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Nature Microbiology | Shandong University and other multi-unit cooperation, Wang Haibo and others found that calcium signal transduction is essential for the survival of Listeria
Time of Update: 2021-03-25
The research found Listeria monocytogenes (an intracellular bacterial pathogen) inhibits LC3-related phagocytosis (LAP) by regulating mitochondrial Ca2 + (mtCa2 +) signaling in order to survive in the cell.
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JGG | Identification of melanin-forming genes of Shimeji mushroom based on high-quality genome deciphering and population genetics
Time of Update: 2021-03-25
This study analyzed the chromosome-level genome of Shimeji mushroom for the first time, clarified the evolutionary position of Shimeji mushroom in the phylum Basidiomycota, and identified related genes that control the gray-white color of the strain.
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The 3D "blockbuster" is here: the new coronavirus turns out to be like this...
Time of Update: 2021-03-25
As early as September 15 last year, the international authoritative academic journal "Cell" published an online report of the Li Sai Laboratory of the School of Life Sciences of Tsinghua University and the Academician Li Lanjuan Research Group of the State Key Laboratory of Infectious Disease Diagnosis and Treatment of the First Affiliated Hospital of Zhejiang University School of Medicine.
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Nat Microbiol | Gao Xiang's group and others reveal the pathogenic mechanism of Salmonella effector protein SopD
Time of Update: 2021-03-25
On February 19, 2021, Gao Xiang's research group from the State Key Laboratory of Microbial Technology of Shandong University and Professor Jorge Galán from Yale University published an article The Salmonella effector protein SopD targets Rab8 to positively and negatively modulate the inflammatory response in Nature Microbiology.
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Researchers reveal that RNA virus polymerase has a characteristic region related to host adaptation
Time of Update: 2021-03-25
, PLoS Pathogens 2020), and in collaboration with the team of Wuhan Institute of Virology researcher Zhang Bo, systematically revealed the conformational diversity and conservation of NS5 and the molecular mechanism of MTase regulating RdRP (Li et al.
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A creature that feeds on hydrogen in the dark
Time of Update: 2021-03-25
. What is even more exciting for researchers is that the microbial communities under the glacier can combine hydrogen and carbon dioxide to produce more organic matter (ie biomass) through a chemical synthesis process.
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"Science" hot discussion: the genetic material of the new coronavirus will be inserted into the human genome!
Time of Update: 2021-03-25
They subsequently confirmed through in vitro cell line studies that part of the nucleic acid sequence of the new coronavirus can be integrated into the human genome based on the widespread LINE-1 retrotransposon in the human body or the HIV-1 reverse transcriptase in HIV-infected persons.
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The map of known mosquito vectors and their viruses in my country is completed
Time of Update: 2021-03-25
Recently, researchers from the Wuhan Institute of Virology, Chinese Academy of Sciences investigated all Chinese and English documents related to "mosquitoes" and "viruses" published from 1953 to 2019 in China, and extracted information such as mosquito species, virus types, distribution, and time, and created The first known comprehensive geographic information dataset of vector mosquitoes and viruses in my country.
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[Nature News] Blessed are those who love vegetarian food!
Time of Update: 2021-03-25
To help overcome the existing challenges associated with large-scale human research, the international research team launched the Individualized Response Study of Dietary Composition 1 (PREDICT 1) to study the interaction of diet-microbiome in metabolic health, a project involving individuals from the United States And British subjects.
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Nat Med | Liu Quan/Wang Wei/Qian Jun teamed up to discover a new species of Neiro virus-Songling virus
Time of Update: 2021-03-25
On February 18, 2021, Professor Liu Quan of Foshan University of Science and Technology, Dean Wang Wei of Inner Mongolia Forestry General Hospital and Professor Qian Jun of Zhongshan Medical College of Sun Yat-Sen University and other research teams jointly published an article Identification of a new orthonairovirus associated in Nature Medicine with human febrile illness in China.
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Nature Sub-Journal: How to isolate, cultivate and identify root bacteria with high throughput
Time of Update: 2021-03-25
On January 13, 2021, Nature Protocols magazine published an online research paper titled "High-throughput cultivation and identification of bacteria from the plant root microbiota" from the Baiyang Group of the Institute of Genetics and Development of the Chinese Academy of Sciences.
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Cell Review | Using CRISPR gene editing technology to analyze the biological problems of the new coronavirus
Time of Update: 2021-03-25
Scientists have obtained a large amount of information on the biology of SARS-CoV-2 based on the whole genome CRISPR-Cas9 screening method.
Finally, several host factors that help SARS-CoV-2 to leave the cell were also identified, such as phosphatidylinositol kinase (PIK3C3, PICfyve) and TMEM106B to allow the virus to leave the infected cell through exocytosis.
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Multi-group study methods of intestinal bacteria
Time of Update: 2021-03-25
Through microbial rRNA gene sequencing, metagenomics, macrotranscriptomics and non-targeted metabolomics and other methods, combined with the core strategy of "whole microbiome association analysis (MWAS)", it can accurately decode the composition spectrum, functional spectrum and Expression profile, excavate key biomarkers, and then clarify the complex interaction mechanism and causality between "bacteria-host-environment (ecosystem)".
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Intestinal flora research: from correlation to causality
Time of Update: 2021-03-25
Three studies published last year identified the role of certain key bacteria in aggravating/alleviating cancer and metabolic diseases through in vitro culture of intestinal microbes.
coli strain isolated from colorectal cancer (CRC) tissue can produce a gene toxin that induces human intestinal organoids to develop mutations similar to those of CRC patients.
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Small cells, big impact: RNA-protein complexes in cyanobacteria
Time of Update: 2021-03-25
Scientific question: What are the RNA-binding proteins involved in important post-transcriptional regulation processes in cyanobacteria that have not been clearly studied in other bacteria?
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The Chinese Academy of Sciences Institute of Microbiology has made progress in the study of new coronavirus binding to pangolin receptors
Time of Update: 2021-03-25
Recently, "Science Bulletin" published the article "The molecular mechanism of new coronavirus binding to pangolin ACE2 receptor" by the research team of the Institute of Microbiology, Chinese Academy of Sciences.
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The discovery and naming conventions of type VII toxin/antitoxin system | Cell Press Express Articles
Time of Update: 2021-03-25
Review article.
This article reports the discovery of type seven toxin/antitoxin (TA) and proposes the naming convention for type seven TA.
Researcher Wang Xiaoxue, the author, was invited to interpret the review article on the WeChat official account of Cell Press.
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Nature Sub-Journal: The Romance of the Three Kingdoms in Bacteria, not the survival of the strong
Time of Update: 2021-03-25
Unlike the perfectly balanced rock-scissors-cloth game where three species kill each other at equal speeds, they focus on describing an asymmetric system in which the relative competitive advantage between each predator-prey pair is different.
Using their three-strain ecology, they experimentally proved that the weakest species is the most likely to win an evenly distributed rock-cloth-scissors game.
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The RNA virus polymerase revealed by Wuhan virus has a characteristic region related to host adaptation
Time of Update: 2021-03-25
Gong Peng’s team, a researcher at the Wuhan Institute of Virology, Chinese Academy of Sciences, has long been engaged in the study of the catalysis and regulation mechanism of viral RdRP.
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Bacteria + Yeast =?
Time of Update: 2021-03-25
Recently, researchers from Imperial College and Massachusetts Institute of Technology took inspiration from a fermented tea, developed a new method of making these living materials, and created "living substances" that can be used to purify and filter water.
