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Rucotinib combination therapy provides a new solution for the treatment of intolerant or drug-resistant MF patients
Time of Update: 2021-10-21
Figure 2 The results of the study on the proportion of patients with different daily doses show that the rucotinib dosage regimen has a significant effect on spleen shrinkage and symptom improvement in patients with anemic MF.
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Nat Med: Analysis of the efficacy of dual targeting CART cells in children and young adults with relapsed or refractory B-ALL
Time of Update: 2021-10-20
>Chimeric antigen receptor (CAR) T cells targeting CD19 or CD22 have significant activity in the treatment of B-cell acute lymphoblastic leukemia (B-ALL) <span
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Does your hospital carry out these special blood tests?
Time of Update: 2021-10-20
Red blood cell incubation osmotic fragility test significance This test is sensitive to the detection of mild hereditary spherocytosis, and is also seen in pyruvate kinase deficiency and other enzyme-deficient hemolytic anemia .
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Nat Med: The prevalence of anemia among women of childbearing age in low- and middle-income countries from 2000 to 2018
Time of Update: 2021-10-20
(15-49 years old) in 82 low- and middle-income countries from 2000 to 2018 Annual geospatial estimate of the rate, and stratification of anemia by severity and summary results . >><span
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Ann Hematol: Molecular genetics and clinicopathological characteristics of thymic MALT lymphoma
Time of Update: 2021-10-20
A foreign research team investigated the clinicopathological characteristics of 11 cases of thymic MALT lymphoma from a single center .
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AJKD: The humoral and cellular responses of hemodialysis patients to mRNA-1273 and BNT162b2 SARS-CoV-2 vaccine
Time of Update: 2021-10-20
Compared with the general population, patients with renal failure who are undergoing maintenance dialysis are at higher risk of contracting new coronary pneumonia and have worse clinical outcomes after infection .
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Neurology: Serum S100B concentration as a substitute outcome parameter after mechanical thrombectomy
Time of Update: 2021-10-20
>an objective biomarker of astrocyte tissue damage after mechanical thrombus removal in patients with acute ischemic stroke . Things </span
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HAEMATOLOGICA: Ibrutinib treatment fails to induce the clonal evolution of TP53 in chronic lymphocytic leukemia
Time of Update: 2021-10-20
In CLL patients with TP53 mutations, ibrutinib in any treatment regimen reduces the complexity of TP53 for at least the first few years of treatment, and unlike CIT, it does not impose positive selection on existing TP53 mutant clones.
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AJH: Comparison of the incidence of second primary malignancies in treated and untreated patients with chronic lymphocytic leukemia
Time of Update: 2021-10-20
of data comparison between treated and untreated CLL patients, it is not clear whether this increase in SPM can be attributed to CLL innate immune deficiency, CLL and SPM common environmental
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AJH: The effect of plasma non-transferrin-bound iron on systemic iron overload and intravenous iron supplementation
Time of Update: 2021-10-20
Non-transferrin bound iron (NTBI) has been classically used to represent potentially toxic plasma components detected in whole body iron overload, and is related to end-organ iron accumulation and biological damage .
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J Clin Oncol: Ibrutinib combined with Venetog as the first-line treatment of chronic lymphocytic leukemia has a good prognosis
Time of Update: 2021-10-20
Ibrutinib Plus Venetoclax for First-Line Treatment of Chronic Lymphocytic Leukemia: Primary Analysis Results From the Minimal Residual Disease Cohort of the Randomized Phase II CAPTIVATE Study .
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BLOOD: Effective treatment of AML with RUNX1 mutation by co-treatment with protein translation inhibitor and bcl2
Time of Update: 2021-10-20
R Green, Yuan Qi , Xiaoping Su, Joseph D. Khoury, Kapil N Bhalla; Effective therapy of AML with RUNX1 mutation by co-treatment with inhibitors of protein translation and BCL2. Blood</span
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Ann Hematol: Quality of life of survivors one year after diagnosis of diffuse large b-cell lymphoma: a LYSA study
Time of Update: 2021-10-20
> . Health-related quality of life (HRQoL) is a multidimensional concept that includes physical, emotional, social and cognitive functions, disease symptoms, and side effects
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BJH: Conflict influence of tocilizumab and colchicine in coagulation associated with new coronavirus pneumonia
Time of Update: 2021-10-20
to understand how these two anti-inflammatory drugs have different effects on d-dimer levels, it is hoped that these results can be used to improve the efficacy of patients with covid-19, rheumatoid arthritis and other inflammatory diseases</span
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Lancet Haemat: The safety of intratumoral injection of TTI-621 in the treatment of relapsed or refractory mycosis fungoides or Sézary syndrome
Time of Update: 2021-10-19
, intralesional injections of TTI-621 (single injection of 1 mg, 3 mg or 10 mg, or 10 mg*3 times/week*1-2 weeks) are performed in a continuous dose-escalation manner; in the expansion phase, The maximum tolerated dose induces treatment for 2 weeks
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AJH: Hyperoxia-affinity hemoglobinopathies-associated polycythemia: 41 cases of clinical outcome and treatment impact
Time of Update: 2021-10-19
> management guidelines lack information on phlebotomy in HOA hemoglobinopathy-associated erythrocytosis Supporting evidence used in; however, a target hematocrit (Hct) of 52% is arbitrarily recommended in cases where
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Aspaveli (pegcetacoplan) for the treatment of paroxysmal nocturnal hemoglobinuria (PNH), has received positive opinions from EU CHMP
Time of Update: 2021-10-19
>Paroxysmal nocturnal hemoglobinuria (PNH) is a rare, complex and acquired fatal blood disease. It was discovered in the 19th century. Approximately one to two people
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Lancet oncol: Phase 3 daratumumab + lenalidomide first-line treatment of multiple myeloma not suitable for transplantation can be expected!
Time of Update: 2021-10-19
0 months), daretal was used compared with newly diagnosed multiple myeloma patients who were not eligible for transplantation treated with lenalidomide and dexamethasone The progression-free survival of patients treated with yuumab combined with lenalidomide and dexamethasone was significantly prolonged .
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BLOOD: Targeted membrane-bound anionic phospholipid anticoagulation therapy can improve the outcome of traumatic brain injury in mice
Time of Update: 2021-10-19
of circulating EVs, with the highest levels found on BDEV . Compared with EVs from endothelial cells and platelets (79. 1, 15. 2, and 3. 5 nM/mg
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Professor Ying Zhitao talks about CAR-T treatment
Time of Update: 2021-10-11
In order to help friends who missed the live broadcast to understand CAR-T cell therapy, the editor summarizes the knowledge content shared by Professor Ying Zhitao for your reference .
