteers exposed to the new coronavirus
New research: Using bacteria to degrade cancer gene MYC promises to be a cancer treatment...

 Time of Update: 2021-03-07

results were published online February 11, 2021 in the journal Nature Biotechnology under the title "Adal protease depletes c-MYC and MYC and increases survival in mouse models of bladder and colon cancer".
Nature paper interpretation! Discover a natural protein that boosts muscle stem cell growth...

 Time of Update: 2021-03-07

studying cells that migrate to muscle damage in zebrafish, the researchers found a group of immune cells called macrophages that appear to play a role in triggering muscle stem cell regeneration.
New research suggests that life-long antiretroviral therapy promises to eradicate mother-to-child transmission of HIV

 Time of Update: 2021-03-07

in the Department of Public Health at the Karolinska Institute. ," he continued, "these findings point to other important challenges when it comes to obtaining the full long-term benefits of program B-plus." , for example, to focus

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Digestive System Information

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Sanofi anti-allergy drug hydrochloric acid fiefina tablets have been approved in China

 Time of Update: 2021-03-07

divided into the first and second generation of two categories, the second generation of antihistamines have better subject specificity and selectivity, the central inhibition rate is low and so on. hydrochloric acid non-sofinadine (Allegra
The State Drug Administration revised the six-flavored yellow preparation instruction manual

 Time of Update: 2021-03-07

On February 18, the State Drug Administration issued a notice announcing that it had decided to revise the instructions (adverse reactions) and "precautions" for six-flavored yellow preparations (including pills, capsules, tablets, enseging agents
Dig Dis Sci: Inflammatory bowel disease does not affect mortality, but increases hospital stays in patients with acute myocardial infarction

 Time of Update: 2021-03-03

, a national queue study in Denmark looked at 86,790 patients with primary heart attack (MI), 1,030 of whom had IBD (75.9% UC and 24.1% CD), and found that IBD seizures at MI were associated with an increased risk of recurrence within MI30. study aims
AP-T: Analysis of the efficacy of hyperbaric oxygen therapy in 20 cases of Crohn's disease

 Time of Update: 2021-02-26

the authors of this study found significant clinical, radiological and biochemical improvements in crohn's disease patients with resuscable fistula after hyperbaric oxygen therapy.
AP-T: Compared to endoscopic mucosa healing in Crohn's disease, intestinal permeable wall healing and MRI healing are associated with a lower risk of progression of intestinal damage

 Time of Update: 2021-02-26

and permeable wall therapy of 51.9% (80/154), 10.4% (16/154), 19.5% (30/154) and 18.2% (28/154) cures, respectively. the risk of intestinal damage is lower than that of permeable wall healing (HR s 0.05 s 0.00-0.40, P s 0.002) and MRI healing (HR s
BMC Gastroenterology: Serum hemolytic phospholipidase self-secretion protein (ATX) and hemolytic phospholipid acid (LPA) can be used as potential biomarkers for the diagnosis of pancreatic cancer

 Time of Update: 2021-02-25

this study has shown that LPA and ATX levels and CA19-9 level measurements of patients can be used for early detection and diagnosis of PCs.
AGA guidelines update: With minimal attempt to eradicate the incurable Helicobacterium infection

 Time of Update: 2021-02-25

or quinone drugs should avoid LOX or kramycin as the basis for treatment, and use tetrycline or amoxicillin as an alternative treatment. 4) It is recommended to use proton pump inhibitors (PPI) that are efficient and not metabolized by the liver CYP2C19
BMJ Gastroenterology: Low-dose aspirin causes low gastrointestinal bleeding and reduces the risk of colorectal tumors

 Time of Update: 2021-02-25

therefore, this study aims to explore whether the use of small doses of aspirin through lower gastrointestinal bleeding (LGIB) may lead to colonoscopy and pyridotomy before obvious CRC symptoms.
BMJ Gastroenterology: The visceral fat index is a predictive indicator of colorectal cancer

 Time of Update: 2021-02-25

has been reported in several studies that metabolic syndromes, i.e. obesity, reduced glucose tolerance, high blood pressure and abnormal blood lipids, are all associated with CRC risk.
BMJ Gastroenterology: Local application of epinephrine after endoscopic retrograde pancreatic bile tube bladder can not prevent the occurrence of papitis

 Time of Update: 2021-02-25

There are currently a number of strategies to reduce PEP risk, including active fluid resuscitation, PD stent implantation, use of urethane, statins, trypsin, antibiotics, rectal anti-inflammatory pain and epinephrine, etc.

