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Bcl-2 inhibitor APG-2575 for use in chronic lymphocytic leukemia or small lymphocytic lymphoma in Phase Ib/II clinical, approved by NMPA

 Time of Update: 2020-06-24

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Ascentage Pharma announced that it has received approval from the State Drug Administration of China (NMPA) for its Ib/II phase of its new Bcl-2 selective inhibitor APG-2575 to treat recurrent/refra
JASN: Intravenous iron dose and risk of infection in hemodialysis patients

 Time of Update: 2020-06-24

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The results of experimental and observational studies have raised concerns that intravenous injections (IV) of iron in patients (e.g individuals receiving maintenance hemodialysis) may increase the
FDA approves heavy anti-cancer target drug Daretou monoderinoma subcutaneous injection sis! The administration was reduced from 3 hours to 5 minutes!

 Time of Update: 2020-06-24

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On May 1, 2020, the FDA approved the subcutaneous injection sisyds of daratumab (Chinese product names: ®, Darzalex, daretoumonotag) and hyaluronic acid enzyme-fihpro for adult patients with newly d
PI3K inhibitor umbralisib-CD20 inhibitor ublituximab for CLL trial was discontinued early due to significant efficacy

 Time of Update: 2020-06-24

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Chronic lymphocytic leukemia (chronic lymphocytic leukemia, CLL), chronic lymphocytic leukemia (chronic lymphocytic leukemia, CLL), an elderly disease characterized by the cloned proliferation of hi
CAR-T treatment of children with recurrent B-cell acute lymphoblastic leukemia gets complete remission

 Time of Update: 2020-06-24

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On May 27, 2020, CAR-T treatment was re-examined for 9 and a half months, and the bone marrow was in a continuous and complete state of remission this year's Children's Day, Hebei children Xiaoxia
AACR 2020: Ibtinib and Litoxi monotherapy follicle lymphoma Phase III Research Launch (PERSPECTIVE Study)

 Time of Update: 2020-06-24

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research background For elderly or patients with fissyllosic lymphoma (FL), the first-line chemo-free (no chemotherapy) treatment options are very limited At present, rituximatomaishasis has been
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 Time of Update: 2020-06-24

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01 Foreword We all know many common causes of false hyperkale, and samples are refrigerated or frozen before separating serum? The specimen was not processed in time? Hard beat the blood collection
Zebutini, developed by Baiji Shenzhou, is listed in China today!

 Time of Update: 2020-06-24

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On June 3, The Baiji Shenzhou BTK inhibitor, The ® of Bacbane Zeitini ( generic name: Zebutini Capsules), was approved by the State Drug Administration to treat two adaptations in patients wit
Blood: The interplay of the endogenous mesh protein SEC22B and NBEAL2 regulates the formation of alpha particles of macronuclear cells

 Time of Update: 2020-06-24

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Gray platelet syndrome,GPS, also known as alpha storage pool disease, is a rare haemorrhagic disease of autosomal recessive genetics, characterized by mild platelet reduction accompanied by large pl
Blood: Aging-induced IL27Ra signal can damage hematopoietic stem cells

 Time of Update: 2020-06-24

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Hematopoietic stem cell (HSC) aging is associated with bone marrow growth-related diseases and an increased risk of immune aging In the study, researchers found that aging-related inflammatory resp
Blood: Three aspirin treatment options in optimizing isoplate hyperpluse patients with antiplatelet treatment comparison

 Time of Update: 2020-06-24

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Ispeciallyanocal hyperplasia (ET) is characterized by abnormal macrocytocell production and an increased risk of blood clots Daily small-dose (od) aspirin is the recommended antithrombotic treatment
Blood: Supplementing IL-2 improves prognosis in patients with ispecificatic aplastic anemia

 Time of Update: 2020-06-24

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Iexclusiveirerere anemia (AA) has two main characteristics: autoimmune response to hematopoietic stem cells/progenitor cells and regulatory Tregs defects Researchers have previously demonstrated a r
Blood: Different effects of platelet protein S in venous thrombosis

 Time of Update: 2020-06-24

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Anticoagulant S (PS) in platelets (PSplt) is similar to plasma PS and is released when platelets are activated; in this study, the researchers innovated the mouse PSplt with Pf4-Cre genetically mod
Blood: BTK inhibitor therapy can be effective in treating venetoclax drug resistance CLL

