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J Neuroinflammation—Tang Yamei's team discovered the mechanisms by which pregabalin mitigates microglial activation and neuronal damage in radioactive brain injury
Time of Update: 2022-10-14
Written by - Zhang Zhan, Editor-in-Chief—Sizhen Wang—Xia Ye radiotherapy is an important adjunct treatment for patients with head and neck tumors such as nasopharyngeal carcinoma, primary or metastati
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Neuron Jiayi Zhang/Liang Chen/Ying Mao of Fudan University reveals a new neural mechanism encoding time prediction information
Time of Update: 2022-10-13
To address the question of which brain regions play a key role in human time perception in the order of seconds to ten seconds, the authors used stereoplephalogram (SEEG) recordings of 11 epilepsy patients to localize seizures.
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Frequent nightmares, or omen of dementia! The Lancet: Nightmares ≥ once a week increase the risk of dementia by 120%!
Time of Update: 2022-10-13
An association between nightmares and cognitive decline was found: higher frequency nightmares (1 or more times a week) were nearly 3-fold higher than the risk of cognitive decline in middle age, and the likelihood of developing dementia in older age was increased by 120%!
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Cell: First discovery! Social fear or social cattle, the key to see this neural pathway!
Time of Update: 2022-10-13
In addition, the researchers also found that the anatomy of PIL in rats and human brains and the distribution of PTH2 receptors in MPOA are very similar, indicating that PIL → MPOA pathways in humans are likely to play a similar role in regulating social behavior.
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Nature Brainstem ADCYAP1+ neurons mediate pathological behavior
Time of Update: 2022-10-13
Written by | Jun infection is one of the serious threats that organisms need to face in survival [1], while inducing immune cell responses, infection will also trigger a series of changes in the body,
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Science: Obesity is a neurodevelopmental disorder, early brain development or the main determinant of obesity
Time of Update: 2022-10-13
Notably, classical studies in mice and humans have shown that during critical periods of early development, nutritional status can permanently alter the body's energy balance regulation and lead to obesity, a phenomenon known as "developmental programming.
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The Nat Biomed Eng Depunch/Luanlan team develops a variety of long-term, high-density neural signal recording solutions based on ultrasoft neural electrode arrays
Time of Update: 2022-10-13
The study pointed out that ultrasoft nerve electrode arrays can record visual cortex neural signals at high density to increase the decoding accuracy of visual stimuli in mice, can simultaneously observe the plasticity changes produced by optogenetic stimuli on a large number of cells, and monitor coupling between neural signals in different brain regions that are far apart at a scale of several months.
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Microbiome Army Medical University Fan Xiaotang / Soochow University Xu Xingshun et al. have discovered possible mechanisms of anxiety-like behavior induced by inflammatory bowel disease
Time of Update: 2022-10-13
These findings suggest that the gut microbiota plays a key role in mediating colitis disease activity and anxiety-like behavior through abnormal neural processing within the gut-brain axis.
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【Review】Depression treatment moves towards precision medicine, and immune targeted therapy "comorbid depression"
Time of Update: 2022-10-13
1 The causal relationship between immune disorders and depressionA large number of studies have shown that immune disorders and depression are correlated: elevated levels of pro-inflammatory cytokines and proteins in the blood and cerebrospinal fluid (CSF) in patients with MDD, weakened adaptive immune responses, changes in relative abundance of specific immune cell types, bias towards autoimmunity, increased microglia activation, and other immune changes.
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Typical radiographic findings of intracranial hemorrhage, summarized in one article
Time of Update: 2022-10-13
Hemorrhagic contusion of the right anterior temporal lobe and subarachnoid hemorrhage covering the brain sulcus (triangular arrow) are shown in the figure, and arc-shaped subdural hematoma foci (long tail arrow) are visible under the bone plate.
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"Brain Behavior and Immunization" is heavy! Scientists have found that taking specific probiotics during adolescence can regulate endotoxin-induced immune responses and bowel disorders, and improve depressive-like behavior
Time of Update: 2022-10-13
235 issues | Gut Junjun WeeklyDepression, probiotics; Bariatric surgery, intestinal morphology, glucose absorption; Sugar, bacterial imbalance, metabolic syndromeHappy National Day to the people of the whole country!
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Nat Aging—Alzheimer's mouse glial cells participate in synaptic clearance through the complement pathway
Time of Update: 2022-10-13
Written by Jane Cheng, Editor-in-Chief—Sizhen Wang—Chronic neuroinflammation in Xia Ye is a hallmark of Alzheimer's Disease (AD), manifested by glial hyperplasia, elevated levels of pro-inflammatory f
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JAMA Sub-Journal: The Fudan team found that healthy eating and exercise or reducing the risk of death in Parkinson's disease patients are two magic weapons!
Time of Update: 2022-10-13
The study assessed the value of healthy eating patterns and active lifestyles before and after Parkinson's disease onset using a well-researched large prospective follow-up cohort of well-gathered information, and the association between the two and the reduced risk of death is expected to provide clinicians with new ideas for improving outcomes and allowing more patients to benefit from relatively simple interventions.
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Poor teeth are susceptible to dementia? New Study: The culprit turned out to be it
Time of Update: 2022-10-13
Meanwhile, another study in the Journal of Alzheimer's Disease Reports found that porphyrin monas gums also cause elevated levels of many pro-inflammatory factors in the brain, including interleukin-1 and interleukin-6.
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【Neuron】Fudan Department of Brain and Huashan Hospital Team: The important role of the optic cortex in temporal information prediction
Time of Update: 2022-10-13
This article is the original of the translational medicine network, please indicate the source when reprinting Author: LilyAlthough time is important in our daily lives, our understanding of how the h
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What are the advantages of universal "chimeric cells" for DMD over gene therapy that prove long-term effectiveness?
Time of Update: 2022-10-13
The official website of each company——List of recent hot events——▼October 18, the application and development trend of biopharmaceutical safety detection technologyOctober 8, 2022 eMedClub News/-September 26, 2022, Dystrogen Therapeutics announced that a clinical study of DT-DEC01, a research-based engineered cell therapy for Duchenne muscular dystrophy (DMD), was achieved six months later in a clinical study under a hospital exemption agreement.
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Astrocyte glutamate metabolism regulates depressive behavior induced by long-term high-fat diets
Time of Update: 2022-10-13
Intraperitoneal injection or vHP injection of Riluzole in the brain region can significantly increase GLAST and GLT-1 protein levels, inhibit glutamate glutamate input overactivation caused by high-fat diets, and significantly improve depressive behavior.
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Problems with the mouth may plant the seeds of Alzheimer's disease
Time of Update: 2022-10-13
Meanwhile, another study in the Journal of Alzheimer's Disease Reports found that porphyrin monas gums also cause elevated levels of many pro-inflammatory factors in the brain, including interleukin-1 and interleukin-6.
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"Immunity": The team of the Second Hospital of Zhejiang University found for the first time that resting microglia can directly affect the electrical excitability of neurons!
Time of Update: 2022-10-13
The removal of microglia-derived PDGFB leads to a weakening of the K+ current in PVN presympathetic neurons and sympathetic excitation+Studies have shown that PDGFB binds to two receptors, PDGFRα and PDGFRβ.
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Express promotes the main DMD gene therapy into the clinic, and the new sharp joint efforts to create a gene therapy pipeline
Time of Update: 2022-10-13
▲If you have any business needs, please long press to scan the QR code above, or▎Editor of WuXi AppTec content teamSolid Biosciences today announced a merger agreement with AavantiBio to acquire AavantiBio's gene therapy pipeline.