A two-dimensional supramolecular polymer based on organoplatinum metal macrocycle

Protein phosphorylation modification is an important type of post-translational modification, which regulates cell activity through phosphorylation/dephosphorylation modification and participates in a variety of biological processes
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The researchers first prepared a new type of supramolecular polymer with organoplatinum metal macrocycles as the core framework by combining metal coordination self-assembly and post-modification polymerization
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Figure 1.
The morphology of two-dimensional supramolecular polymers
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At the same time, thanks to the unique stimulus response performance of the polymer core skeleton (Figure 2) and the huge difference in binding ability with phosphorylated peptides before and after the response, the smart supramolecular polymer can achieve effective elution and elution of phosphorylated peptides.
Release
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Figure 2.
Stimulus response characteristics of two-dimensional supramolecular polymers (a) and its capture and release of phosphorylated peptides (bd)
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This work has opened up a new way for the design of phosphorylated proteomics enrichment materials
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