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Blood: Ancient evolutionary mechanisms for gene expression of red blood cells in different species

 Time of Update: 2020-06-24

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The oxygen transport function of hemoglobin (HB) is thought to have occurred about 500 million years ago, roughly in line with the differentiation of inocyclic vertebrates (jawless) and jaw-based ve
Blood: Yap1-Scribble polarization determines the fate of hematopoietic stem cells

 Time of Update: 2020-06-24

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YAP1 and its analogue Taz largely control the growth of epithelial tissue Althoff and others have confirmed that hematopoietic stem cell (HSC) responds to stress depending on YAP1 and Taz The abs
Cell Death Dis: Ion Channel TRPM2 Promotes AML Cell Proliferation by Regulating Mitochondrial Function, ROS and Autophagy

 Time of Update: 2020-06-24

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The study found that levels of reactive oxygen (ROS) increased in acute myeloid leukemia (AML) Mitochondria are the main source of ROS, which damages tissue simply through protein oxidation, lipid p
Blood:III Trial: Thrombosis in myeloma patients treated with different protocols

 Time of Update: 2020-06-24

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Newly diagnosed patients treated with immunomodulation drugs (IMiDs) have a higher risk of venous thrombosis (VTE), but there is no data from a large number of forward-looking queues This study is
NEJM: Leva saban for venous thrombosis prevention after lower limb orthopaedic surgery

 Time of Update: 2020-06-24

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Non-major lower-body orthopaedic plastic surgery can lead to a brief decline in the patient's mobility, or even vein thromboembolism, and the prevention effect of delavsaban may be comparable to enn
Menarini targets drug tagraxofusp by acquisition of layout CD123

 Time of Update: 2020-06-24

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Italian drugmaker Menarini Group has announced the acquisition of Stemline Therapeutics for a of up to $677m and acquired the drug Elzonris, which targets CD123 CD123 is expressed in BPDCN and ma
J Thromb Haemost: Recurrent thrombosis in patients with antiphospholipid-positive venous or arterial thrombosis

 Time of Update: 2020-06-24

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Patients with positive antiphospholipid antibodies (aPL) and thromboembolism (TE) are at risk of TE recurrence However, few studies have been able to distinguish patients from initial events recen
Brit J Heamatol: Prevalence of non-anemia iron deficiency in the elderly and associated mortality

 Time of Update: 2020-06-24

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Iron is the core of many biological pathways, and in certain diseases, the treatment of non-anemia iron deficiency (NAID) is beneficial However, it is not clear whether NAID is associated with an in
Regenerative Element and Reding Pharmaceuticals develop REGN1979 (CD20xCD3 bispecific antibody) for the treatment of non-Hodgkin's lymphoma

 Time of Update: 2020-06-24

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Regeneron and Zai Lab announced a strategic partnership to develop and commercialize REGN1979 (CD20xCD3 dual-specific antibodies) in Chinese mainland, Hong Kong, Taiwan and Macau This partnership wi
NEJM: Prevention of adverse prognosis for peripheral arterial disease in patients with peripheral artery disease used in vascular reconstruction

 Time of Update: 2020-06-24

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Recently, researchers examined the effect of Delavaban on the prevention of major adverse limb and cardiovascular events in patients with peripheral artery disease in the lower extremities patie
Brit J Heamatol: Acute kidney injury in children with sickle cell disease is related to disease and use of medical resources

 Time of Update: 2020-06-24

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Kidney disease is a common complication in patients with sickle cell disease (SCD), although the epidemiology of acute kidney injury (AKI) in pediatric patients and its effect on long-term kidney ou
Blood: Macrophage Epo receptor signals promote red line differentiation during stress-forming

 Time of Update: 2020-06-24

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Center point: classic Wnt signal drives the proliferation of immature stress edifying red blood cells Epo signals in macrophages induce lipid media to promote stressed red blood cell progenitor
Cell Death Dis：mPGES-1/PGE2/MTDH轴调控T-ALL细胞生长

 Time of Update: 2020-06-24

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Acute lymphoblastic leukemia is a highly heterogeneous aggressive hematologic malignancy that affects about one in every 100,000 adults Despite the very similar treatment strategies, The prognosis o
Blood: SGLT2 inhibitor Ipalenet net successfully corrected neutrophil reduction and dysfunction of glucogen stored product Ib

