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Blood: Different effects of platelet protein S in venous thrombosis

 Last Update: 2020-06-24
 Source: Internet
 Author: User

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plasma platelets

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Anticoagulant S (PS) in platelets (PSplt) is similar to plasma PS and is released when platelets are activated;in this study, the researchers innovated the mouse PSplt with Pf4-Cre genetically modified (pro1-lox/loxPf4-Cre-
) and promoted thrombosis in the shear-like veins, without affecting the neckartes with high shearing ratesshear rate is low, PSplt acts as a cofactor of activated protein C and hertogenic pathway inhibitors, limits the activation of X-factor seofs in growth thrombosis, and ensures that highly activated platelets and fibrin are confined to the damage siteAt high concentrations of coagulase, blood clots from pro1-lox/loxPf4-Cre-
mice contract, while blood clots from pro1lox/loxPf4-Cre-
mice do not contract because of the high density of the fibrin networkso PSplt regulates platelet activation and clotting in large vein thrombosis, which is not the case in aorta thrombosis

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