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Drugs Articles

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The first domestically produced new crown neutralizing antibody combination therapy is coming!

 Time of Update: 2021-10-21

> (EUA) application to the US Food and Drug Administration (FDA) for its SARS-CoV-2 combination therapy BRII-196/BRII-198<span
Revealed: 31 drugs or therapies around the world won the Nobel Prize. What is the next Nobel Prize for "New Drug Research and Development"?

 Time of Update: 2021-10-21

For example, the 2019 Nobel Prize in Physiology or Medicine is awarded to scientists who have made important contributions in the field of oxygen sensing pathway research .
Thinking about how to solve the dilemma of setting medical insurance payment standards caused by multiple indications?

 Time of Update: 2021-10-21

cause trouble is the following thinking path: the pricing of a new drug in a certain indication should consider the therapeutic effect of the drug for this indication, and its effect is better than other drugs
Notice on Publicly Soliciting Opinions on the "Technical Guidelines for the Design of Clinical Trials of Long-acting Granulocyte Colony Stimulating Factor Preventing Infection after Chemotherapy (Draft for Solicitation of Comments)"

 Time of Update: 2021-10-21

docx "Long-acting Granulocyte Colony Stimulating Factor Clinical Trial Design Technical Guidelines for the Prevention of Infection after Chemotherapy (Draft for Solicitation of Comments)" feedback form for soliciting opinions.
Exploration and Thoughts on the Price Formation Mechanism of Innovative Drugs

 Time of Update: 2021-10-21

Through national talks, the price reduction of innovative drugs to achieve medical insurance access and speed up the commercialization process is of great significance for improving accessibility .
Johnson & Johnson's CD38 monoclonal antibody subcutaneous injection formulation was approved in China, greatly shortening the administration time

 Time of Update: 2021-10-21

com/us-food-and-drug-administration-approves-darzalex-fasprotm-daratumumab-and-hyaluronidase-fihj-new [3] Genmab Announces Positive Topline Results in Phase III ANDROMEDA Study of Daratumumab in Light-chain (AL) Amyloidosis.
Benchmark Medical/Twist Bioscience pan-cancer methylation products are launched globally

 Time of Update: 2021-10-21

from https:// The pan-cancer methylation product jointly developed by Benchmark Medical and Twist Bioscience is launched globally.
Children's medication: Hengrui "Cyclophosphamide Capsules" plans to be reviewed first, the first domestic product

 Time of Update: 2021-10-21

A total of 10 injection products have been approved for marketing, but only 1 Hengrui has just passed the consistency evaluation on September 23, and no other companies have started the consistency evaluation work .
The "Giant Whale" is swinging its tail and the industry is turning-where will the "new golden decade" of China's innovative drugs go?

 Time of Update: 2021-10-21

>. > It is true that in the current pharmaceutical industry in China, there are only a handful of companies that can meet the above three conditions, among which are the “big factories” worthy of the name and no one
Merck, Bayer, Novartis and others are optimistic about whether STING can become a "dark horse" in the field of immunotherapy?

 Time of Update: 2021-10-21

In view of these findings, the STING signaling pathway has become a promising target for researchers to develop new therapies for the treatment of cancer and inflammatory diseases .

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Feed Industry News

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800 pigs were flooded with only 2 left!

 Time of Update: 2021-10-21

YgQ China Feed Industry Information Network-Based on feed, serving animal husbandry 　　In recent days, extreme heavy rainfall has occurred in most parts of Shanxi, and floods have aroused national attention .
Next year or is the year of loss for pig farming?

 Time of Update: 2021-10-21

that the number of piglets will continue to increase in the fourth quarter . The slaughter weight of live pigs continued to drop slightly on a weekly basis, down to about 123kg/head, which was the upper
The overall loss of the pig industry has exceeded the previous two times. When will this pig cycle be possible?

 Time of Update: 2021-10-21

/> Among them, in Hebei and some parts of Beijing, the first snowfall since the beginning of autumn this year occurred, and the temperature in many places has dropped sharply, which has hindered the pace of farmers' slaughtering
Interview with Chairman Lai Zhouwen: 18 years of deep cultivation of lipid nutrition and health, "four dimensions in one" solution

 Time of Update: 2021-10-21

its due role;eaL China Feed Industry Information Network-Based on feed, serving animal husbandry>　　(6) After all, all alternatives are inseparable from the core of butyric acid
The income of white chickens has increased greatly, and the volume and price of yellow chickens have risen. Wen's, probiotics

 Time of Update: 2021-10-21

>. FjR China Feed Industry Information Network-Based on feed, serving animal husbandry>　　Sales of Yellow Feather Broilers in September:<span
Who drove the Chinese pig to the "jedi"?