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Blood System

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2020 CRO average net profit industry first performance decline only three of the highest ...

 Time of Update: 2021-03-07

of innovative drugs and medical devices, of which, in the NMPA, FDA innovative drug IND stage has more than 40, in the clinical stage of more than 20, is bound to increase. , with the completion of a portion of CDMO production capacity at a later stage
Biopharmaceonceons with volume procurement approaching

 Time of Update: 2021-03-07

that they should be harvested", and the next day (1 At a regular briefing on State Council policy held on September 29, the head of the Health Insurance Bureau further stressed that "there are differences in the quality evaluation methods of generic
Review of the EU 2020 PRIME Priority Medicines Program

 Time of Update: 2021-03-07

to be reviewed under the EMA's accelerated evaluation mechanism. this means that fast tracks are not established and it is not uncommon for products through PRIME to be reviewed within the standard time range. 84 determinations have been
Five years later, 60% of patients are still in remission for the long-term effects of CAR-T therapy

 Time of Update: 2021-03-07

60% of patients with B-cell lymphoma treated with Kymriah are still in remission after 5 years of treatment.
A non-"biological" man who had a biological child sued the hospital for compensation of 300,000

 Time of Update: 2021-03-07

technology, refers to married couples borrowing modern biotechnology, through unnatural sexual pregnancy of children. , 11 January 2021, the Office of the National Health Council issued the Guidelines for the Application of Human Assisted Reproductive
Will Chinese medicine be a good business?

 Time of Update: 2021-03-07

, the clinical trial of the drug has data or high-quality Chinese medicine human experience evidence shows efficacy and can predict its clinical value, it may be approved with conditions. Amend the Regulations on the Protection of Chinese Medicine Species
BMC Gastroenterology: Angiogen 2 can predict the degree of hemangiogenic and fibrosis in patients with hepatitis C

 Time of Update: 2021-02-26

as by inhibiting the proliferation of tumor cells through Raf-mediated pathogens and the subject tyrosine kinase. reported that elevated levels of angiogenesin (ANGP)-2 in the blood of patients with chronic hepatitis C (CHC) were associated with fibrosis
AP-T: Comparison of direct oral anticoagulants and vitamin K antagonists in the risk of bleeding in the upper digestive tract

 Time of Update: 2021-02-26

in order to compare the effects and side effects of new drugs and huafalin, this study analyzed the epidemiology and outcome of upper digestive tract bleeding (UGIB) caused by oral anticoagulant therapy.
JAHA: Plate plate rest therapy in patients with acute coronary artery syndrome who received coronary artery bridge

 Time of Update: 2021-02-26

meta-analysis, the researchers compared patients with coronary arterial bridge surgery who had received more effective antiplate plateplate suppression strategies and less effective plateplate suppression strategies, respectively.
The FDA has accepted a new application from BRUKINSA (Zanubrutinib) for the treatment of Waldenström globulinemia

 Time of Update: 2021-02-26

The U.S. Food and Drug Administration (FDA) has accepted an application from BRUKINSA (zanubrutinib) for a new drug (sNDA) to treat adult patients with Waldenström globulinemia (WM), the company announced today.

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Endocrine System

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ADA: Exercise during pregnancy can better reduce the risk of gestational diabetes

 Time of Update: 2021-03-03

, hemorrhoids and leg cramps. , mothers-to-be can get a good night's sleep through exercise and help control their weight. , however, these exercises need to be done safely. gestational diabetes (GDM) is a common complication during
Nat Commun: Limiting eating time can reduce the risk of post-menotinal breast cancer

 Time of Update: 2021-03-03

study showed that TRF inhibited the growth of obesity-enhanced breast tumors in both models without limiting calories or losing weight.
JCEM: Relationship between stuttering and type 2 diabetes

 Time of Update: 2021-03-03

of the 4,443 adolescent men (0.4%) who stuttered, 162 (3.7%) had type 2 diabetes, compared with 25,678 (2.1%) of men who did not stutter (with an adjusted ratio of 1.3, 95% CI of 1.1-1.6).
Lancet: Metabolic surgery promises hope for a cure for type 2 diabetes!