 Time of Update: 2020-06-24

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Highly active BTK inhibitors (BTKi) and BCL2 inhibitorvenetoclax change the therapeutic prospects of chronic lymphoblastic leukemia (CLL) prospective clinical trial results show that venetoclax ha
Cell Metab: Lactic acid regulates muscle ischemia

 Time of Update: 2020-06-24

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Endothelial cells (EC) produce signals that help organs regenerate, but there have been reports of metabolic communication within blood vessels recently, researchers found that EC-specific glycoen
Blood: Platelet-VWF prevents plasma leakage when heyyertic cells seepage by stimulating Tie-2

 Time of Update: 2020-06-24

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Neutrophil oozing requires opening the endothelial barrier in the blood vessel, but it does not automatically cause plasma leakage The shrunken actin wire surrounds the outer seepage of the blood ce
Blood: Single-cell sequencing reveals developmental trajectory from endothelial cells to hematopoietic stem cell precursors

 Time of Update: 2020-06-24

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Hematopoietic stem cells and progenitor cells (HSPCs) in bone marrow are derived from a small group of hematal endothelial cells (HE) in the aorta of mammalian embryos He cells undergo transformatio
Blood: Pharmacokinetics, Efficacy and Safety of Oral Cedazuridine/Tisitabin Therapeutics MDS and CMML

 Time of Update: 2020-06-24

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This study is a Phase 2 clinical trial designed to compare the exposure, demethylation activity and safety of the cedazuridine 100mg/Ditathabin 35mg and standard Sitabin 20mg/m2(IV) treatment for th
Blood: Effects of arginine therapy on mitochondrial function during vascular closed pain in sickle cell disease in children

 Time of Update: 2020-06-24

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The mitochondrial function of sickle cell disease (SCD) changes, in part because of the low bioavailability of nitric oxide (NO) Arginine is the substrate that produces NO and becomes severely defic
Blood Adv: Increased infection after treatment with myelin HCT in patients with CR1 AML

 Time of Update: 2020-06-24

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It is estimated that the reduction of intensity/non-myelin therapy (RIC/NMA) for alloblastation (alloHCT) is low compared to myelin therapy (MAC); in the study of the International Blood and Bon

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Blood System

Bcl-2 inhibitor APG-2575 for use in chronic lymphocytic leukemia or small lymphocytic lymphoma in Phase Ib/II clinical, approved by NMPA

JASN: Intravenous iron dose and risk of infection in hemodialysis patients

FDA approves heavy anti-cancer target drug Daretou monoderinoma subcutaneous injection sis! The administration was reduced from 3 hours to 5 minutes!

PI3K inhibitor umbralisib-CD20 inhibitor ublituximab for CLL trial was discontinued early due to significant efficacy

CAR-T treatment of children with recurrent B-cell acute lymphoblastic leukemia gets complete remission

AACR 2020: Ibtinib and Litoxi monotherapy follicle lymphoma Phase III Research Launch (PERSPECTIVE Study)

True "potassium" is difficult to distinguish, false only in one mind between

Zebutini, developed by Baiji Shenzhou, is listed in China today!

Blood: The interplay of the endogenous mesh protein SEC22B and NBEAL2 regulates the formation of alpha particles of macronuclear cells

Blood: Aging-induced IL27Ra signal can damage hematopoietic stem cells

Blood: Three aspirin treatment options in optimizing isoplate hyperpluse patients with antiplatelet treatment comparison

Blood: Supplementing IL-2 improves prognosis in patients with ispecificatic aplastic anemia

Blood: Different effects of platelet protein S in venous thrombosis

Blood: BTK inhibitor therapy can be effective in treating venetoclax drug resistance CLL

Cell Metab: Lactic acid regulates muscle ischemia

Blood: Platelet-VWF prevents plasma leakage when heyyertic cells seepage by stimulating Tie-2

Blood: Single-cell sequencing reveals developmental trajectory from endothelial cells to hematopoietic stem cell precursors

Blood: Pharmacokinetics, Efficacy and Safety of Oral Cedazuridine/Tisitabin Therapeutics MDS and CMML

Blood: Effects of arginine therapy on mitochondrial function during vascular closed pain in sickle cell disease in children

Blood Adv: Increased infection after treatment with myelin HCT in patients with CR1 AML