Blood: Platelet-VWF prevents plasma leakage when heyyertic cells seepage by stimulating Tie-2
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Last Update: 2020-06-24
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Source: Internet
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Author: User
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Neutrophil oozing requires opening the endothelial barrier in the blood vessel, but it does not automatically cause plasma leakageThe shrunken actin wire surrounds the outer seepage of the blood cell, keeping the opening tightly enclosed around the migrating neutrophils, thus preventing plasma leakagerecently, Braun and others have identified receptor systems that are responsible for preventing plasma leakageUsing fluorescent microspheres, the researchers found that the die-2 of silent or inactivated endothelial cells can lead to microvesines seeping out of the misolile cells after capillariesPlasma leakage depends on the external osteocyte oozing, because plasma leakage does not exist when neutrophils are depletedthe researchers found that the Cdc42 GTPase exchange factor FGD5 is a downstream target for Tie-2 and plays a key role in preventing plasma leakage in the plasma leakage process of the neutrophil isoloby processIn the search for Tie-2 agonists and their sources, the researchers found that angiogenesis-1 from platelet sources is essential to prevent leakage caused by neutrophilsinteresting, blocking angiogenic hemophilia factor (VWF) can cause blood vessels to leak plasma during white blood cell migration, suggesting that the interaction between platelets and endothelial VWF activates Tie-2 by secreting angiogenesis-1, thereby preventing plasma leakage induced by blood cell omelet
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