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Declassify the world's first ATAC-seq and CUT-Tag joint application to reveal a new mechanism for tumor immune escape.
Time of Update: 2020-07-22
PAC1 reduces chromatin openness (ATAC SEQ test), histone acetylation, and the binding ability of chd4 to DNA (cut & amp; tag test) by recruiting nucleosome reconstruction and deacetylation (NuRD) complex, and specifically inhibits T lymphocyte defense function, resulting in T cell failure and cancer immune escape.
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Science . . . A panoramic view of plant immune response triggered by effect factors.
Time of Update: 2020-07-22
the researchers further screened NLRs related to 19 ETI elicitor families in Arabidopsis thaliana, expressed each ETI elicitor in DC3000, then infected different NLR mutant plants, confirmed the corresponding relationship in ETI response through phenotypic experiment, and finally identified the NLR protein that can be induced by all ETI elicitors.
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A randomized trial for the treatment of gout by epwhoseine and autumn daffodils was compared.
Time of Update: 2020-07-22
in the UK trial, 399 patients with acute gout were randomly assigned to either the naproxen group (initial dose 750 mg; followed by 250 mg tid for 1 week) or the colchicine group (0.5 mg tid for 4 days).
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Nature sub-issue: The immune system calls you to eat on time! Scientists have found that the gut's inherent immune function increases at the time of eating, preventing the infection of the eating pathogen.
Time of Update: 2020-07-22
in this week, the circadian rhythm of mice had not changed significantly, but at T4, compared with the day eating mice who had just started eating, the ilc3 of the mice who had just eaten at night was significantly more active, and the proportion of cells secreting IL-22 was about 2 times higher.
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New crown outbreak current, call for rheumatoid cornerstone drug hydroxychloroquine to carry out more evidence-based research!
Time of Update: 2020-07-22
in 2015, the Asia Pacific Alliance Against Rheumatism (aplar) and ACR guidelines recommended methotrexate (MTX) as the first-line drug in the treatment of RA; when MTX is intolerable, other traditional dmrads such as hydroxychloroquine can also be used as the first-line drug; when the single drug has poor efficacy or has adverse prognostic factors, it can be treated with combined regimen.
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Latest! China's systematic lupus diagnosis and treatment guidelines issued, these 12 updates a text to master! Guide time.
Time of Update: 2020-07-22
Stamp "read the original text" and check the original guide! Systemic lupus erythematosus (SLE) is a systemic autoimmune disease, its diagnosis and treatment are very complex. it is imperative to form
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The Lancet Sub-Journal: New Uses of Metformin? It is expected to improve metabolic health in patients with chronic inflammation.
Time of Update: 2020-07-22
in phase 2 clinical trials, metformin can improve metabolic health and reduce the serious side effects of glucocorticoid treatment in patients with chronic inflammatory diseases.
Image Source: pixabay based on these studies, the research team of Queen Mary University in London led the phase II clinical trial of this randomized, double-blind, placebo-controlled, proof of concept.
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Does the intestinal flora aggravate osteoarthritis? Cyclophosphamide cures disease or causes cancer? A week of "wind" clouds.
Time of Update: 2020-07-22
in a study involving 1427 patients with OA, the relative and absolute abundance of Streptococcus species in fecal microbiota samples were associated with the severity of OA disease and the increased knee pain associated with OA.
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See only the elderly? Pain is hallucinations? You have these three misconceptions about fibromyalgia!
Time of Update: 2020-07-22
For some people with fibromyalgia syndrome, the pain may be very serious, accompanied by fatigue, sleep disorders, morning stiffness, depression, anxiety and other mental symptoms, greatly reduce the quality of life of patients, and even affect the normal study, work and life.
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How does the body's immune system protect itself when a new coronavirus invades? The SARS-CoV-2 immune response is that things.
Time of Update: 2020-07-22
in this process, macrophages recognize antigens and phagocytize the components of the host's innate immune system, and detect virus infection by using pattern recognition receptors (PRRS) to recognize pathogen related molecular patterns (PAMPs) · Immature dendritic cells (DCS) have a strong ability to phagocytize antigens.
