-
Categories
-
Pharmaceutical Intermediates
-
Active Pharmaceutical Ingredients
-
Food Additives
- Industrial Coatings
- Agrochemicals
- Dyes and Pigments
- Surfactant
- Flavors and Fragrances
- Chemical Reagents
- Catalyst and Auxiliary
- Natural Products
- Inorganic Chemistry
-
Organic Chemistry
-
Biochemical Engineering
- Analytical Chemistry
- Cosmetic Ingredient
-
Pharmaceutical Intermediates
Promotion
ECHEMI Mall
Wholesale
Weekly Price
Exhibition
News
-
Trade Service
The new crown epidemic is raging around the world.
How did a small virus infect nearly 100 million people around the world? For the first time, an international team including Chinese researchers "shooted" a 3D image of the new coronavirus.
On the nano-scale images, the new coronavirus with an average diameter of less than 100 nanometers is like a strange planet, with spike protein "tentacles" that can swing freely on its surface.
Inside the "planet", ultra-long ribonucleic acid (RNA) strands are densely wound on an ordered ribonucleoprotein complex (RNP).
On January 21, this high-definition science image of the new crown virus, which is a collaboration between the Lisay Laboratory of the School of Life Sciences of Tsinghua University, Nanographics of Austria, and Ivan Viola of King Abdullah University of Science and Technology in Saudi Arabia, came out.
For humans, the new coronavirus is a "familiar and unfamiliar" existence.
It belongs to the same family of coronaviruses as the severe acute respiratory syndrome (SARS) coronavirus and the Middle East respiratory syndrome (MERS) coronavirus.
It is the third type of coronavirus that has caused large-scale human infections in the past 18 years.
The new coronavirus mainly infects the human body through the binding of the spike protein spike on the surface of the virus to the human ACE2 receptor.
The spike protein is like a "key", and the ACE2 receptor on the cell is like a "lock".
When the key opens the lock, the virus can enter the cell.
The main goal of developing a new crown vaccine is also to prevent the key from opening the lock to prevent the virus from infecting cells.
The latest 3D images show the process of the new coronavirus invading human cells: at the moment of invasion, the new coronavirus binds to the receptor and fuses with the cell membrane.
Li Sai's research team introduced to reporters on the 23rd that the study found that the spike protein is flexible and can swing freely on the surface of the virus like a chain hammer.
The swinging characteristics of the spike protein will make the new coronavirus more flexible when attacking cells, which is conducive to the binding of the spike protein to the ACE2 receptor on the cell.
The video image shows the angle between the spike protein and the tangent perpendicular to the new coronavirus membrane, and the angle range of the spike protein swinging on the surface of the virus membrane.
As early as September 15 last year, the international authoritative academic journal "Cell" published an online report of the Li Sai Laboratory of the School of Life Sciences of Tsinghua University and the Academician Li Lanjuan Research Group of the State Key Laboratory of Infectious Disease Diagnosis and Treatment of the First Affiliated Hospital of Zhejiang University School of Medicine.
Results of cooperation.
They successfully analyzed the three-dimensional structure of the new coronavirus by using cryo-electron microscopy tomography and sub-tomographic average reconstruction technology.
This research result provides the basis for the latest 3D virus popular science images.
A cryo-EM image of the new coronavirus inactivated by paraformaldehyde (photo courtesy of Li Sai's laboratory) In the laboratory of Tsinghua University, the inactivated new coronavirus is placed under a cryo-EM, and a photo is taken every 3° rotation.
Taking 41 pictures, and then performing three-dimensional reconstruction, is like doing a "whole body CT examination" for a virus.
The team also "strikes a flashlight" to the inside of the virus, passing through the envelope, clearly illuminating the arrangement of ribonucleoprotein complexes inside the virus, showing the most complete image of the new coronavirus so far.
Cryogenic transmission electron microscope is currently a scientific research tool widely used in structural biology.
It uses electrons as a "light source" to penetrate virus samples to obtain structural information inside the virus.
The three-dimensional fine structure of the whole virus of the inactivated new coronavirus (photo courtesy of Li Sai Laboratory) Based on the virus structure analyzed by cryo-electron microscope tomography and sub-tomographic average reconstruction technology, the international research team used 3D rendering technology to create a fine 3D image of the new coronavirus.
Let us get a glimpse of the inside and outside of the virus.
