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What are the causes of limb pain in children? Be alert to acute leukemia!
Time of Update: 2022-10-12
3)； E2A-PBX1(TCF3-PBX1)It is said that in the 5th edition of the WHO classification of hematopoietic and lymphoid tissue tumors, acute B lymphoblastic leukemia with reproducible genetic abnormalities has the following types:The penultimate is B-ALL with TCF3::P BX1 (E2A::P BX1), which emphasizes the importance of fusion genes and uses double colons instead of horizontal lines.
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Nat Commun: Nano-oxide graphyne can specifically kill DNMT3A mutant AML cells
Time of Update: 2022-10-12
On September 26, 2022, Qian Pengxu's research group at the School of Basic Medicine/Liangzhu Laboratory of Zhejiang University and Chen Chunying, a researcher at the National Center for Nanoscience, published an online article entitled "Graphdiyne oxide nanosheets display selective anti-leukemia efficacy against DNMT3A-mutant AML.
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Nosocomial infection during ECMO
Time of Update: 2022-10-12
In a recent study, the immune response in the initial phase of V-AECMO showed the expression of immunosuppressive factors associated with an increased risk of infection in severely ill patients, which is significantly different from traditional therapeutic control [25].
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Intern Med: A rare complication of thrombosis in patients with warm autoimmune hemolytic anemia in Japan
Time of Update: 2022-10-12
Therefore, a research team studied the complications and characteristics of thrombosis in patients with warm AIHA (WAIHA) in Japan to determine whether Japanese patients are at increased risk of thrombosis and should receive preventive treatment for venous thromboembolism.
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Blood: Small residual lesions predict prognosis in patients with mantle cell lymphoma in real time
Time of Update: 2022-10-12
Punctual and kinetic MRD analysis from the Fondazione Italiana Linfomi MCL0208 phase 3 trial in mantle cell lymphoma.
Punctual and kinetic MRD analysis from the Fondazione Italiana Linfomi MCL0208 phase 3 trial in mantle cell lymphoma.
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Expert interview: Professor Jiang Erlie related to the progress of autologous hematopoietic stem cell transplantation technology
Time of Update: 2022-10-12
Can you review what significant developments have been made in this area in recent years?Professor Jiang: The Blood Disease Hospital of the Chinese Academy of Medical Sciences is the earliest autologous hematopoietic stem cell transplant in China, dating back to 1986.
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Front Oncol: Correlation between clinical and circulatory metabolic biomarkers and constitutional and functional impairment in chronic lymphocytic leukemia in adults
Time of Update: 2022-10-12
In the univariate analysis of clinical factors, a longer period of time since diagnosis is associated with a higher likelihood of aerobic fitness for dysfunction (OR = 3.
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Iron tetra iron deficiency anemia four brothers
Time of Update: 2022-10-12
elevated serum TIBC:Iron anemia, acute hepatitis, etcDecreased serum TIBC:Cirrhosis, nephropathy, uremia and hemochromatosisIron four-item combined test Iron deficiency anemia is the most common type of anemia and is a small cell hypochromic anemia caused by insufficient iron storage in the body affecting hemoglobin synthesis.
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[CLEAR Currier a daily case] thalassemia
Time of Update: 2022-10-12
Chest mass is usually seen in patients with thalassemia or congenital hemolytic anemia3.
Chest mass is usually seen in patients with thalassemia or congenital hemolytic anemia3.
Chest mass is usually seen in patients with thalassemia or congenital hemolytic anemia3.
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Blood: The new drug for leukemia! Recombinant Irving bacterium asparagine enzyme JZP458 Phase 2/3 test results are effective and safe!
Time of Update: 2022-10-12
AALL1931 is a Phase 2/3 study conducted in collaboration with the Pediatric Oncology Gene Association to evaluate the efficacy and safety of JZP458 (a recombinant erwinia asparaginase from a new expression platform) in patients with acute lymphoblastic leukemia/lymphoblastic lymphoma who develop allergy/silencing inactivation of E.
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J Clin Med.: Are brain networks less efficient in young survivors of acute lymphoblastic leukemia? Evidence from individual morphological brain network analysis
Time of Update: 2022-10-12
In one study, the research team constructed a single-subject GM network based on multiple morphological characteristics and multiple Euclidean distances, and applied graph theory analysis to study the connection topology of young survivors of acute lymphoblastic leukemia.
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Blood: Darafinil plus trametinib for relapsed/refractory BRAF V600E mutant hair cell leukemia
Time of Update: 2022-10-12
This paper reports the efficacy and safety of Dabrafenib plus trametinib in the treatment of patients with HCL who are positive for relapsed/refractory BRAF V600E mutations.
This paper reports the efficacy and safety of Dabrafenib plus trametinib in the treatment of patients with HCL who are positive for relapsed/refractory BRAF V600E mutations.
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Blood: Tigrelor prophylaxis does not reduce vascular occlusive crisis in children with sickle cell disease
Time of Update: 2022-10-12
The Phase 3 HESTIA3 study aimed to evaluate the efficacy and safety of the reversible P2Y12 inhibitor tigrelor vs placebo in preventing vascular occlusive crisis in children with sickle cell disease.
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Lancet Haematol: Iberdomide plus dexamethasone for relapsed/refractory multiple myeloma
Time of Update: 2022-10-12
This multi-cohort, open-label Phase 1/2 trial in Europe, Canada, and the United States enrolled multiple myeloma patients aged 18 years and older who had received at least second-line treatment, including lenalidomide or pomatomide and proteasome inhibitors.
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Blood Routine Test Experience Sharing - Interesting Scatter Plot
Time of Update: 2022-10-12
02 Case passedIn the daily blood routine result review, the author encountered a patient specimen with a malignant tumor of the liver, and the abnormal scatter in the lower left corner of the patient's white blood cell scatter map increased significantly.
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Bewildering plasma cells
Time of Update: 2022-10-12
Myelodysis is low, the granules are predominantly non-hematopoietic, the three lines of cells are significantly reduced, mature lymphocytes and plasma cells are increased, biopsy shows extremely low hyperplasia, other secondary bone marrow failure is excluded, and AA is temporarily considered.
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Blood: Efficacy and safety of Valemetostat in relapsed/refractory adult ATL
Time of Update: 2022-10-12
The primary endpoint was the overall response rate (ORR) assessed by the Independent Efficacy Evaluation Committee (IEAC).
The primary endpoint was the overall response rate (ORR) assessed by the Independent Efficacy Evaluation Committee (IEAC).
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VHL syndrome (von Hipple-Lindau syndrome)
Time of Update: 2022-10-12
The basic components of VHL syndrome are divided into two parts:(1) Angioblastoma of the retina, brainstem, cerebellum or spinal cord;(2) Lesions of abdominal organs (pheochromocytoma, renal cyst or renal cell carcinoma, pancreatic cyst, etc.
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【Focus on the frontier】AI diagnosis of acute promyelocytic leukemia
Time of Update: 2022-10-12
To avoid these early deaths, early initiation of treatment is recommended, so a quick and accurate diagnosis is key to reducing early mortality in APL.
To avoid these early deaths, early initiation of treatment is recommended, so a quick and accurate diagnosis is key to reducing early mortality in APL.
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Front oncol: Professor Huilai Zhang's team retrospectively analyzed the clinical features and outcomes of 926 cases of follicular lymphoma
Time of Update: 2022-10-12
Results of the study Follicular lymphoma (FL) is an indolent lymphoma in most patients who are sensitive to chemotherapy or immunochemotherapy (IC), and although overall survival in patients during the rituximab era improves, FL is considered an incurable disease.