 Time of Update: 2021-10-19

in the previous years has been lost . pWU China Feed Industry Information Network-Based on feed, serving animal husbandry>　　According to media
The Butterfly Effect!

 Time of Update: 2021-10-10

to change halfway . It can be seen that the fluctuation of pork prices naturally has a magnifying effect . QAQ China Feed
Shandong people buy a pound of pork and spend 15 yuan less than the beginning of the year, and the pigs will be slaughtered in the first half of the year

 Time of Update: 2021-10-10

>Optimize the sow stock structure and eliminate low-efficiency sowsFkm China Feed Industry Information Network-Based on feed, serving animal husbandry>　　At present
Chairman of China Animal Husbandry Association: This round of pig price decline is longer than before.

 Time of Update: 2021-10-10

ZRz China Feed Industry Information Network-Based on feed, serving animal husbandry　　When reviewing his analysis, Li Xirong said that the price of live pigs has fallen sharply this year, and now some areas have fallen below 5 yuan/500 grams .
Animal husbandry under "power curtailment": more than 20 soybean factories shut down, soybean meal exceeds 4000 yuan/ton, Hunan

 Time of Update: 2021-10-10

processing plants across the country have been affected . This will directly lead to a decline in domestic soybean meal supply, and the market is increasingly concerned about

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Antitumor Therapy

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[Nature Sub-Journal] More accurate identification of colorectal cancer through microbiome composition

 Time of Update: 2021-10-21

Therefore, there is an urgent need for new Highly specific, inexpensive and sensitive non-invasive screening and testing methods to improve the detection of colorectal precancerous lesions and cancers to reduce disease morbidity and mortality .
Molecular Cancer Fan Zusen/Tian Yong and others discover new potential therapeutic targets for hepatocellular carcinoma

 Time of Update: 2021-10-21

40) entitled "Circular RNA circIPO11 drives self-renewal of liver cancer initiating cells via Hedgehog signaling "In the research paper, this study identified highly conserved circRNAs in humans and mice from three primary HCC samples through the circRNA array .
STTT Fuzhou University Jia Li and other teams found potential therapeutic targets for melanoma

 Time of Update: 2021-10-21

In summary, this study shows that NOL7 plays a cancer-promoting effect on the progression and metastasis of melanoma .
Professor Shen Lin: The whole management strategy of esophageal cancer in the immunotherapy era 2021 CSCO famous doctor Kungfu tea

 Time of Update: 2021-10-21

*Only for medical professionals to read and refer to Professor Shen Lin as a guest doctor Kung Fu Tea, sharing the entry points and development ideas of clinical research related to esophageal cancer immunotherapy .
[Prevention of cancer metastasis] Genetic testing may predict cancer metastasis organs in advance!

 Time of Update: 2021-10-21

predict cancer metastasis organs in advance? In addition to guiding clinical medication, genetic testing may predict cancer metastasis to which organs in advance? Today, let’s take a look at a study on the correlation between
2021 CSCO Academician Yu Jinming: Progress and future of combined radiotherapy in the age of immunotherapy

 Time of Update: 2021-10-21

During the 2021 CSCO conference, Yimaitong had the honor to interview Academician Yu Jinming of Shandong Cancer Hospital to share with us the research progress and future development direction of radiotherapy combined immunotherapy .
MyPathway study proves that HER2 is a viable target for cholangiocarcinoma

 Time of Update: 2021-10-21

Comment This trial shows that in HER2-positive cholangiocarcinoma patients, HER2 is a viable target for the development of new drugs .
Climbing to the top of JCO again, KEYNOTE-024 sets a benchmark for domestic PD-1 inhibitors

 Time of Update: 2021-10-21

For PD-L1 highly expressed driver gene-negative advanced non-small cell lung cancer (NSCLC), pembrolizumab The median overall survival (OS) of the first-line treatment of drugs and chemotherapy was 26.
Express gene editing to create "ready-to-use" CAR-T therapy, phase 1 clinical trial results are positive

 Time of Update: 2021-10-21

therapy CTX110, modified with CRISPR gene editing technology, has achieved positive safety and efficacy in a phase 1 clinical trial for the treatment of CD19-positive B-cell cancers Result . <span
Express first-line treatment of advanced liver cancer, ALK-1 monoclonal antibody/Opdivo combination is clinically approved in China

 Time of Update: 2021-10-21

com/news-releases/kintor-pharma-announces-china-nmpa-approves-clinical-trial-of-alk-1-and-nivolumab-combination-therapy-for-the-first-line-treatment-of-advanced -hepatocellular-carcinoma-301396741.

