Cell Metab: Lactic acid regulates muscle ischemia
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Last Update: 2020-06-24
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Source: Internet
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Author: User
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Endothelial cells (EC) produce signals that help organs regenerate, but there have been reports of metabolic communication within blood vesselsrecently, researchers found that EC-specific glycoenzyme regulator pfkfb3 can alleviate the damage to ischemic revascularization and muscle regenerationThis is due to the reduced ability of macrophages to take primary vascular and primary regenerative M2-like phenotypesthe mechanism, the loss of pfkfb3 reduced lactic acid secreted by ECs and reduced lactic acid levels in ischemic musclesAdding lactic acid to the pfkfb3 defect of ECs restores M2 polarization of MCT1 dependenceECs that supply lactic acid enable macrophages to promote the proliferation and fusion of muscle progenitor cellsIn addition, the production of VEGF for lactate-polarized macrophages increases, resulting in a positive feedback loop that further stimulates angiogenesisfinally, increasing lactic acid levels during ischemia can save macrophages from differentiation and improve muscle reperfusion and regeneration, while macrophage-specific mct1 deletion prevents M2-like differentiation, ECs use glycoases to provide lactic acid for angioendocrine and guide muscle ischemia
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