Blood: Yap1-Scribble polarization determines the fate of hematopoietic stem cells

YAP1 and its analogue Taz largely control the growth of epithelial tissueAlthoff and others have confirmed that hematopoieticstem cell(HSC) responds to stress depending on YAP1 and TazThe absence of YAP1 and Taz can lead to loss of hSC stillness and symmetrical self-renewal, making HSC more susceptible to series of myelin 5-fluorouria therapyThis effect relies on the plasma polarization dominated by YAP1 through its interaction with scaffolding Scribble mediated by its PDZ domainScrible and YAP1 work together to control the activity of cytoplasmic Cdc42 and the fate of the hSC in vivoThe absence of Scribble can disrupt the copolarization of YAP1 and Cdc42, weaken the activity of Cdc42, and lead to an increase in the number of HSCs in self-renewal with competitive reconstruction advantagesthe above data show that Scribble/YAP1 copolarization is essential for the asymmetrical split and destiny activity of The HSC dependent on CdC42The joint deletion of Scribble, YAP1, and Taz can lead to transcription increase, Rac activation, and HSC adaptive recovery of rac-specific ostrich nucleotide exchange factorsScrible's connection to the cell slurry function of the Hippo signal cascade determines the fate of the HSC