Blood: Macrophage Epo receptor signals promote red line differentiation during stress-forming

Center point:classic Wnt signal drives the proliferation of immature stress edifying red blood cellsEpo signals in macrophages induce lipid media to promote stressed red blood cell progenitor cell differentiationSummary:anemia stress-induced stress-induced red blood cells, rapidly producing new red blood cells to restore tissue oxygenationStressed red blood cell production is most easily understood in mice and occurs mainly in the spleen myelinBut both human and mouse stress-induced erythrocytes are used to promote red blood cells in a stable state to produce different signals and progenitor cellsimmature stress edifying cells (SEPs) are derived from short-term hematopoietic stem cells (ST-HSCs)Although SEPs have the ability to self-renew, red blood cells are limitedInflammation and anemia stress induce rapid proliferation of SEPs, but differentiation occurs only after elevated serum erythropoietin (Epo) levelsrecently, researchers found that Epo does not directly regulate SEPs, but rather promotes the transition from proliferation to differentiation by macrophages acting in the spleen's ecological positionDuring the proliferation phase, macrophages produce a classic Wnt ligand that promotes proliferation and inhibits differentiationThe Epo/Stat5-dependent signaling pathway induces macrophages to produce bioactive lipid mediaIncreased prostatin J2 (PGJ2) production activates the dependence of peroxidase proliferation activation receptor (PPARg) on Wnt expression, while the increase of prostatin E2 (PGE2) promotes the differentiation of SEPs