However, it should be noted that the contrasting colors of the virus in the video do not represent the true colors, but the effect of 3D rendering.
The analysis of the structure of the new coronavirus has also made the development of vaccines and neutralizing antibodies more "targeted.
"
For example, the Li Sai team observed that the spike protein on the surface of the new coronavirus is randomly distributed and in a variety of states.
Such a complex antigen distribution makes it necessary to consider the specific distribution and structure of the spike protein on the surface of the virus when developing vaccines and neutralizing antibodies.
Li Sai told reporters that some institutions had released some hypothetical 3D models of the new coronavirus, but there were a lot of errors, such as the distribution of the spike protein and the overall proportion of the virus.
The research team hopes that every detail of the image of the virus can respect the cutting-edge scientific discoveries of the virus.
Photo of Li Sai’s team (photo courtesy of Li Sai’s laboratory) In August last year, after seeing the scientific research results submitted by Li Sai’s laboratory on the life science preprint paper platform bioRxiv, the computer vision team of King Abdullah University of Science and Technology in Saudi Arabia Proactively contact, hoping to jointly create more scientific and realistic new coronavirus science images.
The two parties hit it off, using their structural biology, virology expertise, and image processing and programming advantages, after months of long-distance communication, the real 3D image of the virus was constructed, and the video was finally produced by the Austrian Nanographics company.
"This is not a result that can publish papers, but the original intention for us to spend so much time producing these new coronavirus image materials is to show the true image of the virus and provide it to the world for free as an epidemic prevention and control propaganda and science education material.
"Li Sai said that in some countries there are still people questioning the real existence of the new crown virus.
These images will be scientific evidence to prove the existence of the virus. Top 101 hot articles in 2019.
The big cow who has reversed type 2 diabetes has published another article: Type 2 diabetes is a simple disease, lose weight or reverse the condition! 2.
Just now, Science released the top ten scientific breakthroughs in 2019! 3.
Science is heavy! Broccoli "awakens" anti-tumor genes 4.
Readers' tears! "The Lancet" published a Chinese medical doctor's "Family Letter" in Chinese: A Letter to Father 5.
"Science" is heavy! Your "honey", my "arsenic.
.
.
" 6.
Drink alcohol, especially those who are still blushing, or face a higher risk of dementia 7.
Nature is heavy! The first completely synthetic creature that completely changed the DNA code was born 8.
This is not a big hazelnut! Science has published a new type of oral insulin, or it will replace traditional injections 9.
Science's anti-balding tips: start with no hair loss.
.
.
10.
Can changing sperm speed affect the sex of the offspring?
How did a small virus infect nearly 100 million people around the world? For the first time, an international team including Chinese researchers "shooted" a 3D image of the new coronavirus.
On the nano-scale images, the new coronavirus with an average diameter of less than 100 nanometers is like a strange planet, with spike protein "tentacles" that can swing freely on its surface.
Inside the "planet", ultra-long ribonucleic acid (RNA) strands are densely wound on an ordered ribonucleoprotein complex (RNP).
On January 21, this high-definition science image of the new crown virus, which is a collaboration between the Lisay Laboratory of the School of Life Sciences of Tsinghua University, Nanographics of Austria, and Ivan Viola of King Abdullah University of Science and Technology in Saudi Arabia, came out.
For humans, the new coronavirus is a "familiar and unfamiliar" existence.
It belongs to the same family of coronaviruses as the severe acute respiratory syndrome (SARS) coronavirus and the Middle East respiratory syndrome (MERS) coronavirus.
It is the third type of coronavirus that has caused large-scale human infections in the past 18 years.
The new coronavirus mainly infects the human body through the binding of the spike protein spike on the surface of the virus to the human ACE2 receptor.
The spike protein is like a "key", and the ACE2 receptor on the cell is like a "lock".
When the key opens the lock, the virus can enter the cell.
The main goal of developing a new crown vaccine is also to prevent the key from opening the lock to prevent the virus from infecting cells.
The latest 3D images show the process of the new coronavirus invading human cells: at the moment of invasion, the new coronavirus binds to the receptor and fuses with the cell membrane.
Li Sai's research team introduced to reporters on the 23rd that the study found that the spike protein is flexible and can swing freely on the surface of the virus like a chain hammer.
The swinging characteristics of the spike protein will make the new coronavirus more flexible when attacking cells, which is conducive to the binding of the spike protein to the ACE2 receptor on the cell.
