Awareness and control of allergenic chemicals (5)

6.

According to the national standard "Chemical Skin Sensitization Test Method" (GB/T21608-2008) and the national occupational health standard "Chemical Toxicology Evaluation Procedure and Test Method Part 7: Skin Sensitization Test" (GBZ/T240.

(1) Allergenic chemicals containing halogen elements

1.

Halogen-containing inorganic compounds, such as PBr ₃ (sensitization and corrosion), Br ₂ (sensitization and corrosion), POCl ₃ , RuCl ₃ and so on

2.

Halogen-containing organic reagent, such as of NBS ( N-bromosuccinimide ), chloro (bromo) acetonitrile, nitrogen mustards, of DAST (diethylaminosulfur trifluoride) and the like

3.

1) Compounds substituted with halogen at the α position

α-halogenated derivatives of aldehydes, ketones, acids and esters, such as

2) Compounds in which the allyl and benzylic positions are substituted by halogen

Compounds in which the allylic position is substituted by halogen, such as

Compounds in which the benzylic position of the aromatic ring or heterocyclic ring is substituted by halogen, such as

Many allergic symptoms indicate that in the above structure, the sensitization effect of the bromine-substituted compound is stronger than the sensitization effect of the corresponding chlorine-substituted compound

4.

For five-membered or six-membered heterocyclic aromatic compounds that comply with the Huckel rule, if the ring of these compounds contains halogens (C1, Br, I), they will be strongly sensitized to the human body, and strict isolation protection is required.

1) Halides of five-membered aromatic heterocycles

Single or multiple heteroatoms five-membered aromatic heterocycles and fused five-membered aromatic heterocycles are substituted by halogens, which may exhibit sensitization, such as

2) Halogenation of six-membered aromatic heterocyclic ring

Including the following six-membered mono- or poly-nitrogen aromatic heterocycles, as well as fused six-membered aromatic heterocycles, these series of six-membered aromatic heterocyclic compounds, once the ring is substituted by a halogen, may show sensitization, most of them compare Strong, such as

Including fused rings, the rule of thumb is that the more halogen substitutions of the same series of aromatic heterocyclic compounds, the stronger the allergenicity; brominated aromatic heterocyclic compounds are generally more sensitizing than the corresponding chlorinated aromatic heterocyclic compounds Much stronger, which may be caused by the chemical reactivity of brominated aromatic heterocycles than the corresponding chlorinated aromatic compounds, that is, in some cases, chemical reactivity is directly proportional to sensitization , This needs to be verified by further specialized research
.