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Tsinghua University and other units for the first time found the immunological characteristics of the newly recovered patients.
Time of Update: 2020-07-22
on March 20, 2020, Dong Chen team of Institute of immunology of Tsinghua University, Chen Fang team of Chuiyangliu Hospital Affiliated to Tsinghua University and Qin Chengfeng team of Academy of Military Medical Sciences published a research paper entitled "characterization of anti-virus immunity in recovered individuals affected by sars-cov-2" in medrxiv.
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Rheumatic stomatism these drugs should be careful! Waist thickening, knee osteoarthritis may worsen? A week of wind and clouds.
Time of Update: 2020-07-22
for patients with knee osteoarthritis, there is a risk of decreased physical function in the second year after the increase in waist circumference, which may be reduced by maintaining the waist circumference, according to the researchers.
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What are the effects of short-term deactivation of methotrexate on disease activity in RA patients? Which type of RA patient is more likely to quit smoking?
Time of Update: 2020-07-22
What are the effects of short-term discontinuation of methotrexate on disease activity in patients with rheumatoid arthritis?
the researchers indicated that it was safe to discontinue methotrexate for 2 weeks, while withdrawal for 4 weeks might increase the risk of disease activity in RA patients.
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Immunity . . . Li Xiaoxue and others reveal how fruit flies cope with THE accumulation of ROS in the body.
Time of Update: 2020-07-22
in this paper, the authors used Drosophila melanogaster as a model, and found that pathogen infection or tissue damage could lead to the excretion of lipids from haemolymph (insect blood) by the Malpighian tubules (insect kidney).
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Cell . . . The intestinal nervous system participates in the mucous membrane immune barrier by secreting IL18.
Time of Update: 2020-07-22
previous studies have deeply analyzed the important role of the interaction between epithelial cells and immune system in maintaining intestinal homeostasis in intestinal tissues, but how ens and epithelial cells interact, what are the mediators, and what is the mode of action are still unknown.
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A new regulatory mechanism of innate immunity of plants.
Time of Update: 2020-07-22
in conclusion, our results elucidate a new regulatory mechanism that PLD δ is transported through the exocytosis pathway, which helps plants to perform penetrating defense responses against fungal pathogens.
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Nature. A new immune mechanism that regulates fat sympathetic nerves and heat production.
Time of Update: 2020-07-22
In particular, in heat source adipose tissue, γ δ T cells and il-17rc jointly regulate sympathetic innervation and thermogenesis through TGF β 1 pathway.
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Science Advances . . . Breakthrough, Zhejiang University Tang Ruikang / Wang Ben developed a universal panda blood, is expected to solve the problem of rare blood type blood transfusion.
Time of Update: 2020-07-22
on March 21, 2020, Tang Ruikang and Wang Ben of Zhejiang University published a joint communication entitled "surface anchored framework for generating RHD epitope steady red blood" Cells "research paper, which is designed to produce RhD negative RBC through the three-dimensional (3D) cross-linked skeleton of a rational design of polysialic acid (PSA) tyramine hydrogel to produce negative RBC, has a flexible texture to ensure cell membrane stability.
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Sci Adv . . . Xu Wenyue's team reveals new mechanisms for malaria parasite immunity.
Time of Update: 2020-07-22
Malaria is one of the three most serious infectious diseases in the world. There are nearly 200 million malaria cases and 450000 deaths in the world every year. although the discovery of the antimalar
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How does the influenza virus, which kills hundreds of thousands of people around the world in silence every year, escape the recognition of the body's immune system?
Time of Update: 2020-07-22
this study reports the biological effects of influenza virus NS1 protein binding to host receptor protein RIG-I, which directly eliminates the alarm of activating cellular innate immunity.
this study highlights the importance of how mutations in the NS1 protein of influenza virus strains affect their ability to respond to host cell immunity.