The video image shows the angle between the spike protein and the tangent perpendicular to the new coronavirus membrane, and the angle range of the spike protein swinging on the surface of the virus membrane.
As early as September 15 last year, the international authoritative academic journal "Cell" published an online report of the Li Sai Laboratory of the School of Life Sciences of Tsinghua University and the Academician Li Lanjuan Research Group of the State Key Laboratory of Infectious Disease Diagnosis and Treatment of the First Affiliated Hospital of Zhejiang University School of Medicine.
Results of cooperation.
They successfully analyzed the three-dimensional structure of the new coronavirus by using cryo-electron microscopy tomography and sub-tomographic average reconstruction technology.
This research result provides the basis for the latest 3D virus popular science images.
A cryo-EM image of the new coronavirus inactivated by paraformaldehyde (photo courtesy of Li Sai's laboratory) In the laboratory of Tsinghua University, the inactivated new coronavirus is placed under a cryo-EM, and a photo is taken every 3° rotation.
Taking 41 pictures, and then performing three-dimensional reconstruction, is like doing a "whole body CT examination" for a virus.
The team also "strikes a flashlight" to the inside of the virus, passing through the envelope, clearly illuminating the arrangement of ribonucleoprotein complexes inside the virus, showing the most complete image of the new coronavirus so far.
Cryogenic transmission electron microscope is currently a scientific research tool widely used in structural biology.
It uses electrons as a "light source" to penetrate virus samples to obtain structural information inside the virus.
The three-dimensional fine structure of the whole virus of the inactivated new coronavirus (photo courtesy of Li Sai Laboratory) Based on the virus structure analyzed by cryo-electron microscope tomography and sub-tomographic average reconstruction technology, the international research team used 3D rendering technology to create a fine 3D image of the new coronavirus.
Let us get a glimpse of the inside and outside of the virus.
However, it should be noted that the contrasting colors of the virus in the video do not represent the true colors, but the effect of 3D rendering.
The analysis of the structure of the new coronavirus has also made the development of vaccines and neutralizing antibodies more "targeted.
"
For example, the Li Sai team observed that the spike protein on the surface of the new coronavirus is randomly distributed and in a variety of states.
Such a complex antigen distribution makes it necessary to consider the specific distribution and structure of the spike protein on the surface of the virus when developing vaccines and neutralizing antibodies.
Li Sai told reporters that some institutions had released some hypothetical 3D models of the new coronavirus, but there were a lot of errors, such as the distribution of the spike protein and the overall proportion of the virus.
The research team hopes that every detail of the image of the virus can respect the cutting-edge scientific discoveries of the virus.
Photo of Li Sai’s team (photo courtesy of Li Sai’s laboratory) In August last year, after seeing the scientific research results submitted by Li Sai’s laboratory on the life science preprint paper platform bioRxiv, the computer vision team of King Abdullah University of Science and Technology in Saudi Arabia Proactively contact, hoping to jointly create more scientific and realistic new coronavirus science images.
The two parties hit it off, using their structural biology, virology expertise, and image processing and programming advantages, after months of long-distance communication, the real 3D image of the virus was constructed, and the video was finally produced by the Austrian Nanographics company.
"This is not a result that can publish papers, but the original intention for us to spend so much time producing these new coronavirus image materials is to show the true image of the virus and provide it to the world for free as an epidemic prevention and control propaganda and science education material.
"Li Sai said that in some countries there are still people questioning the real existence of the new crown virus.
These images will be scientific evidence to prove the existence of the virus. Top 101 hot articles in 2019.
The big cow who has reversed type 2 diabetes has published another article: Type 2 diabetes is a simple disease, lose weight or reverse the condition! 2.
Just now, Science released the top ten scientific breakthroughs in 2019! 3.
Science is heavy! Broccoli "awakens" anti-tumor genes 4.
Readers' tears! "The Lancet" published a Chinese medical doctor's "Family Letter" in Chinese: A Letter to Father 5.
"Science" is heavy! Your "honey", my "arsenic.
.
.
" 6.
Drink alcohol, especially those who are still blushing, or face a higher risk of dementia 7.
Nature is heavy! The first completely synthetic creature that completely changed the DNA code was born 8.
This is not a big hazelnut! Science has published a new type of oral insulin, or it will replace traditional injections 9.
Science's anti-balding tips: start with no hair loss.
.
.
10.
Can changing sperm speed affect the sex of the offspring?
