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Cell︱Prokaryotic new mechanism of self-protection immunity
Time of Update: 2022-08-15
The role and mechanism of the (SPARTA) system, which identifies SPARTA as a prokaryotic immune system, confirms that in RNA-guided detection of invading DNA, "short" pAgo and related proteins can co-trigger NAD(P)+ depletion, leading to invasion by decreased cell viability, thereby removing it from bacterial cultures .
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A&R: Assessment of immune cell subsets and genetic mutations in rheumatoid factor- and anti-citrulline antibody-negative patients with striated rheumatism
Time of Update: 2022-08-15
Gene enrichment analysis of RNA-sequencing data from sorted CD14+CD11b+CD36+/CD4+CD25-CD69+ cells revealed involvement in inflammation/stress response, phagocytosis and apoptosis regulation .
Gene enrichment analysis of RNA-sequencing data from sorted CD14+CD11b+CD36+/CD4+CD25-CD69+ cells revealed involvement in inflammation/stress response, phagocytosis and apoptosis regulation .
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ARD: EULAR/ACR 2021: Diagnosis, management and monitoring of interleukin 1-mediated autoinflammatory diseases to consider
Time of Update: 2022-08-15
Background : Interleukin- 1 ( IL-1 )-mediated systemic autoinflammatory diseases, including cold porphyrin-associated periodic syndrome ( CAPS ), tumor necrosis factor receptor-associated periodic syndrome ( TRAPS ), onychomycosis Valonate Kinase Deficiency ( MKD ) and IL-1 Receptor Antagonist Deficiency (DIRA) , belong to a group of rare immune dysregulation disorders that mainly present in early childhood with multiorgan involvement .
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A&R: The conundrum of pulmonary disease and drug anaphylactoid reactions in systemic juvenile idiopathic arthritis
Time of Update: 2022-08-15
. Here, two authors review SJIA-LD and its associated DRESS -like phenotype, proposing an alternative explanation, the cytokine plasticity hypothesis, proposing an environment in which IL-1 and IL-6 blockade regulates T cell development , resulting in pathological immune responses elicited by exposure to common microorganisms or other exogenous or endogenous antigens, rather than the drug itself .
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A&R: IgG anti-citrullinated protein antibody variable domain glycosylation increases before the onset of rheumatoid arthritis and stabilizes thereafter
Time of Update: 2022-08-15
The abundance of IgG ACPA VDG increases with RA onset and correlates with the maturity of the ACPA response .
The abundance of IgG ACPA VDG increases with RA onset and correlates with the maturity of the ACPA response .
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Clinical application of hydroxychloroquine in rheumatology
Time of Update: 2022-08-15
Hydroxychloroquine (HCQ) has been reported to improve lifespan and dyslipidemia outcomes in SLE patients, but the mechanism is unclearMethods: The study included SLE patients who received supplemental HCQ between January 2016 and September 2020 and maintained low disease activity .
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Interpretation of Phase 2 clinical trials of hydroxychloroquine
Time of Update: 2022-08-15
Checkpoint inhibitors can be combined from Benefit from re-treatment with BRAF and MEK inhibitors ("re-challenge") Patients with advanced (defined as unresectable or metastatic) v-Raf mouse sarcoma virus oncogene homolog B V600 (BRAFV600) mutated melanoma patients who were previously treated with v-Raf mouse sarcoma virus oncogene homolog B (BRAFV600) )/mitogen-activated protein kinase (MEK) inhibitors and programmed cell death 1 (PD-1) and cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) immunotherapy have progressed after immunotherapy.
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A&R: A Safety and Efficacy Study of Bimegizumab in Active Psoriatic Arthritis
Time of Update: 2022-08-15
Long-term safety, tolerability, and efficacy of bimegizumab in psoriatic arthritis (PsA )METHODS: Adult patients with active PsA who completed the double-blind and dose-blind phases of the BE-active randomized controlled trial could enroll in an open-label extension (OLE) study at week 48 , after which patients received 160 mg of bimegizumab every four weeks .
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A&R: Prevalence, incidence, and progression of radiographic and symptomatic hand osteoarthritis
Time of Update: 2022-08-15
The aim of this study was to describe the prevalence, incidence, and progression of radiographic and symptomatic hand OA, and to assess differences by age, sex, ethnicity, and other risk factors.