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Study of Nervous System

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Tau protein misfolded this week's "Nature" cover story

 Time of Update: 2021-10-21

Subsequently, the researchers used these different folds to determine the hierarchical classification of tau protein diseases based on structure .
Why do we need comfort when Nature's experiment failed?

 Time of Update: 2021-10-21

In conclusion, the study showed that mice exhibited pro-social comforting behavior and revealed a neural circuit mechanism that is the basis for the coding and control of affinity touch during pro-social interaction .
Nature Hong Weizhe's team reveals the neural coding mechanism of prosocial behavior

 Time of Update: 2021-10-21

This work conducted an in-depth study of prosocial behavior in mice and revealed important neurobiological mechanisms in the brain that encode and control this behavior .
Is intravenous thrombolysis safe for patients with ischemic stroke with saccular aneurysm?

 Time of Update: 2021-10-21

In order to evaluate whether IVT treatment of AIS can cause UIA rupture and intracranial hemorrhage (ICH) in patients with unruptured UIA, Jyri Virta, MD, from the Department of Neurology, University of Helsinki, Finland, conducted a study.
The relationship between patent foramen ovale and migraine, dizziness and vestibular migraine, this article explains very clearly

 Time of Update: 2021-10-21

Judging from the current research, whether it is the relationship between PFO and migraine or with vertigo or VM, most studies are still focused on clinical research.
Sub-Journal of Nature: The answer to Alzheimer's disease has already appeared?

 Time of Update: 2021-10-21

published in Nature Aging magazine[1] may answer this question to some extent . The team of researcher Huang Yadong from the Gladstone Institute found that a powerful fast-acting diuretic
NCN 2021 Interview-Focus on rare diseases of the nervous system and SMA

 Time of Update: 2021-10-21

Compared with pediatric spinal muscular atrophy (SMA), Professor Wu Shiwen has two characteristics in the current status of adult SMA in China: (1) poorer quality of life and mental health; (2) low social attention .
For the prevention and treatment of acute ischemic stroke complications in the acute phase, see expert guidance!

 Time of Update: 2021-10-21

, anticoagulation) therapy and other bleeding-causing drugs; ②Reversing drugs can be selected according to the cause of the bleeding, but the pros and cons should be weighed and the side effects of the drugs should be weighed; ③ Timing of resumption
[Cell] Scientists at Harvard University have discovered a mechanism that helps explain why certain parts of the body are so sensitive to external perceptions

 Time of Update: 2021-10-21

Recently, scientists at Harvard Medical School discovered a mechanism in a new study they led that could help They recognize what causes some skin areas to be more sensitive .
Historic breakthrough: Acupuncture and moxibustion research appears on Nature, and Harvard Chinese scholars provide modern neuroanatomical basis for the existence of acupoints

 Time of Update: 2021-10-21

Acupuncture and moxibustion belong to traditional Chinese medicine. As an auxiliary therapy for pain relief, it has a long history in improving and preventing pain recurrence <span

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Immunology News

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Immunity Tsinghua University's Dong Chen team discovered a new regulatory mechanism for T follicular helper cell development

 Time of Update: 2021-10-21

Therefore, this study determined that the ERK-Zfp831 axis, which is regulated by costimulatory signals, plays a key regulatory role in Tfh cell development .
What are the six classic signs of common rheumatism?

 Time of Update: 2021-10-21

Therefore, in clinical practice, many doctors always have headaches in their diagnosis, but some patients with very typical signs are not helpful in diagnosing the disease.
Because of this rheumatism, I almost cut off my testicles!

 Time of Update: 2021-10-21

The positive staining rate of IgG4 in some areas is as high as 50%, confirming the diagnosis of IgG4-related paratesticular fibrous pseudotumor (Figure 3) .
Suffering from ankylosing spondylitis for decades, this "pain reliever" was always available at home, and the kidney broke down in the end...

 Time of Update: 2021-10-21

/> These drugs have a certain impact on renal function . In the normal population, 1% to 5% of people have adverse renal reactions due to the side effects of drugs (including NSAIDs
The bone mass "emptied" by rheumatism, experts will bring you back

 Time of Update: 2021-10-21

This article is only used to provide scientific information to medical and health professionals, and does not represent the platform's position .
The Shen Xihui team of Northwest A&F University and others published a paper on PNAS, revealing the important role of manganese ions in anti-bacterial natural immunity

 Time of Update: 2021-10-21

of Science and Technology, the Shen Xihui Laboratory of Northwest A&F University and the Zhou Dongsheng Laboratory of the Military Medical College jointly published an online publication titled T6SS in the Proceedings of the National Academy
[The BMJ] Are you still worried that Pfizer will have very little antibodies after 6 months of vaccination, but its protective effect against serious diseases still exists!