 Time of Update: 2020-06-24

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Center Point: SGLT2 inhibitors improve Neutrophil Reduction/Neutrophil Dysfunction in GSD-Ib by reducing intracellular 1,5-aqueous glucose-6-phosphate Empagliflozin, used for the treatment of t
J Thromb Haemost: Incidence of venous thromboembolism in patients with COVID-19

 Time of Update: 2020-06-24

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2019 coronavirus disease (COVID-19) can lead to systemic clotting activation and complications of thrombosis In a recent study published in journal Sthrombosis and Haemostasis, an authoritative jour
EU approves Shionogi's new antibiotic Fetcroja for all KEY Gram-negative pathogens designated by THEA

 Time of Update: 2020-06-24

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Japan's Shionogi's antibiotic Fetcroja (cefiderocol) has been granted permission by the European Union to treat adult patients with a limited selection of Gram-negative bacterial infections approv
Blood: Researchers of normal and malignant hematopoietic stem cells OF SIRPA knock into model

 Time of Update: 2020-06-22

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In human-mouse xenotransplantation, the polymorphism of signal-regulating protein alpha (SIRPA) determines its binding affinity with human CD47, which is essential to the implantefficiency of human
Blood: Venetoclax joint LDAC improves clinical prognosis in AML patients not suitable for intensive chemotherapy

 Time of Update: 2020-06-22

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For patients with acute myeloid leukemia (AML) who are unable to tolerate intensive chemotherapy, effective treatment options are limited This study is an international, randomized, double-blind,
Blood: MTOR activation enhancement for iexclusiveithasic multicenter Castleman disease

 Time of Update: 2020-06-22

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Iblast multicenter Castleman disease (iMCD) is a rare and incomprehensible blood disease characterized by lymph node disease, systemic inflammation, decreased blood cells, and multi-organ dysfunctio
Blood: Atypical 3q26/MECOM rearrangement of acute myeloid leukemia is comparable to inv (3)/t (3; 3)

 Time of Update: 2020-06-22

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Acute myeloid leukemia (AML), which carries inv (3)/t (q21q26), is recognized by WHO as a unique subtype characterized by invasive sexually transmitted diseases and poor prognosis In this AML subtyp

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Blood System

Blood: Ancient evolutionary mechanisms for gene expression of red blood cells in different species

Blood: Yap1-Scribble polarization determines the fate of hematopoietic stem cells

Cell Death Dis: Ion Channel TRPM2 Promotes AML Cell Proliferation by Regulating Mitochondrial Function, ROS and Autophagy

Blood:III Trial: Thrombosis in myeloma patients treated with different protocols

NEJM: Leva saban for venous thrombosis prevention after lower limb orthopaedic surgery

Menarini targets drug tagraxofusp by acquisition of layout CD123

J Thromb Haemost: Recurrent thrombosis in patients with antiphospholipid-positive venous or arterial thrombosis

Brit J Heamatol: Prevalence of non-anemia iron deficiency in the elderly and associated mortality

Regenerative Element and Reding Pharmaceuticals develop REGN1979 (CD20xCD3 bispecific antibody) for the treatment of non-Hodgkin's lymphoma

NEJM: Prevention of adverse prognosis for peripheral arterial disease in patients with peripheral artery disease used in vascular reconstruction

Brit J Heamatol: Acute kidney injury in children with sickle cell disease is related to disease and use of medical resources

Blood: Macrophage Epo receptor signals promote red line differentiation during stress-forming

Cell Death Dis：mPGES-1/PGE2/MTDH轴调控T-ALL细胞生长

Blood: SGLT2 inhibitor Ipalenet net successfully corrected neutrophil reduction and dysfunction of glucogen stored product Ib

J Thromb Haemost: Incidence of venous thromboembolism in patients with COVID-19

EU approves Shionogi's new antibiotic Fetcroja for all KEY Gram-negative pathogens designated by THEA

Blood: Researchers of normal and malignant hematopoietic stem cells OF SIRPA knock into model

Blood: Venetoclax joint LDAC improves clinical prognosis in AML patients not suitable for intensive chemotherapy

Blood: MTOR activation enhancement for iexclusiveithasic multicenter Castleman disease

Blood: Atypical 3q26/MECOM rearrangement of acute myeloid leukemia is comparable to inv (3)/t (3; 3)