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How to balance stable blood pressure lowering and brain function protection in the perioperative management of cerebrovascular disease?
Time of Update: 2023-02-03
Based on this, this issue of the "Urgent Threesome: Big Coffee Online" expert interview forum specially invited Professor Wang Chunlei of the First Affiliated Hospital of Harbin Medical University as the host of the conference, Professor Xu Shancai of the First Affiliated Hospital of Harbin Medical University and Professor Wen Zhifeng of the First Affiliated Hospital of China Medical University gathered in the cloud to discuss the perioperative blood pressure management strategies of patients with cerebrovascular diseases.
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Increased risk of dementia due to shift shifts? These 3 types have different performances!
Time of Update: 2023-02-03
Different types of frontotemporal dementia have different clinical manifestations, let's take a look!Frontotemporal lobe degeneration (FTLD) is a group of dementia syndromes characterized by progressive psychobehavioral abnormalities, executive dysfunction, and language impairment, and its pathology is characterized by selective progressive atrophy of the frontal and/or temporal lobes.
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2022 Neurology Clinical Foundation Good Article Summary|Year-end Inventory
Time of Update: 2023-02-03
Year-end inventory ☟☟☟of the top 12 classic cases of neurology in 2022 to help you develop clinical thinkingIllustrated | 8 pictures teach you to master the basic skills➤Should know: The 5 most common central causes of dizzinessMultiple sclerosisMultiple sclerosisMultiple sclerosisMultiple sclerosis is a chronic, immune-mediated central nervous system disorder characterized by inflammation, demyelinating, and eventually axon loss.
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Neuron Ma Qiufu's team at Westlake University revealed the mechanism of transmitting visceral pain information
Time of Update: 2023-02-03
Importantly, under inflammatory and central desuppressive conditions, these neurons are dispensable for driving sensitized VMRs. Anatomically, a subset of VGLUT3 neurons projects to the parabrachial nucleus, whose photoactivation sufficiently produces aversion in mice with gastrointestinal inflammation without affecting VMRs. In summary, this study suggests the presence of different spinal cord substrates that transmit visceral sensory messages in pain and emotional dimensions.
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Expert comment: NBT Li Yulong's laboratory has developed a new oxytocin fluorescent probe to reveal the spatiotemporal dynamic regulation of neuropeptides
Time of Update: 2023-02-03
In summary, in this work, the authors developed a novel genetically encoded oxytocin fluorescent probe, which achieved high spatiotemporal resolution recording of extracellular oxytocin in vitro and in vivo, and reported the similarities and differences in the molecular mechanisms of oxytocin in the two release modes of neuronal axon terminals and somal dendrites, which provided a new reference for understanding the complexity of neuropeptide function.
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Year-end inventory: GLP-1RA is used for progression of other diseases
Time of Update: 2023-02-03
Polycystic ovary syndrome GLP-1RA treatment can simultaneously address various comorbidities of PCOS, such as improving insulin sensitivity, reducing the risk of cardiovascular disease (CVD), and controlling weight.
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The team of Professor Tang Yamei of Sun Yat-sen University at Neuron discovered a new mechanism by which microglia infiltrate the brain parenchyma through chemotaxis peripheral CD8+ T cells
Time of Update: 2023-02-03
On January 5, 2023, Professor Tang Yamei's team from the Brain Science Research Center of Sun Yat-sen Memorial Hospital of Sun Yat-sen University published a report entitled "Microglia drive transient insult-induced brain injury by chemotactic recruitment of CD8+T" on Nelon lymphocytes" research paper elucidates the mechanism by which microglia secrete chemokines CCL2 and CCL8 after radiation attract CD8+ T cells to infiltrate brain tissue and cause brain damage, and propose new intervention strategies for the treatment of radiation brain injury.
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Diabetes Care: SGLT2 inhibitors reduce the risk of dementia in people with type 2 diabetes
Time of Update: 2023-02-03
▲Weighted Kaplan-Meier curves of subjects using SGLT2 and DPP-4 inhibitors (Image source: Reference [1])Overall, this large population-based cohort study showed a clinically significant association between SGLT2 inhibitor use and a lower risk of dementia at an average follow-up of 2.
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Nature Metabolism: Professor Xu/Liu Feng's team revealed that hypothalamic junction protein enhances leptin signaling to promote weight loss
Time of Update: 2023-02-03
Figure 1: Knocking out Grb10 on AgRP neurons promotes obesity2Increasing Grb10 in POMC neurons enhances leptin sensitivityImmunofluorescence experiments showed that almost all (95%) POMC neurons expressed Grb10, and after specifically reducing Grb10 on arcuate POMC neurons through genetic tools, it did not cause changes in energy metabolism in ordinary diet, but after high-fat diet, it could significantly accelerate weight gain, fat gain, increased serum leptin and insulin levels, and reduced energy expenditure in mice.