 Time of Update: 2021-10-21

of age or older, and immunosuppressed people . As well as observing the effectiveness of the BNT162b2 vaccine against any serious or fatal cases of new coronavirus, the report said
[Nature] How does the immune system maintain the balance of intestinal flora?

 Time of Update: 2021-10-21

[Science Sub-Journal] Salt has the effect of inhibiting tumors ? Scientists explain unexpected discoveries for you through mouse experiments! Recommendation·Activity The 5th Symposium on Modern Clinical Molecular Diagnosis at the 3rd Shanghai International Cancer Conference
Immunity Zheng Jie's team reveals K63-polyUb-mediated MDA5-MAVS antiviral signaling pathway assembly program and activation mechanism

 Time of Update: 2021-10-21

the assembly of MDA5 CARDs and the molecular mechanism of recruitment and activation of MAVS CARD is an unresolved scientific problem . Although K63-polyUb is required for MDA5-mediated
Arthritis & Rheumatology: Genetic and epigenetic fine-tuning of TGFB1 expression in human osteoarthritis joints

 Time of Update: 2021-10-20

OA risk SNP rs75621460 affects TGFB1 expression by regulating enhancer function Original source:Original source:Rice SJ, Roberts JB, Tselepi M, Brumwell A, Falk J, Steven C, Loughlin J.

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Infection

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"Nature" new research confirms that mRNA vaccine is effective against 16 mutated new coronaviruses including Delta

 Time of Update: 2021-10-21

The Yale University research team tested blood samples from vaccinators and confirmed that two existing mRNA vaccines can enhance the immune system’s response to infection and prevent more than a dozen new coronavirus variants, including the delta variant .
Express the prevention and treatment of COVID-19, and the neutralizing antibody combination obtains FDA priority review qualification

 Time of Update: 2021-10-21

(over 12 years old and weighing at least 40 kg) . The most common side effect is injection site reactions. At least 1% of subjects experienced itchy skin redness
NEJM/Lancet continuously published data on over 60 million people and found that HPV vaccination significantly reduced male anogenital warts and female cervical HPV infection rates

 Time of Update: 2021-10-21

in preventing occasional and persistent cervical HPV infection 10 years after vaccination compared with two or three doses of vaccine . On October 8, 2021, Partha Basu
The modeling is successful!

 Time of Update: 2021-10-21

1038/s41467-021-25903-x First of all, the research team has generated a SARS-CoV-2 (MASCp6) mouse-adapted strain in previous studies, which can cause moderate lung damage in mice .
ESICM2021 Hot Interpretation-How to treat the inconsistency of the macrocirculation and microcirculation in patients with sepsis?

 Time of Update: 2021-10-21

benefits to patients . The degradation of eGC can cause microcirculation disorders. Human albumin carries sphingosine-1-phosphonic acid (S1P) derived from red blood cells
Metz Morning Reading｜After inactivated vaccination and boosted vaccination with mRNA vaccine, neutralizing antibody increased by 46.6 times

 Time of Update: 2021-10-21

In recent weeks, the number of new crown virus infections and hospitalizations in southern states such as Florida has begun to show a sharp decline, and relevant epidemic indicators have improved .
Will the long-term effect decline after the new crown vaccine?

 Time of Update: 2021-10-21

▲The effectiveness of BNT162b2 vaccine in preventing infection (A) and COVID-19 hospitalization (B) in different time periods after complete vaccination (picture source: reference [1]) 3.
New crown oral medicine is coming?

 Time of Update: 2021-10-21

Compared with placebo, 407 patients received the antibody treatment within 7 days after the onset of symptoms, and the risk of developing severe disease or death from the new coronary disease was reduced by 50% .
Express delivery of oral anti-coronavirus therapy application for emergency use authorization is expected to add new weapons to the fight against the epidemic

 Time of Update: 2021-10-21

announced that Merck has submitted an emergency use authorization (EUA) application to the US FDA for the oral antiviral therapy molnupiravir under investigation for the treatment of mild to moderate COVID-19 Adult patients, they may be at risk of getting
Radiology: Residual lung lesions on chest CT examination 1 year after COVID-19 infection

 Time of Update: 2021-10-19

Independent risk factors include age 50 years or older, peripheral blood lymphopenia, severe pneumonia, and/or ARDS diseaseOriginal source:Lee KS, Wi YM, Residual Lung Lesions at 1-year CT after COVID-19.

