Blood: Aging-induced IL27Ra signal can damage hematopoietic stem cells
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Last Update: 2020-06-24
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Source: Internet
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Author: User
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Hematopoietic stem cell (HSC) aging is associated with bone marrow growth-related diseases and an increased risk of immune agingIn the study, researchers found that aging-related inflammatory responses can promote the aging process of HSC through the TNF alpha/ERK/ETS1/IL27Ra signaling pathwayduring aging, the expression level of TNf alpha, a well-known inflammatory biomarker, increases, and the expression of IL27Ra in HSC is induced through the ERK/ETS1 signaling pathwayKnocking out the expression of IL27Ra can save the functional decline of HSC and bone marrow differentiation bias, and reverse the inhibition of TNf alpha on HSCThe proportion of myelin differentiation bias HSC decreased in the aged mice that IL27Ra had knocked out, while in wild mice there was no changeCompared to IL27Ra-HSC, IL27Ra-HSC has impaired reconstruction capacity and bone marrow differentiation bias, and can be used as a myelin recovery bank after inflammation damageIn addition, inflammatory-related genes are enriched in IL27Ra-HSC, and their expression levels increase with agestudies have shown that the aging-induced IL27Ra signaling pathway can cause harmful effects on hematopoietic stem cells, and increase the interference with the IL27Ra pathway provides potential treatment opportunities when it comes to combating the harmful effects of the aging process on hematopoietic function
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