A new strategy for light-controlled release of pyridine compounds proposed by chemistry

In recent years, Photoremovable Protecting Groups (PPGs) have been widely used in the fields of chemical biology and organic synthes.

Recently, Fang Xiaohong, a researcher at the Key Laboratory of Molecular Nanostructure and Nanotechnology, Institute of Chemistry, Chinese Academy of Sciences, has developed a new strategy to release pyridine by inhibiting intramolecular electron transfer in the photolysis of N-alkylpyridinium salt in aqueous soluti.

This photolysis reaction strategy has good universality, is suitable for most pyridine derivatives, imidazole and thiazole, and has high chemical yie.

Related results were published in "Germany Applied Chemistry", the first author of the paper is .

Introducing heavy atoms to improve the photolysis efficiency of N-alkylpyridinium salts

Indibulin, a tubulin polymerization inhibitor containing a pyridine structure, releases Indibulin in living cells to achieve its regulatory function