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Digestive System Information

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One table and one picture: Summary of high scores in the diagnosis and management of chronic abdominal distension

 Time of Update: 2021-10-21

: fermentable Sugars, disaccharides, monosaccharides and polyols; HBT: Hydrogen Breath Test Summary Abdominal bloating and abdominal bulging are very common symptoms, which can have a negative impact on patients suffering from a series of basic medical
J Hepatol (IF=25) Significant progress!

 Time of Update: 2021-10-21

Dopamine receptor D2 (DRD2) antagonism selectively blocks YAP in macrophages and prevents liver fibrosis in rodents and large animal models, showing the potential of GPCR-based NASH therapy .
Can coffee reduce the risk of liver cirrhosis?

 Time of Update: 2021-10-21

Subjects with coffee or tea intake> 3 cups have a lower risk of LSM ≥ 9.
Courier's stimulating antibody level is 3.5 to 7.5 times that of the approved vaccine, and the results of phase 3 clinical trials of the new hepatitis B vaccine are released

 Time of Update: 2021-10-21

▎Editor of WuXi AppTec's content team On October 13, 2021, VBI Vaccines announced that it is investigating the third-generation 3 hepatitis B virus (HBV) candidate vaccine Sci-B-Vac, which is being tested in 18-45-year-old adults.
Cell Discovery │ He Ming/Zhao Qian from Shanghai Jiaotong University reveals new mechanisms and therapeutic targets for alcoholic liver disease

 Time of Update: 2021-10-21

On October 12, 2021, He Ming and Zhao Qian from Shanghai Jiaotong University jointly published a research paper entitled "SIRT2-mediated deacetylation and deubiquitination of C/EBPβ prevents ethanol-induced liver injury" in Cell Discovery (IF=10.
How to choose a gastrointestinal motility drug for functional dyspepsia?

 Time of Update: 2021-10-21

■Prescription 1 domperidone tablet 10mg, 3 times a day, orally half an hour before meals. Indications: Patients with abdominal fullness and early satiety symptoms above FD <br
TAF can improve liver reserve and glomerular filtration rate in patients with hepatitis B cirrhosis after TIPS treatment

 Time of Update: 2021-10-21

The study found that, 24 months after TIPS, compared with entecavir (ETV) and tenofovir disoproxil fumarate (TDF), tenofovir fumarate (TAF) improved liver reserve function and estimated renal small Sphere filtration rate (eGFR) has significant advantages [5] .
What is the effect of changing to propofol tenofovir for patients with poor response to nucleoside treatment?

 Time of Update: 2021-10-21

2. A univariate analysis of the efficacy of TAF and previous TDF response showed that in the entire cohort, poor response to previous TDF treatment was significantly associated with a lower MVR rate (OR 0.
Repeated vomiting blood and black stool for several days, but the hemostatic drugs are ineffective...Where is the bleeding?

 Time of Update: 2021-10-21

Multiple ulcers in the duodenal bulb (stage S2) (combined with the patient's medical history, considering the possibility of bleeding in the upper and middle small intestines, further examination is recommended) .
You can have both fish and bear paws!

 Time of Update: 2021-10-21

, and velizumab was maintained at every 8 weeks after induction therapy at 0, 2 and 6 weeks (intravenous injection of 300 mg) . In July 2021, the colonoscopy was rechecked after 14

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Endocrine System

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On the Double Ninth Festival, Caring for the Elderly——An Expert's Message from China's First Guide to Diabetes for the Elderly

 Time of Update: 2021-10-21

Professor Guo pointed out that elderly patients with diabetes have their particularities, including relatively poor cognitive function, more complications and/or concomitant diseases, and the presence of multiple medications, Features such as decreased liver and kidney function .
Considering writing into an international guide?

 Time of Update: 2021-10-21

amount of weight can also reduce the life-changing, to help better manage blood sugar and blood pressure, reduce diabetes The risk of complications . ” commented Professor Lucy Chambers
2 cases, 4 questions, let you sort out how to manage patients with diabetes and CKD (drug management)

 Time of Update: 2021-10-21

Analysis For diabetic patients, the commonly used injection drugs include insulin and glucagon-like peptide-1 (GLP-1) receptor agonists .
Children also get thyroid nodules?

