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Blood: Platelet-VWF prevents plasma leakage when heyyertic cells seepage by stimulating Tie-2
Time of Update: 2020-06-24
Neutrophil oozing requires opening the endothelial barrier in the blood vessel, but it does not automatically cause plasma leakage The shrunken actin wire surrounds the outer seepage of the blood ce
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Blood: Intestinal microbiome triamine N-oxide aggravates GVHD by inducing M1 macrophage polarization
Time of Update: 2020-06-24
The diversity of the human microbial community indicates the difference in the effects of intestinal microbial metabolites on allogeneic transplants for host disease (GVHD), although short-chain fat
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Blood: Single-cell sequencing reveals developmental trajectory from endothelial cells to hematopoietic stem cell precursors
Time of Update: 2020-06-24
Hematopoietic stem cells and progenitor cells (HSPCs) in bone marrow are derived from a small group of hematal endothelial cells (HE) in the aorta of mammalian embryos He cells undergo transformatio
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Blood: Pharmacokinetics, Efficacy and Safety of Oral Cedazuridine/Tisitabin Therapeutics MDS and CMML
Time of Update: 2020-06-24
This study is a Phase 2 clinical trial designed to compare the exposure, demethylation activity and safety of the cedazuridine 100mg/Ditathabin 35mg and standard Sitabin 20mg/m2(IV) treatment for th
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CC-486 Treatment of Acute Myeloid Leukemia: FDA Grants Priority Review
Time of Update: 2020-06-24
Bristol Myers Squibb recently said the FDA has granted CC-486 priority review rights for the treatment of acute myeloid leukemia (AML) in adults The award was based on the results of the QuaZAR AML-
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Blood: Mitochondrial vector homologous gene MTCH2 is essential for AML survival
Time of Update: 2020-06-24
Center point: inhibition of MTCH2 can increase the levels of acetone acid and PDH in the nucleus, resulting in AML differentiation and loss of transplant potential this study defines a new mecha
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Linemycin D nanoparticles for the treatment of acute myeloid leukemia
Time of Update: 2020-06-24
Tiziana, a biotech company focused on innovative therapies for inflammation, autoimmune and infectious diseases, recently announced that it had acquired all of rasna Pharmaceuticals' intellectual pr
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Blood: Multi-species RNA tomography sequence reveals origin of embryonic aortic microenvironment molecular regulation
Time of Update: 2020-06-24
Stem cells in a specific position in the niche through complex external regulation to regulate their fate, behavior and molecular characteristics, but its specific potential molecular mechanism is f
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Blood Adv: Increased infection after treatment with myelin HCT in patients with CR1 AML
Time of Update: 2020-06-24
It is estimated that the reduction of intensity/non-myelin therapy (RIC/NMA) for alloblastation (alloHCT) is low compared to myelin therapy (MAC); in the study of the International Blood and Bon
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Blood: Effects of arginine therapy on mitochondrial function during vascular closed pain in sickle cell disease in children
Time of Update: 2020-06-24
The mitochondrial function of sickle cell disease (SCD) changes, in part because of the low bioavailability of nitric oxide (NO) Arginine is the substrate that produces NO and becomes severely defic
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Gene therapy Valoctocogene Roxaparvovec For Severe Haemophilia A: Long-term Data Again Validates Effectiveness and Safety
Time of Update: 2020-06-24
BioMarin Pharmaceuticals recently announced that the gene therapy Valoctocogene Roxaparvovec for the treatment of severe haemophilia A's Open Label I/II study has yielded new results to be announced
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Blood: The role of the ECM-integrator receptor axis in the abnormal proliferation of primary bone marrow fibrosis macronuclear cells
Time of Update: 2020-06-24
Excessive accumulation of extracellular matrix (ECM) is a marker in primary bone marrow fibrosis (PMF) bone marrow (BM) environments Because cells have the ability to adhere to the surrounding ECM t
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1 case of Philadelphia chromosome after relapse of chromosomal negative acute myeloid leukemia in Philadelphia
Time of Update: 2020-06-24
MD-Ara-C solution solid 5 cycles, during the review of bone wear original infant single are less than 5%, flow cytokine detection of small residual leukemia (MRD) abnormal myeloid cells fluctuations in about 0.2%?
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Blood: High-throughput sequencing of immunoglobulin variable domainreveals reveals specific mutation map of POEMS syndrome
Time of Update: 2020-06-24
POEMS syndrome is a rare multi-system disease caused by plasma cell (PC) disorder the pathophysiological physiology of the disease remains However, the role of monoclonal immunoglobulin (Ig) light
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J Thromb Haemost: Recombinant human soluble thrombosis-regulated protein sepsis efficacy and safety in patients with sepsis-related clotting disorders
Time of Update: 2020-06-24
The efficacy and safety of the recombinant human soluble thrombosis-regulated protein (rhsTM) has not been clearly proven and its effects may depend on the presence or absence of sepsis-related clot
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Circulation: Potential relationship between white blood cell count levels and blood pressure!
Time of Update: 2020-06-24
Hypertension (BP) is a risk factor for cardiovascular disease incidence and mortality Although blood pressure is regulated by renal function, blood vessels and the sympathetic nervous system, recent
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NEJM: HLH-case reporting associated with diffuse TB
Time of Update: 2020-06-24
The patient was a 63-year-old man with chronic obstructive pulmonary disease (COPD) who went to the emergency department for fever, shortness of breath and confusion He had a six-month history of fa
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J Thromb Haemost: Relationship between platelet reduction and mortality in patients with COVID-19
Time of Update: 2020-06-24
Acute coronavirus 2019 (COVID-19) caused by Severe Acute Respiratory Syndrome (SARS-CoV-2) is spreading rapidly worldwide Platelet reduction in patients with COVID-19 has not been fully analyzed Rec
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Blood: Plasma particles affect endothelial cells differently when patients with sickle cell disease have different effects on endothelial cells
Time of Update: 2020-06-24
Particles (MPs) are submicron extracellular vesicles that can be detected in large quantities in the blood circulation of patients with sickle cell anemia (SS) Several studies have studied the biolo
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Blood: Anti-BMP6 antibody combined with EPO to treat chronic anemia!
Time of Update: 2020-06-24
Recombinant erythropoietin (EPO) and iron metabolites are standard treatments for anemia associated with chronic inflammation, including chronic nephrotic anemia A black box that warns of EPO therap