 Time of Update: 2021-03-03

Follow-up analysis data from a randomized controlled trial showed that weight loss surgery was more effective in long-term control of type 2 diabetes (T2DM) than traditional medical treatment, with 37.5 percent of patients undergoing surgery
Brit J Cancer: Changes in bone density in post-menoptocras for 5 years after treatment with anatreptide

 Time of Update: 2021-03-03

, the researchers observed a 1.25% increase in lumbar BMD after anatrophosopy (95% CI is 0.73-1.77) (P-0.0004), a significant increase over the placebo group (-0.29-0.56). hips, BMD remained unchanged for 5-7 years in patients taking the anatrophotosis
JAHA: Small and dense LDL cholesterol is the lipoprotein index most likely to cause atherosclerosis

 Time of Update: 2021-02-25

researchers measured total cholesterol, triglycerides, HDL-C, LDL triglycerides, residual lipoprotein cholesterol, lipoprotein-rich lipoprotein cholesterol and lipoprotein (a) levels in plasma samples of 3,094 asphalt subjects without ASCVD using standardized automated analysis.
Eur J Heart Fail: Relationship between body mass index, cardiovascular biomarkers and heart failure

 Time of Update: 2021-02-25

only NT-proBNP, MR-proANP, and cTnT are still associated with HF occurrence (P-lt;0.001) and no significant interaction between biomarkers and BMI (interaction P-gt;0.1) has been observed.
JAHA:Sirtuin 3 relieves diabetic cardiomyopathy by regulating TIGAR and myocardial metabolism

 Time of Update: 2021-02-25

under HG conditions, TIGAR knock-out improved the metabolism of myocardial cells, and SIRT3 reduced diabetic cardiomyopathy by regulating p53 acetylation and TIGAR expression.
JAHA: The effect of medical disprogency on malignant arrhyth arrhythmic in prostate cancer patients

 Time of Update: 2021-02-25

thus, medical de-trending prolongs QT/QTc intervals in most prostate cancer patients, which can lead to TdP/VFs even in patients who do not have an extended risk of QT interstitiosis before treatment.
Diabetes, Obesity and Metabolism: Data from 500,000 people suggest that cognitive impairment may begin in prediabetes

 Time of Update: 2021-02-25

a recent study published in the journal Diabtes, Obesity and Metabolism found that people with higher-than-normal blood sugar levels were 42 percent more likely to have cognitive decline and an average 54 percent higher risk of developing vascular dementia.

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Anesthesia Topics

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BMJ: Nearly 3 million population data reveal the relationship between opioid use during pregnancy and congenital malformations in offspring

 Time of Update: 2021-02-26

, the study showed that the use of prescription opioids in early pregnancy was not associated with the risk of most considered types of malformation, but led to an increased risk of cleft palate and cleft mouth in future generations.
Am J Gastroenterol: Measuring damage to the regulation of the heart's lost nerve predicts an improvement in pain in nerve stimulation in the ear profile

 Time of Update: 2021-02-03

study included 92 adolescents with functional abdominal pain and conducted a four-week randomized, double-blind, false-controlled trial of ear-level nerve stimulation.
Anesthesiology: Complex spinal and heart surgery patients with complex spinal and cardiac analgesic pain and analgesic needs in the first year of surgery

 Time of Update: 2021-02-03

) and P-0.004). patients who underwent methadone treatment for heart surgery reported less frequent pain after surgery at 1 month (median score 0) than patients who received fentanyl (median score of 2 (twice a week), P s 0.004). In summary
BMJ: Antidepressants are used to assess the effects of pain in back pain and osteoarthritis

 Time of Update: 2021-01-29

Back pain, clinically manifested as low back pain or neck pain, can be accompanied by or not accompanied by nerve root symptoms, and osteoarthritis seriously affects the quality of life of patients. , worldwide, the prevalence of back pain
Drug price reform has four questions to answer

 Time of Update: 2021-01-21

Administration for deepening the spirit of the Opinions on Deepening the Reform of the Medical Security System (the Opinions). With the theme of "Perfecting the Drug Price Formation Mechanism", Professor Wu Jing made an in-depth discussion on how
2020 Medical People Eat Melon Summary Report

 Time of Update: 2021-01-21

and more normal. in the medical circles began to stage one after another "farce", stirring up the mood of the crowd. "play people" hold their hearts, "outsiders" eat melons. , turn around and look back, and we might as well look
Lisheng pharmaceutical pyrethride tablets are evaluated by generic drug consistency

 Time of Update: 2021-01-07

of pyridocemic tablets (hereinafter referred to as "the drug"), and that the drug had been evaluated by the quality and efficacy of generic drugs. fusemi tablet adaptation: 1. Edema-related diseases include congestive heart failure, cirrhosis of the liver
Turn a profit for the first time! Ali Health shows what kind of Internet medical development path

 Time of Update: 2021-01-07

2021 fiscal year interim results announcement data show that Ali Health Pharmaceutical's own business revenue of 6.04 billion yuan, up 75.7% YoY, pharmaceutical e-commerce platform service revenue of 930 million yuan, up 71.4% YoY.
"Pharmaceutical Headlines" 500 list announced that "medicine again record high these white horses but...