 Time of Update: 2021-10-21

Most patients with benign thyroid nodules have no clinical symptoms, and some children may be accompanied by hypothyroidism and hyperthyroidism .
To sort out the management of patients with diabetes and CKD through cases and problems (Glucose Management)

 Time of Update: 2021-10-21

Tests such as UKPDS and VADT have shown that, for patients with type 2 diabetes, intensive blood glucose control can reduce the incidence of CKD and the progression of kidney disease, but the impact on cardiovascular disease is limited .
Chongyang Special Edition Reveals the "Love, Hate and Enmity" between Thyroid Hormone and Health and Longevity (Part 2)

 Time of Update: 2021-10-21

Therefore, when the general health status of the elderly changes recently, attention should be paid to screening thyroid function to rule out hyperthyroidism; delays in diagnosis and treatment can easily cause or aggravate elderly weakness and disability .
"Type 1 Diabetes" global circulation data released!

 Time of Update: 2021-10-21

, the proportion of patients with type 1 diabetes is as high as 52%, with upper middle income Countries (UMICs), low-middle-income countries (LMICs) and low-income countries (LIC) accounted for 19%, 27%, and 2%, respectively <span
Results of Phase II Study of New Drug for Osteoporosis Treatment-Oral PTH Announced!

 Time of Update: 2021-10-21

Introduction: Oral parathyroid hormone (PTH 1-34, tablet) EB 613 achieved the main efficacy results in a phase 2 dose study involving low bone mineral density (BMD) postmenopausal women .
Chongyang Special Edition Reveals the "Love, Hate and Enmity" between Thyroid Hormone and Health and Longevity (Part 1)

 Time of Update: 2021-10-21

➤70-80-year-old elderly patients with subclinical hypothyroidism: ①TSH≥10mU/L: If there are symptoms of hypothyroidism and cardiovascular disease risk factors, consider LT4 treatment; ②TSH<10mU/L: It is recommended to follow-up observation and monitor every 6 months 1 Secondary thyroid function .
Express significantly improves the vision of patients with diabetic macular edema, and the Phase 2 clinical results of the innovative bicyclic peptide therapy are positive

 Time of Update: 2021-10-21

▎Editor of WuXi AppTec's content team recently, Oxurion announced that THR-149, an investigational therapy jointly developed with Bicycle Therapeutics, has obtained positive results in a phase 2 clinical trial for the treatment of patients with diabetic macular edema (DME) .

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Blood System

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Rucotinib combination therapy provides a new solution for the treatment of intolerant or drug-resistant MF patients

 Time of Update: 2021-10-21

Figure 2 The results of the study on the proportion of patients with different daily doses show that the rucotinib dosage regimen has a significant effect on spleen shrinkage and symptom improvement in patients with anemic MF.
Nat Med: The prevalence of anemia among women of childbearing age in low- and middle-income countries from 2000 to 2018

 Time of Update: 2021-10-20

(15-49 years old) in 82 low- and middle-income countries from 2000 to 2018 Annual geospatial estimate of the rate, and stratification of anemia by severity and summary results . >><span
AJH: The effect of plasma non-transferrin-bound iron on systemic iron overload and intravenous iron supplementation

 Time of Update: 2021-10-20

Non-transferrin bound iron (NTBI) has been classically used to represent potentially toxic plasma components detected in whole body iron overload, and is related to end-organ iron accumulation and biological damage .
J Clin Oncol: Ibrutinib combined with Venetog as the first-line treatment of chronic lymphocytic leukemia has a good prognosis

 Time of Update: 2021-10-20

Ibrutinib Plus Venetoclax for First-Line Treatment of Chronic Lymphocytic Leukemia: Primary Analysis Results From the Minimal Residual Disease Cohort of the Randomized Phase II CAPTIVATE Study .
BJH: Conflict influence of tocilizumab and colchicine in coagulation associated with new coronavirus pneumonia

 Time of Update: 2021-10-20

to understand how these two anti-inflammatory drugs have different effects on d-dimer levels, it is hoped that these results can be used to improve the efficacy of patients with covid-19, rheumatoid arthritis and other inflammatory diseases</span
AJKD: The humoral and cellular responses of hemodialysis patients to mRNA-1273 and BNT162b2 SARS-CoV-2 vaccine

 Time of Update: 2021-10-20

Compared with the general population, patients with renal failure who are undergoing maintenance dialysis are at higher risk of contracting new coronary pneumonia and have worse clinical outcomes after infection .
Neurology: Serum S100B concentration as a substitute outcome parameter after mechanical thrombectomy

 Time of Update: 2021-10-20

>an objective biomarker of astrocyte tissue damage after mechanical thrombus removal in patients with acute ischemic stroke . Things </span
AJH: Comparison of the incidence of second primary malignancies in treated and untreated patients with chronic lymphocytic leukemia

 Time of Update: 2021-10-20

of data comparison between treated and untreated CLL patients, it is not clear whether this increase in SPM can be attributed to CLL innate immune deficiency, CLL and SPM common environmental
HAEMATOLOGICA: Ibrutinib treatment fails to induce the clonal evolution of TP53 in chronic lymphocytic leukemia

