ACS Nano: Li Yaping's team from Shanghai Institute of Medicine found that light activated spatiotemporal controllable nanoparticles can effectively treat triple negative breast cancer metastasis

Three negative breast cancer (TNBC) has high heterogeneity There are a large number of mesenchymal cells with high metastatic capacity in its core and rapidly proliferating cells in its periphery There are significant differences in biological characteristics and drug sensitivity between these two types of cells At present, the conventional therapy is mainly to kill the rapidly proliferating cells, but it has little effect on the mesenchymal like cells, which is also one of the main reasons for the failure of clinical treatment of TNBC Under the guidance of researcher Li Yaping and associate researcher Zhang Pengcheng, Meng qingshuo and Meng Jia, graduate students of Shanghai Institute of pharmaceutical research, Chinese Academy of Sciences, synthesized the photodynamic polymer ce6-pdoei, and formed polymer micelles by self-assembly with the chemotherapy drugs docetaxel (DTX) and dspe-peg5000, then adsorbed and compressed the anti twist on the surface through positive and negative charge action SiRNA, a kind of light driven and spatiotemporal controllable cdtn nanoparticles, was constructed PDT / CT / GT combined therapy (DOI: 10.1021 / acsno 7b09210) was initially realized for metastatic breast cancer The researchers found that cdtns remained stable in the blood circulation, achieved light activation after reaching the tumor and giving local light to the tumor In the superficial tumor tissue with enough light input, cdtns mainly killed the rapidly proliferating TNBC peripheral cells through PDT, and inhibited the metastasis of residual cancer cells through gt; while in the deep tumor tissue with weak light input, PDT effect weakened but promoted The function of DTX and twist siRNA lysosomal escape was enhanced By enhancing the killing effect of CT on TNBC cells and GT, the expression of twist protein in mesenchymal tumor cells was down regulated, killing tumor cells and inhibiting tumor metastasis The inhibition efficiency of tumor growth in situ and lung metastasis was more than 80% This study revealed the mechanism of cdtns against TNBC metastasis, and provided a new idea for the effective treatment of TNBC metastasis About the author: researcher Li Yaping