Angelw: Professor Deng Hexiang's team of Wuhan University has developed a rapid urinalysis nano paper based on MOF molecular forceps

The international authoritative journal angelwandte Chemie International Edition (German Applied Chemistry) online published the new research results of Deng Hexiang, Professor of School of chemistry and molecular science, Wuhan University, who created molecular tweezers in MOF (metal organic framework) structure The nano test paper based on the molecular tweezers can be used for rapid urinalysis In traditional coordination chemistry, the spatial geometry of metal complexes often changes with the change of organic ligands According to the crystal state and porous properties of MOF materials, the research team replaced four linked organic ligands with one three linked and one single linked organic ligand Due to the fixed position of metal building units in the net weight of MOF, three linked organic ligands and single linked ligands can achieve one-to-one correspondence, just like pliers, which can precisely coordinate the metals entering into their holes Three linked ligands are used to coordinate the active metal introduced into MOF, similar to the fixed part of pliers; while the length and functional group of single linked ligands can be easily changed, so as to affect the coordination ability of the introduced active metal through the steric effect and weak molecular force, just like the active part of pliers Therefore, it is the first time to realize the precise adjustment of coordination bond length without changing the geometry of metal coordination space Based on this method, a series of molecular tweezers MOF materials with different coordination environments were synthesized by changing the ratio of three and four ligands and selecting different single ligands These molecular tweezers can coordinate with a variety of metal ions, including Mg 2 +, Al 3 +, Cr 3 +, Mn 2 +, Fe 3 +, CO 2 +, Ni 2 +, Cu 2 +, Zn 2 +, Ag +, Cd 2 + and Pb 2 +, and can adjust the coordination constants in a large range (kobs from 1.56 × 102 to 1.70 × 104 lmol-1) This kind of MOF containing molecular tweezers can be used to accurately detect cysteine, homocysteine and glutathione, which are closely related to human health, and the detection limit is as low as 22.4 nmol It is worth noting that these highly customized molecular tweezers have good recognition performance, and their efficient detection is not interfered by water or body fluids (such as urine) The team has successfully developed low-cost test paper for urine detection and applied for related patents through nano-sized MOF materials These test papers are easy to carry and preserve, can instantly determine whether the mercapto amino acid is over the standard, and can be repeatedly used after being washed by alcohol, which is very suitable for health detection in remote and poor areas The title of this paper is "molecular vise approach to create metal - binding sites in MOFs and detection of biomarkers" (DOI: 10.1002 / anie 201803201) Deng Hexiang, the corresponding author, is a professor of Wuhan University College of chemistry, Wang Yang, a doctoral student, and Liu Qi, a postdoctoral student, are the co first authors of this paper, while other authors include Zhang Qin, a 2014 undergraduate, and Peng Bosi, a 2013 undergraduate The research was supported by the youth thousand talents program of the Central Organization Department, key research projects, cultivation projects, general projects of the Fund Committee, key projects of Hubei Province, innovation team of Wuhan University and key post doctoral projects of Wuhan University.