 Time of Update: 2021-10-20

In CLL patients with TP53 mutations, ibrutinib in any treatment regimen reduces the complexity of TP53 for at least the first few years of treatment, and unlike CIT, it does not impose positive selection on existing TP53 mutant clones.
Nat Med: Analysis of the efficacy of dual targeting CART cells in children and young adults with relapsed or refractory B-ALL

 Time of Update: 2021-10-20

>Chimeric antigen receptor (CAR) T cells targeting CD19 or CD22 have significant activity in the treatment of B-cell acute lymphoblastic leukemia (B-ALL) <span

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Anesthesia Topics

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Under general anesthesia, does one breathe?

 Time of Update: 2021-10-20

At this time, the anesthesiologist is very important, and they are the people who are responsible for " life-saving " .
Neural Regen Res: Electroacupuncture can affect the pain sensation of nicotine-dependent hyperalgesia model rats

 Time of Update: 2021-10-20

with morphine, acupuncture is more effective, faster and better tolerated . Studies have shown that one way to avoid chronic opioid dependence is to use
Remember the article on World Pain Relief Day!

 Time of Update: 2021-10-19

However, for patients with cancer pain, adverse reactions sometimes reduce the patient’s quality of life or even life-threatening when receiving analgesia , such as constipation, nausea, and respiratory depression often caused by opioids .
The State Food and Drug Administration approves Hengrui Pharmaceuticals Pregabalin Sustained-Release Tablets for the treatment of chronic neuropathic pain in adults

 Time of Update: 2021-10-09

On September 28, the official website of the National Food and Drug Administration (NMPA) announced that the pregabalin sustained-release tablets declared by Hengrui Medicine had been approved for listing in China .
JAMA: Painless labor or anesthesia?

 Time of Update: 2021-10-09

In this national Danish child cohort study, mothers’ exposure to epidural analgesia during childbirth was not significantly associated with autism spectrum disorders in their offspring .
Talking about the Four Realms of Anesthesia

 Time of Update: 2021-10-02

Although anesthesiology is a first-level clinical department, in the eyes of most people, we are just
BMC Anesthesiol: The effect of dexmedetomidine-assisted analgesia on postoperative delirium in patients recovering from orthopedic surgery: a randomized controlled trial

 Time of Update: 2021-09-28

001); it also improves the subjective sleep quality of patients in the first 3 days after surgery: the median difference on the first day is -1 (95% confidence interval -1 to 0), P=0.
JAAD: Observation of liposuction effect of local anesthesia in 3430 consecutive cases of swelling with different concentrations of lidocaine

 Time of Update: 2021-09-18

The study sought to determine the lowest concentration of lidocaine in the swelling solution needed to provide adequate anesthesia in liposuction patients using only TLA .
BMJ: One in five people suffers from it-marijuana is a "turning over" in the treatment of chronic pain

 Time of Update: 2021-09-18

>Medical cannabis is administered orally (n=30) or topical (n=2) . The clinical population includes chronic non-cancer pain (n=28) and cancer-related pain (n=4) <span
Interpretation of nerve blocks in 8 parts of the face in one article

 Time of Update: 2021-09-11

Anesthesia method: After palpating the zygomatic frontal suture, the puncture needle is inserted into the posterior orbital side under the surface mark about 5mm, and the local anesthetic is injected 10mm below the lateral canthus .

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Diagnostic Test

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The prefabricated building will develop in an all-round way, and it cannot be escorted without the industrial endoscope

 Time of Update: 2021-10-09

or demonstrate the Olympus IPLEX series video endoscopes , please visit the following webpage to find the contact information: or you can also call our phone: 400- 969-0456
Spontaneous combustion on the road!

 Time of Update: 2021-10-09

#### Video number Need to order and demonstrate?
You know that CIX100 is a master of cleanliness testing, but you don’t necessarily know that it is still a material analysis

 Time of Update: 2021-09-28

> Ubiquitous cleanliness testing> For modern industry and manufacturing, cleanliness testing has become a very important link in the manufacturing process </span
Why does car glass "blow"?

 Time of Update: 2021-09-28

materials contain trace amounts of nickel and sulfur> Sulfur-containing fuel used> > <br
Secretary-General Wu Peiguo: BICES 2021, to create a safe, satisfactory and high-quality industry

 Time of Update: 2021-09-18

, effective, safe, and smooth, and prepare BICES 2021 epidemic prevention and control guidelines in a timely manner, and timely contact exhibitors Communicate with users, etc. to ensure maximum convenience for the exhibition activities
Strong update of WeldSight!