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Pay attention to "orthostatic intolerance after stroke", these 4 points to know!
Time of Update: 2023-02-03
Patient examination dataCase 783-year-old male, limb weakness, shaking for more than 1 month, symptoms appear when upright, lying flat can be relieved; History of previous hypertension and stroke, mRS score of 3 before admission.
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Progress in the study of the mechanism of new circuits of anxiety-like behavior in mice
Time of Update: 2023-02-03
On December 3, 2022, Nature Communications published online the research group of Xu Xiaohong, a researcher at the Center for Excellence in Brain Science and Intelligent Technology (Institute of Neuroscience) and State Key Laboratory of Neuroscience, Chinese Academy of Sciences, entitled "A circuit from the ventral subiculum to anterior hypothalamic nucleus.
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NBT(IF=68) Li Yulong's team at Peking University developed a highly sensitive and spatiotemporal resolution oxytocin release sensor
Time of Update: 2023-02-03
On January 2, 2023, Li Yulong's research group of Peking University published a report entitled "A genetically encoded sensor measures temporal oxytocin release from different neuronal compartments" in the journal Nature Biotechnology This study developed a highly sensitive GPCR activation-based (GRAB) sensor, GRABOT1.
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Levodopa prodrug plus carbidopa prodrug significantly improves Parkinson's disease symptoms
Time of Update: 2023-02-03
Copyright InformationThis article was translated, written or commissioned by Jiahui Medical Research and Education Group (J-Med) in collaboration with the New England Journal of Medicine (NEJM) for NEJM Medical Frontiers.
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Vertigo that may be caused by a viral infection? Pay attention to the choice of treatment plan...
Time of Update: 2023-02-03
Don't ignore this comorbidity!Check the diagnosis and treatment plan, how "6" is "Medical Knowledge Source"?
Don't ignore this comorbidity!Vertigo and dizziness only considered vestibular lesions?
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Nature Medicine: Professor Xu Yong antipsychotropic target receptor mediates the occurrence of obesity
Time of Update: 2023-02-03
1038/s41591-022-02106-5The images in the article are from references13 rare mutations in the gene encoding the 5-HT 2C receptorFigure 2: F327L mutant mice promote obesity in miceFigure 2: F327L mutant mice promote obesity in miceAfter further knocking the 5-HT2CR-F327L mutant into mice (referred to as F327L mutant mice) through CRISPR-Cas9 technology, even after the ordinary diet, excessive feeding, weight gain, fat and fat increase.
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Scientists have confirmed for the first time that the "human-mouse brain" has a functional connection, and organoid research has gone further!
Time of Update: 2023-02-03
▲ Human brain organoids and microelectrodes were implanted into the brains of mice for recording (Image source: Reference [1]) When the researchers applied visual stimulation to mice with white light, they found that according to the neuroelectrical activity recorded by the electrodes, Human brain organoids share the same electrical activity patterns as the rat brain tissue around them.
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Neuron Ma Qiufu's lab discovered spinal cord pathways that selectively transmit affective visceral pain
Time of Update: 2023-02-03
On December 29, 2022, Professor Ma Qiufu and his postdocs Qi Lu and Lin Xinghong published an article in Neuron Spinal VGLUT3 lineage neurons drive visceral mechanical allodynia but not sensitized Viscero motor reflexes, which studies visceral pain from the intestines.
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Studies of more than 60 million people have revealed that the greener the living environment, the lower the risk of dementia!
Time of Update: 2023-02-03
Recently, a study published in JAMA Network Open found that living in areas with a high proportion of parks and rivers seems to slow the risk of progression of neurological diseases, such as Alzheimer's disease and Parkinson's.
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Neurointerventional treatment with uncontrollable perioperative blood pressure? Big coffee teaches you how to shoot
Time of Update: 2023-02-03
Although the effect of interventional treatment is good, perioperative blood pressure management is still indispensable due to changes in social environment and changes in living habits, coupled with hypertension, hyperlipidemia, Under the influence of major risk factors such as hyperglycemia, cerebrovascular diseases have occupied the first cause of death in China in recent years [1].
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"Chinese Expert Recommendations for the Diagnosis and Treatment of Acute Cerebral Infarction under DRG/DIP Payment Method" released, deepening medical reform and benefiting the people!
Time of Update: 2023-02-03
The reform of medical insurance payment method is an important measure to deepen the reform of the medical system and medical security system, standardize the diagnosis and treatment behavior, reduce