 Time of Update: 2021-01-07

, but these white horses fell who fell the worst? Hurun Research Institute recently announced the 2020 China's top 500 private enterprises list. , more pharmaceutical companies made the list, taking nearly 20 percent of the seats. but behind
Hengrui Pharmaceutical Toluene Sulphate Remazene declared a third adaptive disorder

 Time of Update: 2021-01-07

, the author speculates that the declared new adaptation is general anaesthetic. Mention of Ripinen, it has to be said that the human-fu pharmaceutical industry's benzodialyc acid remathorum, the drug is a product obtained by human-blessed

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Diagnostic Test

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Develop an ornamental genetic modification enzyme targeted therapy! Imago completes $80 million...

 Time of Update: 2020-11-30

Text . . On November 19th Imago BioSciences announced the completion of an $80 million round of C financing. round of financing is led by Farallon Capital Management, followed by T. Rowe Price Associates, Surveyor Capital, Irving Investors
Is License-in a good model?

 Time of Update: 2020-11-29

, but also in the clinical drug terminal origin, the expulsion of the domestic widespread presence of inferior drugs, high-quality varieties can also form a competitive effect. long term, both China's innovative pharmaceutical industry and society
HOW hard is it to conquer Alzheimer's?

 Time of Update: 2020-11-29

/> Aducanumab (BIIB037) is a monoclonal antibody that targets β amyloid proteins and selectively binds to amyloid deposition in the patient's brain, reducing the build-up of β amyloid proteins, thereby slowing disease progression. monoantigen binding
Multivariable risk prediction model for neurosurgery

 Time of Update: 2020-11-28

used data from 175,313 neurosurgery cases in the National Surgical Quality Improvement Program (NSQIP) to determine the predictive factors for a 30-day prognosis for neurosurgery, including chronic obstructive pulmonary disease, congestive heart failure
Premature children with indoor hemorrhage clear the relationship between blood breakdown products in cerebrospinal fluid and hydrocephaline.

 Time of Update: 2020-09-10

, transirin, binding globin and hemoglobin binding proteins in cerebrospinal fluids. study found that hemoglobin levels in the cerebrospinal fluid of newborns in the PHH group were significantly higher than those in the control group, the low
The level of lactate in the subcavity of the cobweb film predicted the occurrence of hydrocephalus after aSAH.

 Time of Update: 2020-08-06

surgery, to study their biochemical components, including protein, glucose, ferrite and lactate levels, and to analyze the relationship between the cessallevel levels of the cerebrometinos in the permeitus and the sub-cobweb sciatica of the patients
Increased serum IL-33 concentration indicates poor prognosis in aSAH patients

 Time of Update: 2020-06-28

The serum IL-33 concentration was measured by enzyme-linked immunosorption, the severity of aSAH was assessed using the WFNS scale and the improved Fisher grading scale, and the GOS scale scored 1-3 for poor prognosis.
When did patients with mild cranial trauma who were initially CT-positive review CT?

 Time of Update: 2020-06-28

the authors, there was no significant benefit for patients with mild brain trauma who were positive in the initial CT scan and clinically stable.
Changes in serum lipoprotein concentration seis isoproteins associated with increased aSAH risk

 Time of Update: 2020-06-28

For every additional standard deviation concentration (1.28 mmol/l) of TC, the male aSAH risk increased by 1.15 times (95% CI, 1.00-1.32).
The surgical efficacy of trigeminal nerve pain was predicted by DTI dispersion parameters

 Time of Update: 2020-06-28

Ref: Hung PS, et al. Neuroimage Clin. 2017 Jun 12;15:710-718. doi: 10.1016/j.nicl.2017.06.017. eCollection 2017.) Trigeminal Nerve Pain (TN) is characterized by facial shock-like pain, microvascular decompression (MVD) relieves pain caused

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