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Master of Immunization: Academician Dong Chen's high-level review
Time of Update: 2022-08-15
Since the review published by Mr. Dong Chen covers multiple fields of immunology, the editor will select representative works from the direction of Th development and differentiation, the direction of immune disease and the direction of system immunology for interpretation .
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Another shield against the new crown!
Time of Update: 2022-08-15
. Like ambavirumab/romisevirumab, the Fc segment of Evusheld (Tixagevimab/Cilgavimab) pair of neutralizing antibodies has also been modified by YTE [23], and their half-life in the human body is as long as 90.
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Immunity Intestinal flora initiates systemic antiviral immunity through cGAS-STING-IFN-I signaling
Time of Update: 2022-08-15
In mice, it was found that the intestinal flora maintains the basal level of IFN-I production in the resting state by activating the body's cGAS-STING signaling pathway, which plays an important role in the body's resistance to DNA and RNA virus infection .
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Rheumatology: Serum cholesterol loading capacity of macrophages in RA patients is regulated by seropositivity and C-reactive protein
Time of Update: 2022-08-15
Oxidized low-density lipoprotein mediates the effect of oxPL-apoB100 on CLC and has clinical significance for cardiovascular risk preventionSource:Source:Karpouzas GA, Papotti B, Ormseth SR, et al.
Oxidized low-density lipoprotein mediates the effect of oxPL-apoB100 on CLC and has clinical significance for cardiovascular risk preventionSource:Source:Karpouzas GA, Papotti B, Ormseth SR, et al.
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ARD: Efficacy and Safety of the Selective TYK2 Inhibitor Decavatinib in a Phase II Trial of Psoriatic Arthritis
Time of Update: 2022-08-15
. CONCLUSIONS : Treatment with the selective TYK2 inhibitor decavatinib was well-tolerated and had greater effects than placebo on ACR-20 , multiple-controlled secondary endpoints, and other exploratory efficacy measures in patients with PsA .
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2 almost misdiagnosed cases, don't confuse it with tonic!
Time of Update: 2022-08-15
. However, this standard has strong specificity and poor sensitivity (AS patients may only have symptoms of low back pain in the early stage of the disease, and no radiological changes).
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Hydroxychloroquine and Covid-19: The never-ending story
Time of Update: 2022-08-15
For example, enthusiasm for hydroxychloroquine accelerated after a study showed that hydroxychloroquine could block SARS-Cov-2 infection in cells derived from monkey kidneys .
For example, enthusiasm for hydroxychloroquine accelerated after a study showed that hydroxychloroquine could block SARS-Cov-2 infection in cells derived from monkey kidneys .
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Eating "polyunsaturated fatty acids" like this can really control rheumatism!
Time of Update: 2022-08-15
The meta-analysis included 30 of 42 studies, with a total of 710 adult patients (RA, AS, PsA) receiving oral supplementation with omega-3 and/or omega-6 PUFAs; 710 controls were given placebo ;Compare the parameters of disease activity between the two groups: duration of morning stiffness (MS), visual analogue scale (VAS), DAS28, joint tenderness (TJC), joint swelling (SJC), Health Assessment Questionnaire (HAQ) score, red blood cells Sedimentation rate (ESR) and C-reactive protein (CRP) levels .
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Huazhong Agricultural University Han Wenyuan's team discovered a new mechanism for the prokaryotic Argonaute system to mediate immune response Cell Press Dialogue with scientists
Time of Update: 2022-08-15
Life science On May 19, 2022, the team of Han Wenyuan from Huazhong Agricultural University published the research results of analyzing the immune function of the new prokaryotic Argonaute (Ago) system in the form of Article in the journal Cell Host & Microbe .
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Can a ketogenic diet improve osteoarthritis?
Time of Update: 2022-08-15
Download the Doctor Station App and subscribe anytime, anywhere~ *For medical professionals to read and refer to clinical information, 1s touches ▎Clinical question: What protective mechanism does ketogenic diet (KD) use to improve osteoarthritis (OA)?
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Rheumatology: alkaline calcium phosphate crystals induce the expression of extracellular matrix remodeling enzymes in tendons
Time of Update: 2022-08-15
Real-time PCR was used to determine changes in the expression of tendon-related genes and extracellular matrix remodeling enzymes (metalloproteinases, MMPs; disintegrins and metalloproteinases, ADAMTS; tissue inhibitors of metalloproteinases, TIMPs) .
