Angelw: the Institute of chemistry of the Chinese Academy of Sciences has made important progress in the controllable assembly and functionalization of short peptides

As a component of protein in organism, short peptide has the characteristics of strong self-assembly, easy modification and structural diversity, and its assembly has significant application potential in biomedicine In recent years, phenylalanine dipeptide has been widely concerned because of its strong self-assembly ability and its unique photoelectric properties as a biological assembly body With the support of NSFC, the Ministry of science and technology and the Chinese Academy of Sciences, the researchers of the Key Laboratory of colloid, interface and chemical thermodynamics of the Institute of chemistry have been committed to the research of molecular self-assembly and functional regulation of phenylalanine dipeptide for a long time, and made a series of research progress In recent years, they have developed two new methods to precisely control the arrangement of ultra long dipeptide single crystal fibers, which lays an important foundation for the construction of peptide based optoelectronic devices At the same time, it was found that the assembly of dipeptide can effectively induce the assembly and disassembly of liposomes in vivo, and lead to the overflow of cell membrane and the formation of endoplasmic reticulum under physiological conditions Through cryogenic liquid nitrogen freezing / thawing cycles, it was found that the nanofibers formed by phenylalanine two peptide could be transformed into highly ordered single crystals, and could enhance the chiral signal and fluorescence emission of the system Recently, the Li Junbai research team has directly introduced appropriate amount of light acid molecules in the phenylalanine two peptide organic gel system through the pion piling process, and achieved the in situ reversible transformation of the two peptide assembly gel sol by visible light irradiation, which provided a new idea for the application of short peptide molecular assembly gel Relevant research results were published in angelw Chem Int ed (DOI: 10.1002 / ange 201711547) Corresponding author: researcher Li junbai