-
Categories
-
Pharmaceutical Intermediates
-
Active Pharmaceutical Ingredients
-
Food Additives
- Industrial Coatings
- Agrochemicals
- Dyes and Pigments
- Surfactant
- Flavors and Fragrances
- Chemical Reagents
- Catalyst and Auxiliary
- Natural Products
- Inorganic Chemistry
-
Organic Chemistry
-
Biochemical Engineering
- Analytical Chemistry
-
Cosmetic Ingredient
- Water Treatment Chemical
-
Pharmaceutical Intermediates
Promotion
ECHEMI Mall
Wholesale
Weekly Price
Exhibition
News
-
Trade Service
N-[4-[(3-Chloro-4-fluorophenyl)amino]-7-[[(3S)-tetrahydro-3-furanyl]oxy]-6-quinazolinyl]-4-(dimethylamino)-2-butenamide, also known as Compound X, is an organic compound that is used in a variety of industrial processes.
The compound is synthesized through a multi-step process that involves several chemical reactions.
In this article, we will take a closer look at the production process of N-[4-[(3-Chloro-4-fluorophenyl)amino]-7-[[(3S)-tetrahydro-3-furanyl]oxy]-6-quinazolinyl]-4-(dimethylamino)-2-butenamide and its applications in the chemical industry.
Step 1: Synthesis of 3-Chloro-4-fluorophenylamine
The first step in the production of N-[4-[(3-Chloro-4-fluorophenyl)amino]-7-[[(3S)-tetrahydro-3-furanyl]oxy]-6-quinazolinyl]-4-(dimethylamino)-2-butenamide is the synthesis of 3-chloro-4-fluorophenylamine.
This compound is synthesized by reacting 4-fluorophenylhydrazine with hydrochloric acid.
The reaction is carried out in the presence of a solvent such as dichloromethane, and the resulting product is then extracted with water and dried.
Step 2: Synthesis of (3S)-tetrahydro-3-furanyl-oxy-amide
The second step in the production of N-[4-[(3-Chloro-4-fluorophenyl)amino]-7-[[(3S)-tetrahydro-3-furanyl]oxy]-6-quinazolinyl]-4-(dimethylamino)-2-butenamide is the synthesis of (3S)-tetrahydro-3-furanyl-oxy-amide.
This compound is synthesized by reacting (3S)-tetrahydro-3-furanamide with hydroxy chloride in the presence of a solvent such as methanol.
The resulting product is then purified using a chromatography column.
Step 3: Synthesis of N-[4-[(3-Chloro-4-fluorophenyl)amino]-7-[[(3S)-tetrahydro-3-furanyl]oxy]-6-quinazolinyl]-4-(dimethylamino)-2-butenamide
The third step in the production of N-[4-[(3-Chloro-4-fluorophenyl)amino]-7-[[(3S)-tetrahydro-3-furanyl]oxy]-6-quinazolinyl]-4-(dimethylamino)-2-butenamide is the synthesis of the final compound.
This is achieved by reacting N-[(4-aminophenyl)sulfonyl]-4-(dimethylamino)-2-butenamide with 4-chloro-3-fluorophenylamine in the presence of a solvent such as dichloromethane.
The resulting product is then purified using a chromatography column.
Applications in the Chemical Industry
N-[4-[(3-Chloro-4-fluorophenyl)amino]-7-[[(3S)-tetrahydro-3-furanyl]oxy]-6-quinazolinyl]-4-(dimethylamino)-
