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The Safety of 6-Chloro-3-nitroimidazo[1,2-b]pyridazine
Time of Update: 2023-05-16
In addition to its potential cancer-causing effects, 6-chloro-3-nitroimidazo[1,2-b]pyridazine can also have other harmful effects on human health.
In addition to its potential cancer-causing effects, 6-chloro-3-nitroimidazo[1,2-b]pyridazine can also have other harmful effects on human health.
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A milestone in cell biology! A database of 200,000 cell images to understand our cellular building blocks
Time of Update: 2023-02-03
The composite average of cells that transformed the image on the screen showed 17 selected structuresA division of the Allen Institute, the Allen Institute for Cell Science, produced a digital description of the internal organization of human cells by processing hundreds of thousands of high-resolution images — a biological concept that has so far been very difficult to quantify.
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European Radiology: Radiographic, noninvasive grading diagnosis of mandibular squamous cell carcinoma
Time of Update: 2022-11-14
In A, the tumor is far away from the mandible canal (MC), while in B, the tumor appears to infiltrate the MCThis studyretrospectively included 24 patients with mandibular squamous cell carcinoma (SCC),eachof whom underwent MRI prior to surgery, including CS-3D-T1TFE and MDCT examinations.
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Differences between neurofibromatosis types 1 and 2
Time of Update: 2022-11-01
Research results NF1 is the most common and is considered a diagnostic feature with major clinical manifestations including café au lait spots, axillary or inguinal freckles, neurofibroma or plexiform neurofibromas, optic gliomas, Lisch nodules, and bone lesions such as sphenoid dysplasia.
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Studies have found that social isolation affects brain gene expression and is prone to tooth loss
Time of Update: 2022-10-26
This article is the original of Translational Medicine Network, please indicate the source of reprintingAuthor: kopeStudies have shown that social isolation directly causes structural changes in the brain associated with memory, reduces brain volume, and is associated with a 26% increased risk of dementia.
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What is the efficacy and safety of the first-line treatment of metastatic lung cancer under the double exemption regimen
Time of Update: 2022-09-21
(If you need the original text, you can add Xiaobian WeChat yxj_oncology to obtain) 1Jounal of Thoracic Oncology: Navuliyumab plus ipicumab has good safety and efficacy as a first-line treatment option for patients with metastatic non-small cell lung cancer▎ Clinical issues: The safety outcomes of navuliyuzumab plus ipicumab as a first-line treatment regimen in patients with metastatic non-small cell lung cancer (NSCLC) and the efficacy outcomes after discontinuation due to treatment-related adverse events (TRAEs) are unclear.
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Hepatology Shanghai Jiaotong University Wang Xiaoping's team develops new method to alleviate copper accumulation in a mouse model of hepatolenticular degeneration
Time of Update: 2022-04-28
On March 27, 2022, Wang Xiaoping's team from Shanghai Jiao Tong University published a research paper online in Hepatology (IF=17) entitled "ATP7B gene therapy of autologous reprogrammed hepatocytes alleviates copper accumulation in a murine model of Wilson's disease".
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Eur Urol Oncol: Immune milieu and differentiation signatures predict bladder cancer outcome
Time of Update: 2022-04-23
Determined whether immune cell subsets and cancer cell intrinsic characteristics are associated with BC outcome and response to first-line chemotherapyThe researchers used multiplex immunofluorescence (CD3, CD8, FOXP3, CD20, CD68, CD163 and MHC-I) and immunohistochemistry (pancytokeratin, CK5/6, GATA3, PD-1 and PD-L1) on 785 BC patients ( Ta-T4b) primary tumor tissue was examined, and the staining results of the cancerous and stromal portions of the tumor were quantified by digital image analysis .
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3D-engineered human tissue successfully restores walking ability in chronically paralyzed mice for the first time
Time of Update: 2022-03-08
Tal Dvir and Lior Wertheim [Sagol Centre for Regenerative Biotechnology]Dvir said: "This is the world's first example of an animal model implanted with engineered human tissue that has a restorative effect on long-term chronic paralysis, the most relevant model for the treatment of paralysis in humans .
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Immunity Feng Jue et al. used clonal lineage tracing to reveal the common origin of traditional dendritic cells and plasmacytoid dendritic cells
Time of Update: 2022-03-06
Clonal lineage tracing reveals shared origin of conventional and plasmacytoid dendritic cells.
This coupled with CITE-Seq analysis of differentiated hematopoietic stem cells and Cx3cr1+ progenitors identified progressive stages of pDC development including Cx3cr1+ Ly-6D+ pro-pDCs distinct from lymphoid progenitors .
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Clin Cancer Res: Cabozantinib Monotherapy for Advanced Soft Tissue Sarcoma
Time of Update: 2022-02-20
High levels of activated MET receptors have been reported in various sarcoma cell lines, coupled with elevated vascular endothelial growth factor (VEGF) levels in patients with STS, suggesting the use of the multi-receptor tyrosine kinase inhibitor cabozantinib Dual targeting of the VEGF and MET pathways by nisin would yield clinical benefit in this population .
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New function of the old protein: tBID can directly trigger cell death
Time of Update: 2021-12-24
" Garcia-Saez said: "For example, when other known apoptosis signaling pathways fail or lack the protein that executes it, activation of tBID may induce cell apoptosis.
In Shigella infections, proteins that normally induce apoptosis are not activated .
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A few milliliters of urine for non-invasive and accurate diagnosis of bladder cancer
Time of Update: 2021-11-01
Chen Hai-ge team for the first time revealed the urine samples of patients with urothelial bladder cancer in urine tumor DNA (utDNA) demonstrated tumor DNA (tDNA) multidimensional consistency degrees, while developed based on TP53, KDM6A, FGFR3, PIK3CA The precise detection kit developed by five genes including ARID1A and ARID1A is expected to be an effective method for early risk classification, dynamic tumor monitoring, detection of small residual lesions, and individualized precision treatment for patients with bladder cancer .
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Whole-grain foods can prevent colorectal cancer
Time of Update: 2021-10-21
A recent report by the World Cancer Research Fund and the American Cancer Institute pointed out that foods containing dietary fiber, especially whole grains, can reduce the risk of CRC .
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Baoyuan Pharmaceutical and Cinda Bio-Announce Phase 2 Clinical Data of ROS1/NTRK Inhibitors
Time of Update: 2021-10-11
At this conference, Baoyuan Pharmaceutical and Innovent announced the interim data of a new generation of ROS1/NTRK inhibitor taletrectinib for the phase 2 trial of ROS1-positive non-small cell lung cancer (NSCLC) in the form of the conference theme report .
