Circulation: Potential relationship between white blood cell count levels and blood pressure!

Hypertension (BP) is a risk factor for cardiovascular disease incidence and mortalityAlthough blood pressure is regulated by renal function, blood vessels and the sympathetic nervous system, recent experimental data suggest that immune cells may play a role in high blood pressurestudy looked at the relationship between major types of white blood cells and blood pressurethe fiveth digits of lymphocyte, mononucleoblast ational, and neutrophil counts are positively correlated with systolic, diastolic pressure, and pulse pressure increases (e.g., corrected systolic pressure for lymphocytes, mononucleosis, and neutrophil counts: 1st digit vs 5th position: 140.13-0 .08 vs 141.62?0.07 mmHg, 139.51-0.08 v, s 141.84-0.07 mmHg, 137.96?0.08 vs 142.71-0.07 mmHg)Using 121 single nucleotide polymorphisms in Mendel Randomization (MR), the researchers determined the potential causal relationship between lymphocyte count and systolic and diastolic pressure, consistent with the observed resultsThe exclusion of the SH2B3 gene rs3184504 bit SNP weakened the amplitude of some signals in the MR analysisReverse MR found that the BP index had a positive effect on the count of mononucleoblasts, neutrophils, and eostophilic granulocytes, while there was no positive effect on lymphocytes and alkaline granulocyte countsSubsequently, in the genetic background associated with renal function or resting and post-exercise heart rate, the lymphocyte count was mr-tested and a positive correlation between lymphocyte count and urinary albumin-creatinine ratio was foundobservations and genetic analysis showed a consistent positive potential causal relationship between lymphocyte count and systolic and diastolic pressure