 Time of Update: 2021-09-10

/> > WeldSight TCG brings the very best calibration speed and repeatability on the market, including simultaneous or continuous point creation, 12-bit amplitude resolution and 400% saturation limit </span
If new energy vehicles are the future, then the handheld spectrometer is the guarantee of the future!

 Time of Update: 2021-09-10

This time, we will introduce several detection solutions provided by Olympus Handheld Fluorescence Spectrometer (HHXRF) for the new energy automobile industry .
How does a large data center like "Guizhou on the Cloud" physically maintain data security?

 Time of Update: 2021-08-26

and resources . The comprehensive electricity price of large industrial enterprises in Guizhou is 0. 44 yuan/kWh, and the electricity price of large data centers has dropped to 0. 35 yuan
Wearing glasses can make you lead poisoning?

 Time of Update: 2021-08-26

) issued a statement that in the 21,500 pairs of children's sunglasses circulating on the market that year, it was found that the lead (Pb) content in the surface coating was seriously excessive and needed to be recycled. Otherwise, acute lead
Five ultimate experiences that have never been felt before

 Time of Update: 2021-07-29

provides users with the option of simultaneously displaying two different inspection files on the screen and comparing the files . If you want to put the views of each side of the weld together

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Urinary System

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Explore the frontiers of urology in 2021 ESMO new progress

 Time of Update: 2021-10-11

(docetaxel ≥300mg/m2 or cabazitaxel ≥80mg/m2) . Patients started to receive dalotamide 600 mg bd or placebo 2-8 weeks after the end of taxane treatment <span
[News] First-line treatment of prostate cancer, Olapali Phase III PROpel test is highly positive

 Time of Update: 2021-10-11

Author: John Guide: Recently, the results of the interim analysis of AstraZeneca Olapali Phase III PROpel trial have been released, showing high rates in first-line treatment of patients with metastatic castration-resistant prostate cancer The level is positive .
[2021EAU] Progress in precise diagnosis and precise treatment of prostate cancer

 Time of Update: 2021-10-03

The above research results indicate that the frequency of gene mutations in Chinese HSPC patients is different from previous reports, and that DDR deficiency/endocrine-related gene mutations have nothing to do with the clinical outcome of neoadjuvant therapy .
Express first-line treatment of advanced bladder cancer, blockbuster PD-1 inhibitor was fully approved by the US FDA

 Time of Update: 2021-10-02

▎MSD, editor of WuXi AppTec's content team, announced today that the US FDA has approved the label update of the anti-PD-1 therapy Keytruda for the first-line treatment of advanced urothelial cancer (bladder cancer) .
A 7-day short course of antibiotics for men with a fever-free urinary tract infection

 Time of Update: 2021-10-02

This article is from the NEJM Journal Watch Antibiotic Treatment Duration for Afebrile Men with Urinary Tract Infections.
Case sharing Abiraterone original research drug vs. generic drug, which one is better?

 Time of Update: 2021-10-02

From the analysis of clinical efficacy data, LATITUDE study 1 confirmed that compared with the control group, Abiraterone combined with prednisone + androgen deprivation therapy (ADT) prolonged The time from mHSPC patients to PSA progression was 4.
Confirmatory clinical failure, K-drug urothelial cancer is not withdrawn and corrected in the first line

 Time of Update: 2021-10-02

its withdrawal from the O-drug small cell lung cancer US market 2. The first-line impact failed and the second-line implicated: AstraZeneca withdrew the PD-L1 monoclonal antibody Imfinzi bladder cancer US Market 3. Liquidation
Courier doubles the "cancer-free survival" time of patients with early bladder cancer, and the blockbuster PD-1 inhibitor is approved by the FDA

 Time of Update: 2021-10-02

/> The trial reached the primary endpoint. The median disease-free survival (DFS) of the nivolumab group was nearly twice that of the placebo group, 20. 8 months [95% CI: 16. 5-27. 6] and 10
For the treatment of prostate cancer, the established oncolytic virus company promotes the entry of genetically modified adenovirus drugs into the third phase of clinical medicine. Mai Meng broke the news

 Time of Update: 2021-10-02

This clinical trial aims to evaluate the therapeutic effect of CAN-2409 in combination with valacyclovir and standard-of-care radiotherapy alone in the treatment of patients with newly diagnosed localized prostate cancer with intermediate and high risk of recurrence .
European Urology (IF=21) What is the healthiest frequency of sexual activity?

 Time of Update: 2021-10-02

iNature prostate cancer (PCa) accounts for approximately 15% of all newly diagnosed cancers in men worldwide, and the global burden of disease continues to increase .

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