Blood: Multi-species RNA tomography sequence reveals origin of embryonic aortic microenvironment molecular regulation
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Last Update: 2020-06-24
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Source: Internet
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Author: User
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Stem cells in a specific position in the niche through complex external regulation to regulate their fate, behavior and molecular characteristics, but its specific potential molecular mechanism is far from fully clarifiedTo explore the molecular characteristics and key components of the aortic microenvironment, where the first hematopoietic stem cells (HSCs) were produced during embryonic development, the researchers sequenced genome-wide RNA tomography of zebrafish, chickens, mice, and human embryosthe resulting pre-rear and back-to-abdominal transcription maps provide a powerful resource for studying active genes and regulatory pathways in the aortic microenvironmentBy comparing RNA-seq analysis and functional assays between species, the researchers explored the complexity of the aortic microenvironment spectrum and the fine-tuning of the time and space in the body that control the production of HSC, including ligand receptors ADM-RAMP2 and SVEP1understanding of the regulatory function of the local environment will pave the way for improved in vitro production of stem cells and clinical cell therapy
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